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  1. Article ; Online: Necrotizing fasciitis with slow progression in a patient with rheumatoid arthritis receiving tocilizumab

    Goto, Kazuya / Kogame, Toshiaki / Kusuba, Nobuhiro / Endo, Yuichiro / Dainichi, Teruki / Kabashima, Kenji

    European journal of dermatology : EJD

    2022  Volume 32, Issue 2, Page(s) 279–280

    Title translation Necrotizing fasciitis with slow progression in a patient with rheumatoid arthritis receiving tocilizumab.
    MeSH term(s) Antibodies, Monoclonal, Humanized/therapeutic use ; Antirheumatic Agents/adverse effects ; Arthritis, Rheumatoid/complications ; Arthritis, Rheumatoid/drug therapy ; Fasciitis, Necrotizing/therapy ; Humans
    Chemical Substances Antibodies, Monoclonal, Humanized ; Antirheumatic Agents ; tocilizumab (I031V2H011)
    Language English
    Publishing date 2022-07-22
    Publishing country France
    Document type Journal Article
    ZDB-ID 1128666-0
    ISSN 1952-4013 ; 1167-1122
    ISSN (online) 1952-4013
    ISSN 1167-1122
    DOI 10.1684/ejd.2022.4249
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Efficacy of intravenous immunoglobulins for the treatment of mucous membrane pemphigoid-like epidermolysis bullosa acquisita.

    Komori, Takaya / Dainichi, Teruki / Kusuba, Nobuhiro / Otsuka, Atsushi / Hashimoto, Takashi / Kabashima, Kenji

    European journal of dermatology : EJD

    2017  Volume 27, Issue 5, Page(s) 563–564

    MeSH term(s) Aged ; Basement Membrane/pathology ; Epidermolysis Bullosa Acquisita/diagnosis ; Epidermolysis Bullosa Acquisita/drug therapy ; Epidermolysis Bullosa Acquisita/pathology ; Humans ; Immunoglobulins, Intravenous/therapeutic use ; Male ; Mouth Diseases/diagnosis ; Mouth Diseases/drug therapy ; Mouth Diseases/pathology ; Pemphigoid, Benign Mucous Membrane/diagnosis
    Chemical Substances Immunoglobulins, Intravenous
    Language English
    Publishing date 2017-10-30
    Publishing country France
    Document type Case Reports ; Letter
    ZDB-ID 1128666-0
    ISSN 1952-4013 ; 1167-1122
    ISSN (online) 1952-4013
    ISSN 1167-1122
    DOI 10.1684/ejd.2017.3118
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Rapid regression of metastatic brain tumours in a melanoma patient after dabrafenib/trametinib therapy.

    Komori, Takaya / Otsuka, Atsushi / Kusuba, Nobuhiro / Taniguchi, Kimika / Endo, Yuichiro / Honda, Tetsuya / Kabashima, Kenji

    European journal of dermatology : EJD

    2017  Volume 27, Issue 5, Page(s) 548–549

    MeSH term(s) Aged ; Antineoplastic Agents/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Brain Neoplasms/drug therapy ; Brain Neoplasms/secondary ; Humans ; Imidazoles/administration & dosage ; Male ; Melanoma/drug therapy ; Melanoma/secondary ; Oximes/administration & dosage ; Proto-Oncogene Proteins B-raf/antagonists & inhibitors ; Pyridones/administration & dosage ; Pyrimidinones/administration & dosage ; Remission Induction ; Skin Neoplasms/pathology
    Chemical Substances Antineoplastic Agents ; Imidazoles ; Oximes ; Pyridones ; Pyrimidinones ; trametinib (33E86K87QN) ; Proto-Oncogene Proteins B-raf (EC 2.7.11.1) ; dabrafenib (QGP4HA4G1B)
    Language English
    Publishing date 2017-10-30
    Publishing country France
    Document type Letter
    ZDB-ID 1128666-0
    ISSN 1952-4013 ; 1167-1122
    ISSN (online) 1952-4013
    ISSN 1167-1122
    DOI 10.1684/ejd.2017.3095
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Safety and Efficacy of FIT039 for Verruca Vulgaris: A Placebo-Controlled, Phase I/II Randomized Controlled Trial.

    Nomura, Takashi / Sumi, Eriko / Egawa, Gyohei / Nakajima, Saeko / Toichi, Eiko / Inoue, Nana / Shibuya, Mami / Okamoto, Natsuko / Mitsuishi, Tsuyoshi / Uozumi, Ryuji / Tada, Harue / Nakagawa, Takayuki / Kusuba, Nobuhiro / Okuno, Aika / Shimizuhira, Chihiro / Ishikawa, Makiko / Tanaka, Shiro / Hagiwara, Masatoshi / Kabashima, Kenji

    JID innovations : skin science from molecules to population health

    2021  Volume 1, Issue 3, Page(s) 100026

    Abstract: Trial design: Human papillomavirus infection causes verruca vulgaris. CDK9 inhibitor FIT039 inhibits DNA virus proliferation in animal models. We conducted a multicenter, single-blind, placebo-controlled, randomized phase I/II clinical trial evaluating ... ...

    Abstract Trial design: Human papillomavirus infection causes verruca vulgaris. CDK9 inhibitor FIT039 inhibits DNA virus proliferation in animal models. We conducted a multicenter, single-blind, placebo-controlled, randomized phase I/II clinical trial evaluating the safety and efficacy of FIT039 against verruca vulgaris.
    Methods: Target lesions were treated with liquid nitrogen once, and a FIT039 patch or placebo patch was applied for 14 days. The primary endpoint was lesion disappearance. The secondary endpoints were safety and changes in dimension, cross-sectional area, and the number of petechial lesions.
    Results: A total of 24 participants were randomly allocated to the FIT039 (n = 13, median age, 54 years) and placebo (n = 11, median age, 62 years) groups. Verruca vulgaris did not disappear. FIT039 decreased the dimension to 76% of the initial value on day 29, followed by an increase to 98% on day 57. Placebo showed a monotonic increase to 107% on day 57. Changes in the cross-sectional area and petechiae number were comparable between the groups.
    Conclusions: No drug-related adverse reactions occurred. FIT039 efficacy was not determined in this study.
    Language English
    Publishing date 2021-05-20
    Publishing country Netherlands
    Document type Clinical Trial
    ISSN 2667-0267
    ISSN (online) 2667-0267
    DOI 10.1016/j.xjidi.2021.100026
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  5. Article ; Online: Inhibition of IL-17-committed T cells in a murine psoriasis model by a vitamin D analogue.

    Kusuba, Nobuhiro / Kitoh, Akihiko / Dainichi, Teruki / Honda, Tetsuya / Otsuka, Atsushi / Egawa, Gyohei / Nakajima, Saeko / Miyachi, Yoshiki / Kabashima, Kenji

    The Journal of allergy and clinical immunology

    2017  Volume 141, Issue 3, Page(s) 972–981.e10

    Abstract: Background: A better understanding of the means by which topical vitamin D analogues exert their therapeutic effect on psoriasis is of theoretical and practical importance.: Objective: We sought to clarify whether and how the topical vitamin D ... ...

    Abstract Background: A better understanding of the means by which topical vitamin D analogues exert their therapeutic effect on psoriasis is of theoretical and practical importance.
    Objective: We sought to clarify whether and how the topical vitamin D analogue calcipotriol (CAL) controls the IL-17A-mediated pathogenesis of murine psoriasis-like dermatitis in vivo.
    Methods: Psoriasis-like dermatitis was induced by the topical application of an imiquimod (IMQ)-containing cream on the murine ear for 4 to 6 consecutive days. For topical CAL treatment, mice were treated daily with CAL solution on the ear before IMQ application.
    Results: Mice treated topically with CAL exhibited much milder IMQ-induced psoriasis-like dermatitis compared with vehicle-treated mice, with impaired accumulation of IL-17A-committed T (T17) cells in the lesional skin. The IMQ-induced upregulation of Il12b and Il23a was marked in the epidermis and was abrogated by CAL application, suggesting CAL-mediated suppression of IL-23 expression. CAL inhibited Il12b and Il23a expression by Langerhans cells ex vivo stimulated with IMQ and CD40 cross-linking. Topical CAL also inhibited T17 cell expansion in the draining lymph nodes of IMQ-treated skin, implying a possible effect on T17 cell-mediated dermatitis at distant sites. In fact, topical CAL application on the IMQ-treated left ear resulted in amelioration of T17 cell accumulation and psoriasis-like dermatitis in the right ear subsequently treated with IMQ.
    Conclusion: Topical CAL can exert its antipsoriatic effect on CAL-treated lesions and, concomitantly, distant lesions by attenuating the T17 cell accumulation in both CAL-treated lesions and draining lymph nodes.
    MeSH term(s) Animals ; Calcitriol/analogs & derivatives ; Calcitriol/pharmacology ; Disease Models, Animal ; Gene Expression Regulation/drug effects ; Gene Expression Regulation/immunology ; Humans ; Imiquimod/adverse effects ; Imiquimod/pharmacology ; Interleukin-12 Subunit p40/immunology ; Interleukin-17/immunology ; Interleukin-23 Subunit p19/immunology ; Mice ; Psoriasis/chemically induced ; Psoriasis/drug therapy ; Psoriasis/immunology ; Psoriasis/pathology ; Th17 Cells/immunology ; Th17 Cells/pathology
    Chemical Substances Il17a protein, mouse ; Il23a protein, mouse ; Interleukin-12 Subunit p40 ; Interleukin-17 ; Interleukin-23 Subunit p19 ; calcipotriene (143NQ3779B) ; Calcitriol (FXC9231JVH) ; Imiquimod (P1QW714R7M)
    Language English
    Publishing date 2017-09-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2017.07.033
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  6. Article ; Online: Thromboxane A

    Ueharaguchi, Yuri / Honda, Tetsuya / Kusuba, Nobuhiro / Hanakawa, Sho / Adachi, Akimasa / Sawada, Yu / Otsuka, Atsushi / Kitoh, Akihiko / Dainichi, Teruki / Egawa, Gyohei / Nakashima, Chisa / Nakajima, Saeko / Murata, Teruasa / Ono, Sachiko / Arita, Makoto / Narumiya, Shuh / Miyachi, Yoshiki / Kabashima, Kenji

    The Journal of allergy and clinical immunology

    2018  Volume 142, Issue 2, Page(s) 680–683.e2

    MeSH term(s) Animals ; Dermatitis/immunology ; Disease Models, Animal ; Humans ; Imiquimod ; Interleukin-17/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Psoriasis/immunology ; Receptors, Antigen, T-Cell, gamma-delta/metabolism ; Receptors, G-Protein-Coupled/metabolism ; Receptors, Thromboxane A2, Prostaglandin H2/genetics ; Receptors, Thromboxane A2, Prostaglandin H2/metabolism ; T-Lymphocytes/immunology ; Thromboxane A2/metabolism ; Thromboxane-A Synthase/genetics ; Thromboxane-A Synthase/metabolism
    Chemical Substances Interleukin-17 ; Receptors, Antigen, T-Cell, gamma-delta ; Receptors, G-Protein-Coupled ; Receptors, Thromboxane A2, Prostaglandin H2 ; Thromboxane A2 (57576-52-0) ; Thromboxane-A Synthase (EC 5.3.99.5) ; Imiquimod (P1QW714R7M)
    Language English
    Publishing date 2018-04-17
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2018.01.054
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  7. Article ; Online: Perivascular leukocyte clusters are essential for efficient activation of effector T cells in the skin.

    Natsuaki, Yohei / Egawa, Gyohei / Nakamizo, Satoshi / Ono, Sachiko / Hanakawa, Sho / Okada, Takaharu / Kusuba, Nobuhiro / Otsuka, Atsushi / Kitoh, Akihiko / Honda, Tetsuya / Nakajima, Saeko / Tsuchiya, Soken / Sugimoto, Yukihiko / Ishii, Ken J / Tsutsui, Hiroko / Yagita, Hideo / Iwakura, Yoichiro / Kubo, Masato / Ng, Lai guan /
    Hashimoto, Takashi / Fuentes, Judilyn / Guttman-Yassky, Emma / Miyachi, Yoshiki / Kabashima, Kenji

    Nature immunology

    2014  Volume 15, Issue 11, Page(s) 1064–1069

    Abstract: It remains largely unclear how antigen-presenting cells (APCs) encounter effector or memory T cells efficiently in the periphery. Here we used a mouse contact hypersensitivity (CHS) model to show that upon epicutaneous antigen challenge, dendritic cells ( ...

    Abstract It remains largely unclear how antigen-presenting cells (APCs) encounter effector or memory T cells efficiently in the periphery. Here we used a mouse contact hypersensitivity (CHS) model to show that upon epicutaneous antigen challenge, dendritic cells (DCs) formed clusters with effector T cells in dermal perivascular areas to promote in situ proliferation and activation of skin T cells in a manner dependent on antigen and the integrin LFA-1. We found that DCs accumulated in perivascular areas and that DC clustering was abrogated by depletion of macrophages. Treatment with interleukin 1α (IL-1α) induced production of the chemokine CXCL2 by dermal macrophages, and DC clustering was suppressed by blockade of either the receptor for IL-1 (IL-1R) or the receptor for CXCL2 (CXCR2). Our findings suggest that the dermal leukocyte cluster is an essential structure for elicitating acquired cutaneous immunity.
    MeSH term(s) Animals ; CD11c Antigen/genetics ; CD4-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; Cell Proliferation ; Chemokine CXCL2/biosynthesis ; Dendritic Cells/immunology ; Dermatitis, Contact/immunology ; Female ; Immunologic Memory/immunology ; Interleukin-1alpha/pharmacology ; Lymphocyte Activation/immunology ; Lymphocyte Function-Associated Antigen-1/immunology ; Macrophages/cytology ; Macrophages/immunology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Models, Animal ; Neutrophils/immunology ; Receptors, Interleukin-1/antagonists & inhibitors ; Receptors, Interleukin-8B/antagonists & inhibitors ; Skin/immunology ; Skin/pathology
    Chemical Substances CD11c Antigen ; Chemokine CXCL2 ; Cxcl2 protein, mouse ; Interleukin-1alpha ; Lymphocyte Function-Associated Antigen-1 ; Receptors, Interleukin-1 ; Receptors, Interleukin-8B
    Language English
    Publishing date 2014-09-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/ni.2992
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    Zs.MG 42: Show issues

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