Article ; Online: Clinical Diagnostic Value of Dkk-1 Level in Ankylosing Spondylitis: Comparison of Test Systems Based on Aptamers and Antibodies.
Bulletin of experimental biology and medicine
2022 Volume 173, Issue 3, Page(s) 317–321
Abstract: In ankylosing spondylitis, the pathological metabolism of the bone tissue is regulated by various proteins; of these, Dkk-1 protein, an antagonist of the Wnt-signaling pathway, is of particular interest. We compared the methods of Dkk-1 detection in the ... ...
| Abstract | In ankylosing spondylitis, the pathological metabolism of the bone tissue is regulated by various proteins; of these, Dkk-1 protein, an antagonist of the Wnt-signaling pathway, is of particular interest. We compared the methods of Dkk-1 detection in the blood serum of patients with ankylosing spondylitis (conventional ELISA and aptamer/antibody assay) and analyzed the relationship between Dkk-1 level and structural progression of ankylosing spondylitis and secondary osteoporosis. Dkk-1 levels in patients were significantly increased and depended on the stage of the disease, but not on the presence/absence of osteoporosis. Thus, Dkk-1 is a potential serum marker of progression of ankylosing spondylitis reflecting a tendency to structural progression of the disease before the appearance of radiographic changes. The results obtained by both methods practically coincided, which suggests good prospects for applying DNA aptamer-based test system. |
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| MeSH term(s) | Antibodies ; Biomarkers ; Humans ; Intercellular Signaling Peptides and Proteins ; Osteoporosis ; Spondylitis, Ankylosing/diagnosis ; Wnt Signaling Pathway | |||||
| Chemical Substances | Antibodies ; Biomarkers ; Intercellular Signaling Peptides and Proteins | |||||
| Language | English | |||||
| Publishing date | 2022-07-19 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 390407-6 | |||||
| ISSN | 1573-8221 ; 0007-4888 ; 0365-9615 | |||||
| ISSN (online) | 1573-8221 | |||||
| ISSN | 0007-4888 ; 0365-9615 | |||||
| DOI | 10.1007/s10517-022-05541-z | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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