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Article ; Online: Efficiency of breeding value genomic assessment of Holstein stud bulls in comparison with the assessment of the offspring quality

Isupova Yulia / Kuznetsova Maria / Gimazitdinova Ekaterina / Martynova Ekaterina

BIO Web of Conferences, Vol 36, p

2021 Volume 06045

Abstract: A comparative analysis of the genomic assessment results of Holstein breed stud bulls and their assessment on the offspring quality in the conditions of the Udmurt Republic was carried out. To analyze the efficiency of using stud bulls assessed by ... ...

Abstract	A comparative analysis of the genomic assessment results of Holstein breed stud bulls and their assessment on the offspring quality in the conditions of the Udmurt Republic was carried out. To analyze the efficiency of using stud bulls assessed by different methods, data from farms included in the ranking of the top 20 enterprises in terms of milk yield per cow for 2019-2020 were used. A high indicator of the complex LPI index (over 2500) was obtained in three bulls at the beginning of the assessment, by the end of the assessment there were two bulls left - J. Koln-M 11087837 and Super 64131037. The outsiders of the LPI ranking were stud bulls Parlament 52800347 and Patrik 51660096. The indicators of the complex LPI index are at a decent level for all analyzed stud bulls. It should be noted that stud bulls, which had the least change in the LPI index from April 1, 2014 to December 1, 2017, performed well. Bulls, which initially had overestimated results on this indicator, subsequently gave a sharp decline in the LPI index. The value of milk productivity of the evaluated stud bulls' daughters ranged from 5930 to 6415 kg, the mass fraction of fat in milk - from 3.79 to 4.02%, protein - from 3.06 to 3.11%. In most cases, the genomic assessment does not accurately reflect the change in the productive quality of stud bulls' daughters. But in the case of a predicted change to a positive or negative side in the genome, it is also confirmed by the results of assessing the offspring quality, that is, if a bull is predicted to have a sharp decrease in milk yield, then negative indicators are observed according to the “daughter-peer” method.
Keywords	Microbiology ; QR1-502 ; Physiology ; QP1-981 ; Zoology ; QL1-991
Subject code	630
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The effectiveness of the use of low-nutrient feed in industrial poultry farming

Krotova Maria / Sangadzhieva Olga / Kuznetsova Maria / Dzhabrueva Larisa / Krotova Olga / Khalgaeva Kermen

E3S Web of Conferences, Vol 431, p

2023 Volume 01046

Abstract: For the first time in the Lower Volga region, comprehensive studies have been conducted to study the effectiveness of the use of compound feeds with different structures when adding cellobacterin and acidifiers to them in egg poultry farming. Their ... ...

Abstract	For the first time in the Lower Volga region, comprehensive studies have been conducted to study the effectiveness of the use of compound feeds with different structures when adding cellobacterin and acidifiers to them in egg poultry farming. Their influence on the digestibility and digestibility of nutrients in diets, physiological and biochemical parameters of young and laying hens, egg productivity and egg quality, economic efficiency of production has been studied. As a result of research, the possibility of replacing animal feed with vegetable feed in compound feeds with the use of cellobacterin and acidifiers has been established, which, despite a slight increase in the consumption of compound feeds, leads to a reduction in the cost of rations per 1 laying hen to 11.48 rubles. Morphobiochemical blood parameters remain within the limits of physiological norms. The results of the studies conducted on laying hens showed that the safety of the livestock was 98%, egg production was 309.1 pieces in the control group and 310.7 pieces per laying hen in the experimental group, hematological indicators of laying hens in the control and experimental groups were almost at the same level. The consumption of compound feed for the period of experience in the control group of laying hens was 4414.41 kg in the amount of 67010.74 rubles, in the experimental group 4791.71 kg and 65886.01 rubles, respectively, that is, the difference in the cost of feed costs in favor of the experimental group was 1124.73 rubles. The production approbation confirmed the economic efficiency of the introduction of compound feeds into the poultry diet, in which animal feed is replaced with vegetable feed with the addition of cellobacterin and acidifiers.
Keywords	Environmental sciences ; GE1-350
Subject code	630
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Efficiency of breeding value genomic assessment of Holstein stud bulls in comparison with the assessment of the offspring quality

Isupova Yulia / Kuznetsova Maria / Gimazitdinova Ekaterina / Martynova Ekaterina

BIO web of conferences. 2021, v. 36

2021

Abstract	A comparative analysis of the genomic assessment results of Holstein breed stud bulls and their assessment on the offspring quality in the conditions of the Udmurt Republic was carried out. To analyze the efficiency of using stud bulls assessed by different methods, data from farms included in the ranking of the top 20 enterprises in terms of milk yield per cow for 2019-2020 were used. A high indicator of the complex LPI index (over 2500) was obtained in three bulls at the beginning of the assessment, by the end of the assessment there were two bulls left - J. Koln-M 11087837 and Super 64131037. The outsiders of the LPI ranking were stud bulls Parlament 52800347 and Patrik 51660096. The indicators of the complex LPI index are at a decent level for all analyzed stud bulls. It should be noted that stud bulls, which had the least change in the LPI index from April 1, 2014 to December 1, 2017, performed well. Bulls, which initially had overestimated results on this indicator, subsequently gave a sharp decline in the LPI index. The value of milk productivity of the evaluated stud bulls' daughters ranged from 5930 to 6415 kg, the mass fraction of fat in milk - from 3.79 to 4.02%, protein - from 3.06 to 3.11%. In most cases, the genomic assessment does not accurately reflect the change in the productive quality of stud bulls' daughters. But in the case of a predicted change to a positive or negative side in the genome, it is also confirmed by the results of assessing the offspring quality, that is, if a bull is predicted to have a sharp decrease in milk yield, then negative indicators are observed according to the “daughter-peer” method.
Keywords	Holstein ; bulls ; cows ; genome ; genomics ; milk ; milk yield
Language	English
Publishing place	EDP Sciences
Document type	Article
ZDB-ID	2673408-4
ISSN	2117-4458
ISSN	2117-4458
DOI	10.1051/bioconf/20213606045
Database	NAL-Catalogue (AGRICOLA)

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Book ; Online: Spatial structure and economic network formation of manufacturing exports in Russia

Kuznetsova, Maria

(Working paper series / Economics Education and Research Consortium ; no. E16/08)

2016

Author's details	Maria Kuznetsova
Series title	Working paper series / Economics Education and Research Consortium ; no. E16/08
Keywords	Export ; Spillover-Effekt ; Agglomerationseffekt ; Unternehmensnetzwerk ; Exportwirtschaft ; Industrie ; Russland
Language	English
Size	1 Online-Ressource (circa 34 Seiten), Illustrationen
Publisher	Economics Education and Research Consortium
Publishing place	Moscow
Document type	Book ; Online
Database	ECONomics Information System

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Article: Recent Advances in DNA Nanomaterials.

Bekkouche, Incherah / Kuznetsova, Maria N / Rejepov, Dovlet T / Vetcher, Alexandre A / Shishonin, Alexander Y

Nanomaterials (Basel, Switzerland)

2023 Volume 13, Issue 17

Abstract: Applications of DNA-containing nanomaterials (DNA-NMs) in science and technology are currently attracting increasing attention in the fields of medicine, environment, engineering, etc. Such objects have become important for various branches of science ... ...

Abstract	Applications of DNA-containing nanomaterials (DNA-NMs) in science and technology are currently attracting increasing attention in the fields of medicine, environment, engineering, etc. Such objects have become important for various branches of science and industries due to their outstanding characteristics such as small size, high controllability, clustering actions, and strong permeability. For these reasons, DNA-NMs deserve a review with respect to their recent advancements. On the other hand, precise cluster control, targeted drug distribution in vivo, and cellular micro-nano operation remain as problems. This review summarizes the recent progress in DNA-NMs and their crossover and integration into multiple disciplines (including in vivo/in vitro, microcircles excisions, and plasmid oligomers). We hope that this review will motivate relevant practitioners to generate new research perspectives and boost the advancement of nanomanipulation.
Language	English
Publishing date	2023-08-29
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662255-5
ISSN	2079-4991
ISSN	2079-4991
DOI	10.3390/nano13172449
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Mimicking the cellular environment does not cause monocyte-derived macrophages to become phenotypically similar to Kupffer cells.

Elchaninov, Andrey / Vishnyakova, Polina / Kuznetsova, Maria / Lokhonina, Anastasiya / Soboleva, Anna / Trofimov, Dmitry / Fatkhudinov, Timur / Sukhikh, Gennady

Immunology and cell biology

2024 Volume 102, Issue 5, Page(s) 381–395

Abstract: Resident macrophages of various mammalian organs are characterized by several distinctive features in their gene expression profile and phenotype, including involvement in the regulation of organ functions, as well as reduced sensitivity to ... ...

Abstract	Resident macrophages of various mammalian organs are characterized by several distinctive features in their gene expression profile and phenotype, including involvement in the regulation of organ functions, as well as reduced sensitivity to proinflammatory activation factors. The reasons for the formation of such a specific phenotype remain the subject of intensive research. Some papers emphasize the role of the origin of organ macrophages. Other studies indicate that monocytes that develop in the red bone marrow are also able to form resident macrophages with a phenotype characteristic of a particular organ, but this requires appropriate microenvironmental conditions. In this article, we studied the possibility of differentiation of monocyte-derived macrophages into cells with a Kupffer-like phenotype under the influence of the main stromal components of Kupffer cells macrophage niche: Ito cells, liver sinusoid endotheliocytes and hepatocyte growth factor (HGF). It was found that Kupffer cells are characterized by several features, including increased expression of transcription factors Spic and Id3, as well as MUP family genes, Clusterin and Ngp genes. In addition, Kupffer cells were characterized by a higher proliferative activity. The expression of marker genes of Kupffer cells (i.e. Id3, Spic, Marco and Timd4) increased in monocyte-derived macrophages during coculture with Ito cells, liver sinusoid endothelial cells, macrophage colony-stimulating factor and HGF cells only by 3 days. However, the expression level of these genes was always higher in Kupffer cells. In addition, a complete coincidence of the expressed gene profile in monocyte-derived macrophages and Kupffer cells did not occur even after 3 days of culturing.
MeSH term(s)	Kupffer Cells/metabolism ; Kupffer Cells/cytology ; Cell Differentiation ; Phenotype ; Macrophages/metabolism ; Cellular Microenvironment ; Animals ; Monocytes/metabolism ; Monocytes/cytology ; Hepatocyte Growth Factor/metabolism ; Endothelial Cells/metabolism ; Coculture Techniques ; Humans ; Cell Proliferation ; Cells, Cultured ; Liver/cytology ; Liver/metabolism ; Mice
Chemical Substances	Hepatocyte Growth Factor (67256-21-7)
Language	English
Publishing date	2024-04-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	284057-1
ISSN	1440-1711 ; 0818-9641
ISSN (online)	1440-1711
ISSN	0818-9641
DOI	10.1111/imcb.12746
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The Distinct Effects of the Mitochondria-Targeted STAT3 Inhibitors Mitocur-1 and Mitocur-3 on Mast Cell and Mitochondrial Functions.

Pavlyuchenkova, Anastasia N / Chelombitko, Maria A / Fedorov, Artem V / Kuznetsova, Maria K / Zinovkin, Roman A / Razin, Ehud

International journal of molecular sciences

2023 Volume 24, Issue 2

Abstract: There is accumulating evidence that mitochondria and mitochondrial STAT3 are involved in the activation of mast cells. The mitochondria-targeted curcuminoids Mitocur-1 and Mitocur-3 have been suggested to reduce antigen-dependent mast cell activation by ... ...

Abstract	There is accumulating evidence that mitochondria and mitochondrial STAT3 are involved in the activation of mast cells. The mitochondria-targeted curcuminoids Mitocur-1 and Mitocur-3 have been suggested to reduce antigen-dependent mast cell activation by inhibiting mitochondrial STAT3. The aim of the current work was to investigate the mechanisms of action of these mitocurcuminoids on mast cells and mitochondrial functions. The pretreatment of rat basophilic leukemia cells RBL-2H3 with Mitocur-1 and Mitocur-3 decreased antigen-dependent degranulation but did not affect spontaneous degranulation. Both compounds caused mitochondrial fragmentation and increased mitochondrial ROS. Inhibition of Drp1 prevented mitochondrial fragmentation induced by Mitocur-3 but not by Mitocur-1. The antioxidant N-acetylcysteine inhibited mitochondrial fission induced by Mitocur-1 but not Mitocur-3. Mitochondrial fragmentation caused by Mitocur-3 but not Mitocur-1 was accompanied by activation of Drp1 and AMPK. These data suggest a distinct mechanism of action of mitocurcuminoids on the mitochondria of RBL-2H3 cells: Mitocur-3 stimulated AMPK and caused Drp1-dependent mitochondrial fragmentation, while Mitocur-1-induced mitochondrial fission was ROS-dependent. This difference may contribute to the higher toxicity of Mitocur-3 compared to Mitocur-1. The findings contribute to further drug development for inflammatory and allergic diseases.
MeSH term(s)	Rats ; Animals ; Cell Degranulation ; Mast Cells/metabolism ; Reactive Oxygen Species/metabolism ; AMP-Activated Protein Kinases/metabolism ; Antigens/metabolism ; Mitochondria
Chemical Substances	Reactive Oxygen Species ; AMP-Activated Protein Kinases (EC 2.7.11.31) ; Antigens
Language	English
Publishing date	2023-01-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24021471
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Novel Approaches to Possible Targeted Therapies and Prophylaxis of Uterine Fibroids.

Kuznetsova, Maria V / Tonoyan, Narine M / Trubnikova, Elena V / Zelensky, Dmitry V / Svirepova, Ksenia A / Adamyan, Leila V / Trofimov, Dmitry Y / Sukhikh, Gennady T

Diseases (Basel, Switzerland)

2023 Volume 11, Issue 4

Abstract: Uterine leiomyomas are the most common benign tumors in women of childbearing age. They may lead to problems of conception or complications during the gestational period. The methods of treatment include surgical (myomectomy and hysterectomy, ... ...

Abstract	Uterine leiomyomas are the most common benign tumors in women of childbearing age. They may lead to problems of conception or complications during the gestational period. The methods of treatment include surgical (myomectomy and hysterectomy, embolization of arteries) and therapeutic treatment (ulipristal acetate, leuprolide acetate, cetrorelix, goserelin, mifepristone). Both approaches are efficient but incompatible with pregnancy planning. Therefore, there is a call for medical practice to develop therapeutical means of preventing leiomyoma onset in patients planning on becoming pregnant. Based on the analysis of GWAS data on the search for mononucleotide polymorphisms associated with the risk of leiomyoma, in meta-transcriptomic and meta-methylomic studies, target proteins have been proposed. Prospective therapeutic treatments of leiomyoma may be based on chemical compounds, humanized recombinant antibodies, vaccines based on markers of the uterine leiomyoma cells that are absent in the adult organism, or DNA and RNA preparations. Three different nosological forms of the disease associated with driver mutations in the
Language	English
Publishing date	2023-11-01
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2720869-2
ISSN	2079-9721
ISSN	2079-9721
DOI	10.3390/diseases11040156
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Different Trajectories for Diabetes Mellitus Onset and Recovery According to the Centralized Aerobic-Anaerobic Energy Balance Compensation Theory.

Vetcher, Alexandre A / Zhukov, Kirill V / Gasparyan, Bagrat A / Borovikov, Pavel I / Karamian, Arfenia S / Rejepov, Dovlet T / Kuznetsova, Maria N / Shishonin, Alexander Y

Biomedicines

2023 Volume 11, Issue 8

Abstract: We recently reported that the restoration of cervical vertebral arterial blood flow access (measured as systolic peak (PS)) to the rhomboid fossa leads to the recovery of the HbA1c level in the case of patients with a pre-Diabetes Mellitus (pre-DM) ... ...

Abstract	We recently reported that the restoration of cervical vertebral arterial blood flow access (measured as systolic peak (PS)) to the rhomboid fossa leads to the recovery of the HbA1c level in the case of patients with a pre-Diabetes Mellitus (pre-DM) condition. The theory of centralized aerobic-anaerobic energy balance compensation (TCAAEBC) provides a successful theoretical explanation for this observation. It considers the human body as a dissipative structure. Reported connections between arterial hypertension (AHT) and the level of HbA1c are linked through OABFRH. According to the TCAAEBC, this delivers incorrect information about blood oxygen availability to the cerebellum. The restoration of PS normalizes AHT in 5-6 weeks and HbA1c in 12-13 weeks. In the current study, we demonstrate the model which fits the obtained experimental data. According to the model, pathways of onset and recovery from pre-DM are different. The consequence of these differences is discussed. The great significance of the TCAAEBC for medical practice forces the creation of an appropriate mathematical model, but the required adjustment of the model needs experimental data which can only be obtained from an animal model(s). The essential part of this study is devoted to the analysis of the advantages and disadvantages of widely available common mammalian models for TCAAEBC cases.
Language	English
Publishing date	2023-07-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines11082147
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: How the enriched get richer? Experience-dependent modulation of microRNAs and the therapeutic effects of environmental enrichment.

Kuznetsova, Maria / Wilson, Carey / Hannan, Anthony J / Renoir, Thibault

Pharmacology, biochemistry, and behavior

2020 Volume 195, Page(s) 172940

Abstract: Environmental enrichment and physical exercise have many well-established health benefits. Although these environmental manipulations are known to delay symptom onset and progression in a variety of neurological and psychiatric conditions, the mechanisms ...

Abstract	Environmental enrichment and physical exercise have many well-established health benefits. Although these environmental manipulations are known to delay symptom onset and progression in a variety of neurological and psychiatric conditions, the mechanisms underlying these effects remain poorly understood. A notable candidate molecular mechanism is that of microRNA, a family of small noncoding RNAs that are important regulators of gene expression. Research investigating the many diverse roles of microRNAs has greatly expanded over the past decade, with several promising preclinical and clinical studies highlighting the role of dysregulated microRNA expression (in the brain, blood and other peripheral systems) in understanding the aetiology of disease. Altered microRNA levels have also been described following environmental interventions such as exercise and environmental enrichment in non-clinical populations and wild-type animals, as well as in some brain disorders and associated preclinical models. Recent studies exploring the effects of stimulating environments on microRNA levels in the brain have revealed an array of changes that are likely to have important downstream effects on gene expression, and thus may regulate a variety of cellular processes. Here we review literature that explores the differential expression of microRNAs in rodents following environmental enrichment and exercise, in both healthy control animals and preclinical models of relevance to neurological and psychiatric disorders.
MeSH term(s)	Animals ; Brain/metabolism ; Brain Diseases/genetics ; Brain Diseases/metabolism ; Exercise ; Gene Expression ; Humans ; Mental Disorders/genetics ; Mental Disorders/metabolism ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Physical Conditioning, Animal ; Rodentia/psychology ; Social Behavior ; Social Interaction
Chemical Substances	MicroRNAs
Language	English
Publishing date	2020-05-13
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	191042-5
ISSN	1873-5177 ; 0091-3057
ISSN (online)	1873-5177
ISSN	0091-3057
DOI	10.1016/j.pbb.2020.172940
Database	MEDical Literature Analysis and Retrieval System OnLINE

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