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  1. Article: Feasibility of Emotional Freedom Techniques in Patients with Posttraumatic Stress Disorder: a pilot study.

    Choi, Yujin / Kim, Yunna / Kwon, Do-Hyung / Choi, Sunyoung / Choi, Young-Eun / Ahn, Eun Kyoung / Cho, Seung-Hun / Kim, Hyungjun

    Journal of pharmacopuncture

    2024  Volume 27, Issue 1, Page(s) 27–37

    Abstract: Objectives: Posttraumatic stress disorder (PTSD) is a prevalent mental health condition, and techniques using sensory stimulation in processing traumatic memories have gained attention. The Emotional Freedom Techniques (EFT) is a psychotherapy that ... ...

    Abstract Objectives: Posttraumatic stress disorder (PTSD) is a prevalent mental health condition, and techniques using sensory stimulation in processing traumatic memories have gained attention. The Emotional Freedom Techniques (EFT) is a psychotherapy that combines tapping on acupoints with exposure to cognitive reframing. This pilot study aimed to assess the feasibility of EFT as a treatment for PTSD by answering the following research questions 1) What is the compliance and completion rate of patients with PTSD with regard to EFT protocol? Is the dropout rate reasonable? 2) Is the effect size of EFT protocol for PTSD sufficient to justify a future trial?
    Methods: Thirty participants diagnosed with PTSD were recruited. They received weekly EFT sessions for five weeks, in which they repeated a statement acknowledging the problem and accepting themselves while tapping the SI3 acupoint on the side of their hand. PTSD symptoms were evaluated using the PTSD Checklist for DSM-5 (PCL-5) before and after the intervention.
    Results: Of the 30 PTSD patients (mean age 34.1 ± 9.1, 80% female), 96.7% showed over 80% compliance to the EFT sessions, and 86.7% completed the entire study process. The mean PCL-5 total score decreased significantly after the intervention, with a large effect size (change from baseline -14.33 [95% CI -19.79, -8.86], p < 0.0001, d = 1.06).
    Conclusion: The study suggests that EFT is a feasible treatment for PTSD, with high session compliance and low dropout rates. The effect size observed in this study supports the need for a larger trial in the future to further investigate EFT as a treatment for PTSD. However, the lack of a control group and the use of a self-rated questionnaire for PTSD symptoms are limitations of this study. The findings of this pilot study can be used to plan a future trial.
    Language English
    Publishing date 2024-03-27
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2747301-6
    ISSN 2234-6856 ; 2093-6966
    ISSN (online) 2234-6856
    ISSN 2093-6966
    DOI 10.3831/KPI.2024.27.1.27
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Emotional freedom technique versus written exposure therapy versus waiting list for post-traumatic stress disorder: protocol for a randomised clinical MRI study.

    Choi, Yujin / Kim, Yunna / Choi, Sunyoung / Choi, Young-Eun / Kwon, Ojin / Kwon, Do-Hyung / Lee, Seung-Ho / Cho, Seung-Hun / Kim, Hyungjun

    BMJ open

    2023  Volume 13, Issue 6, Page(s) e070389

    Abstract: Introduction: The emotional freedom technique (EFT) is an acupuncture-based psychotherapy that combines tapping on acupoints with cognitive reframing. EFT has been previously shown to have potential for treating post-traumatic stress disorder (PTSD). ... ...

    Abstract Introduction: The emotional freedom technique (EFT) is an acupuncture-based psychotherapy that combines tapping on acupoints with cognitive reframing. EFT has been previously shown to have potential for treating post-traumatic stress disorder (PTSD). However, further clinical evidence and underlying mechanisms of EFT are yet to be fully explored. This proposed clinical trial aims to examine the effect of EFT on patients with PTSD compared with the waitlist (WL) and active controls.
    Methods and analysis: This study was designed as a randomised, assessor-blinded, three-arm clinical MRI study. A total of 120 eligible patients with PTSD will be recruited and randomised into EFT, written exposure therapy (WET) or WL groups. EFT and WET will be applied once a week for 5 weeks. For patients in the WL group, EFT will be performed after 12 weeks. PTSD symptoms, depression, anxiety, somatic symptoms and quality of life will be evaluated. Assessments will be conducted at baseline (week 0), post-treatment (week 6) and follow-up (week 12). Structural and functional brain images and recording videos of facial expressions to emotional stimuli will be obtained before and after treatment. Sixty participants without lifetime traumatic experiences will be enrolled as healthy controls. The primary objective of the study is to compare the change from baseline in the Clinician-Administered PTSD Scale after treatment (week 6) between EFT and WL groups and between EFT and WET groups.
    Ethics and dissemination: Ethical approval was obtained from the Institutional Review Board of the Kyung Hee University Korean Medicine Hospital. The research findings will be shared at national and international conferences and will be published in peer-reviewed journals.
    Trial registration number: Clinical Research Information Service KCT0007360 https://cris.nih.go.kr/cris/search/detailSearch.do/21974.
    MeSH term(s) Humans ; Stress Disorders, Post-Traumatic/therapy ; Stress Disorders, Post-Traumatic/psychology ; Waiting Lists ; Implosive Therapy ; Quality of Life ; Cognitive Behavioral Therapy/methods ; Freedom ; Randomized Controlled Trials as Topic
    Language English
    Publishing date 2023-06-22
    Publishing country England
    Document type Clinical Trial Protocol ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2022-070389
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Efficacy of Yukmijihwang-tang on symptoms of Alzheimer disease: A protocol for systematic review and meta-analysis.

    Lee, Seunghee / Kwon, Do Hyung / Kim, Ju Yeon / Kim, Yunna / Cho, Seung-Hun / Jung, In Chul

    Medicine

    2021  Volume 100, Issue 25, Page(s) e26363

    Abstract: Background: Alzheimer disease (AD) is the most common cause of dementia, which may lead to severe memory loss and other cognitive disorders. Yukmijihwang-tang (YMJ), a type of Korean traditional herbal medicine, has been shown to be effective against ... ...

    Abstract Background: Alzheimer disease (AD) is the most common cause of dementia, which may lead to severe memory loss and other cognitive disorders. Yukmijihwang-tang (YMJ), a type of Korean traditional herbal medicine, has been shown to be effective against neurodegenerative diseases. Although a meta-analysis on the efficacy of YMJ on AD exists, the study had some limitations, and there have been several newly published studies assessing the effect of YMJ. Therefore, the purpose of this study is to evaluate the efficacy and safety of YMJ as a treatment for AD through a meta-analysis.
    Methods: A systematic search of the following electronic databases will be conducted to identify eligible studies: MEDLINE (PubMed), Elsevier (EMBASE), The Cochrane Central Register of Controlled Trials (CENTRAL), Cumulative Index to Nursing and Allied Health Literature (CINAHL), Korean Medical Database (KMBASE), Oriental Medicine Advanced Searching Integrated System (OASIS), Korean Traditional Knowledge Portal, Citation Information by NII (CiNii), China National Knowledge Infrastructure (CNKI). All randomized controlled trials assessing the efficacy and safety of YMJ on the symptoms of AD will be included. Two independent reviewers will perform article retrieval, deduplication, data screening, data extraction, quality evaluation, and data analyses using RevMan version 5.4. The Cochrane risk of bias tool will be used to assess the quality of the trials.
    Results: This study will provide synthesis of the cognitive function measured with neuropsychological tests, behavioral and psychological symptoms of dementia (BPSD), and activities of daily living (ADL) measured using validated scales. The clinical effective rate and adverse events will also be analyzed to assess the efficacy and safety of YMJ for treating AD.
    Conclusion: This systematic review will provide evidence for the efficacy and safety of YMJ in AD.
    Ethics and dissemination: Ethical approval is not required because individual patient data will not be included in this study. The study findings will be disseminated through conference presentations.
    MeSH term(s) Activities of Daily Living ; Alzheimer Disease/complications ; Alzheimer Disease/diagnosis ; Alzheimer Disease/drug therapy ; Cognition/drug effects ; Drugs, Chinese Herbal/administration & dosage ; Drugs, Chinese Herbal/adverse effects ; Humans ; Meta-Analysis as Topic ; Neuropsychological Tests ; Systematic Reviews as Topic ; Treatment Outcome
    Chemical Substances Drugs, Chinese Herbal ; yukmijihwang-tang
    Language English
    Publishing date 2021-06-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000026363
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: A systematic review on papers that study on Single Nucleotide Polymorphism that affects coronavirus 2019 severity.

    Suh, Siyeon / Lee, Sol / Gym, Ho / Yoon, Sanghyuk / Park, Seunghwan / Cha, Jihi / Kwon, Do-Hyung / Yang, YunSu / Jee, Sun Ha

    BMC infectious diseases

    2022  Volume 22, Issue 1, Page(s) 47

    Abstract: Background: COVID-19, caused by SARS-CoV-2 has become the most threatening issue to all populations around the world. It is, directly and indirectly, affecting all of us and thus, is an emerging topic dealt in global health. To avoid the infection, ... ...

    Abstract Background: COVID-19, caused by SARS-CoV-2 has become the most threatening issue to all populations around the world. It is, directly and indirectly, affecting all of us and thus, is an emerging topic dealt in global health. To avoid the infection, various studies have been done and are still ongoing. COVID-19 cases are reported all over the globe, and among the millions of cases, genetic similarity may be seen. The genetical common features seen within confirmed cases may help outline the tendency of infection and degree severity of the disease. Here, we reviewed multiple papers on SNPs related to SARS-CoV-2 infection and analyzed their results.
    Methods: The PubMed databases were searched for papers discussing SNPs associated with SARS-CoV-2 infection and severity. Clinical studies with human patients and statistically showing the relevance of the SNP with virus infection were included. Quality Assessment of all papers was done with Newcastle Ottawa Scale.
    Results: In the analysis, 21 full-text literature out of 2956 screened titles and abstracts, including 63,496 cases, were included. All were human-based clinical studies, some based on certain regions gathered patient data and some based on big databases obtained online. ACE2, TMPRSS2, and IFITM3 are the genes mentioned most frequently that are related to SARS-CoV-2 infection. 20 out of 21 studies mentioned one or more of those genes. The relevant genes according to SNPs were also analyzed. rs12252-C, rs143936283, rs2285666, rs41303171, and rs35803318 are the SNPs that were mentioned at least twice in two different studies.
    Conclusions: We found that ACE2, TMPRSS2, and IFITM3 are the major genes that are involved in SARS-CoV-2 infection. The mentioned SNPs were all related to one or more of the above-mentioned genes. There were discussions on certain SNPs that increased the infection and severity to certain groups more than the others. However, as there is limited follow-up and data due to a shortage of time history of the disease, studies may be limited.
    MeSH term(s) Angiotensin-Converting Enzyme 2/genetics ; COVID-19 ; Humans ; Membrane Proteins/genetics ; Polymorphism, Single Nucleotide ; Population Health ; RNA-Binding Proteins ; SARS-CoV-2 ; Serine Endopeptidases/genetics
    Chemical Substances IFITM3 protein, human ; Membrane Proteins ; RNA-Binding Proteins ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23) ; Serine Endopeptidases (EC 3.4.21.-) ; TMPRSS2 protein, human (EC 3.4.21.-)
    Language English
    Publishing date 2022-01-12
    Publishing country England
    Document type Journal Article ; Systematic Review
    ZDB-ID 2041550-3
    ISSN 1471-2334 ; 1471-2334
    ISSN (online) 1471-2334
    ISSN 1471-2334
    DOI 10.1186/s12879-022-07034-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Novel sandwich immunoassay detects a shrimp AHPND-causing binary PirAB

    Jeon, Min-Young / Han, Jee Eun / Lee, Dong Gwang / Cho, Young-Lai / Jang, Ju-Hong / Lee, Jangwook / Park, Jong-Gil / Kwon, Do Hyung / Park, Seon Young / Kim, Wantae / Lee, Kyunglee / Kim, Ji Hyung / Lee, Nam-Kyung

    Frontiers in cellular and infection microbiology

    2023  Volume 13, Page(s) 1294801

    Abstract: Introduction: The binary PirA/PirB toxin expressed by : Methods: We utilized a single-chain variable fragment (scFv) antibody library to select scFvs against the PirA or PirB subunits. Phage display panning rounds were conducted to screen and ... ...

    Abstract Introduction: The binary PirA/PirB toxin expressed by
    Methods: We utilized a single-chain variable fragment (scFv) antibody library to select scFvs against the PirA or PirB subunits. Phage display panning rounds were conducted to screen and identify scFv antibodies directed against each recombinant toxin subunit. Selected scFvs were converted into IgGs to develop a sandwich immunoassay to detect recombinant and bacterial PirAB
    Results: Antibodies produced as IgG forms showed sub-nanomolar to nanomolar affinities (K
    Discussion: These results indicate that the developed immunoassay is a reliable method for diagnosing AHPND by detecting PirAB
    MeSH term(s) Animals ; Vibrio parahaemolyticus/genetics ; Penaeidae/microbiology ; Toxins, Biological ; Enzyme-Linked Immunosorbent Assay ; Acute Disease ; Necrosis
    Chemical Substances Toxins, Biological
    Language English
    Publishing date 2023-11-27
    Publishing country Switzerland
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2023.1294801
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Second Skin as Self-Protection Against γ-Hydroxybutyrate.

    Kim, Gyeong-Ji / Park, Seon Joo / Kim, Lina / Kim, Kyung Ho / Kim, Soomin / An, Jai Eun / Shin, Chan Jae / Seo, Sung Eun / Jo, Seongjae / Kim, Jinyeong / Ha, Siyoung / Seo, Hwi Won / Rho, Mun-Chual / Kwon, Do Hyung / Kim, Woo-Keun / Jeong, Gugin / Ryu, Jae Chun / Kim, Jae Joon / Kwon, Oh Seok

    ACS nano

    2023  Volume 17, Issue 24, Page(s) 25405–25418

    Abstract: γ-Hydroxybutyrate (GHB), a date-rape drug, causes certain symptoms, such as amnesia, confusion, ataxia, and unconsciousness, when dissolved in beverages and consumed by a victim. Commonly, assailants use GHB in secret for the crime of drug-facilitated ... ...

    Abstract γ-Hydroxybutyrate (GHB), a date-rape drug, causes certain symptoms, such as amnesia, confusion, ataxia, and unconsciousness, when dissolved in beverages and consumed by a victim. Commonly, assailants use GHB in secret for the crime of drug-facilitated sexual assault because it is tasteless, odorless, and colorless when dissolved in beverages. Generally, GHB detection methods are difficult to use promptly and secretly
    MeSH term(s) Sodium Oxybate ; Rape ; Ethanol
    Chemical Substances Sodium Oxybate (7G33012534) ; Ethanol (3K9958V90M)
    Language English
    Publishing date 2023-12-07
    Publishing country United States
    Document type Journal Article
    ISSN 1936-086X
    ISSN (online) 1936-086X
    DOI 10.1021/acsnano.3c08840
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Two cases of methemoglobinemia induced by the exposure to nitrobenzene and aniline.

    Lee, Chang Hwan / Kim, Soo Hyeon / Kwon, Do Hyung / Jang, Keun Ho / Chung, Yong Hoon / Moon, Jai Dong

    Annals of occupational and environmental medicine

    2013  Volume 25, Issue 1, Page(s) 31

    Abstract: Objective: To report two cases of methemoglobinemia induced by inhaled nitrobenzene and dermally absorbed aniline.: Methods: We have evaluated a 37-year-old male worker exposed to nitrobenzene by inhalation while conducting maintenance job of ... ...

    Abstract Objective: To report two cases of methemoglobinemia induced by inhaled nitrobenzene and dermally absorbed aniline.
    Methods: We have evaluated a 37-year-old male worker exposed to nitrobenzene by inhalation while conducting maintenance job of mononitrobenzene pump and a 25-year-old male worker exposed dermally to aniline while unloading.
    Results: The first case is a 37-year-old male exposed to nitrobenzene. His blood methemoglobin concentration level was initially 19.8%, and chest X-ray was normal. After oxygen therapy, the blood methemoglobin concentration level decreased to 2.1%, and the symptoms were alleviated. The second case is a 25-year-old male exposed dermally to aniline. His chest X-ray was normal, but blood methemoglobin concentration level reached maximally 46.8%. He was treated with methylene blue due to relatively high blood methemoglobin level. Gradually after the treatment, his methemoglobin concentration level was normalized to 0.8% and simultaneously symptoms were resolved.
    Conclusions: After the thorough exposure investigations and medical evaluations, we have concluded that these cases were methemoglobinemia induced by occupational exposure to nitrobenzene and aniline. We suggest that businesses which handle methemoglobinemia-causing substances control the engineering process strictly, implement periodic screening, and establish emergency patient management system.
    Language English
    Publishing date 2013-11-01
    Publishing country Korea (South)
    Document type Case Reports
    ZDB-ID 2729723-8
    ISSN 2052-4374
    ISSN 2052-4374
    DOI 10.1186/2052-4374-25-31
    Database MEDical Literature Analysis and Retrieval System OnLINE

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