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  1. Article ; Online: Role of oxygen vacancies in ferroelectric or resistive switching hafnium oxide.

    Lee, Jaewook / Yang, Kun / Kwon, Ju Young / Kim, Ji Eun / Han, Dong In / Lee, Dong Hyun / Yoon, Jung Ho / Park, Min Hyuk

    Nano convergence

    2023  Volume 10, Issue 1, Page(s) 55

    Abstract: ... ...

    Abstract HfO
    Language English
    Publishing date 2023-12-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2760386-6
    ISSN 2196-5404 ; 2196-5404
    ISSN (online) 2196-5404
    ISSN 2196-5404
    DOI 10.1186/s40580-023-00403-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: An Artificial Olfactory System Based on a Chemi-Memristive Device.

    Chun, Suk Yeop / Song, Young Geun / Kim, Ji Eun / Kwon, Jae Uk / Soh, Keunho / Kwon, Ju Young / Kang, Chong-Yun / Yoon, Jung Ho

    Advanced materials (Deerfield Beach, Fla.)

    2023  Volume 35, Issue 35, Page(s) e2302219

    Abstract: Technologies based on the fusion of gas sensors and neuromorphic computing to mimic the olfactory system have immense potential. However, the implementation of neuromorphic olfactory systems remains in a state of infancy because conventional gas sensors ... ...

    Abstract Technologies based on the fusion of gas sensors and neuromorphic computing to mimic the olfactory system have immense potential. However, the implementation of neuromorphic olfactory systems remains in a state of infancy because conventional gas sensors lack the necessary functions. Therefore, this study proposes a hysteretic "chemi-memristive gas sensor" based on oxygen vacancy chemi-memristive dynamics that differ from that of conventional gas sensors. After the memristive switching operation, the redox reaction with the external gas molecules is enhanced, resulting in the generation and elimination of oxygen vacancies that induce rapid current changes. In addition, the pre-generated oxygen vacancies enhance the post-sensing properties. Therefore, fast responses, short recovery times, and hysteretic gas response are achieved by the proposed sensor at room temperature. Based on the advantageous functionality of the sensor, device-level olfactory systems that can monitor the history of input gas stimuli are experimentally demonstrated as a potential application. Moreover, analog conductance modulation induced by oxidizing and reducing gases enables the conversion of external gas stimuli into synaptic weights and hence the realization of typical synaptic functionalities without an additional device or circuit. The proposed chemi-memristive device represents an advance in the bioinspired technology adopted in creating artificial intelligence systems.
    Language English
    Publishing date 2023-06-25
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1474949-X
    ISSN 1521-4095 ; 0935-9648
    ISSN (online) 1521-4095
    ISSN 0935-9648
    DOI 10.1002/adma.202302219
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  3. Article ; Online: Heterosynaptic Plasticity in a Vertical Two-Terminal Synaptic Device.

    Yim, Haena / Yoon, Chansoo / Ryu, Ahrom / Yoo, So Yeon / Kwon, Ju Young / Oh, Gwangtaek / Kim, Sohwi / Kee, Eun Hee / Chae, Keun Hwa / Yoon, Jung Ho / Park, Bae Ho / Choi, Ji-Won

    Nano letters

    2023  Volume 23, Issue 14, Page(s) 6360–6368

    Abstract: Vertical two-terminal synaptic devices based on resistive switching have shown great potential for emulating biological signal processing and implementing artificial intelligence learning circuitries. To mimic heterosynaptic behaviors in vertical two- ... ...

    Abstract Vertical two-terminal synaptic devices based on resistive switching have shown great potential for emulating biological signal processing and implementing artificial intelligence learning circuitries. To mimic heterosynaptic behaviors in vertical two-terminal synaptic devices, an additional terminal is required for neuromodulator activity. However, adding an extra terminal, such as a gate of the field-effect transistor, may lead to low scalability. In this study, a vertical two-terminal Pt/bilayer Sr
    Language English
    Publishing date 2023-07-06
    Publishing country United States
    Document type Journal Article
    ISSN 1530-6992
    ISSN (online) 1530-6992
    DOI 10.1021/acs.nanolett.3c01057
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  4. Article: Mechanism of action of antimicrobial peptide P5 truncations against Pseudomonas aeruginosa and Staphylococcus aureus.

    Kwon, Ju Young / Kim, Min Kyung / Mereuta, Loredana / Seo, Chang Ho / Luchian, Tudor / Park, Yoonkyung

    AMB Express

    2019  Volume 9, Issue 1, Page(s) 122

    Abstract: Rates of microbial drug resistance are increasing worldwide; therefore, antimicrobial peptides (AMPs) are considered promising alternative therapeutic agents to antibiotics. AMPs are essential components of the innate immune system and exhibit broad- ... ...

    Abstract Rates of microbial drug resistance are increasing worldwide; therefore, antimicrobial peptides (AMPs) are considered promising alternative therapeutic agents to antibiotics. AMPs are essential components of the innate immune system and exhibit broad-spectrum antimicrobial activity. P5 is a Cecropin A-Magainin 2 hybrid analog peptide with antimicrobial activity against Gram-negative and Gram-positive bacteria. In the present study, truncated peptides were designed to reduction length, retainment their antimicrobial activity and low toxicity at high concentrations compared with that of the parent peptide P5. The truncated peptides P5-CT1 and P5-NT1 exhibited antibacterial activities against both Gram-negative and Gram-positive bacteria. In contrast, P5-CT2, P5-CT3, P5-NT2, and P5-NT3 showed higher antibacterial activities against gram-positive bacteria compared to Gram-negative bacteria at low concentration of peptides. The truncated peptides showed lower hemolytic activity and toxic effects against mammalian cells compared with those of the parent peptide P5. The levels of several truncated peptides were maintained in the presence of physiological concentrations of salts, indicating their high stability. The results of flow cytometry, propidium iodide uptake, n-phenyl-1-naphthylamine uptake, and 3,3'-dipropylthiadicarbocyanine iodide assays showed that these truncated peptides killed microbial cells by increasing membrane permeability, thereby causing membrane damage. The results suggested that truncated peptides of P5 have good potential for use as novel antimicrobial agents.
    Language English
    Publishing date 2019-07-30
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2621432-5
    ISSN 2191-0855
    ISSN 2191-0855
    DOI 10.1186/s13568-019-0843-0
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  5. Article: Vibrio extracellular protease with prothrombin activation and fibrinolytic activities.

    Kwon, Ju Young / Chang, Alan K / Park, Jung Eun / Shin, Song Yub / Yoon, Seong Myeong / Lee, Jung Sup

    International journal of molecular medicine

    2007  Volume 19, Issue 1, Page(s) 157–163

    Abstract: A 36 kDa extracellular metalloprotease (designated to as vEP-MO6) was purified and characterized from Vibrio vulnificus sp. strain MO6 24/0. vEP-MO6 cleaved azocasein and a few other proteins such as prothrombin, plasminogen, fibrinogen and Factor Xa, ... ...

    Abstract A 36 kDa extracellular metalloprotease (designated to as vEP-MO6) was purified and characterized from Vibrio vulnificus sp. strain MO6 24/0. vEP-MO6 cleaved azocasein and a few other proteins such as prothrombin, plasminogen, fibrinogen and Factor Xa, which are associated with the blood coagulation pathway. The enzyme activity of vEP-MO6 was inhibited by EDTA, which was reversed by the addition of excess divalent cations. vEP-MO6 showed little or no activity toward various chromogenic substrates that are specific for other proteases. The cleavage of prothrombin by vEP-MO6 produced active thrombin, as revealed by an activity assay with thrombin-specific chromogenic substrate and Western blot analysis with anti-thrombin antibody. The enzyme also actively hydrolyzed fibrin polymer as well as the cross-linked fibrin. These results suggest that vEP-MO6 is a prothrombin-activating and cross-linked fibrin-degrading enzyme belonging to the metalloprotease family.
    MeSH term(s) Amino Acid Sequence ; Chelating Agents/pharmacology ; Enzyme Activation ; Fibrin/metabolism ; Fibrinolysis ; Metalloproteases/antagonists & inhibitors ; Metalloproteases/genetics ; Metalloproteases/isolation & purification ; Metalloproteases/physiology ; Metals/pharmacology ; Molecular Sequence Data ; Protease Inhibitors/pharmacology ; Prothrombin/metabolism ; Sequence Homology, Amino Acid ; Vibrio vulnificus/enzymology ; Vibrio vulnificus/genetics
    Chemical Substances Chelating Agents ; Metals ; Protease Inhibitors ; Prothrombin (9001-26-7) ; Fibrin (9001-31-4) ; Metalloproteases (EC 3.4.-)
    Language English
    Publishing date 2007-01
    Publishing country Greece
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1444428-8
    ISSN 1107-3756
    ISSN 1107-3756
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4942: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: 5-demethylovalicin, as a methionine aminopeptidase-2 inhibitor produced by Chrysosporium.

    Son, Kwang-Hee / Kwon, Ju-Young / Jeong, Ha-Won / Kim, Hyae-Kyeong / Kim, Chang-Jin / Chang, Yie-Hwa / Choi, Jung-Do / Kwon, Byoung-Mog

    Bioorganic & medicinal chemistry

    2001  Volume 10, Issue 1, Page(s) 185–188

    Abstract: 5-Demethylovalicin was isolated from the fermentation broth Chrysosporium lucknowense and the structure was identified by spectroscopic methods. 5-Demethylovalicin inhibited the recombinant human MetAP-2 (IC(50)=17.7 nM) and the growth of human umbilical ...

    Abstract 5-Demethylovalicin was isolated from the fermentation broth Chrysosporium lucknowense and the structure was identified by spectroscopic methods. 5-Demethylovalicin inhibited the recombinant human MetAP-2 (IC(50)=17.7 nM) and the growth of human umbilical vein endothelial cells (HUVEC; IC(50)=100 nM) in cell proliferation assay without cytotoxicity on the transformed and cancer cell lines.
    MeSH term(s) Aminopeptidases/antagonists & inhibitors ; Cells, Cultured ; Chrysosporium/metabolism ; Enzyme Inhibitors/pharmacology ; Humans ; Metalloendopeptidases/antagonists & inhibitors ; Recombinant Proteins/antagonists & inhibitors ; Sesquiterpenes/pharmacology
    Chemical Substances 5-demethylovalicin ; Enzyme Inhibitors ; Recombinant Proteins ; Sesquiterpenes ; Aminopeptidases (EC 3.4.11.-) ; methionine aminopeptidase 2 (EC 3.4.11.18) ; Metalloendopeptidases (EC 3.4.24.-)
    Language English
    Publishing date 2001-12-01
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1161284-8
    ISSN 1464-3391 ; 0968-0896
    ISSN (online) 1464-3391
    ISSN 0968-0896
    DOI 10.1016/s0968-0896(01)00268-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3815: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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