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Article ; Online: [Practice of Ethics Education Using a Documentary Film for Pharmacy Students].

Kusakabe, Yoshio / Nakamura, Yasuhiro / Tanigawa, Kazunari / Karasawa, Ken / Maruyama, Keiji

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan

2023 Volume 143, Issue 7, Page(s) 607–616

Abstract: In today's world, where clinical options are ever increasing and patients' needs are more diverse, it is not possible to conclude that simply practicing medical care based on pathophysiological data and medical evidence is sufficient for patients, ... ...

Abstract	In today's world, where clinical options are ever increasing and patients' needs are more diverse, it is not possible to conclude that simply practicing medical care based on pathophysiological data and medical evidence is sufficient for patients, particularly in terms of seeing each patient as an individual. Medical professionals must maintain a close relationship with their patients and seek treatment and care methods that reflect the patient's values and views on life and death, based on their own ethics in medical care. Ethics education should be provided on a continuing basis from the beginning of medical/pharmacy school. However, ethics education in pharmacy departments is often delivered in a lecture format attended by many students and/or as group training using case studies and hypothetical situations, i.e., "paper" patients. With these teaching methods, there are limited opportunities for the students to foster a sense of ethics or to think deeply about their values and views on life and death with respect to the patients they care for. Therefore, in this study, we conducted ethics exercises for pharmacy students in a group study format using a documentary film of real patients who were facing death. By retrospectively analyzing the results of the questionnaires collected before and after the assignments and exercises, we verified the educational effects and changes in the students' sense of ethics from participating in the group learning exercise; moreover, our results revealed the insight gained by the students in examining the experiences and challenges faced by terminally ill patients.
MeSH term(s)	Humans ; Students, Pharmacy ; Retrospective Studies ; Educational Status ; Learning ; Curriculum ; Ethics, Medical ; Students, Medical
Language	Japanese
Publishing date	2023-05-25
Publishing country	Japan
Document type	English Abstract ; Journal Article
ZDB-ID	200514-1
ISSN	1347-5231 ; 0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
ISSN (online)	1347-5231
ISSN	0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
DOI	10.1248/yakushi.22-00214
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Isolation and identification of the new baicalin target protein to develop flavonoid structure-based therapeutic agents.

Kusakabe, Yoshio / Moriya, Shun-Suke / Sugiyama, Toru / Miyata, Yoshiki

Bioorganic & medicinal chemistry

2023 Volume 90, Page(s) 117362

Abstract: Proteins are vital constituents of all living organisms. As many therapeutic agents alter the activity of functional proteins, identifying functional target proteins of small bioactive molecules isessential for the rational design of stronger medicines. ... ...

Abstract	Proteins are vital constituents of all living organisms. As many therapeutic agents alter the activity of functional proteins, identifying functional target proteins of small bioactive molecules isessential for the rational design of stronger medicines. Flavonoids with antioxidant, anti-allergy, and anti-inflammatory effects are expected to have preventive effects for several diseases closely related to oxidation and inflammation, including heart disease, cancer, neurodegenerative disorders, and eye diseases. Therefore, identifying the proteins involved in the pharmacological actions of flavonoids, and designing a flavonoid structure-based medicine that strongly and specifically inhibits flavonoid target proteins, could aid the development of more effective medicines for treating heart disease, cancer, neurodegenerative disorders, and ocular diseases with few side effects. To isolate the flavonoid target protein, we conducted a novel affinity chromatography in a column wherein baicalin, a representative flavonoid, was attached to Affi-Gel 102. Through affinity chromatography and nano LC-MS/MS, we identified GAPDH as a flavonoid target protein. Then, we performed fluorescence quenching and an enzyme inhibition assay to experimentally confirmbaicalin's binding affinity for, and inhibition of, GAPDH. We also conducted in silico docking simulations to visualize the binding modes of baicalin and the newly identified flavonoid target protein, GAPDH. From the results of this study, it was considered that one of the reasons why baicalin exhibits the effects on cancer and neurodegenerative diseases is that it inhibits the activity of GAPDH. In summary, we showed that Affi-Gel102 could quickly and accurately isolate the target protein for bioactive small molecules, without the need for isotopic labeling or a fluorescent probe. By using the method presented here, it was possible to easily isolate the target protein of a medicine containing a carboxylic acid.
MeSH term(s)	Humans ; Tandem Mass Spectrometry ; Flavonoids/pharmacology ; Flavonoids/metabolism ; Antioxidants ; Inflammation
Chemical Substances	baicalin (347Q89U4M5) ; Flavonoids ; Antioxidants
Language	English
Publishing date	2023-06-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1161284-8
ISSN	1464-3391 ; 0968-0896
ISSN (online)	1464-3391
ISSN	0968-0896
DOI	10.1016/j.bmc.2023.117362
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Zs.A 3815: Show issues

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Article ; Online: Effect of texture preference on food texture perception: Exploring the role of matching food texture and preference.

Kamei, Mio / Nishibe, Misaki / Araki, Risa / Kohyama, Kaoru / Kusakabe, Yuko

Appetite

2023 Volume 192, Page(s) 107078

Abstract: This study aimed to investigate the influence of smooth texture preference on smoothness perception. An online questionnaire (Study 1, n = 464) and a sensory evaluation test (Study 2, n = 65) were administered to Japanese elderly participants (65-74 ... ...

Abstract	This study aimed to investigate the influence of smooth texture preference on smoothness perception. An online questionnaire (Study 1, n = 464) and a sensory evaluation test (Study 2, n = 65) were administered to Japanese elderly participants (65-74 years), with common Japanese confectionery (Daifuku) as test foods. Through the online questionnaire, four distinct texture preference groups were formed based on the factors of preference for smoothness and firmness of the inner bean paste layer. Analysis of the food preference scale for imbalanced diet (FPSID) revealed that smooth-texture likers were more likely to be picky eaters than firm-texture likers. Furthermore, high (HiSm) and low smoothness preference groups (LoSm) were selected for the food sensory evaluation test to compare perceived textures (smoothness and firmness). Only the HiSm group exhibited a positive association between perceived smoothness and overall texture liking, perceiving smoothness significantly more intense than the LoSm group in situations where overall texture liking was high. This finding indicates that smooth texture preference does not act independently but rather interacts with food texture matching to affect perception. Our findings suggest that when food texture aligns with individuals' preferences, it elicits hedonic emotions and dynamically enhances food texture perception. This preference-involved perceptual process may contribute to the development of more explicit texture preferences.
MeSH term(s)	Humans ; Aged ; Taste ; Food ; Food Preferences/psychology ; Diet ; Touch Perception
Language	English
Publishing date	2023-10-28
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1461347-5
ISSN	1095-8304 ; 0195-6663
ISSN (online)	1095-8304
ISSN	0195-6663
DOI	10.1016/j.appet.2023.107078
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Article ; Online: Agonistic/antagonistic properties of lactones in food flavors on the sensory ion channels TRPV1 and TRPA1.

Ogawa, Yukino / Zhou, Lanxi / Kaneko, Shu / Kusakabe, Yuko

Chemical senses

2022 Volume 47

Abstract: Flavor compounds provide aroma and sensations in the oral cavity. They are not present alone in the oral cavity, but rather in combination with several other food ingredients. This study aimed to clarify the relationship between the mixing of pungent ... ...

Abstract	Flavor compounds provide aroma and sensations in the oral cavity. They are not present alone in the oral cavity, but rather in combination with several other food ingredients. This study aimed to clarify the relationship between the mixing of pungent flavor compounds and the response of pungent receptors, TRPV1 and TRPA1 channels. We focused on lactones that activate TRPV1 despite their presence in bland foods, such as dairy products and fruits, and analyzed their interaction with receptors using TRPV1- and TRPA1-expressing HEK293 cells. We found that γ-octalactone, γ-nonalactone, and δ-nonalactone activated TRPA1. When mixed with pungent components, some γ- and δ-lactones inhibited capsaicin-mediated TRPV1 responses, and δ-dodecalactone inhibited allyl isothiocyanate-mediated TRPA1 responses. Furthermore, the dose-response relationship of capsaicin and γ-nonalactone to TRPV1 suggests that γ-nonalactone acts as an agonist or antagonist of TRPV1, depending on its concentration. Conversely, γ-nonalactone and δ-dodecalactone were found to act only as agonists and antagonists, respectively, against TRPA1. These results suggest that lactones in foods may not only endow food with aroma, but also play a role in modulating food pungency by acting on TRPV1 and TRPA1. The dose-response relationships of a mixture of flavor compounds with TRPV1 and TRPA1 provide insights into the molecular physiological basis of pungency that may be the cornerstone for developing new spice mix recipes.
MeSH term(s)	Humans ; Capsaicin/pharmacology ; HEK293 Cells ; Lactones/pharmacology ; Transient Receptor Potential Channels ; TRPA1 Cation Channel/metabolism ; TRPV Cation Channels/metabolism ; Taste
Chemical Substances	Capsaicin (S07O44R1ZM) ; Lactones ; Transient Receptor Potential Channels ; TRPA1 Cation Channel ; TRPA1 protein, human ; TRPV Cation Channels ; TRPV1 protein, human
Language	English
Publishing date	2022-11-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	754122-3
ISSN	1464-3553 ; 0379-864X
ISSN (online)	1464-3553
ISSN	0379-864X
DOI	10.1093/chemse/bjac023
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Book ; Online: Conservative Likelihood Ratio Estimator for Infrequent Data Slightly above a Frequency Threshold

Kikuchi, Masato / Kusakabe, Yuhi / Ozono, Tadachika

2022

Abstract: A naive likelihood ratio (LR) estimation using the observed frequencies of events can overestimate LRs for infrequent data. One approach to avoid this problem is to use a frequency threshold and set the estimates to zero for frequencies below the ... ...

Abstract	A naive likelihood ratio (LR) estimation using the observed frequencies of events can overestimate LRs for infrequent data. One approach to avoid this problem is to use a frequency threshold and set the estimates to zero for frequencies below the threshold. This approach eliminates the computation of some estimates, thereby making practical tasks using LRs more efficient. However, it still overestimates LRs for low frequencies near the threshold. This study proposes a conservative estimator for low frequencies, slightly above the threshold. Our experiment used LRs to predict the occurrence contexts of named entities from a corpus. The experimental results demonstrate that our estimator improves the prediction accuracy while maintaining efficiency in the context prediction task. Comment: The 9th International Conference on Advanced Informatics: Concepts, Theory and Applications (ICAICTA 2022)
Keywords	Statistics - Machine Learning ; Computer Science - Machine Learning
Subject code	310
Publishing date	2022-10-28
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Ghost chest tube after talc pleurodesis.

Matsumoto, Takeshi / Kusakabe, Yusuke / Yamamoto, Naoki / Aihara, Kensaku

Clinical case reports

2020 Volume 8, Issue 11, Page(s) 2306–2307

Abstract: After the talc pleurodesis, CT showed the tract made from the chest tube even after its removal. The unexpanded thoracic space might also contribute to it; thus, gathering specific medical history is important to understand this rare phenomenon. ...

Abstract	After the talc pleurodesis, CT showed the tract made from the chest tube even after its removal. The unexpanded thoracic space might also contribute to it; thus, gathering specific medical history is important to understand this rare phenomenon.
Language	English
Publishing date	2020-07-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2740234-4
ISSN	2050-0904
ISSN	2050-0904
DOI	10.1002/ccr3.3084
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Article ; Online: Odor-Induced Taste Enhancement Is Specific to Naturally Occurring Temporal Order and the Respiration Phase.

Amano, Shogo / Narumi, Takuji / Kobayakawa, Tatsu / Kobayashi, Masayoshi / Tamura, Masahiko / Kusakabe, Yuko / Wada, Yuji

Multisensory research

2022 Volume 35, Issue 7-8, Page(s) 537–554

Abstract: Interaction between odor and taste information creates flavor perception. There are many possible determinants of the interaction between odor and taste, one of which may be the somatic sensations associated with breathing. We assumed that a smell ... ...

Abstract	Interaction between odor and taste information creates flavor perception. There are many possible determinants of the interaction between odor and taste, one of which may be the somatic sensations associated with breathing. We assumed that a smell stimulus accompanied by inhaling or exhaling enhances taste intensity if the order is congruent with natural drinking. To present an olfactory stimulus from the identical location during inhalation and exhalation, we blocked the gap between the tube presenting the olfactory stimulus and the nostril. Participants breathed and ingested the solution according to the instructions on the screen and evaluated the solution's taste intensity. Vanilla odor enhanced the sweet taste in both retronasal and orthonasal conditions when the order of stimuli was congruent with natural drinking, but it did not do so in either condition when they were incongruent. The results suggest that breathing is a determinant of odor-taste interaction. The methods of presenting olfactory stimuli used in this study were compared and discussed in relation to those used in previous studies. Odor-induced taste enhancement depends on the time order of smell with breathing and taste congruency in natural drinking. Taste enhancement was induced by odor in both conditions by minimizing differences in odor presentation between them.
MeSH term(s)	Humans ; Odorants ; Taste ; Smell ; Taste Perception ; Respiration
Language	English
Publishing date	2022-08-23
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2708792-X
ISSN	2213-4808 ; 2213-4794
ISSN (online)	2213-4808
ISSN	2213-4794
DOI	10.1163/22134808-bja10080
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Article ; Online: Imidazole Acceptor for Both Vacuum-Processable and Solution-Processable Efficient Blue Thermally Activated Delayed Fluorescence.

Kusakabe, Yu / Wada, Yoshimasa / Misono, Tomoya / Suzuki, Katsuaki / Shizu, Katsuyuki / Kaji, Hironori

ACS omega

2022 Volume 7, Issue 19, Page(s) 16740–16745

Abstract: The members of the imidazole family have been widely used for electron transporting, host, conventional fluorescent, and phosphorescent materials. Although the imidazole core also has great potential as an acceptor segment of deep-blue thermally ... ...

Abstract	The members of the imidazole family have been widely used for electron transporting, host, conventional fluorescent, and phosphorescent materials. Although the imidazole core also has great potential as an acceptor segment of deep-blue thermally activated delayed fluorescence (TADF) owing to its high triplet energy, the emission color of imidazole-based TADF organic light-emitting diodes (OLEDs) has so far been limited to blue to green. In this work, four acridan-imidazole systems are theoretically designed aiming for deep- or pure-blue emitters. All four emitters exhibit deep-blue to blue emission owing to the high energy levels of the lowest excited singlet states, exhibiting
Language	English
Publishing date	2022-05-04
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.2c01308
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Impact of adding pethidine on disinhibition during bronchoscopy with midazolam: a propensity score matching analysis.

Matsumoto, Takeshi / Kaneko, Akiko / Fujiki, Takahiro / Kusakabe, Yusuke / Nakayama, Emi / Tanaka, Ayaka / Yamamoto, Naoki / Aihara, Kensaku / Yamaoka, Shinpachi / Mishima, Michiaki

Respiratory investigation

2023 Volume 61, Issue 4, Page(s) 409–417

Abstract: Background: We sometimes experience disinhibition during bronchoscopy with sedation. However, the impact of adding pethidine on disinhibition has not yet been investigated. This study aimed to examine the additive impact of pethidine on disinhibition ... ...

Abstract	Background: We sometimes experience disinhibition during bronchoscopy with sedation. However, the impact of adding pethidine on disinhibition has not yet been investigated. This study aimed to examine the additive impact of pethidine on disinhibition during bronchoscopy with midazolam. Methods: This retrospective study involved consecutive patients who underwent bronchoscopy between November 2019 and December 2020 (sedated with midazolam: Midazolam group) and between December 2020 and December 2021 (sedated with midazolam plus pethidine: Combination group). The severity of disinhibition was defined as follows: moderate, disinhibition that always needed restraints by assistants; and severe, disinhibition that needed antagonization of sedation by flumazenil to continue bronchoscopy. One-to-one propensity score matching was used to match baseline characteristics between both groups. Results: After propensity score matching with depression, the type of bronchoscopic procedure, and the dose of midazolam, 142 patients matched in each group. The prevalence of moderate-to-severe disinhibition significantly decreased from 16.2% to 7.8% (P = 0.028) in the Combination group. The Combination group had significantly better scores for sensation after bronchoscopy and feelings toward bronchoscopy duration than did the Midazolam group. Although the minimum SpO Conclusions: Adding pethidine could reduce disinhibition occurrence in patients undergoing bronchoscopy with midazolam, with better subjective patient outcomes during and after bronchoscopy. However, whether more patients may need oxygen supplementation and whether hypoxia occurs during bronchoscopy should be considered. Clinical trial registration: UMIN000042635.
MeSH term(s)	Humans ; Bronchoscopy/methods ; Conscious Sedation/methods ; Hypnotics and Sedatives/adverse effects ; Meperidine ; Midazolam/adverse effects ; Propensity Score ; Retrospective Studies
Chemical Substances	Hypnotics and Sedatives ; Meperidine (9E338QE28F) ; Midazolam (R60L0SM5BC)
Language	English
Publishing date	2023-04-24
Publishing country	Netherlands
Document type	Clinical Trial ; Journal Article
ZDB-ID	2660821-2
ISSN	2212-5353 ; 2212-5345
ISSN (online)	2212-5353
ISSN	2212-5345
DOI	10.1016/j.resinv.2023.03.010
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Article ; Online: Allergy to Omalizumab: Lessons from a Reaction to the Coronavirus 2019 Vaccine.

Matsumoto, Takeshi / Sakurai, Yumiko / Fujiki, Takahiro / Kusakabe, Yusuke / Nakayama, Emi / Tanaka, Ayaka / Yamamoto, Naoki / Aihara, Kensaku / Yamaoka, Shinpachi / Mishima, Michiaki

Internal medicine (Tokyo, Japan)

2023 Volume 62, Issue 8, Page(s) 1219–1222

Abstract: Omalizumab can cause hypersensitivity reactions. We herein report the first case of an 18-year-old woman with refractory cough-predominant asthma that correlated with allergic reactions caused by omalizumab and the coronavirus disease 2019 (COVID-19) ... ...

Abstract	Omalizumab can cause hypersensitivity reactions. We herein report the first case of an 18-year-old woman with refractory cough-predominant asthma that correlated with allergic reactions caused by omalizumab and the coronavirus disease 2019 (COVID-19) vaccine. The patient developed angioedema after taking omalizumab. She had previously experienced intense coughing immediately after receiving a COVID-19 vaccine. A skin prick test was positive for polysorbate 20, which was probably the cause of the allergic reactions to omalizumab and the COVID-19 vaccine. Clinicians should check for an allergic reaction, irrespective of its intensity, triggered by polysorbate and be careful when prescribing biologics to patients in order to avoid allergic reactions.
MeSH term(s)	Adolescent ; Female ; Humans ; Angioedema/chemically induced ; Anti-Allergic Agents/therapeutic use ; Antibodies, Monoclonal, Humanized/therapeutic use ; Coronavirus ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Omalizumab/adverse effects ; Polysorbates/therapeutic use
Chemical Substances	Anti-Allergic Agents ; Antibodies, Monoclonal, Humanized ; COVID-19 Vaccines ; Omalizumab (2P471X1Z11) ; Polysorbates
Language	English
Publishing date	2023-02-01
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	32371-8
ISSN	1349-7235 ; 0021-5120 ; 0918-2918
ISSN (online)	1349-7235
ISSN	0021-5120 ; 0918-2918
DOI	10.2169/internalmedicine.1169-22
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