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  1. Article ; Online: Association between urinary C-megalin levels and progressive kidney dysfunction: a cohort study based on the diabetes distress and care registry at Tenri (DDCRT 24).

    Niihata, Kakuya / Nishiwaki, Hiroki / Kinoshita, Maki / Kurosawa, Kentaro / Sakuramachi, Yui / Matsunaga, Satoshi / Okamura, Shintaro / Tsujii, Satoru / Hayashino, Yasuaki / Kurita, Noriaki

    Acta diabetologica

    2023  Volume 60, Issue 12, Page(s) 1643–1650

    Abstract: Aims: The aim of this cohort study was to evaluate the association between urinary levels of C-megalin, a full-length form of megalin, and kidney dysfunction progression and its dependence on the urinary albumin-creatinine ratio (UACR) in individuals ... ...

    Abstract Aims: The aim of this cohort study was to evaluate the association between urinary levels of C-megalin, a full-length form of megalin, and kidney dysfunction progression and its dependence on the urinary albumin-creatinine ratio (UACR) in individuals with diabetes.
    Methods: We enrolled 1,547 individuals with diabetes who visited the ambulatory clinic at Tenri Hospital, a regional tertiary-care hospital in Tenri City, Nara Prefecture, Japan, with an estimated glomerular filtration (eGFR) of ≥ 30 mL/min/1.73 m
    Results: Urinary C-megalin level was not associated with ≥ 40% eGFR decline in an age-, sex-, eGFR-, systolic blood pressure-, hemoglobin-, and UACR-adjusted model in the 1,547 patients enrolled in the study. However, urinary C-megalin levels were associated with a ≥ 40% decline in eGFR when accounting for the relationship between urinary C-megalin levels and UACR in the model. This association was UACR-dependent.
    Conclusions: High urinary C-megalin levels were associated with progressive kidney dysfunction in individuals with diabetes, and this association was attenuated by high UACRs.
    MeSH term(s) Humans ; Cohort Studies ; Low Density Lipoprotein Receptor-Related Protein-2 ; Diabetes Mellitus, Type 2/complications ; Kidney ; Registries ; Glomerular Filtration Rate ; Albuminuria/etiology ; Albuminuria/complications
    Chemical Substances Low Density Lipoprotein Receptor-Related Protein-2
    Language English
    Publishing date 2023-07-13
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1097676-0
    ISSN 1432-5233 ; 0940-5429
    ISSN (online) 1432-5233
    ISSN 0940-5429
    DOI 10.1007/s00592-023-02144-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 611: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Urinary C-megalin as a novel biomarker of progression to microalbuminuria: A cohort study based on the diabetes Distress and Care Registry at Tenri (DDCRT 22).

    Nishiwaki, Hiroki / Niihata, Kakuya / Kinoshita, Maki / Fujimura, Maki / Kurosawa, Kentaro / Sakuramachi, Yui / Takano, Kiyoko / Matsunaga, Satoshi / Okamura, Shintaro / Kitatani, Mako / Tsujii, Satoru / Hayashino, Yasuaki / Kurita, Noriaki

    Diabetes research and clinical practice

    2022  Volume 186, Page(s) 109810

    Abstract: Aims: Megalin is a multiligand receptor expressed in proximal tubular cells that reabsorbs filtered albumin and correlates cross-sectionally with albuminuria. We investigated the association between urinary C-megalin levels and the incidence of ... ...

    Abstract Aims: Megalin is a multiligand receptor expressed in proximal tubular cells that reabsorbs filtered albumin and correlates cross-sectionally with albuminuria. We investigated the association between urinary C-megalin levels and the incidence of microalbuminuria in patients with diabetes mellitus.
    Methods: This cohort study included 752 patients with type 1 or 2 diabetes mellitus and a urinary albumin-to-creatinine (Cr) ratio (UACR) within the normoalbuminuric range (<30 mg/g Cr). The association between urinary C-megalin and persistent microalbuminuria, accounting for the possible interaction between baseline UACR and urinary C-megalin, was estimated using a Cox proportional hazards model.
    Results: During a median follow-up period of 1.99 years, 179 cases of persistent microalbuminuria were observed. The association between urinary C-megalin and persistent microalbuminuria was UACR-dependent (P for interaction < 0.001), with the highest association observed in the absence of UACR (per 100 fM/gCr of urinary C-megalin: adjusted hazard ratio, 1.13; 95% CI 1.07-1.19), gradually decreasing as UACR increased to 30 mg/g Cr. UACR dependence was confirmed by sensitivity analyses according to low-normal (<10 mg/gCr) or high-normal (10-<30 mg/gCr) UACR.
    Conclusions: Urinary C-megalin is associated with progression to microalbuminuria, especially in those with low-normal UACR levels, and its usefulness to identify high risk patients requires further investigation.
    MeSH term(s) Albumins ; Albuminuria/urine ; Biomarkers ; Cohort Studies ; Creatinine/urine ; Diabetes Mellitus, Type 2/epidemiology ; Female ; Humans ; Low Density Lipoprotein Receptor-Related Protein-2 ; Male ; Registries
    Chemical Substances Albumins ; Biomarkers ; Low Density Lipoprotein Receptor-Related Protein-2 ; Creatinine (AYI8EX34EU)
    Language English
    Publishing date 2022-03-02
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 632523-3
    ISSN 1872-8227 ; 0168-8227
    ISSN (online) 1872-8227
    ISSN 0168-8227
    DOI 10.1016/j.diabres.2022.109810
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2047: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Production of insulin antibody associated with relapsed hodgkin's lymphoma.

    Ikeda, Masatoshi / Fujimura, Masaki / Kurosawa, Kentaro / Tsugawa, Shunsuke / Sakuramachi, Yui / Takano, Kiyoko / Okamura, Shintaro / Kitatani, Masako / Iioka, Futoshi / Tsujii, Satoru / Hayashino, Yasuaki

    Diabetology international

    2021  Volume 13, Issue 2, Page(s) 456–460

    Abstract: A 72-year-old man with type 2 diabetes mellitus with good glucose control for 20 years and maintained on oral hypoglycaemic agents was diagnosed with Hodgkin's Lymphoma (HL) and started on insulin glargine for glycaemic control. Despite increased doses ... ...

    Abstract A 72-year-old man with type 2 diabetes mellitus with good glucose control for 20 years and maintained on oral hypoglycaemic agents was diagnosed with Hodgkin's Lymphoma (HL) and started on insulin glargine for glycaemic control. Despite increased doses of insulin, his blood glucose levels went up dramatically. The anti-insulin antibody test proved to be positive, and Scatchard plot analysis showed 2 binding sites with relatively low-affinity constants:
    Supplementary information: The online version contains supplementary material available at 10.1007/s13340-021-00550-1.
    Language English
    Publishing date 2021-10-16
    Publishing country Japan
    Document type Case Reports
    ZDB-ID 2574501-3
    ISSN 2190-1686 ; 2190-1678
    ISSN (online) 2190-1686
    ISSN 2190-1678
    DOI 10.1007/s13340-021-00550-1
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  4. Article ; Online: Association of urinary C-megalin with albuminuria and renal function in diabetes: a cross-sectional study (Diabetes Distress and Care Registry at Tenri [DDCRT 21]).

    Kurita, Noriaki / Kinoshita, Maki / Fujimura, Maki / Kurosawa, Kentaro / Sakuramachi, Yui / Takano, Kiyoko / Okamura, Shintaro / Kitatani, Mako / Tsujii, Satoru / Norton, Edward C / Hayashino, Yasuaki

    Journal of nephrology

    2021  Volume 35, Issue 1, Page(s) 201–210

    Abstract: Background: A urinary biomarker sensitive to glomerular functional or structural changes in diabetic kidney disease is required. This study examined whether urinary C-megalin reflects renal function or albuminuria in diabetes.: Methods: This was a ... ...

    Abstract Background: A urinary biomarker sensitive to glomerular functional or structural changes in diabetic kidney disease is required. This study examined whether urinary C-megalin reflects renal function or albuminuria in diabetes.
    Methods: This was a cross-sectional study involving 1576 patients with type 1 or 2 diabetes. The exposure variables were estimated glomerular filtration rate (eGFR) and urinary albumin-to-creatinine ratio (UACR), and the outcomes were urinary C-megalin excretion and concentration. Two-part models were used to examine the associations between eGFR and UACR with urinary C-megalin excretion or concentration.
    Results: The UACR was linearly associated with urinary C-megalin excretion (per 100 mg/gCr of UACR; 11.8 fM/gCr [95% CI 8.9-14.7]). There was no association between decreasing eGFR and increasing urinary C-megalin excretion. The UACR was also linearly associated with the urinary C-megalin concentration (per 100 mg/gCr of UACR, 7.7 fM/L [95% CI 5.8-9.6]). At eGFR values > 60 mL/min/1.73 m
    Conclusion: Urinary C-megalin excretion as well as concentration levels are potentially useful biomarkers to detect early changes in diabetic kidney disease.
    MeSH term(s) Albuminuria/complications ; Albuminuria/etiology ; Creatinine/urine ; Cross-Sectional Studies ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/diagnosis ; Diabetic Nephropathies/diagnosis ; Diabetic Nephropathies/etiology ; Glomerular Filtration Rate ; Humans ; Kidney/physiology ; Low Density Lipoprotein Receptor-Related Protein-2 ; Registries
    Chemical Substances Low Density Lipoprotein Receptor-Related Protein-2 ; Creatinine (AYI8EX34EU)
    Language English
    Publishing date 2021-03-01
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 1093991-x
    ISSN 1724-6059 ; 1120-3625 ; 1121-8428
    ISSN (online) 1724-6059
    ISSN 1120-3625 ; 1121-8428
    DOI 10.1007/s40620-021-00995-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3369: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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