LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Back to previous search Search history
Advanced search

Your last searches

  1. AU="Kuroiwa, Kiyoko"
  2. AU="Gabrys, Bogdan"
  3. AU="Wiznerowicz, Maciej"
  4. AU="Webby, Richard J"
  5. AU="Hubert Nielly"
  6. AU="Mueller, F."
  7. AU="Kumar, Pooja S"
  8. AU="Ejzak L."
  9. AU="Sisti, M"
  10. AU="White, B."
  11. AU=Gaeta Christopher
  12. AU="Zhou, Tony"
  13. AU=Haji Jumana Yusuf AU=Haji Jumana Yusuf
  14. AU="O'Neill, Anne"
  15. AU="Dima, Maria"
  16. AU="Hu, Jize"
  17. AU="Park, Eun Chan" AU="Park, Eun Chan"
  18. AU="Kwon, DeokKyu"
  19. AU="Szabo, Istvan Adorjan"
  20. AU="Pasdeloup, David"
  21. AU="Baikova, Olga Y"
  22. AU="Woo-Do Lee"
  23. AU="Dubouchaud, Hervé"

Search results

Result 1 - 3 of total 3

Search options

  1. Article ; Online: Fabrication of gold-calcium phosphate composite nanoparticles through coprecipitation mediated by amino-terminated polyethylene glycol.

    Nakamura, Maki / Oyane, Ayako / Kuroiwa, Kiyoko / Kosuge, Hisanori

    Colloids and surfaces. B, Biointerfaces

    2020  Volume 194, Page(s) 111169

    Abstract: Calcium phosphate (CaP) nanoparticles immobilizing gold (Au) nanocrystals (Au-CaP composite nanoparticles) would be useful in diagnoses and/or treatments with Au nanocrystals. In this study, we achieved the rapid one-pot fabrication of such nanoparticles ...

    Abstract Calcium phosphate (CaP) nanoparticles immobilizing gold (Au) nanocrystals (Au-CaP composite nanoparticles) would be useful in diagnoses and/or treatments with Au nanocrystals. In this study, we achieved the rapid one-pot fabrication of such nanoparticles via coprecipitation in labile supersaturated CaP solutions by using appropriate Au sources, namely, Au nanocrystals coated with amino-terminated polyethylene glycol (PEG). In this process, amino groups at the PEG terminal played a crucial role in the coprecipitation with CaP through affinity interactions, and thus in the formation of Au-CaP composite nanoparticles; however, the molecular weight of the PEG chain was not a controlling factor in the coprecipitation. The important role of the functional groups at the PEG terminal was suggested by comparison with Au nanocrystals coated with carboxyl- and methoxy-terminated PEG, both of which barely coprecipitated with CaP and failed to form Au-CaP composite nanoparticles. Au nanocrystals coated with amino-terminated PEG were immobilized on the CaP nanoparticles, thereby regulating their size (∼140 nm in hydrodynamic diameter) and their dispersion in water. This coprecipitation process and the resulting Au-CaP composite nanoparticles have great potential in biomedical applications.
    MeSH term(s) Calcium Phosphates ; Gold ; Metal Nanoparticles ; Nanoparticles ; Polyethylene Glycols
    Chemical Substances Calcium Phosphates ; Polyethylene Glycols (3WJQ0SDW1A) ; Gold (7440-57-5)
    Language English
    Publishing date 2020-06-02
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1500523-9
    ISSN 1873-4367 ; 0927-7765
    ISSN (online) 1873-4367
    ISSN 0927-7765
    DOI 10.1016/j.colsurfb.2020.111169
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: In vivo

    Nakamura, Maki / Kosuge, Hisanori / Oyane, Ayako / Kuroiwa, Kiyoko / Shimizu, Yoshiki / Aonuma, Kazutaka

    Nanotechnology

    2021  Volume 32, Issue 34

    Abstract: Atherosclerosis is a macrophage-related inflammatory disease that remains a leading cause of death worldwide. Magnetic iron oxide (IO) nanocrystals are clinically used as magnetic resonance imaging contrast agents and their application as a detection ... ...

    Abstract Atherosclerosis is a macrophage-related inflammatory disease that remains a leading cause of death worldwide. Magnetic iron oxide (IO) nanocrystals are clinically used as magnetic resonance imaging contrast agents and their application as a detection agent for macrophages in arterial lesions has been studied extensively. We recently fabricated heparin-modified calcium phosphate (CaP) nanoparticles loaded with a large number of IO nanocrystals via coprecipitation from a supersaturated CaP solution supplemented with heparin and ferucarbotran (IO nanocrystals coated with carboxydextran). In this study, we further increased the content of IO nanocrystals in the heparin-modified IO-CaP composite nanoparticles by increasing the ferucarbotran concentration in the supersaturated CaP solution. The increase in nanoparticle IO content caused a decrease in particle diameter without impairing its dispersibility; the nanoparticles remained dispersed in water for up to 2 h due to electrostatic repulsion between particles due to the surface modification with heparin. The nanoparticles were more effectively taken up by murine RAW264.7 macrophages compared to free ferucarbotran without showing significant cytotoxicity. A preliminary
    MeSH term(s) Administration, Intravenous ; Animals ; Atherosclerosis/drug therapy ; Atherosclerosis/etiology ; Calcium Phosphates/administration & dosage ; Calcium Phosphates/chemical synthesis ; Calcium Phosphates/chemistry ; Calcium Phosphates/pharmacology ; Dextrans/chemistry ; Disease Models, Animal ; Ferric Compounds/chemistry ; Magnetic Iron Oxide Nanoparticles/chemistry ; Magnetite Nanoparticles/chemistry ; Male ; Mice ; Nanocomposites ; RAW 264.7 Cells ; Streptozocin/adverse effects ; Treatment Outcome
    Chemical Substances Calcium Phosphates ; Dextrans ; Ferric Compounds ; Magnetite Nanoparticles ; ferric oxide (1K09F3G675) ; Streptozocin (5W494URQ81) ; calcium phosphate (97Z1WI3NDX) ; ferumoxides (G6N3J05W84)
    Language English
    Publishing date 2021-05-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 1362365-5
    ISSN 1361-6528 ; 0957-4484
    ISSN (online) 1361-6528
    ISSN 0957-4484
    DOI 10.1088/1361-6528/ac007d
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Facile one-pot fabrication of calcium phosphate-based composite nanoparticles as delivery and MRI contrast agents for macrophages.

    Nakamura, Maki / Oyane, Ayako / Kuroiwa, Kiyoko / Shimizu, Yoshiki / Pyatenko, Alexander / Misawa, Masaki / Numano, Tomokazu / Kosuge, Hisanori

    Colloids and surfaces. B, Biointerfaces

    2018  Volume 162, Page(s) 135–145

    Abstract: We developed a facile one-pot fabrication process for magnetic iron oxide-calcium phosphate (IO-CaP) composite nanoparticles via coprecipitation in labile supersaturated CaP solutions containing IO nanocrystals. All the source solutions used were ... ...

    Abstract We developed a facile one-pot fabrication process for magnetic iron oxide-calcium phosphate (IO-CaP) composite nanoparticles via coprecipitation in labile supersaturated CaP solutions containing IO nanocrystals. All the source solutions used were clinically approved for injection, including water and magnetic IO nanocrystals (ferucarbotran, used as a negative magnetic resonance imaging (MRI) contrast agent). This ensured that the resulting nanoparticles were pathogen- and endotoxin-free. The dispersants used were clinically approved heparin sodium (heparin) or adenosine triphosphate disodium hydrate (ATP), which were added to the IO-containing labile supersaturated CaP solutions. Both heparin and ATP coprecipitated with CaP and ferucarbotran to form heparin- and ATP-modified IO-CaP nanoparticles, respectively, with a hydrodynamic diameter of a few hundred nanometers. Both the resulting nanoparticles exhibited relatively large negative zeta potentials, caused by the negatively charged functional groups in heparin and ATP, which improved the particle dispersibility when compared to non-modified IO-CaP nanoparticles. The heparin-modified IO-CaP nanoparticles were effectively ingested by murine macrophages (RAW264.7) without showing significant cytotoxicity but barely ingested by non-phagocytotic human umbilical vein endothelial cells, indicating the potential of these nanoparticles for targeted delivery to macrophages. The heparin-modified IO-CaP nanoparticles exhibited a negative contrast enhancing ability for MRI. Our results show that IO-CaP nanoparticles have potential as delivery and MRI contrast agents for macrophages.
    MeSH term(s) Adenosine Triphosphate/chemistry ; Animals ; Biological Transport ; Calcium Phosphates/chemistry ; Contrast Media/chemistry ; Dextrans/chemistry ; Drug Carriers ; Ferric Compounds/chemistry ; Heparin/chemistry ; Human Umbilical Vein Endothelial Cells ; Humans ; Magnetic Resonance Imaging/methods ; Magnetite Nanoparticles/chemistry ; Mice ; Nanocomposites/chemistry ; Nanocomposites/ultrastructure ; Nanoparticles/chemistry ; Nanoparticles/metabolism ; Nanoparticles/ultrastructure ; RAW 264.7 Cells ; Species Specificity ; Static Electricity
    Chemical Substances Calcium Phosphates ; Contrast Media ; Dextrans ; Drug Carriers ; Ferric Compounds ; Magnetite Nanoparticles ; ferric oxide (1K09F3G675) ; Adenosine Triphosphate (8L70Q75FXE) ; Heparin (9005-49-6) ; calcium phosphate (97Z1WI3NDX) ; ferumoxides (G6N3J05W84)
    Language English
    Publishing date 2018-02-01
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1500523-9
    ISSN 1873-4367 ; 0927-7765
    ISSN (online) 1873-4367
    ISSN 0927-7765
    DOI 10.1016/j.colsurfb.2017.11.034
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top