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  1. Article: Effect of liquid nitrogen pre-treatment on various types of wool waste fibres for biogas production.

    Kuzmanova, Elena / Zhelev, Nikolai / Akunna, Joseph C

    Heliyon

    2018  Volume 4, Issue 5, Page(s) e00619

    Abstract: This study investigated the role of liquid nitrogen ( ... ...

    Abstract This study investigated the role of liquid nitrogen (LN
    Language English
    Publishing date 2018-05-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2018.e00619
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Plasma desmosine for prediction of outcomes after acute myocardial infarction.

    Ali, Kashan / Israr, Muhammad Zubair / Ng, Leong L / Mordi, Ify / Lang, Chim C / Kuzmanova, Elena / Huang, Jeffrey T-J / Choy, Anna-Maria

    Frontiers in cardiovascular medicine

    2022  Volume 9, Page(s) 992388

    Abstract: Background: Elastin degradation is implicated in the pathology of vulnerable plaque. Recent studies show promising results for plasma desmosine (pDES), an elastin-specific degradation product, as a marker of cardiovascular disease (CVD) outcomes. The ... ...

    Abstract Background: Elastin degradation is implicated in the pathology of vulnerable plaque. Recent studies show promising results for plasma desmosine (pDES), an elastin-specific degradation product, as a marker of cardiovascular disease (CVD) outcomes. The aim of this study was to investigate the potential role of pDES as a marker of clinical outcome in patients with acute myocardial infarction (AMI).
    Materials and methods: In this case-control study, we studied 236 AMI patients: 79 patients who had death and/or myocardial infarction (MI) at 2 years, and 157 patients who did not have an event at 2 years. pDES was measured using a validated liquid chromatography-tandem mass spectrometry method. Association of pDES with adverse outcomes, and the incremental value of pDES to global registry of acute coronary events (GRACE) score for risk stratification was assessed.
    Results: pDES levels were elevated in patients with the composite outcome of death/MI at 2 years (
    Conclusion: pDES concentrations predict clinical outcomes in patients with AMI, demonstrating its potential role as a prognostic marker in AMI.
    Language English
    Publishing date 2022-11-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2022.992388
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Endotyping Chronic Obstructive Pulmonary Disease, Bronchiectasis, and the "Chronic Obstructive Pulmonary Disease-Bronchiectasis Association".

    Huang, Jeffrey T-J / Cant, Erin / Keir, Holly R / Barton, Alun K / Kuzmanova, Elena / Shuttleworth, Morven / Pollock, Jennifer / Finch, Simon / Polverino, Eva / Bottier, Mathieu / Dicker, Alison J / Shoemark, Amelia / Chalmers, James D

    American journal of respiratory and critical care medicine

    2023  Volume 206, Issue 4, Page(s) 417–426

    Abstract: Rationale: ...

    Abstract Rationale:
    MeSH term(s) Bronchiectasis ; Humans ; Microbiota ; Pulmonary Disease, Chronic Obstructive/genetics ; RNA, Ribosomal, 16S ; Sputum/microbiology
    Chemical Substances RNA, Ribosomal, 16S
    Language English
    Publishing date 2023-02-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202108-1943OC
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh II Zs.80: Show issues Location:
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  4. Article ; Online: Endotypes of Exacerbation in Bronchiectasis: An Observational Cohort Study.

    Gao, Yonghua / Richardson, Hollian / Dicker, Alison J / Barton, Alun / Kuzmanova, Elena / Shteinberg, Michal / Perea, Lidia / Goeminne, Pieter C / Cant, Erin / Hennayake, Chandani / Pollock, Jennifer / Abo Leyah, Hani / Choi, Hayoung / Polverino, Eva / Blasi, Francesco / Welte, Tobias / Aliberti, Stefano / Long, Merete / Shoemark, Amelia /
    Sibila, Oriol / Huang, Jeffrey T J / Chalmers, James D

    American journal of respiratory and critical care medicine

    2024  

    Abstract: Rationale: Bronchiectasis is characterised by acute exacerbations but the biological mechanisms underlying these events is poorly characterised. Objectives To investigate the inflammatory and microbial characteristics of exacerbations of bronchiectasis.! ...

    Abstract Rationale: Bronchiectasis is characterised by acute exacerbations but the biological mechanisms underlying these events is poorly characterised. Objectives To investigate the inflammatory and microbial characteristics of exacerbations of bronchiectasis.
    Methods: 120 patients with bronchiectasis were enrolled and presented with acute exacerbations within 12 months. Spontaneous sputum samples were obtained during a period of clinical stability and again at exacerbation prior to receipt of antibiotic treatment. A validated rapid PCR assay for bacteria and viruses was used to classify exacerbations as bacterial, viral or both. Sputum inflammatory assessments included label free Liquid chromography/mass spectrometry and measurement of sputum cytokines and neutrophil elastase activity. 16s rRNA sequencing was used to characterise the microbiome.
    Measurements and main results: Bronchiectasis exacerbations showed profound molecular heterogeneity. At least one bacteria was identified in 103 samples (86%) and a high bacterial load (total bacterial load >10(7) copies/g) was observed in 81 patients (68%). Respiratory viruses were identified in 55 (46%) patients with rhinovirus being the most common virus (31%). PCR was more sensitive than culture. No consistent change in the microbiome was observed at exacerbation. Exacerbations were associated with increased neutrophil elastase, proteinase-3, Il-1beta and CXCL8. There markers were particularly associated with bacterial and bacterial+viral exacerbations. Distinct inflammatory and microbiome profiles were seen between different exacerbation subtypes, including bacterial, viral and eosinophilic events in both hypothesis led, and hypothesis-free analysis using integrated microbiome and proteomics, demonstrating 4 subtypes of exacerbation.
    Conclusion: Bronchiectasis exacerbations are heterogeneous events with contributions from bacteria, viruses and inflammatory dysregulation.
    Language English
    Publishing date 2024-05-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202310-1729OC
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Serum Desmosine Is Associated with Long-Term All-Cause and Cardiovascular Mortality in Bronchiectasis.

    Huang, Jeffrey T-J / Kuzmanova, Elena / Dicker, Alison J / Keir, Holly R / Finch, Simon / Aliberti, Stefano / Fardon, Thomas C / Chalmers, James D

    American journal of respiratory and critical care medicine

    2020  Volume 202, Issue 6, Page(s) 897–899

    MeSH term(s) Aged ; Biomarkers/blood ; Bronchiectasis/blood ; Bronchiectasis/mortality ; Bronchiectasis/physiopathology ; Cardiovascular Diseases/blood ; Cardiovascular Diseases/mortality ; Cardiovascular Diseases/physiopathology ; Cause of Death ; Desmosine/blood ; Female ; Humans ; Male ; Middle Aged
    Chemical Substances Biomarkers ; Desmosine (11003-57-9)
    Language English
    Publishing date 2020-05-12
    Publishing country United States
    Document type Letter
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202002-0434LE
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Isotope Dilution-Based Targeted and Nontargeted Carbonyl Neurosteroid/Steroid Profiling.

    Sharp, Sheila / Mitchell, Scott J / Vallée, Monique / Kuzmanova, Elena / Cooper, Michelle / Belelli, Delia / Lambert, Jeremy J / Huang, Jeffrey T-J

    Analytical chemistry

    2018  Volume 90, Issue 8, Page(s) 5247–5255

    Abstract: Neurosteroids are brain-derived steroids, capable of rapidly modulating neuronal excitability in a nongenomic manner. Dysregulation of their synthesis or metabolism has been implicated in many pathological conditions. Here, we describe an isotope ... ...

    Abstract Neurosteroids are brain-derived steroids, capable of rapidly modulating neuronal excitability in a nongenomic manner. Dysregulation of their synthesis or metabolism has been implicated in many pathological conditions. Here, we describe an isotope dilution based targeted and nontargeted (ID-TNT) profiling of carbonyl neurosteroids/steroids. The method combines stable isotope dilution, hydroxylamine derivatization, high-resolution MS scanning, and data-dependent MS/MS analysis, allowing absolute quantification of pregnenolone, progesterone, 5α-dihydroprogesterone, 3α,5α-tetrahydroprogesterone, and 3β,5α-tetrahydroprogesterone, and relative quantification of other carbonyl containing steroids. The utility and validity of this approach was tested in an acute stress mouse model and via pharmacological manipulation of the steroid metabolic pathway with finasteride. We report that brain levels of 3α,5α-tetrahydroprogesterone, a potent enhancer of GABA
    Language English
    Publishing date 2018-03-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.8b00055
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