Article ; Online: Protective actions of a luminally acting 5-HT
Neurogastroenterology and motility
2023 Volume 35, Issue 11, Page(s) e14673
Abstract: Background: 5-hydroxytryptamine 4 receptors (5-HT: Methods: The dextran sodium sulfate (DSS), trinitrobenzene sulfonic acid (TNBS), and interleukin 10 knockout (IL-10KO) models of colitis were used to test the protective effects of the luminally ... ...
| Abstract | Background: 5-hydroxytryptamine 4 receptors (5-HT Methods: The dextran sodium sulfate (DSS), trinitrobenzene sulfonic acid (TNBS), and interleukin 10 knockout (IL-10KO) models of colitis were used to test the protective effects of the luminally acting 5-HT Key results: Daily enema of 5HT4-LA1 attenuated the development of, and accelerated recovery from, active colitis. Enema administration of 5HT4-LA1 did not attenuate the development of colitis in 5-HT Conclusions and inferences: Luminally restricted 5-HT |
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| MeSH term(s) | Humans ; Mice ; Animals ; Serotonin ; Caco-2 Cells ; Colitis/chemically induced ; Colitis/drug therapy ; Colitis/pathology ; Mice, Knockout ; Water | |||||
| Chemical Substances | Serotonin (333DO1RDJY) ; Water (059QF0KO0R) | |||||
| Language | English | |||||
| Publishing date | 2023-10-13 | |||||
| Publishing country | England | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 1186328-6 | |||||
| ISSN | 1365-2982 ; 1350-1925 | |||||
| ISSN (online) | 1365-2982 | |||||
| ISSN | 1350-1925 | |||||
| DOI | 10.1111/nmo.14673 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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