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  1. Book ; Online: An Examination of New York State's Integrated Primary and Mental Health Care Services for Adults with Serious Mental Illness

    Scharf, Deborah M / Breslau, Joshua / Schmidt, John W / Kusuke, Daniela / Staplefoote, B. Lynette

    2014  

    Keywords Complementary therapies, healing & health ; History of the Americas ; Medical equipment & techniques ; Health systems & services ; Public health & preventive medicine ; History ; Health Sciences ; Public Health
    Language English
    Size 1 Online-Ressource
    Publisher RAND Corporation
    Document type Book ; Online
    Note English
    HBZ-ID HT030612184
    ISBN 9780833089748 ; 0833089749
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: Primary and Behavioral Health Care Integration Program: Impacts on Health Care Utilization, Cost, and Quality.

    Breslau, Joshua / Sorbero, Mark J / Kusuke, Daniela / Yu, Hao / Scharf, Deborah M / Hackbarth, Nicole Schmidt / Pincus, Harold Alan

    Rand health quarterly

    2021  Volume 9, Issue 2, Page(s) 3

    Abstract: This article describes an extension of the RAND Corporation's evaluation of the Substance Abuse and Mental Health Services Administration's Primary and Behavioral Health Care Integration (PBHCI) grants program. PBHCI grants are designed to improve the ... ...

    Abstract This article describes an extension of the RAND Corporation's evaluation of the Substance Abuse and Mental Health Services Administration's Primary and Behavioral Health Care Integration (PBHCI) grants program. PBHCI grants are designed to improve the overall wellness and physical health status of people with serious mental illness or co-occurring substance use disorders by supporting the integration of primary care and preventive PH services into community behavioral health centers where individuals already receive care. From 2010 to 2013, RAND conducted a program evaluation of PBHCI, describing the structure, process, and outcomes for the first three cohorts of grantee programs (awarded in 2009 and 2010). The current study extends previous work by investigating the impact of PBHCI on consumers' health care utilization, total costs of care to Medicaid, and quality of care in three states. The evidence suggests that PBHCI was successful in reducing frequent use of emergency room and inpatient services for physical health conditions, reducing costs of care, and improving follow-up after hospitalization for a mental illness. However, PBHCI evidence does not suggest that PBHCI had a consistent effect on quality of preventive care and health monitoring for chronic physical conditions. These findings can guide the design of future cohorts of PBHCI clinics to build on the strengths with respect to shifting emergency department and inpatient care to less costly and more effective settings and address the continuing challenge of integrating care between specialty behavioral health providers and general medical care providers.
    Language English
    Publishing date 2021-08-16
    Publishing country United States
    Document type Journal Article
    ISSN 2162-8254
    ISSN 2162-8254
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: How do tobacco power walls influence adolescents? A study of mediating mechanisms.

    Setodji, Claude M / Martino, Steven C / Gong, Min / Dunbar, Michael S / Kusuke, Daniela / Sicker, Angela / Shadel, William G

    Health psychology : official journal of the Division of Health Psychology, American Psychological Association

    2017  Volume 37, Issue 2, Page(s) 188–193

    Abstract: Objectives: Tobacco power walls display hundreds of tobacco products and are known to be a key part of the impact of point-of-sale tobacco advertising on risk for smoking in adolescents. The current study examined factors that are hypothesized to ... ...

    Abstract Objectives: Tobacco power walls display hundreds of tobacco products and are known to be a key part of the impact of point-of-sale tobacco advertising on risk for smoking in adolescents. The current study examined factors that are hypothesized to mediate the effect of tobacco power wall exposure on adolescents' susceptibility for smoking in the future.
    Method: Participants (N = 148) aged 11-17 years were invited to shop in the RAND StoreLab, a life-sized replica of a convenience store. They were randomized to 1 of 2 conditions: one in which the power wall was located in its typical position behind the cashier and the other in which it was hidden behind an opaque wall. Participants shopped in the RAND StoreLab and then completed measures of susceptibility for smoking in the future, perceived smoking norms, and perceived accessibility of cigarettes. Participants' movements in the store were electronically tracked.
    Results: Having the tobacco power wall behind the cashier increased adolescents' susceptibility for smoking in the future by 14.3% (total effect) compared with when the power wall was hidden (p = .01), and 14% of this effect was mediated by participants' perceived smoking norms. Time spent in front of the cashier and perceived accessibility of cigarettes did not play a role in the association between study condition and susceptibility for smoking in the future.
    Conclusions: The tobacco power wall increases adolescents' smoking risk, and this effect is partly explained by the effect of the power wall on adolescents' perceptions of how normative smoking is. (PsycINFO Database Record
    MeSH term(s) Adolescent ; Adolescent Behavior/psychology ; Advertising/methods ; Child ; Female ; Humans ; Male ; Perception ; Risk ; Smoking/psychology ; Nicotiana/adverse effects ; Tobacco Products/standards
    Language English
    Publishing date 2017-11-20
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 226369-5
    ISSN 1930-7810 ; 0278-6133
    ISSN (online) 1930-7810
    ISSN 0278-6133
    DOI 10.1037/hea0000558
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 2908: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Placing Antismoking Graphic Warning Posters at Retail Point-of-Sale Locations Increases Some Adolescents' Susceptibility to Future Smoking.

    Shadel, William G / Martino, Steven C / Setodji, Claude / Dunbar, Michael / Kusuke, Daniela / Lanna, Serafina / Meyer, Amanda

    Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco

    2017  Volume 21, Issue 2, Page(s) 220–226

    Abstract: Objectives: This experiment tested whether introducing graphic antitobacco posters at point-of-sale (POS) had any effect on adolescents' susceptibility to future cigarette smoking and whether these effects were moderated by adolescents' baseline risk of ...

    Abstract Objectives: This experiment tested whether introducing graphic antitobacco posters at point-of-sale (POS) had any effect on adolescents' susceptibility to future cigarette smoking and whether these effects were moderated by adolescents' baseline risk of cigarette smoking.
    Methods: The study was conducted in the RAND StoreLab, a life-sized replica of a convenience store that was developed to experimentally evaluate how changing aspects of tobacco advertising displays in retail POS environments influence tobacco use risk and behavior during simulated shopping experiences. In this study, 441 adolescents were randomized to one of the four conditions in a 2 (graphic antismoking poster placed near the tobacco power wall: no, yes) × 2 (graphic antismoking poster placed near the cash register: no, yes) experimental design. The outcome of interest was susceptibility to future cigarette smoking.
    Results: The addition of antismoking posters at POS led to a significant increase in future smoking susceptibility among those adolescents who already were at high risk for smoking in the future (p < .045). The introduction of graphic antismoking posters had no impact on committed never smokers, regardless of poster location; never smokers' susceptibility to future smoking was uniformly low across experimental conditions.
    Conclusions: Introducing graphic antismoking posters at POS may have the unintended effect of further increasing cigarette smoking susceptibility among adolescents already at risk.
    MeSH term(s) Adolescent ; Adolescent Behavior/psychology ; Advertising/economics ; Advertising/methods ; Advertising/trends ; Child ; Female ; Forecasting ; Humans ; Male ; Marketing/economics ; Marketing/methods ; Marketing/trends ; Smoking Cessation/economics ; Smoking Cessation/methods ; Smoking Cessation/psychology ; Tobacco Products/economics ; Tobacco Smoking/economics ; Tobacco Smoking/psychology ; Tobacco Smoking/trends
    Language English
    Publishing date 2017-12-18
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1452315-2
    ISSN 1469-994X ; 1462-2203
    ISSN (online) 1469-994X
    ISSN 1462-2203
    DOI 10.1093/ntr/ntx239
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5789: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: An Examination of New York State's Integrated Primary and Mental Health Care Services for Adults with Serious Mental Illness.

    Scharf, Deborah M / Breslau, Joshua / Hackbarth, Nicole Schmidt / Kusuke, Daniela / Staplefoote, B Lynette / Pincus, Harold Alan

    Rand health quarterly

    2014  Volume 4, Issue 3, Page(s) 13

    Abstract: The poor physical health of adults with serious mental illnesses is a public health crisis. Greater integration of mental health and primary medical care services at the clinic and system levels could address this need. In New York state, there are ... ...

    Abstract The poor physical health of adults with serious mental illnesses is a public health crisis. Greater integration of mental health and primary medical care services at the clinic and system levels could address this need. In New York state, there are several ongoing initiatives that promote integrated care for adults with serious mental illness, provided or coordinated by community mental health center staff. This study examines three initiatives. Data were collected by RAND through site visits and surveys of mental health clinic administrators and associated professionals. Results showed that Primary and Behavioral Health Care Integration grantees developed infrastructure that supported a broad scope of primary and preventive health care services; these broad changes appeared to contribute to clinic-wide culture shifts toward integration and shared accountability for consumers' "whole person" health. Clinics participating in the Medicaid Incentive tended to implement only those services for which they could bill, which resulted in newly identified consumer physical health care needs but did not help consumers to connect to physical health care services. Finally, while administrators and providers were optimistic that Medicaid Health Homes have potential to improve access to care for adults with serious mental illness, the newness of the initiative made it difficult to assess the degree to which Health Home networks would meet these goals. We conclude with recommendations to state policymakers, clinical providers, and technical assistance providers and recommendations for future research, all designed to strengthen New York state's integrated care initiatives for adults with serious mental illness.
    Language English
    Publishing date 2014-12-30
    Publishing country United States
    Document type Journal Article
    ISSN 2162-8254
    ISSN 2162-8254
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Hiding the tobacco power wall reduces cigarette smoking risk in adolescents: using an experimental convenience store to assess tobacco regulatory options at retail point-of-sale.

    Shadel, William G / Martino, Steven C / Setodji, Claude M / Scharf, Deborah M / Kusuke, Daniela / Sicker, Angela / Gong, Min

    Tobacco control

    2015  

    Abstract: Objectives: This experiment tested whether changing the location or visibility of the tobacco power wall in a life sized replica of a convenience store had any effect on adolescents' susceptibility to future cigarette smoking.: Methods: The study was ...

    Abstract Objectives: This experiment tested whether changing the location or visibility of the tobacco power wall in a life sized replica of a convenience store had any effect on adolescents' susceptibility to future cigarette smoking.
    Methods: The study was conducted in the RAND StoreLab (RSL), a life sized replica of a convenience store that was developed to experimentally evaluate how changing aspects of tobacco advertising displays in retail point-of-sale environments influences tobacco use risk and behaviour. A randomised, between-subjects experimental design with three conditions that varied the location or visibility of the tobacco power wall within the RSL was used. The conditions were: cashier (the tobacco power wall was located in its typical position behind the cash register counter); sidewall (the tobacco power wall was located on a sidewall away from the cash register); or hidden (the tobacco power wall was located behind the cashier but was hidden behind an opaque wall). The sample included 241 adolescents.
    Results: Hiding the tobacco power wall significantly reduced adolescents' susceptibility to future cigarette smoking compared to leaving it exposed (ie, the cashier condition; p=0.02). Locating the tobacco power wall on a sidewall away from the cashier had no effect on future cigarette smoking susceptibility compared to the cashier condition (p=0.80).
    Conclusions: Hiding the tobacco power wall at retail point-of-sale locations is a strong regulatory option for reducing the impact of the retail environment on cigarette smoking risk in adolescents.
    Language English
    Publishing date 2015-11-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 1146554-2
    ISSN 1468-3318 ; 0964-4563
    ISSN (online) 1468-3318
    ISSN 0964-4563
    DOI 10.1136/tobaccocontrol-2015-052529
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3651: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Methylation of death-associated protein kinase is associated with cetuximab and erlotinib resistance.

    Ogawa, Takenori / Liggett, Thomas E / Melnikov, Anatoliy A / Monitto, Constance L / Kusuke, Daniela / Shiga, Kiyoto / Kobayashi, Toshimitsu / Horii, Akira / Chatterjee, Aditi / Levenson, Victor V / Koch, Wayne M / Sidransky, David / Chang, Xiaofei

    Cell cycle (Georgetown, Tex.)

    2012  Volume 11, Issue 8, Page(s) 1656–1663

    Abstract: Anti-EGFR therapy is among the most promising molecular targeted therapies against cancer developed in the past decade. However, drug resistance eventually arises in most, if not all, treated patients. Emerging evidence has linked epigenetic changes, ... ...

    Abstract Anti-EGFR therapy is among the most promising molecular targeted therapies against cancer developed in the past decade. However, drug resistance eventually arises in most, if not all, treated patients. Emerging evidence has linked epigenetic changes, such as DNA methylation at CpG islands, to the development of resistance to multiple anticancer drugs. In addition, genes that are differentially methylated have increasingly been appreciated as a source of clinically relevant biomarker candidates. To identify genes that are specifically methylated during the evolution of resistance to anti-EGFR therapeutic agents, we performed a methylation-specific array containing a panel of 56 genes that are commonly known to be regulated through promoter methylation in two parental non-small cell lung cancer (NSCLC) and head and neck squamous cell carcinoma (HNSCC) cell lines and their resistant derivatives to either erlotinib or cetuximab. We found that death-associated protein kinase (DAPK) was hypermethylated in drug-resistant derivatives generated from both parental cell lines. Restoration of DAPK into the resistant NSCLC cells by stable transfection re-sensitized the cells to both erlotinib and cetuximab. Conversely, siRNA-mediated knockdown of DAPK induced resistance in the parental sensitive cells. These results demonstrate that DAPK plays important roles in both cetuximab and erlotinib resistance, and that gene silencing through promoter methylation is one of the key mechanisms of developed resistance to anti-EGFR therapeutic agents. In conclusion, DAPK could be a novel target to overcome resistance to anti-EGFR agents to improve the therapeutic benefit, and further evaluation of DAPK methylation as a potential biomarker of drug response is needed.
    MeSH term(s) Antibodies, Monoclonal/chemistry ; Antibodies, Monoclonal/pharmacology ; Antibodies, Monoclonal, Humanized ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Apoptosis Regulatory Proteins/antagonists & inhibitors ; Apoptosis Regulatory Proteins/genetics ; Apoptosis Regulatory Proteins/metabolism ; Calcium-Calmodulin-Dependent Protein Kinases/antagonists & inhibitors ; Calcium-Calmodulin-Dependent Protein Kinases/genetics ; Calcium-Calmodulin-Dependent Protein Kinases/metabolism ; Carcinoma, Non-Small-Cell Lung/enzymology ; Carcinoma, Non-Small-Cell Lung/pathology ; Carcinoma, Squamous Cell/enzymology ; Carcinoma, Squamous Cell/pathology ; Cell Line, Tumor ; Cetuximab ; DNA Methylation/drug effects ; Death-Associated Protein Kinases ; Drug Resistance, Neoplasm ; Erlotinib Hydrochloride ; Head and Neck Neoplasms/enzymology ; Head and Neck Neoplasms/pathology ; Humans ; Lung Neoplasms/enzymology ; Lung Neoplasms/pathology ; Promoter Regions, Genetic ; Quinazolines/chemistry ; Quinazolines/pharmacology ; RNA Interference ; RNA, Small Interfering/metabolism
    Chemical Substances Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized ; Antineoplastic Agents ; Apoptosis Regulatory Proteins ; Quinazolines ; RNA, Small Interfering ; Erlotinib Hydrochloride (DA87705X9K) ; Death-Associated Protein Kinases (EC 2.7.11.1) ; Calcium-Calmodulin-Dependent Protein Kinases (EC 2.7.11.17) ; Cetuximab (PQX0D8J21J)
    Language English
    Publishing date 2012-04-15
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2146183-1
    ISSN 1551-4005 ; 1538-4101 ; 1554-8627
    ISSN (online) 1551-4005
    ISSN 1538-4101 ; 1554-8627
    DOI 10.4161/cc.20120
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5881: Show issues Location:
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