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Article ; Online: Different Presentations of Invasive

Arslan, Asli / Avcu, Gülhadiye / Erci, Ece / Aydemir, Sabire Şöhret / Kurugol, Zafer / Sahbudak Bal, Zumrut

2024 , Page(s) 99228241254270

Language	English
Publishing date	2024-05-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	207678-0
ISSN	1938-2707 ; 0009-9228
ISSN (online)	1938-2707
ISSN	0009-9228
DOI	10.1177/00099228241254270
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Zs.A 454: Show issues

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Article: Diagnostic Accuracy of the Mean Platelet Volume in the Prediction of Upper Urinary Tract Infections.

Gökçe, Şule / Kurugöl, Zafer

Clinical laboratory

2020 Volume 66, Issue 3

Abstract: Background: The studies have reported that mean platelet volume may be a marker in the discrimination of upper and lower urinary tract infections. We investigated whether the mean platelet volume was a reliable indicator in upper and lower urinary tract ...

Abstract	Background: The studies have reported that mean platelet volume may be a marker in the discrimination of upper and lower urinary tract infections. We investigated whether the mean platelet volume was a reliable indicator in upper and lower urinary tract infections. Methods: One hundred and eighty-two patients between the ages of 1 month and 14 years who were diagnosed with urinary tract infection were included in this study. The mean platelet volume values, clinical and other laboratory characteristics of the groups were compared. The discriminative ability of each biomarker for patients with UUTI was evaluated by drawing receiver operating characteristic (ROC) curves for the biomarkers. All values of p < 0.05 were considered statistically significant. Results: The leukocyte count, C-reactive protein, and erythrocyte sedimentation rates of the patients with upper urinary tract infection were significantly higher than the patients with lower urinary tract infections (p < 0.001). However, there was no statistically significant difference in terms of the mean platelet volume values between patients with upper and lower urinary tract infection ([7.2 (1.3) vs. 7.2 (1.6) fL]; p = 0.79, respectively). The value of the area under the curve of MPV's p-value was > 0.05. However, p-values of CRP and ESR were significant in ROC analysis. Conclusions: Our study showed that there was no significant difference in the mean platelet volume values between patients with upper and lower urinary tract infections. The use of mean platelet volume as an indicator of upper urinary tract infection is controversial.
MeSH term(s)	Adolescent ; Child ; Child, Preschool ; Female ; Hospitalization ; Humans ; Infant ; Male ; Mean Platelet Volume ; ROC Curve ; Urinary Tract Infections/blood ; Urinary Tract Infections/classification ; Urinary Tract Infections/diagnosis ; Urinary Tract Infections/epidemiology
Language	English
Publishing date	2020-03-11
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1307629-2
ISSN	1433-6510 ; 0941-2131
ISSN	1433-6510 ; 0941-2131
DOI	10.7754/Clin.Lab.2019.190647
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Ud II Zs.170: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Response to a letter to the editor regarding ' the comparison of seroconversion rates among different varicella vaccines administered Turkish children; MAV/06 and vOka'.

Sahbudak Bal, Zumrut / Zeytinoglu, Aysin / Ozkinay, Ferda / Kurugol, Zafer

Human vaccines & immunotherapeutics

2022 Volume 18, Issue 5, Page(s) 2073760

MeSH term(s)	Chickenpox/epidemiology ; Chickenpox/prevention & control ; Chickenpox Vaccine ; Child ; Herpesvirus 3, Human ; Humans ; Seroconversion ; Vaccines, Attenuated ; Viral Vaccines
Chemical Substances	Chickenpox Vaccine ; Vaccines, Attenuated ; Viral Vaccines
Language	English
Publishing date	2022-05-16
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	2664176-8
ISSN	2164-554X ; 2164-5515
ISSN (online)	2164-554X
ISSN	2164-5515
DOI	10.1080/21645515.2022.2073760
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Article: Outbreak of varicella in preschool children despite one-dose vaccination.

Kurugöl, Zafer / Gökçe, Şule

The Turkish journal of pediatrics

2018 Volume 60, Issue 1, Page(s) 56–62

Abstract: Kurugöl Z, Gökçe Ş. Outbreak of varicella in preschool children despite one-dose vaccination. Turk J Pediatr 2018; 60: 56-62. In Turkey, a single-dose varicella vaccine was introduced into the National Immunization Program in 2013. Before this ... ...

Abstract	Kurugöl Z, Gökçe Ş. Outbreak of varicella in preschool children despite one-dose vaccination. Turk J Pediatr 2018; 60: 56-62. In Turkey, a single-dose varicella vaccine was introduced into the National Immunization Program in 2013. Before this implementation, varicella vaccine had been available in the private sector since 2000. However, varicella outbreaks continued to occur in preschools and elementary schools. We investigated a varicella outbreak to estimate the effectiveness of 1-dose varicella vaccine and to evaluate potential risk factors for breakthrough disease. This study was carried out during a varicella outbreak in 3 preschools in İzmir, Turkey, in April 2016. Using questionnaires, data including children`s medical and vaccination histories were collected from their parents. Attack rates in vaccinated and unvaccinated children were calculated and the analyses of vaccine effectiveness and of risk factors for breakthrough disease were conducted. A total of 124 children were enrolled in the study. Of the 124 children, 77 (62%) had received 1-dose varicella vaccine before the outbreak. Varicella developed in 34 of 124 children during the outbreak, and 18 of them (53%) had breakthrough varicella. The attack rate was 23.4% among vaccinated children and 34% among unvaccinated children. The effectiveness of single-dose varicella vaccine was 33.6% against varicella disease of any severity and 82.5% against moderate or severe varicella. Children vaccinated 5 or more years before the outbreak had 3.5 times the risk of disease than those who had been vaccinated more recently (OR 3.5 [95% CI, 1.08-11.5]); p= 0.046). Age at vaccination ( < 15 months vs.≥15 months) and the brands of varicella vaccine were not associated with the increased risk of breakthrough varicella. Our study suggests that one-dose of varicella vaccine is not sufficient to prevent school outbreaks. A 2-dose varicella vaccination program may help to prevent varicella outbreaks and achieve effective control of the disease.
MeSH term(s)	Chickenpox/epidemiology ; Chickenpox/prevention & control ; Chickenpox Vaccine/administration & dosage ; Child ; Child, Preschool ; Disease Outbreaks/prevention & control ; Female ; Herpesvirus 3, Human ; Humans ; Incidence ; Infant ; Male ; Risk Factors ; Schools, Nursery ; Surveys and Questionnaires ; Turkey/epidemiology ; Vaccination
Chemical Substances	Chickenpox Vaccine
Language	English
Publishing date	2018-08-13
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	123487-0
ISSN	0041-4301
ISSN	0041-4301
DOI	10.24953/turkjped.2018.01.008
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Article: Primary ovarian rhabdomyosarcoma coexisting with Pseudo-Meigs' syndrome in a young patient: a case report and brief literature review.

Gökçe, Şule / Kurugöl, Zafer / Orujov, Elvin / Serin, Gürdeniz

Turk pediatri arsivi

2020 Volume 55, Issue 2, Page(s) 203–206

Abstract: Primary rhabdomyosarcoma is one of the malignant soft tissue sarcomas of childhood originating from embryonic mesenchyme. The tumor can occur in the head, neck region, and limbs, and genitourinary system. Primary ovarian rhabdomyosarcoma is an extremely ... ...

Abstract	Primary rhabdomyosarcoma is one of the malignant soft tissue sarcomas of childhood originating from embryonic mesenchyme. The tumor can occur in the head, neck region, and limbs, and genitourinary system. Primary ovarian rhabdomyosarcoma is an extremely rare malignancy with a few documented pediatric patients in the literature. Pseudo-Meigs' syndrome is a type of Meigs' syndrome that is usually associated with other benign ovarian tumors or any other type of malignant tumors. It is a rare condition characterized by ascites, pleural effusion, benign ovarian tumors or fibroma-like tumors, and resolution of ascites and pleural effusion after the removal of the tumor. A patient of Asian origin came to our clinic with symptoms of mild dyspnea, and gradually increasing abdominal swelling. Magnetic resonance imaging scans indicated masses with solid cystic components on both ovaries with a suspicion of malignancy, showing bilateral pleural effusion and massive ascites. This is the first reported case of a pure primary ovarian rhabdomyosarcoma associated with a Pseudo-Meigs syndrome in a young girl.
Language	English
Publishing date	2020-06-19
Publishing country	Turkey
Document type	Case Reports
ISSN	1306-0015
ISSN	1306-0015
DOI	10.14744/TurkPediatriArs.2019.82474
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Article ; Online: Predictive role of laboratory markers and clinical features for recurrent Henoch-Schönlein Purpura in childhood: A study from Turkey.

Gökçe, Şule / Kurugöl, Zafer / Koturoğlu, Güldane / Aslan, Aslı

Modern rheumatology

2020 Volume 30, Issue 6, Page(s) 1047–1052

Abstract: Objectives: ...

Abstract	Objectives:
MeSH term(s)	Adolescent ; Arthritis/epidemiology ; Child ; Child, Preschool ; Female ; Gastrointestinal Diseases/epidemiology ; Humans ; Kidney Diseases/epidemiology ; Male ; Purpura, Schoenlein-Henoch/complications ; Purpura, Schoenlein-Henoch/epidemiology ; Purpura, Schoenlein-Henoch/pathology ; Recurrence ; Skin Diseases/epidemiology
Language	English
Publishing date	2020-02-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2078157-X
ISSN	1439-7609 ; 1439-7595
ISSN (online)	1439-7609
ISSN	1439-7595
DOI	10.1080/14397595.2019.1690966
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Article ; Online: Effectiveness of Pelargonium sidoides in pediatric patients diagnosed with uncomplicated upper respiratory tract infection: a single-blind, randomized, placebo-controlled study.

Gökçe, Şule / Dörtkardeşler, Burçe Emine / Yurtseven, Ali / Kurugöl, Zafer

European journal of pediatrics

2021 Volume 180, Issue 9, Page(s) 3019–3028

Abstract: Upper respiratory tract infections (URTIs) are a condition characterized by upper airway inflammation often caused by viruses in humans. The present study aimed to assess the effectiveness of the liquid herbal drug preparation from the root extracts of ... ...

Abstract	Upper respiratory tract infections (URTIs) are a condition characterized by upper airway inflammation often caused by viruses in humans. The present study aimed to assess the effectiveness of the liquid herbal drug preparation from the root extracts of Pelargonium sidoides in improving symptoms of uncomplicated URTIs. One hundred sixty-four patients with URTI were randomized and given either verum containing the root extracts of Pelargonium sidoides (n = 82) or a matching placebo (n = 82) in a single-blind manner for 7 days. The median total scores of all symptoms (TSS) showed a significant decreasing trend in the group treated with the root extracts derived from Pelargonium sidoides compared to the placebo group from day 0 to day 7 (TSS significantly decreased by 0.85 points in the root extract group compared to a decrease of 0.62 points, p = 0.018). "Cough frequency" showed a significant improvement from day 0 to day 3 (p = 0.023). There was also detected a significant recovery in "sneezing" on day 3 via Brunner-Langer model, and it was detected that the extract administration given in the first 24 h onset of the symptoms had provided a significant improvement in day 0 to day 3 (difference of TSS 0.18 point, p = 0.011).Conclusion: The findings of the study revealed that the Pelargonium sidoides extracts are effective in relieving the symptom burden in the duration of the disease. It may be regarded as an alternative option for the management of URTIs. What is Known: • Upper respiratory tract infections (URTIs), an inflammation on the upper airways, are the most common infectious disease in children. • Pelargonium sidoides, a traditional medicinal plant native to South Africa, is one of the ornamental geraniums that is thought to be effective in treating URTIs What is New: • It may be revealed that the dried root extract of Pelargonium sidoides compared with placebo might be an alternative treatment in improving the symptoms such as dry cough, sneezing, and relieving cough frequency. • The administration of the root extract at the onset of URTIs' signs may be regarded as an adjunctive option for the management of URTIs due to its effectiveness in decreasing the symptom burden of the disease.
MeSH term(s)	Child ; Humans ; Pelargonium ; Phytotherapy ; Plant Extracts/therapeutic use ; Respiratory Tract Infections/drug therapy ; Single-Blind Method
Chemical Substances	Plant Extracts
Language	English
Publishing date	2021-07-24
Publishing country	Germany
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	194196-3
ISSN	1432-1076 ; 0340-6199 ; 0943-9676
ISSN (online)	1432-1076
ISSN	0340-6199 ; 0943-9676
DOI	10.1007/s00431-021-04211-y
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Article ; Online: A Rare Cause of Orbital Cellulitis: Eikenella corrodens.

Erci, Ece / Avcu, Gulhadiye / Ozer, Emine Cigdem / Bal, Zumrut Sahbudak / Ozkinay, Ferda / Kurugol, Zafer / Gode, Sercan / Aydemir, Sabire Sohret

The Pediatric infectious disease journal

2023 Volume 42, Issue 7, Page(s) e257

MeSH term(s)	Humans ; Eikenella corrodens ; Orbital Cellulitis/diagnosis ; Orbital Cellulitis/drug therapy ; Gram-Negative Bacterial Infections/diagnosis ; Gram-Negative Bacterial Infections/drug therapy
Language	English
Publishing date	2023-03-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	392481-6
ISSN	1532-0987 ; 0891-3668
ISSN (online)	1532-0987
ISSN	0891-3668
DOI	10.1097/INF.0000000000003909
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Article: The Present and Future Aspects of Life-Long Pertussis Prevention: Narrative Review with Regional Perspectives for Türkiye.

Pehlivan, Tamer / Dinleyici, Ener Cagri / Kara, Ateş / Kurugöl, Zafer / Tezer, Hasan / Aksakal, Nur Baran / Biri, Aydan / Azap, Alpay

Infectious diseases and therapy

2023 Volume 12, Issue 11, Page(s) 2495–2512

Abstract: Pertussis, caused by Bordetella pertussis, remains one of the most widespread, contagious, and vaccine-preventable diseases. It results in notable morbidity and mortality as well as severe medical, social, and economic burden. Despite high global vaccine ...

Abstract	Pertussis, caused by Bordetella pertussis, remains one of the most widespread, contagious, and vaccine-preventable diseases. It results in notable morbidity and mortality as well as severe medical, social, and economic burden. Despite high global vaccine coverage, pertussis continues to be a significant epidemiologic problem, with outbreak episodes every few years just as in the pre-vaccination era. In Türkiye, there is a lack of comprehensive data on the current burden of pertussis in different age and risk groups, leading to underdiagnosis and underreporting of the disease, especially in adults who are often not considered at risk. Available data from Türkiye also reveal inadequate levels of protective antibodies in preterm newborns, emphasizing the need for additional preventive measures. Authors stated that improving physician awareness of pertussis symptoms in patients with prolonged cough, increasing access to routine pertussis tests, and conducting surveillance studies would aid in accurate diagnosis and reporting in Türkiye. As the Turkish Ministry of Health Antenatal Care Management Guide suggests routine second and third pregnancy check-up visits at weeks 18-24 and 28-32 correspondingly, this period can be considered the ideal vaccination time for Türkiye. Introducing a booster dose of Tdap at around 10 years of age or during national military service would reduce transmission and protect susceptible individuals. Identifying individuals at high risk of severe pertussis and prioritizing them for a booster dose is also crucial in Türkiye. Enhancing surveillance systems, increasing healthcare professionals' awareness through training, and organizing catch-up visits for missed vaccinations during the COVID-19 pandemic are mentioned as additional strategies to improve pertussis prevention in Türkiye. This review focuses on the global and regional burden of pertussis and obstacles to effective prevention and evaluates existing strategies to achieve lifelong pertussis prevention. Literature and current strategies were also discussed from a Turkish national standpoint.
Language	English
Publishing date	2023-10-10
Publishing country	New Zealand
Document type	Journal Article ; Review
ZDB-ID	2701611-0
ISSN	2193-6382 ; 2193-8229
ISSN (online)	2193-6382
ISSN	2193-8229
DOI	10.1007/s40121-023-00876-0
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Article ; Online: Electrocardiographic changes in hospitalised children with COVID-19.

Avcu, Gulhadiye / Arslan, Aslı / Bal, Zumrut Sahbudak / Ay, Oguzhan / Levent, Erturk / Ozkinay, Ferda / Kurugol, Zafer

Cardiology in the young

2023 Volume 33, Issue 4, Page(s) 525–531

Abstract: Objectives: Cardiac manifestations of the coronavirus disease 2019 (COVID-19) have mainly been reported in adults. Therefore, we aimed to determine the electrocardiographic abnormalities in hospitalised paediatric patients with COVID-19 and ... ...

Abstract	Objectives: Cardiac manifestations of the coronavirus disease 2019 (COVID-19) have mainly been reported in adults. Therefore, we aimed to determine the electrocardiographic abnormalities in hospitalised paediatric patients with COVID-19 and multisystemic inflammatory syndrome in children. Methods: We retrospectively evaluated hospitalised paediatric patients <18 years of age with a diagnosis of COVID-19 (n = 168) and multisystem inflammatory syndrome in children (n = 48) between March 2021 and December 2021. A daily electrocardiography was performed for the patients who had electrocardiographic abnormalities on admission or developed electrocardiographic abnormality on the follow-up. The characteristics of these patients, underlying predisposing conditions, and clinical course were also examined. Results: Two-hundred sixteen paediatric patients (55% were male) with a mean age of 10.7 ± 4.69 years were evaluated. There was an underlying disease in 84 (38.8%) patients and 51 (23.6%) required paediatric ICU admission. Electrocardiography abnormality was detected in 12 (5.5%) which were as follows: 7 (3.2%) had sinus bradycardia, 3 (1.4%) patients had transient ST elevation and concomitant T negativity, and 2 (0.9%) developed first-degree Atrioventricular (AV) block. The median time from the onset of disease symptoms to detecting electrocardiographic abnormality was 9 days. Electrocardiographic abnormalities returned to normal uneventfully 3 days later. Conclusions: The prevalence of arrhythmia in paediatric patients with COVID-19 was detected in 5.5% of the patients. While two-thirds of the electrocardiography abnormalities were sinus bradycardia, ST elevation was remarkable (1.4%). Clinicians should be aware of electrocardiographic abnormalities and consider electrocardiographic monitoring in paediatric patients with COVID-19 and multisystemic inflammatory syndrome in children.
MeSH term(s)	Adult ; Humans ; Male ; Child ; Adolescent ; Female ; COVID-19/complications ; COVID-19/diagnosis ; Bradycardia ; Retrospective Studies ; Child, Hospitalized ; ST Elevation Myocardial Infarction ; Arrhythmias, Cardiac/diagnosis ; Arrhythmias, Cardiac/epidemiology ; Arrhythmias, Cardiac/etiology ; Atrioventricular Block/diagnosis ; Electrocardiography ; Syndrome
Language	English
Publishing date	2023-01-23
Publishing country	England
Document type	Journal Article
ZDB-ID	1078466-4
ISSN	1467-1107 ; 1047-9511
ISSN (online)	1467-1107
ISSN	1047-9511
DOI	10.1017/S1047951123000100
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