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  1. Article ; Online: Complete Genome Sequence and Characteristics of Mycobacteriophage IkeLoa.

    Wheatley, Hannah R / Kushner, Sarah R / Baliraine, Frederick N

    Microbiology resource announcements

    2022  Volume 11, Issue 11, Page(s) e0098522

    Abstract: Mycobacteriophage IkeLoa is a lytic myovirus. It has a circularly permuted 155,280-bp genome containing 233 putative protein-coding genes, 32 tRNA genes, one tmRNA gene, and 64.7% G+C content. The RNA genes are distributed in five clusters across the ... ...

    Abstract Mycobacteriophage IkeLoa is a lytic myovirus. It has a circularly permuted 155,280-bp genome containing 233 putative protein-coding genes, 32 tRNA genes, one tmRNA gene, and 64.7% G+C content. The RNA genes are distributed in five clusters across the genome. Only 28% of IkeLoa's protein-coding genes can be assigned functions.
    Language English
    Publishing date 2022-10-26
    Publishing country United States
    Document type Journal Article
    ISSN 2576-098X
    ISSN (online) 2576-098X
    DOI 10.1128/mra.00985-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: DRG afferents that mediate physiologic and pathologic mechanosensation from the distal colon.

    Wolfson, Rachel L / Abdelaziz, Amira / Rankin, Genelle / Kushner, Sarah / Qi, Lijun / Mazor, Ofer / Choi, Seungwon / Sharma, Nikhil / Ginty, David D

    Cell

    2024  Volume 186, Issue 16, Page(s) 3368–3385.e18

    Abstract: The properties of dorsal root ganglia (DRG) neurons that innervate the distal colon are poorly defined, hindering our understanding of their roles in normal physiology and gastrointestinal (GI) disease. Here, we report genetically defined subsets of ... ...

    Abstract The properties of dorsal root ganglia (DRG) neurons that innervate the distal colon are poorly defined, hindering our understanding of their roles in normal physiology and gastrointestinal (GI) disease. Here, we report genetically defined subsets of colon-innervating DRG neurons with diverse morphologic and physiologic properties. Four colon-innervating DRG neuron populations are mechanosensitive and exhibit distinct force thresholds to colon distension. The highest threshold population, selectively labeled using Bmpr1b genetic tools, is necessary and sufficient for behavioral responses to high colon distension, which is partly mediated by the mechanosensory ion channel Piezo2. This Aδ-HTMR population mediates behavioral over-reactivity to colon distension caused by inflammation in a model of inflammatory bowel disease. Thus, like cutaneous DRG mechanoreceptor populations, colon-innervating mechanoreceptors exhibit distinct anatomical and physiological properties and tile force threshold space, and genetically defined colon-innervating HTMRs mediate pathophysiological responses to colon distension, revealing a target population for therapeutic intervention.
    MeSH term(s) Ganglia, Spinal ; Mechanoreceptors/physiology ; Colon ; Neurons ; Skin/innervation
    Language English
    Publishing date 2024-01-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2023.07.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Online: Levitating Rigid Objects with Hidden Rods and Wires

    Kushner, Sarah / Ulinski, Risa / Singh, Karan / Levin, David I. W. / Jacobson, Alec

    2020  

    Abstract: We propose a novel algorithm to efficiently generate hidden structures to support arrangements of floating rigid objects. Our optimization finds a small set of rods and wires between objects and each other or a supporting surface (e.g., wall or ceiling) ... ...

    Abstract We propose a novel algorithm to efficiently generate hidden structures to support arrangements of floating rigid objects. Our optimization finds a small set of rods and wires between objects and each other or a supporting surface (e.g., wall or ceiling) that hold all objects in force and torque equilibrium. Our objective function includes a sparsity inducing total volume term and a linear visibility term based on efficiently pre-computed Monte-Carlo integration, to encourage solutions that are as-hidden-as-possible. The resulting optimization is convex and the global optimum can be efficiently recovered via a linear program. Our representation allows for a user-controllable mixture of tension-, compression-, and shear-resistant rods or tension-only wires. We explore applications to theatre set design, museum exhibit curation, and other artistic endeavours.
    Keywords Computer Science - Graphics
    Publishing date 2020-04-30
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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