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  1. Article: A Case of Adult-Onset Still's Disease With Hypocomplementemia.

    Kurosawa, Yoichi / Takamura, Sayuri / Wakamatsu, Ayako / Kobayashi, Daisuke / Narita, Ichiei

    Cureus

    2024  Volume 16, Issue 1, Page(s) e52605

    Abstract: Adult-onset Still's disease (AOSD) causes fever, rash, pharyngalgia, and arthralgia through autoinflammation. Its complement titer has not previously received attention because this usually increases during the inflammatory process. Our female patient in ...

    Abstract Adult-onset Still's disease (AOSD) causes fever, rash, pharyngalgia, and arthralgia through autoinflammation. Its complement titer has not previously received attention because this usually increases during the inflammatory process. Our female patient in her 60s was admitted to the hospital with fever, rash, arthralgia, and pharyngalgia. Her white blood cell count was 19,130/μL, hemoglobin was 11.0 g/dL, platelet count was 26.0 × 10
    Language English
    Publishing date 2024-01-20
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.52605
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Japan Coma Scale and the Disorientation of the Nervous System.

    Saeki, Soichiro / Kurosawa, Yohei / Tomiyama, Koichiro

    Journal of epidemiology

    2023  Volume 33, Issue 10, Page(s) 543

    MeSH term(s) Humans ; Coma ; Japan ; Confusion ; Hospital Mortality
    Language English
    Publishing date 2023-01-31
    Publishing country Japan
    Document type Letter ; Comment
    ZDB-ID 1442118-5
    ISSN 1349-9092 ; 0917-5040
    ISSN (online) 1349-9092
    ISSN 0917-5040
    DOI 10.2188/jea.JE20220247
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4931: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Propionic Acid Groups and Multiple Aromatic Rings Induce Binding of Ketoprofen and Naproxen to the Hydrophobic Core of Bovine Serum Albumin.

    Tsurushima, Minori / Kurosawa, Yuya / Goto, Satoru

    Molecular pharmaceutics

    2023  Volume 20, Issue 7, Page(s) 3549–3558

    Abstract: Ketoprofen (KP), which causes photosensitivity by interacting with serum albumin (SA), and three drugs, ibuprofen (IBP), naproxen (NPX), and diazepam (DZP), which share the same binding site, were investigated for their interaction with bovine SA (BSA). ... ...

    Abstract Ketoprofen (KP), which causes photosensitivity by interacting with serum albumin (SA), and three drugs, ibuprofen (IBP), naproxen (NPX), and diazepam (DZP), which share the same binding site, were investigated for their interaction with bovine SA (BSA). For KP, DZP, and IBP, where drug-concentration-dependent quenching of BSA-intrinsic fluorescence was observed, a modified Stern-Volmer plot showed that dynamic quenching was dominant for KP and static quenching was dominant for DZP and IBP. However, this alone cannot be compared with NPX. Therefore, by performing singular value decomposition (SVD) fluorescence spectroscopy, we were able to find the behavior of the drug-concentration-dependent Langmuir-type principal component vectors.
    MeSH term(s) Serum Albumin, Bovine/chemistry ; Naproxen ; Ketoprofen ; Spectrometry, Fluorescence/methods ; Binding Sites ; Protein Binding
    Chemical Substances Serum Albumin, Bovine (27432CM55Q) ; Naproxen (57Y76R9ATQ) ; Ketoprofen (90Y4QC304K) ; propionic acid (JHU490RVYR)
    Language English
    Publishing date 2023-06-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2138405-8
    ISSN 1543-8392 ; 1543-8384
    ISSN (online) 1543-8392
    ISSN 1543-8384
    DOI 10.1021/acs.molpharmaceut.3c00169
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6250: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Elucidating the mechanisms of additive effects at high concentrations on hydrophobic interaction chromatography.

    Arakawa, Tsutomu / Tomioka, Yui / Kurosawa, Yasunori / Akuta, Teruo

    Journal of chromatography. A

    2023  Volume 1702, Page(s) 464091

    Abstract: Hydrophobic interaction chromatography (HIC) is a commonly used chromatography technique for purifying proteins. It utilizes salting-out salts to facilitate the binding of native proteins to weakly hydrophobic ligands. There have been three proposed ... ...

    Abstract Hydrophobic interaction chromatography (HIC) is a commonly used chromatography technique for purifying proteins. It utilizes salting-out salts to facilitate the binding of native proteins to weakly hydrophobic ligands. There have been three proposed mechanisms for the promoting effects of salting-out salts, which include the dehydration of proteins by salts, cavity theory, and salt exclusion. To evaluate the above three mechanisms, an HIC study was conducted on Phenyl Sepharose using four different additives. These additives included a salting-out salt (NH
    MeSH term(s) Humans ; Salts/chemistry ; Dehydration ; Chromatography/methods ; Proteins/chemistry ; Sodium Chloride/chemistry ; Polyethylene Glycols/chemistry ; Hydrophobic and Hydrophilic Interactions
    Chemical Substances Salts ; Proteins ; Sodium Chloride (451W47IQ8X) ; Polyethylene Glycols (3WJQ0SDW1A)
    Language English
    Publishing date 2023-05-25
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1171488-8
    ISSN 1873-3778 ; 0021-9673
    ISSN (online) 1873-3778
    ISSN 0021-9673
    DOI 10.1016/j.chroma.2023.464091
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 813: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Don't look back on failure: spontaneous uncertainty monitoring in chimpanzees.

    Tomonaga, Masaki / Kurosawa, Yoshiki / Kawaguchi, Yuri / Takiyama, Hiroya

    Learning & behavior

    2023  Volume 51, Issue 4, Page(s) 402–412

    Abstract: During computer-controlled cognitive tasks, chimpanzees often look up at the food dispenser, which activates at the same time as feedback for the correct choice but not for feedback for the incorrect choice. Do these "looking back" behaviors also ... ...

    Abstract During computer-controlled cognitive tasks, chimpanzees often look up at the food dispenser, which activates at the same time as feedback for the correct choice but not for feedback for the incorrect choice. Do these "looking back" behaviors also indicate signs of spontaneous monitoring of their confidence in their choices? To address this question, we delayed the feedback for 1 s after their choice responses and observed their look-back behaviors during the delay period. Two chimpanzees looked up at the food dispenser significantly less frequently when their choice was incorrect (but the feedback was not given) than when it was correct. These look-back behaviors have not been explicitly trained under experimental contexts. Therefore, these results indicate that chimpanzees spontaneously change the frequency of their look-back behaviors in response to the correctness or incorrectness of their own choices, even without external feedback, suggesting that their look-back behaviors may reflect the level of "confidence" or "uncertainty" of their responses immediately before.
    MeSH term(s) Animals ; Uncertainty ; Pan troglodytes/psychology ; Choice Behavior/physiology
    Language English
    Publishing date 2023-03-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2048665-0
    ISSN 1543-4508 ; 1543-4494
    ISSN (online) 1543-4508
    ISSN 1543-4494
    DOI 10.3758/s13420-023-00581-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Conditions of tumor-associated antigens as a proper target for therapeutic antibodies against solid cancers.

    Kurosawa, Y

    Journal of stem cells & regenerative medicine

    2011  Volume 7, Issue 1, Page(s) 14–28

    Abstract: Since the success of rituximab and trastuzumab for treatment of non-Hodgkin's lymphoma and breast cancer, respectively, a huge therapeutic potential of monoclonal antibodies (mAbs) was realized and development of therapeutic mAbs has been widely tried ... ...

    Abstract Since the success of rituximab and trastuzumab for treatment of non-Hodgkin's lymphoma and breast cancer, respectively, a huge therapeutic potential of monoclonal antibodies (mAbs) was realized and development of therapeutic mAbs has been widely tried against various cancers. However, the successful examples are still limited and therapeutic mAbs are not yet available for the majority of human cancers. We established a procedure for comprehensive identification of tumor-associated antigens (TAAs) through the extensive isolation of human mAbs that may become therapeutic. Thirty-twoTAAs have been identified and 555 mAbs that bound to one of the TAAs have been isolated to date. Now we are trying to select TAAs as proper targets for therapy and candidate mAbs as drugs from among them. The immunohistochemical analysis using many fresh lung cancer specimens suggested probabilities of proper targets, and moreover, presence of cancer-specific epitopes that could be distinguished from normal epitopes on the same molecules by mAbs. For Abs to efficiently kill the cancer cells they should have the ability to induce immunological cytotoxicity such as ADCC and/or CDC. They should also be able to inhibit the function mediated by the target Ags. For clinical point of view, the continuous presence of the target molecule on the cell surface until cell death might be essential for successful treatment. Therefore, it will be required for targets TAAs to play essential roles in tumorigenesis. Otherwise the cancer cells that do not express them could selectively survive during treatment and finally become dominant. It was also suggested that even the same molecules could play different roles in tumorigenesis quite often in different patients. Therefore when we develop therapeutic Abs, we should obtain information about the conditions of patients including genetic background to whom the treatment will be effective. I will discuss how we can accomplish this purpose.
    Language English
    Publishing date 2011-04-01
    Publishing country India
    Document type Journal Article
    ZDB-ID 2587301-5
    ISSN 0973-7154
    ISSN 0973-7154
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Determination of

    Ouchi, Kazuki / Haraga, Tomoko / Hirose, Kazuki / Kurosawa, Yuika / Sato, Yoshiyuki / Shibukawa, Masami / Saito, Shingo

    Analytica chimica acta

    2024  Volume 1298, Page(s) 342399

    Abstract: Background: The Fukushima Daiichi Nuclear Power Plant accident (2011) released large amounts of radioactive substances into the environment and generated highly radioactive debris. Post-accident countermeasures are currently in the phase of fuel debris ... ...

    Abstract Background: The Fukushima Daiichi Nuclear Power Plant accident (2011) released large amounts of radioactive substances into the environment and generated highly radioactive debris. Post-accident countermeasures are currently in the phase of fuel debris removal, which requires the analysis of radioactive contaminants in the environment and fuel. The spectra of solely β-emitting nuclides, such as
    Results: In this study, we developed a
    Significance and novelty: Our method allows for the handling of high-dose radioactive samples at the microliter level and is substantially faster than conventional ion exchange protocols, whereas ctITP has not been used for practical applications due to inaccurate collection and lack of a suitable chemical system. The concentration-separation-fractionation protocol in ctITP is successful due to the existence of a rare inert Sr
    Language English
    Publishing date 2024-02-20
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1483436-4
    ISSN 1873-4324 ; 0003-2670
    ISSN (online) 1873-4324
    ISSN 0003-2670
    DOI 10.1016/j.aca.2024.342399
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: A novel Antibody based approach to Cancer Treatment.

    Kurosawa, Y

    Journal of stem cells & regenerative medicine

    2010  Volume 6, Issue 3, Page(s) 166

    Language English
    Publishing date 2010-10-30
    Publishing country India
    Document type Journal Article
    ZDB-ID 2587301-5
    ISSN 0973-7154
    ISSN 0973-7154
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Increased selectivity of sodium deoxycholate to around Tryptophan213 in bovine serum albumin upon micellization as revealed by singular value decomposition for excitation emission matrix

    Kurosawa, Yuya / Otsuka, Yuta / Goto, Satoru

    Colloids and surfaces. 2022 Apr., v. 212

    2022  

    Abstract: In the present study, we investigated the effect of bile salts (sodium deoxycholate, NaDC) on the conformation of a globular protein (bovine serum albumin, BSA). The two Tryptophan (Trp) residues of BSA and the fluorescence energy of NaDC are in a three- ... ...

    Abstract In the present study, we investigated the effect of bile salts (sodium deoxycholate, NaDC) on the conformation of a globular protein (bovine serum albumin, BSA). The two Tryptophan (Trp) residues of BSA and the fluorescence energy of NaDC are in a three-way relationship, and singular value decomposition (SVD) was used to separate each element in the fluorescence spectra. SVD was used to separate the elements in the fluorescence spectra. SVD showed that NaDC had a particularly large effect on the microenvironment around Trp213 and that micellar NaDC enhanced the selectivity for Trp213. In addition, the Stern-Volmer plots of the warfarin (WAR) specific domain (domain I) and ketoprofen (KP) specific domain (domain II) in the presence and absence of NaDC showed that the effect of NaDC was selective for domain II, where Trp213 is located. These results indicate that NaDC induces a localized and selective conformational change in BSA, and that the selectivity varies depending on the aggregation state of NaDC.
    Keywords bile ; bovine serum albumin ; deoxycholic acid ; energy ; fluorescence ; ketoprofen ; tryptophan ; warfarin
    Language English
    Dates of publication 2022-04
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 1500523-9
    ISSN 1873-4367 ; 0927-7765
    ISSN (online) 1873-4367
    ISSN 0927-7765
    DOI 10.1016/j.colsurfb.2022.112344
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: Interaction mode of hydroxypropyl-β-cyclodextrin with vaccine adjuvant components Tween 80 and Triton X-100 revealed by fluorescence increasing-quenching analysis.

    Kurosawa, Yuya / Goto, Satoru / Mitsuya, Kengo / Otsuka, Yuta / Yokoyama, Hideshi

    Physical chemistry chemical physics : PCCP

    2023  Volume 25, Issue 8, Page(s) 6203–6213

    Abstract: The nonionic surfactants Tween 80 (Tw80) and Triton X-100 (TX100), which are used as components of adjuvants, were used with bovine serum albumin (BSA) and hydroxfypropyl-β-cyclodextrin (HP-β-CD) as model antigens. The interaction patterns of Tw80 and ... ...

    Abstract The nonionic surfactants Tween 80 (Tw80) and Triton X-100 (TX100), which are used as components of adjuvants, were used with bovine serum albumin (BSA) and hydroxfypropyl-β-cyclodextrin (HP-β-CD) as model antigens. The interaction patterns of Tw80 and TX100 with the hydrophobic cores of the model antigens were investigated. The fluorescence of 8-anilinonaphthalene-1-sulfonic acid (ANS), a hydrophobic fluorescent probe, was used to evaluate the effect of surfactants on each model antigen. A Hanes Woolf plot was used to analyze the adsorption of ANS to BSA, and an activator-inhibitor model was used to analyze the concentration-dependent increase and decrease of ANS fluorescence intensity. For BSA, TX100 occupies the ANS binding site inside the BSA hydrophobic core, while Tw80 does not contribute to the ANS binding site in the hydrophobic core. For HP-β-CD, the ANS concentration required for analyzable fluorescence intensity extended to the range where ANS concentration-dependent quenching was not negligible. Using the activator inhibitor model, we were able to separate the activators and inhibitors of ANS fluorescence and evaluate the affinity of ANS for HP-β-CD and surfactants. The results obtained showed that TX100 provided a hydrophobic environment to the ANS while being encapsulated by HP-β-CD, while Tw80 did not interact with HP-β-CD and provided a hydrophobic environment to the ANS independently of each other. The interpretations obtained were corroborated by the determination of the CMC of TX100 and Tw80, the effect of salt on ANS fluorescence, and
    MeSH term(s) 2-Hydroxypropyl-beta-cyclodextrin ; Polysorbates ; Octoxynol ; Adjuvants, Vaccine ; Fluorescence ; Serum Albumin, Bovine/chemistry ; Surface-Active Agents ; Spectrometry, Fluorescence/methods
    Chemical Substances 2-Hydroxypropyl-beta-cyclodextrin (1I96OHX6EK) ; Polysorbates ; Octoxynol (9002-93-1) ; Adjuvants, Vaccine ; Serum Albumin, Bovine (27432CM55Q) ; Surface-Active Agents
    Language English
    Publishing date 2023-02-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 1476244-4
    ISSN 1463-9084 ; 1463-9076
    ISSN (online) 1463-9084
    ISSN 1463-9076
    DOI 10.1039/d3cp00094j
    Database MEDical Literature Analysis and Retrieval System OnLINE

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