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Article ; Online: Regnase-2 inhibits glioblastoma cell proliferation.

Sowinska, Weronika / Wawro, Mateusz / Kochan, Jakub / Solecka, Aleksandra / Polak, Jarosław / Kwinta, Borys / Kasza, Aneta

Scientific reports

2024 Volume 14, Issue 1, Page(s) 1574

Abstract: Regnase-2 (Reg-2/MCPIP2/ZC3H12B) is uniquely expressed at a high level in the healthy brain and down-regulated in samples from patients with glioma, reaching the lowest level in high-grade glioblastoma multiforme (GBM). This RNase is involved in the ... ...

Abstract	Regnase-2 (Reg-2/MCPIP2/ZC3H12B) is uniquely expressed at a high level in the healthy brain and down-regulated in samples from patients with glioma, reaching the lowest level in high-grade glioblastoma multiforme (GBM). This RNase is involved in the regulation of neuroinflammation through the degradation of IL-6 and IL-1 mRNAs, key pro-inflammatory cytokines for GBM pathology. Reg-2 is a strong inhibitor of the proliferation of human glioblastoma cell lines and blocks their potential to form colonies. Here, we describe that overexpression of Reg-2 stalls glioblastoma cells in the G1 phase of the cell cycle and reduces the level of transcripts implicated in cell cycle progression. These newly identified targets include CCND1, CCNE1, CCNE2, CCNA2, CCNB1, and CCNB2, encoding the cyclins as well as AURKA and PLK1, encoding two important mitosis regulators. By RNA immunoprecipitation we confirmed the direct interaction of Reg-2 with the investigated transcripts. We also tested mRNA regions involved in their interaction with Reg-2 on the example of CCNE2. Reg-2 interacts with the 3'UTR of CCNE2 in a dose-dependent manner. In conclusion, our results indicate that Reg-2 controls key elements in GBM biology by restricting neuroinflammation and inhibiting cancer cell proliferation.
MeSH term(s)	Humans ; Glioblastoma/pathology ; Neuroinflammatory Diseases ; Cell Line, Tumor ; Brain Neoplasms/pathology ; Cell Proliferation/genetics ; Gene Expression Regulation, Neoplastic
Language	English
Publishing date	2024-01-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-51809-x
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Article: Unruptured intracranial aneurysms: Why should we focus on small aneurysms? A comprehensive update of recent findings.

Frączek, Maciej Jakub / Krzyżewski, Roger Marek / Kliś, Kornelia Maria / Kwinta, Borys Maria / Popiela, Tadeusz Jan / Stachura, Krzysztof

Polish journal of radiology

2024 Volume 89, Page(s) e13–e23

Abstract: Intracranial aneurysms (IAs) are a significant public health concern because they have the potential to cause deva-stating consequences, including death and disability. Despite advances in diagnostic and treatment modalities, the outcomes for patients ... ...

Abstract	Intracranial aneurysms (IAs) are a significant public health concern because they have the potential to cause deva-stating consequences, including death and disability. Despite advances in diagnostic and treatment modalities, the outcomes for patients with aneurysmal subarachnoid haemorrhage (aSAH) remain poor, with high rates of rebleeding, vasospasm, and cerebral ischaemia. IAs are a significant risk factor for aSAH, and it is estimated that up to 3% of the general population have IAs. Recent studies using novel imaging modalities have shown that the prevalence of IAs may be much higher, with 6.6% of adults aged 40-84 years having intradural saccular IAs ≥ 2 mm. The risk of rupture for IAs is difficult to predict, and the decision to treat them invasively is based on a balance between the estimated rupture risk and the procedural risks of the treatment. However, the mortality and morbidity rates among patients treated for IAs can be as high as 5%. There is a need for clear guidelines on the treatment of IAs, and this review aims to provide an update on recent findings in this area. To achieve this goal, the authors identified and summarized recent, high-impact studies on IAs. The review focuses on the diagnostic and treatment options for IAs, as well as the risks associated with these interventions. The authors also provide an overview of the natural history of IAs and discuss the challenges and uncertainties in managing these patients.
Language	English
Publishing date	2024-01-12
Publishing country	Poland
Document type	Journal Article ; Review
ZDB-ID	2675143-4
ISSN	1899-0967 ; 1733-134X
ISSN (online)	1899-0967
ISSN	1733-134X
DOI	10.5114/pjr.2024.134424
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Article ; Online: Association of Imaging-based Predictors with Outcome in Different Treatment Options for Intracerebral Hemorrhage.

Krzyżewski, Roger M / Kwinta, Borys M / Stachura, Krzysztof / Popiela, Tadeusz J / Pułyk, Roman / Słowik, Agnieszka / Gąsowski, Jerzy / Kliś, Kornelia M

Clinical neuroradiology

2024

Abstract: Purpose: Intracerebral hemorrhage is the deadliest form of stroke. This study aimed to enhance the prediction of 30-day mortality in intracerebral hemorrhage patients by integrating computational parameters.: Methods: This study retrospectively ... ...

Abstract	Purpose: Intracerebral hemorrhage is the deadliest form of stroke. This study aimed to enhance the prediction of 30-day mortality in intracerebral hemorrhage patients by integrating computational parameters. Methods: This study retrospectively analyzed 435 patients with spontaneous intracerebral hemorrhage (ICH). Utilizing the acquired computed tomography (CT) images, we extracted the contour and visual representation of ICH. For the extracted contour, the analysis encompassed factors including compactness, fractal dimension, Fourier factor, and circle factor. For the images depicting ICH, we calculated various factors related to density distribution including mean, coefficient of variance, skewness and kurtosis, as well as texture parameters, such as energy, entropy, contrast and homogeneity. To assess the impact of surgical treatment on 30-day mortality, logistic regression analysis was used. Results: A total of 126 patients (29.09%) died within 30 days. A total of 62 (14.25%) patients underwent surgical treatment. Multivariate logistic regression analysis revealed that surgical treatment was independently associated with a lower risk of 30-day mortality (odds ratio, OR 0.226, 95% confidence interval, CI 0.049-0.85; p = 0.039). Based on the moderated analysis, we found that the volume of ICH (OR 0.905, 95% CI 0.902-0.908; p < 0.001) and ICH energy (OR 1.389, 95%CI 0.884-0.988; p = 0.010) had positive moderating effect on such associations while the presence of intraventricular blood had negative moderating effect (OR 1.154, 95% CI 1.034-1.628; p = 0.010). Conclusion: Patients exhibiting a higher volume and energy of ICH might benefit from surgical treatment; however, this efficacy was found to be diminished in cases involving the presence of intraventricular blood.
Language	English
Publishing date	2024-04-26
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2234662-4
ISSN	1869-1447 ; 0939-7116 ; 1869-1439
ISSN (online)	1869-1447
ISSN	0939-7116 ; 1869-1439
DOI	10.1007/s00062-024-01406-2
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Zs.A 3413: Show issues

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Article: Retrospective evaluation of endoscopic treatment in colloid cyst of the third ventricle.

Stachura, Krzysztof / Grzywna, Ewelina / Krzyżewski, Roger M / Kwinta, Borys Maria

Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques

2021 Volume 16, Issue 3, Page(s) 604–611

Abstract: Introduction: Endoscopic methods have gained a well-established position in surgical treatment of colloid cysts of third ventricle. However, the possibility of total tumor removal with this method and the long-term effectiveness of treatment are being ... ...

Abstract	Introduction: Endoscopic methods have gained a well-established position in surgical treatment of colloid cysts of third ventricle. However, the possibility of total tumor removal with this method and the long-term effectiveness of treatment are being questioned. Aim: Personal twenty years' experience in treatment of third ventricle colloid cysts is presented on the basis of retrospective analysis. Material and methods: The study group included 58 patients diagnosed by neuroimaging (head CT/MRI) with third ventricle colloid cyst. Post-hospital follow-up ranged from 18 to 42 months. Long-term follow-up head CT/MRI was performed in 39 patients. Results: The colloid cyst was removed totally in 47 (81%) patients. In 11 cases, the colloid cyst's wall was tightly adherent to the roof of the third ventricle, which limited the radicality of the procedure. Sixteen patients demonstrated memory impairments, 4 patients epilepsy and another 2 akinetic mutism in the direct postoperative course. One patient died as a result of complications unrelated to the procedure. The average hospitalization was 5 days. In the late period after surgery, remission of the most, previously, reported ailments and symptoms has been reported. Surgical treatment for hydrocephalus was needed in 7 patients. In 3 cases cyst recurrence was diagnosed which required reoperation. Conclusions: The endoscopic methods allow the total removal of a third ventricle colloid cyst in most patients. Leaving a small coagulated fragment of the cyst rarely results in its recurrence. This method results in effective treatment with a low complications rate, shortens hospitalization time and brings the patient a high level of satisfaction with a quick recovery.
Language	English
Publishing date	2021-02-26
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2596147-0
ISSN	2299-0054 ; 1895-4588
ISSN (online)	2299-0054
ISSN	1895-4588
DOI	10.5114/wiitm.2021.103957
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Article ; Online: The influence of embolization of internal carotid artery aneurysms on arterial tortuosity: a prospective cohort study.

Krzyżewski, Roger M / Kliś, Kornelia M / Kwinta, Borys M / Stachura, Krzysztof / Popiela, Tadeusz J / Brzegowy, Paweł / Łasocha, Bartłomiej / Urbanik, Andrzej / Grodzicki, Tomasz / Milczarek, Olga / Gąsowski, Jerzy

Journal of vascular and interventional radiology : JVIR

2024

Abstract: Purpose: To compare quantitative tortuosity descriptors of Internal Carotid Artery (ICA) on aneurysmal and non-aneurysmal side before and after embolization of aneurysm and to determine possible factors associated with its change.: Material and ... ...

Abstract	Purpose: To compare quantitative tortuosity descriptors of Internal Carotid Artery (ICA) on aneurysmal and non-aneurysmal side before and after embolization of aneurysm and to determine possible factors associated with its change. Material and methods: An analysis of 52 patients with intracranial aneurysm, treated with endovascular procedure, was performed. Based on their Digital Subtraction Angiography images, obtained prior to the procedure and after first follow-up examination, tortuosity of ICA, both on the side of embolization and on the other side was analysed. For each patient tortuosity descriptors were calculated: Relative Length, Sum of Angle Metrics, Triangular Index, Product of Angle Distance, and Inflection Count Metric. To represent changes in tortuosity, for each descriptor delta value (Δ) was defined as value of the descriptor prior to embolization - value of the descriptor on follow-up examination. Results: In the follow-up We found no statistically significant changes in tortuosity on non-embolized side. On the embolized side SOAM (2.89±0.92 vs. 2.38±0.94;p<0.001), PAD (5.01±1.83 vs. 3.95±1.72 ;p<0.001) and ICM (12.18±4.55 vs. 9.76±4.04 vs.;p = 0.006) was significantly higher after embolization than before embolization. Mean ΔRelative Length (-0.02 [-0.045--0.002] vs. -0.01 [-0.02-0.003];p - 0.003),ΔProduct of Angle Distance (0.84 [0.30 - 1.82] vs. 0.10 [-0.001 - 1.10];p<0.001) and ΔInflection Count Metric (2.05 [0.42 - 3.50] vs. 0.27 [0.02 - 2.16];p = 0.004) were significantly higher on the embolized side. Conclusion: Following study showed that embolization may increase the tortuosity of ICA.
Language	English
Publishing date	2024-04-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	1137756-2
ISSN	1535-7732 ; 1051-0443
ISSN (online)	1535-7732
ISSN	1051-0443
DOI	10.1016/j.jvir.2024.04.012
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Zs.A 3720: Show issues

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Article ; Online: Possible association between β-blocker use and a risk of intracranial aneurysm rupture.

Krzyżewski, Roger M / Kliś, Kornelia M / Kwinta, Borys M / Stachura, Krzysztof / Piotrowicz, Karolina / Popiela, Tadeusz J / Frączek, Maciej J / Grodzicki, Tomasz / Gąsowski, Jerzy

Polish archives of internal medicine

2024 Volume 134, Issue 2

Abstract: Introduction: Aneurysmal subarachnoid hemorrhage is a devastating type of stroke, associated with high mortality and morbidity. One of modifiable risk factors of aneurysm rupture is hypertension, however, it is still not clear whether any particular ... ...

Abstract	Introduction: Aneurysmal subarachnoid hemorrhage is a devastating type of stroke, associated with high mortality and morbidity. One of modifiable risk factors of aneurysm rupture is hypertension, however, it is still not clear whether any particular antihypertensive drugs play a significant role in the prevention of aneurysm rupture. Objectives: We decided to investigate whether there is any association between acetylsalicylic acid, α-blockers, β‑blockers, angiotensin‑converting enzyme inhibitors, angiotensin II receptor blockers, calcium channel blockers, diuretics, statins, and anticoagulants and a risk of intracranial aneurysm rupture. Patients and methods: We retrospectively analyzed 334 patients with ruptured and unruptured intracranial aneurysm. Based on logistic regression models, we obtained unadjusted and adjusted odds ratios (ORs) of subarachnoid hemorrhage associated with the use of vasoactive medications and with indices of tortuosity. Results: We found that β‑blocker intake was significantly related to higher tortuosity of the cerebral arteries. Also, the intake of β‑blockers (OR, 0.41; 95% CI, 0.21-0.77; P = 0.01) and statins (OR, 0.23; 95% CI, 0.05-0.68; P = 0.01) significantly decreased the risk of aneurysm rupture, a result driven by a decreased rupture risk of anterior circulation aneurysms. No such association was found for the posterior part of the cerebral circulation. Conclusions: Aneurysm located in the anterior cerebral circulation might be less likely to rupture if patients receive β‑blockers or statins.
MeSH term(s)	Humans ; Intracranial Aneurysm/complications ; Retrospective Studies ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects ; Subarachnoid Hemorrhage/complications ; Risk Factors ; Aneurysm, Ruptured/complications ; Adrenergic beta-Antagonists/adverse effects
Chemical Substances	Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Adrenergic beta-Antagonists
Language	English
Publishing date	2024-01-02
Publishing country	Poland
Document type	Journal Article
ZDB-ID	123500-x
ISSN	1897-9483 ; 0032-3772
ISSN (online)	1897-9483
ISSN	0032-3772
DOI	10.20452/pamw.16642
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Article: Endovascular therapy of symptomatic high-grade stenosis of left internal carotid artery in C6 segment using Elutax "3" Neuro pDEB.

Latacz, Paweł / Popiela, Tadeusz / Brzegowy, Paweł / Kwinta, Borys / Chwała, Maciej / Simka, Marian

Postepy w kardiologii interwencyjnej = Advances in interventional cardiology

2021 Volume 17, Issue 3, Page(s) 332–333

Language	English
Publishing date	2021-09-14
Publishing country	Poland
Document type	Journal Article
ISSN	1734-9338
ISSN	1734-9338
DOI	10.5114/aic.2021.109162
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Article ; Online: Sub-cellular elemental imaging of human muscle tissues affected by neuromuscular diseases

Śliż-Szpytma Patrycja / Lankosz Marek / Dudała Joanna / Adamek Dariusz / Radwanska Edyta / Kwinta Borys / Jakšić Milko / Božičević Mihalić Iva / Provatas Georgios

Nukleonika, Vol 66, Iss 4, Pp 159-

2021 Volume 164

Abstract: Various types of neuromuscular diseases differ in symptoms, pathology, and clinical picture but one of their common elements is muscle weakness, which could lead to human motor activities impairment and in many cases to shortening of life span and even ... ...

Abstract	Various types of neuromuscular diseases differ in symptoms, pathology, and clinical picture but one of their common elements is muscle weakness, which could lead to human motor activities impairment and in many cases to shortening of life span and even death due to respiratory failure. That is why it is very important to better understand the underlying causes of these diseases to be able to implement new methods of treatment more effectively. This paper presents the results of the elemental analysis of human muscular tissues affected by dystrophy and myopathy. For this purpose, the particle-induced X-ray emission method was used, which is perfectly suited for measuring light elements. The samples were analysed for differences in the elemental composition of Na, Mg, P, S, Cl, K, Fe, Zn, and Br. The results were presented in the form of elemental concentration maps and a thorough statistical analysis of the obtained data using the advanced statistical methods.
Keywords	dystrophy ; elemental analysis ; myopathy ; neurodegenerative diseases ; pixe ; Science ; Q
Subject code	610
Language	English
Publishing date	2021-11-01T00:00:00Z
Publisher	Sciendo
Document type	Article ; Online
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Article ; Online: Predictors of intraoperative intracranial aneurysm rupture in patients with subarachnoid hemorrhage: a retrospective analysis.

Frączek, Maciej J / Błoński, Miłosz J / Kliś, Kornelia M / Krzyżewski, Roger M / Polak, Jarosław / Stachura, Krzysztof / Kwinta, Borys M

Acta neurologica Belgica

2022 Volume 123, Issue 5, Page(s) 1717–1724

Abstract: Purpose: Intraoperative cerebral aneurysm rupture (IOR) is a common phenomenon with a frequency of around 19%. Research regarding IOR lacks an analysis of its predictors.: Methods: We retrospectively examined all saccular aneurysms, in 198 patients ... ...

Abstract	Purpose: Intraoperative cerebral aneurysm rupture (IOR) is a common phenomenon with a frequency of around 19%. Research regarding IOR lacks an analysis of its predictors. Methods: We retrospectively examined all saccular aneurysms, in 198 patients with subarachnoid hemorrhage, surgically treated from 2013 to 2019. Operative reports, patient histories, blood test results, discharge summaries, and radiological data were reviewed. IOR was defined as any bleeding from the aneurysm during surgery, preceding putting a clip on its neck, regardless of how trivial. Results: The frequency of IOR was 20.20%. Patients with IOR had higher aneurysm dome size (9.43 ± 8.39 mm vs. 4.96 ± 2.57 mm; p < 0.01). The presence of blood clot on the aneurysm dome was significantly associated with IOR (12.50% vs. 2.53%; p < 0.01). We also associated lamina terminalis fenestration during surgery (7.50% vs. 21.52%; p = 0.04) and multiple aneurysms (5.00% vs. 18.35%; p = 0.038) with a lower risk of IOR. Glucose blood levels were also elevated in patients with IOR (7.47 ± 2.78 mmol/l vs. 6.90 ± 2.22 mmol/l; p = 0.04). Multivariate analysis associated that urea blood levels (OR 0.55, 0.33 to 0.81, p < 0.01) and multiple aneurysms (OR 0.04, 0.00 to 0.37, p = 0.014) were protective factors against the occurrence of IOR. Conclusion: Large dome size of an aneurysm, a blood clot on the aneurysm dome and elevated glucose blood levels can be IOR predictive. Lamina terminalis fenestration, the appearance of multiple aneurysms, and high urea blood levels may be associated with a lower risk of such an event.
MeSH term(s)	Humans ; Intracranial Aneurysm/complications ; Intracranial Aneurysm/diagnostic imaging ; Intracranial Aneurysm/surgery ; Subarachnoid Hemorrhage/diagnostic imaging ; Subarachnoid Hemorrhage/etiology ; Subarachnoid Hemorrhage/surgery ; Retrospective Studies ; Intraoperative Complications/epidemiology ; Intraoperative Complications/surgery ; Aneurysm, Ruptured/complications ; Aneurysm, Ruptured/diagnostic imaging ; Aneurysm, Ruptured/surgery ; Glucose ; Urea
Chemical Substances	Glucose (IY9XDZ35W2) ; Urea (8W8T17847W)
Language	English
Publishing date	2022-06-27
Publishing country	Italy
Document type	Journal Article
ZDB-ID	127315-2
ISSN	2240-2993 ; 0300-9009
ISSN (online)	2240-2993
ISSN	0300-9009
DOI	10.1007/s13760-022-02005-z
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Article ; Online: Subarachnoid Hemorrhage from Ruptured Internal Carotid Artery Aneurysm: Association with Arterial Tortuosity.

Krzyżewski, Roger M / Kliś, Kornelia M / Kwinta, Borys M / Łasocha, Bartłomiej / Brzegowy, Paweł / Popiela, Tadeusz J / Gąsowski, Jerzy

World neurosurgery

2022 Volume 166, Page(s) e84–e92

Abstract: Objective: Many researchers have found a correlation between tortuous arteries and development of aneurysms in cerebral arteries. We decided to determine whether tortuosity of the internal carotid artery can be related to its aneurysm rupture.: ... ...

Abstract	Objective: Many researchers have found a correlation between tortuous arteries and development of aneurysms in cerebral arteries. We decided to determine whether tortuosity of the internal carotid artery can be related to its aneurysm rupture. Methods: We retrospectively analyzed the internal carotid artery anatomy of 149 patients with internal carotid artery aneurysms. For each patient, we calculated relative length (RL), sum of angle metrics (SOAM), triangular index (TI), product of angle distance (PAD), and inflection count metrics (ICM). Results: A total of 33 patients (22.15%) had subarachnoid hemorrhage. These patients had significantly lower SOAM (0.31 ± 0.17 vs. 0.42 ± 0.21; P < 0.01), TI (0.27 ± 0.09 vs. 0.31 ± 0.11; P = 0.03) and ICM (0.25 ± 0.11 vs. 0.31 ± 0.17; P = 0.04). In multivariate logistic regression analysis, higher SOAM (odds ratio, 0.780; 95% confidence interval, 0.619-0.961; P = 0.025) remained independently associated with lower risk of internal carotid artery aneurysm rupture. In addition, we found significant positive correlation of aneurysm dome size with SOAM (R = 0.224; P = 0.013) and PAD (0.269; P < 0.01). Our study also showed that age (R = 0.252; P = 0.036), Glasgow Coma Scale score (R = -0.706; P < 0.01), and TI (R = -0.249; P = 0.042) were independently correlated with modified Rankin Scale score on discharge. Conclusions: Lower tortuosity might be a protective factor against internal carotid artery aneurysm rupture and poor outcome after subarachnoid hemorrhage. Higher tortuosity is correlated with internal carotid artery aneurysm growth.
MeSH term(s)	Aneurysm, Ruptured/complications ; Aneurysm, Ruptured/diagnostic imaging ; Arteries/abnormalities ; Carotid Artery Diseases/complications ; Carotid Artery Diseases/diagnostic imaging ; Carotid Artery, Internal/diagnostic imaging ; Humans ; Intracranial Aneurysm/complications ; Intracranial Aneurysm/diagnostic imaging ; Joint Instability ; Retrospective Studies ; Skin Diseases, Genetic ; Subarachnoid Hemorrhage/complications ; Subarachnoid Hemorrhage/etiology ; Vascular Malformations
Language	English
Publishing date	2022-07-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2534351-8
ISSN	1878-8769 ; 1878-8750
ISSN (online)	1878-8769
ISSN	1878-8750
DOI	10.1016/j.wneu.2022.06.101
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