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Article ; Online: Preservation of Mechanical and Morphological Properties of Porcine Cardiac Outflow Vessels after Decellularization and Wet Storage.

Sergeevichev, David / Vasiliyeva, Maria / Kuznetsova, Elena / Chelobanov, Boris

Biomimetics (Basel, Switzerland)

2023 Volume 8, Issue 3

Abstract: Widely used storage methods, including freezing or chemical modification, preserve the sterility of biological tissues but degrade the mechanical properties of materials used to make heart valve prostheses. Therefore, wet storage remains the most optimal ...

Abstract	Widely used storage methods, including freezing or chemical modification, preserve the sterility of biological tissues but degrade the mechanical properties of materials used to make heart valve prostheses. Therefore, wet storage remains the most optimal option for biomaterials. Three biocidal solutions (an antibiotic mixture, an octanediol-phenoxyethanol complex solution, and a glycerol-ethanol mixture) were studied for the storage of native and decellularized porcine aorta and pulmonary trunk. Subsequent mechanical testing and microstructural analysis showed a slight increase in the tensile strength of native and decellularized aorta in the longitudinal direction. Pulmonary trunk elongation increased 1.3-1.6 times in the longitudinal direction after decellularization only. The microstructures of the tested specimens showed no differences before and after wet storage. Thus, two months of wet storage of native and decellularized porcine aorta and pulmonary trunks does not significantly affect the strength and elastic properties of the material. The wet storage protocol using alcohol solutions of glycerol or octanediol-phenoxyethanol mixture may be intended for further fabrication of extracellular matrix for tissue-engineered biological heart valve prostheses.
Language	English
Publishing date	2023-07-17
Publishing country	Switzerland
Document type	Journal Article
ISSN	2313-7673
ISSN (online)	2313-7673
DOI	10.3390/biomimetics8030315
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Article: Effektivnost' preparata Meksidol v korrektsii postkovidnogo sindroma u patsientov s khronicheskimi tserebrovaskulyarnymi zabolevaniyami.

Kuznetsova, E B / Salina, E A / Kuznetsov, N S

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova

2023 Volume 123, Issue 5, Page(s) 117–122

Abstract: Objective: To evaluate the effectiveness of sequential therapy with Mexidol and Mexidol FORTE 250 in the correction of postcovoid syndrome (PKS) in patients with chronic cerebrovascular diseases (CVD).: Material and methods: The analysis of the ... ...

Title translation	Efficacy of Mexidol in the correction of postcovid syndrome in patients with chronic cerebrovascular diseases.
Abstract	Objective: To evaluate the effectiveness of sequential therapy with Mexidol and Mexidol FORTE 250 in the correction of postcovoid syndrome (PKS) in patients with chronic cerebrovascular diseases (CVD). Material and methods: The analysis of the results of examination and treatment of 110 patients with CVD who underwent COVID-19 was carried out. Patients of the main group (OH, Results: There was a significant improvement in the state of cognitive functions, regression of symptoms of asthenia, improvement of night sleep in patients with OG. The differences were statistically significant both in comparison with the baseline level and the HS. Conclusion: The administration of the drug does not require age-related dose adjustment and is well combined with basic therapy. The recommended regimen for the use of Mexidol: 14 days of 5 ml i/v or i/m, then taking the drug Mexidol FORTE 250 at a dose of 1 table 3 times/day for 2 months.
MeSH term(s)	Humans ; COVID-19/complications ; Antioxidants ; Asthenia ; Cerebrovascular Disorders/complications ; Cerebrovascular Disorders/drug therapy ; Chronic Disease ; Syndrome
Chemical Substances	emoxypine succinate (2R985002CT) ; Antioxidants
Language	Russian
Publishing date	2023-06-14
Publishing country	Russia (Federation)
Document type	English Abstract ; Journal Article
ZDB-ID	1201462-x
ISSN	2309-4729 ; 1997-7298 ; 0044-4588
ISSN (online)	2309-4729
ISSN	1997-7298 ; 0044-4588
DOI	10.17116/jnevro2023123051117
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Article ; Online: Figurate erythema in 11 Eastern European sphynx cats.

Mendoza-Kuznetsova, Ekaterina / Lokianskiene, Viktorija / Matise-VanHoutan, Ilze / Fiskovich, Olesya / Olivry, Thierry

Veterinary dermatology

2024

Abstract: Background: In humans, figurate erythema (FE) represents a heterogenous group of dermatoses with circular or serpiginous erythematous skin lesions; FE has not been reported in cats.: Objectives: To report clinical and histological characteristics and ...

Abstract	Background: In humans, figurate erythema (FE) represents a heterogenous group of dermatoses with circular or serpiginous erythematous skin lesions; FE has not been reported in cats. Objectives: To report clinical and histological characteristics and outcomes of FE in sphynx cats from Baltic sea-bordering countries. Animals: Eleven client-owned sphynx cats with FE. Materials and methods: We recruited cases meeting the following criteria: (i) a sphynx breed, (ii) FE with or without scaling, (iii) a chronic, waxing-and-waning course lasting longer than a month and (iv) an absence of other skin diseases. Results: Of 11 cats, there were seven Donskoys, one Peterbald, one Ukrainian Levkoy and two presumed Canadian sphynxes; all except one were males, and the age of onset was <12 months in eight cats. Skin lesions lasted between 1.2 and 56 months, and they consisted of erythematous plaques with a linear-to-serpiginous, annular, gyrate or iris configuration predominating on the trunk and extremities. Scaling was often seen trailing the edge of the centrifugally expanding erythema. All cats were otherwise asymptomatic or mildly pruritic. Dermatophytosis was ruled out by special stains and/or fungal cultures in eight cats. Microscopic lesions revealed focal, mild-to-moderate epidermal hyperplasia and hyperkeratosis, minimal-to-mild dysplasia and subepidermal collagen smudging. Special stains were negative for dermatophytes. The clinical remission of FE was not achieved with diet changes or medical interventions; yet, a spontaneous, transient, partial or complete improvement occurred in most cats. Conclusion and clinical relevance: This is the first report of FE in sphynx cats from Eastern Europe.
Language	English
Publishing date	2024-01-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2011122-8
ISSN	1365-3164 ; 0959-4493
ISSN (online)	1365-3164
ISSN	0959-4493
DOI	10.1111/vde.13240
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Article: Klinicheskaya anatomiya arterii Bernaskoni—Kassinari.

Kutia, S A / Yarovaya, O Ya / Kuznetsova, E V / Obukhova, D D / Kuznetsov, V I

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova

2024 Volume 124, Issue 3. Vyp. 2, Page(s) 12–17

Abstract: The article provides a comprehensive overview of the Bernasconi-Cassinari's artery (marginal tentorial branch of internal carotid artery, ...

Title translation	Clinical anatomy of the Bernasconi-Cassinari artery.
Abstract	The article provides a comprehensive overview of the Bernasconi-Cassinari's artery (marginal tentorial branch of internal carotid artery,
MeSH term(s)	Humans ; Cardiovascular System ; Carotid Artery, Internal/diagnostic imaging
Language	Russian
Publishing date	2024-03-21
Publishing country	Russia (Federation)
Document type	Review ; English Abstract ; Journal Article
ZDB-ID	1201462-x
ISSN	2309-4729 ; 1997-7298 ; 0044-4588
ISSN (online)	2309-4729
ISSN	1997-7298 ; 0044-4588
DOI	10.17116/jnevro202412403212
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Article ; Online: Coping Strategies During the COVID-19 Pandemic and Self-Determination: A Review of Russian Studies.

Kuznetsova, E A / Moskvicheva, N L / Zinovyeva, E V / Kostromina, S N

Psychology in Russia : state of the art

2023 Volume 16, Issue 2, Page(s) 3–21

Abstract: Background: The COVID-19 pandemic is a multifaceted stressor. Its impact suggests long-term psychological effects. Self-determination promotes flexibility of goals and actions and helps to overcome the difficulties caused by stress.: Objective: To ... ...

Abstract	Background: The COVID-19 pandemic is a multifaceted stressor. Its impact suggests long-term psychological effects. Self-determination promotes flexibility of goals and actions and helps to overcome the difficulties caused by stress. Objective: To analyze coping strategies during the COVID-19 pandemic presented in Russian scientific studies (RQ1), and their relationship with self-determination (RQ2). Design: Relevant studies (2020-2022) were selected from the Russian citation index (RSCI) database. Strict selection criteria were used. Twenty-four articles were selected for the final review. For dynamic analysis, four stages of the pandemic were identified. Results: Prevailing coping strategies have changed over time. At the beginning of the pandemic, respondents used familiar coping mechanisms. Six months later, active coping strategies were more often used, but deprivation and avoidance strategies increased. A year later, there was an increase in denial and avoidance strategies. Using non-constructive coping strategies may indicate that, due to the long course of the pandemic, meeting basic psychological needs became increasingly frustrated, leading to helplessness, alienation, and lack of control. Later dynamics reflect the growth of effective coping strategies and confirm that when basic needs are blocked for a long time, people seek alternative ways to satisfy them. Conclusion: The dynamics of coping strategies during the pandemic reflected their close relationship with basic psychological needs, as described in the theory of self-determination. The results confirmed the importance of self-determination as a dispositional variable in predicting coping mechanisms.
Language	English
Publishing date	2023-06-15
Publishing country	Russia (Federation)
Document type	Journal Article ; Review
ISSN	2307-2202
ISSN (online)	2307-2202
DOI	10.11621/pir.2023.0201
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Article: Neironspetsificheskaya enolaza v otsenke effektivnosti terapii meksidolom patsientov s nevrologicheskimi oslozhneniyami pervichnogo gipotireoza.

Kuznetsova, E B

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova

2016 Volume 116, Issue 12, Page(s) 126–129

Abstract: Aim: To evaluate the activity of neuron specific enolase (NSE) in patients with primary hypothyroidism (PGT) treated with mexidol.: Material and methods: Patients with PGT (n=110) were examined before and after treatment. Neuropsychological and ... ...

Title translation	Neuron specific enolase as a measure of the efficacy of mexidol in patients with neurologic complications of primary hypothyroidism.
Abstract	Aim: To evaluate the activity of neuron specific enolase (NSE) in patients with primary hypothyroidism (PGT) treated with mexidol. Material and methods: Patients with PGT (n=110) were examined before and after treatment. Neuropsychological and neurological status of the patients was studied. To assess the status of the peripheral nervous system, electroneuromyography was performed and serum NSE level was determined. Results and conclusion: The NSE activity depended on gender, age of the patient, duration of endocrinopathy and presence/absence of neurological symptoms. The clear positive dynamics of the majority of the parameters studied was noted during mexidol treatment. The efficacy of antioxidant therapy in these patients was confirmed.
Language	Russian
Publishing date	2016
Publishing country	Russia (Federation)
Document type	English Abstract ; Journal Article
ZDB-ID	1201462-x
ISSN	2309-4729 ; 1997-7298 ; 0044-4588
ISSN (online)	2309-4729
ISSN	1997-7298 ; 0044-4588
DOI	10.17116/jnevro2016116121126-129
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Article: Challenges in energy policies for the economic integration of prosumers in electric energy systems: A critical survey with a focus on Ontario (Canada)

Kuznetsova, Elizaveta / Anjos, Miguel F

Energy policy. 2020 July, v. 142

2020

Abstract: The accessibility and reducing cost of distributed renewable energy sources are stimulating the emergence of small-scale residential prosumers who can produce and consume electricity. This may lead to various scenarios. Such prosumers may increase the ... ...

Abstract	The accessibility and reducing cost of distributed renewable energy sources are stimulating the emergence of small-scale residential prosumers who can produce and consume electricity. This may lead to various scenarios. Such prosumers may increase the uncertainty of consumption behavior, reduce consumption from the grid, and eventually disconnect from the grid. However, they may remain connected, and their energy potential can provide flexibility for the overall system. Current policy in some jurisdictions promotes disconnection through tax increases, grid charges, and other non-commodity costs. In particular, in Ontario (Canada) only 8.7% of the typical electricity bill covers the cost of energy and power; the remainder subsidizes governmental energy-procurement contracts, compensates the grid, pays for environmental initiatives, and covers other taxes. The situation is aggravated by a lack of a global vision for the energy system and of coordinated actions to achieve this vision. We support the preferred scenario in which prosumers remain connected to the grid. As an alternative to Ontario's current attempts to artificially slow the increase in electricity prices, we present an extended critical survey of energy policies to motivate a thoughtful reconsideration of current schemes for the economic integration of prosumers in the energy system.
Keywords	electric power ; electricity ; electricity costs ; energy ; energy policy ; renewable energy sources ; surveys ; taxes ; uncertainty ; Ontario
Language	English
Dates of publication	2020-07
Publishing place	Elsevier Ltd
Document type	Article
ISSN	0301-4215
DOI	10.1016/j.enpol.2020.111429
Database	NAL-Catalogue (AGRICOLA)

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Article: Comorbidity of ectopic thymoma-associated exfoliative dermatitis and pemphigus foliaceus in a cat.

Mendoza-Kuznetsova, Ekaterina / Piedra-Mora, Cesar / Bizikova, Petra

The Canadian veterinary journal = La revue veterinaire canadienne

2021 Volume 62, Issue 10, Page(s) 1067–1070

Abstract: An 8-year-old cat was presented with pruritus, purulent paronychia, scaling, crusting, and spontaneous alopecia. Histopathology revealed intraepidermal neutrophilic pustular acantholytic dermatitis and hyperkeratotic cytotoxic interface dermatitis. No ... ...

Abstract	An 8-year-old cat was presented with pruritus, purulent paronychia, scaling, crusting, and spontaneous alopecia. Histopathology revealed intraepidermal neutrophilic pustular acantholytic dermatitis and hyperkeratotic cytotoxic interface dermatitis. No thoracic mass was seen on a lateral radiograph. Ectopic thymoma was discovered on necropsy. This case highlights the necessity for thorough investigation of any case of feline exfoliative dermatitis and pemphigus foliaceus for the presence of thymoma. Key clinical message: Comorbidity of exfoliative dermatitis and pemphigus foliaceus in a cat should prompt a thorough investigation for presence of a thymoma, possibly with advanced imaging techniques.
MeSH term(s)	Animals ; Cat Diseases ; Cats ; Comorbidity ; Dermatitis, Exfoliative/veterinary ; Pemphigus/veterinary ; Thymoma/complications ; Thymoma/veterinary ; Thymus Neoplasms/veterinary
Language	English
Publishing date	2021-10-03
Publishing country	Canada
Document type	Case Reports ; Journal Article
ZDB-ID	41603-4
ISSN	0008-5286
ISSN	0008-5286
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Article: Okislitel'nyi stress v patogeneze tserebral'nogo insul'ta i ego korrektsiya.

Martynov, M Yu / Zhuravleva, M V / Vasyukova, N S / Kuznetsova, E V / Kameneva, T R

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova

2023 Volume 123, Issue 1, Page(s) 16–27

Abstract: We reviewed the role of oxidative stress (OS) in the pathogenesis of ischemic (IS) and hemorrhagic stroke (HS). OS plays a major role in programmed cell death, increased permeability of the blood-brain barrier, astroglial and microglial activation, and ... ...

Title translation	Oxidative stress in the pathogenesis of stroke and its correction.
Abstract	We reviewed the role of oxidative stress (OS) in the pathogenesis of ischemic (IS) and hemorrhagic stroke (HS). OS plays a major role in programmed cell death, increased permeability of the blood-brain barrier, astroglial and microglial activation, and local inflammatory response. We also reviewed the current state of neuro- and cytoprotection studies and their translation in clinical practice. With respect to experimental and clinical data the efficacy of long term administration of multimodal cytoprotective drug with antioxidant effect - ethylmethylhydroxypyridine succinate (Mexidol) is discussed during the acute and early recovery period after stroke.
MeSH term(s)	Humans ; Stroke/drug therapy ; Oxidative Stress ; Antioxidants/pharmacology ; Antioxidants/therapeutic use ; Apoptosis ; Astrocytes ; Brain Ischemia/drug therapy
Chemical Substances	Antioxidants
Language	Russian
Publishing date	2023-01-31
Publishing country	Russia (Federation)
Document type	Review ; English Abstract ; Journal Article
ZDB-ID	1201462-x
ISSN	2309-4729 ; 1997-7298 ; 0044-4588
ISSN (online)	2309-4729
ISSN	1997-7298 ; 0044-4588
DOI	10.17116/jnevro202312301116
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Article ; Online: Reengineering of a flavin-binding fluorescent protein using ProteinMPNN.

Nikolaev, Andrey / Kuzmin, Alexander / Markeeva, Elena / Kuznetsova, Elizaveta / Ryzhykau, Yury L / Semenov, Oleg / Anuchina, Arina / Remeeva, Alina / Gushchin, Ivan

Protein science : a publication of the Protein Society

2024 Volume 33, Issue 4, Page(s) e4958

Abstract: Recent advances in machine learning techniques have led to development of a number of protein design and engineering approaches. One of them, ProteinMPNN, predicts an amino acid sequence that would fold and match user-defined backbone structure. Its ... ...

Abstract	Recent advances in machine learning techniques have led to development of a number of protein design and engineering approaches. One of them, ProteinMPNN, predicts an amino acid sequence that would fold and match user-defined backbone structure. Its performance was previously tested for proteins composed of standard amino acids, as well as for peptide- and protein-binding proteins. In this short report, we test whether ProteinMPNN can be used to reengineer a non-proteinaceous ligand-binding protein, flavin-based fluorescent protein CagFbFP. We fixed the native backbone conformation and the identity of 20 amino acids interacting with the chromophore (flavin mononucleotide, FMN) while letting ProteinMPNN predict the rest of the sequence. The software package suggested replacing 36-48 out of the remaining 86 amino acids so that the resulting sequences are 55%-66% identical to the original one. The three designs that we tested experimentally displayed different expression levels, yet all were able to bind FMN and displayed fluorescence, thermal stability, and other properties similar to those of CagFbFP. Our results demonstrate that ProteinMPNN can be used to generate diverging unnatural variants of fluorescent proteins, and, more generally, to reengineer proteins without losing their ligand-binding capabilities.
MeSH term(s)	Ligands ; Flavin Mononucleotide/chemistry ; Proteins ; Flavins/chemistry ; Amino Acids
Chemical Substances	Ligands ; Flavin Mononucleotide (7N464URE7E) ; Proteins ; Flavins ; Amino Acids
Language	English
Publishing date	2024-03-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	1106283-6
ISSN	1469-896X ; 0961-8368
ISSN (online)	1469-896X
ISSN	0961-8368
DOI	10.1002/pro.4958
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