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  1. AU="Kwon, Soon-Chan"
  2. AU="Vaidya, Harshit"
  3. AU="Shan, Chongxin"
  4. AU="Arora, Vineet M"
  5. AU="Carey, Alanna"
  6. AU="Habash, Khader I"
  7. AU="Angela Ribeiro"
  8. AU="Radomir Živadinović"
  9. AU=Shakeri Ahmad

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  1. Artikel ; Online: The Association of Perfluoroalkyl Substance Exposure and a Serum Liver Function Marker in Korean Adults.

    Yun, Jisuk / Kwon, Soon-Chan

    Toxics

    2023  Band 11, Heft 12

    Abstract: Perfluoroalkyl substances (PFAS), widely used throughout industry and daily life, are currently one of the environmental pollutants garnering the most attention worldwide. Recently, environmental pollutants have had a high profile as one of the main ... ...

    Abstract Perfluoroalkyl substances (PFAS), widely used throughout industry and daily life, are currently one of the environmental pollutants garnering the most attention worldwide. Recently, environmental pollutants have had a high profile as one of the main causes of chronic liver disease, such as non-alcoholic fatty liver disease. Research on PFAS is actively underway. Although Korea has a remarkably high prevalence of chronic liver disease, and it continues to increase, only a few studies have revealed the relationship between PFAS and liver disease. In addition, regulations on PFAS in Korea are delayed compared to developed countries, such as Europe and the United States, and public interest is insufficient compared to others. Therefore, we would like to investigate the exposure of Koreans to PFAS in the blood and examine the relationship between these substances and markers of liver function (AST, ALT, and GGT). This study was based on the results of the Korean National Environmental Health Survey (KoNEHS) 2018–2020 (Cycle 4), and a total of 2961 subjects were selected. The concentration of PFAS in the blood of Korean adults was measured to be significantly higher based on the geometric mean compared to the results of recently investigated American adults based on the National Health and Nutrition Examination Survey (NHANES, 2017-2018). A multivariable linear regression analysis adjusted for age, sex, body mass index (BMI), smoking status, alcohol intake, and regular exercise was performed to examine changes in three liver function markers as the serum PFAS concentration increased. We found that some of the five PFAS (PFOA, PFOS, PFHxS, PFNA, and PFDeA) were significantly associated with increased liver enzymes. It is necessary to recognize the threat of PFAS to the human body and to discuss regulations and alternatives in earnest. Continuous follow-up studies are required through a well-designed cohort.
    Sprache Englisch
    Erscheinungsdatum 2023-11-28
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2733883-6
    ISSN 2305-6304 ; 2305-6304
    ISSN (online) 2305-6304
    ISSN 2305-6304
    DOI 10.3390/toxics11120965
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  2. Artikel: The association of perfluoroalkyl substances (PFAS) exposure and kidney function in Korean adolescents using data from Korean National Environmental Health Survey (KoNEHS) cycle 4 (2018-2020): a cross-sectional study.

    Yun, Jisuk / Jang, Eun-Chul / Kwon, Soon-Chan / Min, Young-Sun / Lee, Yong-Jin

    Annals of occupational and environmental medicine

    2023  Band 35, Seite(n) e5

    Abstract: Background: Perfluoroalkyl substances (PFAS) are chemicals widely used in various products in everyday life. Due to its unique strong binding force, the half-life of PFAS is very long, so bioaccumulation and toxicity to the human body are long-standing ... ...

    Abstract Background: Perfluoroalkyl substances (PFAS) are chemicals widely used in various products in everyday life. Due to its unique strong binding force, the half-life of PFAS is very long, so bioaccumulation and toxicity to the human body are long-standing concerns. In particular, effects on kidney function have recently emerged and there are no studies on the effect of PFAS on kidney function through epidemiological investigations in Korea. From 2018 to 2020, the Korean National Environmental Health Survey (KoNEHS) cycle 4, conducted an epidemiological investigation on the blood concentration of PFAS for the first time in Korea. Based on this data, the relationship between PFAS blood concentration and kidney function was analyzed for adolescents.
    Methods: We investigated 5 types of PFAS and their total blood concentration in 811 middle and high school students, living in Korea and included in KoNEHS cycle 4, and tried to find changes in kidney function in relation to PFAS concentration. After dividing the concentration of each of the 5 PFAS and the total concentration into quartiles, multivariable linear regression was performed to assess the correlation with kidney function. The bedside Schwartz equation was used as an indicator of kidney function.
    Results: As a result of multivariable linear regression, when observing a change in kidney function according to the increase in the concentration of each of the 5 PFAS and their total, a significant decrease in kidney function was confirmed in some or all quartiles.
    Conclusions: In this cross-sectional study of Korean adolescents based on KoNEHS data, a negative correlation between serum PFAS concentration and kidney function was found. A well-designed longitudinal study and continuous follow-up are necessary.
    Sprache Englisch
    Erscheinungsdatum 2023-03-15
    Erscheinungsland Korea (South)
    Dokumenttyp Journal Article
    ZDB-ID 2729723-8
    ISSN 2052-4374
    ISSN 2052-4374
    DOI 10.35371/aoem.2023.35.e5
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  3. Artikel: Endovascular management of cavernous sinus dural arteriovenous fistulas: Overall review and considerations.

    Lee, Jong Min / Park, Eun Suk / Kwon, Soon Chan

    Journal of cerebrovascular and endovascular neurosurgery

    2021  Band 23, Heft 4, Seite(n) 293–303

    Abstract: Cavernous sinus dural arteriovenous fistulas (CSDAVFs) are arteriovenous shunts between small dural branches arising from the external and/or internal carotid arteries and the cavernous sinus (CS). And now a days, endovascular treatment is the treatment ... ...

    Abstract Cavernous sinus dural arteriovenous fistulas (CSDAVFs) are arteriovenous shunts between small dural branches arising from the external and/or internal carotid arteries and the cavernous sinus (CS). And now a days, endovascular treatment is the treatment of choice in CSDAVF. We review the anatomy and classifications of CSDAVFs, discussing and detailing these considerations in the treatment of CSDAVFs, theoretically and in the light of recent literatures.
    Sprache Englisch
    Erscheinungsdatum 2021-12-17
    Erscheinungsland Korea (South)
    Dokumenttyp Journal Article
    ISSN 2234-8565
    ISSN 2234-8565
    DOI 10.7461/jcen.2021.E2021.04.002
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  4. Artikel: Migrated coil and damaged stent removal during coil embolization, using an additional, retrievable stent: A case report.

    Noh, Hee Seung / Park, Sung Chan / Lee, Jong Min / Kwon, Soon Chan

    Journal of cerebrovascular and endovascular neurosurgery

    2022  Band 25, Heft 2, Seite(n) 196–202

    Abstract: One of the common complications that can occur during coil embolization of cerebral aneurysms, is migration of coil lump alone. The removal of these migrated coils has been reported on a few occasions. On the other hand, rare complications would include ... ...

    Abstract One of the common complications that can occur during coil embolization of cerebral aneurysms, is migration of coil lump alone. The removal of these migrated coils has been reported on a few occasions. On the other hand, rare complications would include the migration of the coil with subsequent stent dislocation. Currently, there is no standardized method to correct the complications of stent dislocation, and very few instances of this complication have been reported previously. In this report, we introduce a case of coil migration combined with stent dislocation. This occurred during coil embolization of an unruptured aneurysm of the distal, left internal carotid artery for a 52-year old woman. We retrieved both the damaged stent and migrated coil using another retrievable stent successfully with no more further complications. In the present report, we describe in detail how we corrected the complication successfully stent, and we discuss why this rescue maneuver is reasonable option for the complication mentioned above.
    Sprache Englisch
    Erscheinungsdatum 2022-12-15
    Erscheinungsland Korea (South)
    Dokumenttyp Case Reports
    ISSN 2234-8565
    ISSN 2234-8565
    DOI 10.7461/jcen.2022.E2022.04.001
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  5. Artikel: Could A1 Aplasia or Hypoplasia Affect the Morphology and Rupture Risk of Anterior Communicating Artery Aneurysm?

    Park, Sung Chan / Jung, Na Young / Park, Eun Suk / Kwon, Soon Chan

    Journal of Korean Neurosurgical Society

    2022  Band 65, Heft 4, Seite(n) 531–538

    Abstract: Objective: Anterior communicating artery (Acom) aneurysm is one of the most common intracranial aneurysms, constituting approximately 30-35% of all aneurysm formation in the brain. Anatomically, the H-complex (the anatomic morphology of both A1 to A2 ... ...

    Abstract Objective: Anterior communicating artery (Acom) aneurysm is one of the most common intracranial aneurysms, constituting approximately 30-35% of all aneurysm formation in the brain. Anatomically, the H-complex (the anatomic morphology of both A1 to A2 segments) is thought to affects the nature of the Acom aneurysm due to its close relationship with the hemodynamics of the vessel. Therefore, we investigated the relative risk factors of aneurysmal rupture, especially focusing on H-complex morphology of the Acom.
    Methods: From January 2016 to December 2020, a total of 209 patients who underwent surgery, including clipping and coiling for Acom aneurysm in our institution were reviewed. There were 102 cases of ruptured aneurysm and 107 cases of unruptured aneurysm. The baseline morphology of aneurysms was investigated and the relationship between the H-complex and the clinical characteristics of patients with Acom aneurysms was assessed.
    Results: Of the 209 patients, 109 patients (52.1%) had symmetrical A1, 79 patients (37.8%) had unilateral hypoplastic A1, and 21 patients (10.0%) had aplastic A1. The hypoplastic A1 group and the aplastic A1 group were grouped together as unilateral dominancy of A1, and were compared with the symmetrical A1 group. There was no significant difference in demographic characteristics and radiological findings of Acom aneurysms between two groups. However, when dichotomizing the patients into ruptured cases and unruptured cases, unilateral dominance of the A1 segment was associated with aneurysmal rupture with statistical significance (p=0.011).
    Conclusion: These results suggest that the unilateral dominance of the A1 segment does not have a significant effect on the morphology of Acom aneurysms, but contributes to aneurysmal rupture. Thus, we can better understand the effects of hemodynamics on Acom aneurysm.
    Sprache Englisch
    Erscheinungsdatum 2022-05-23
    Erscheinungsland Korea (South)
    Dokumenttyp Journal Article
    ZDB-ID 2253817-3
    ISSN 1598-7876 ; 2005-3711 ; 1225-8245
    ISSN (online) 1598-7876
    ISSN 2005-3711 ; 1225-8245
    DOI 10.3340/jkns.2021.0283
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  6. Artikel ; Online: Emotional Demand and Mental Health in Korean Employees.

    Kwon, Soon-Chan / Kim, Inah / Kim, Yu-Mi

    International journal of environmental research and public health

    2021  Band 18, Heft 14

    Abstract: Background: Emotional demand (ED) at work is related to mental health in the general workforce, not just emotional workers. We investigated the relationships between ED and mental health outcomes, including distress, depressive symptoms (DS), experience ...

    Abstract Background: Emotional demand (ED) at work is related to mental health in the general workforce, not just emotional workers. We investigated the relationships between ED and mental health outcomes, including distress, depressive symptoms (DS), experience of depression (DE), and suicidal ideation (SI) on the entire general workforce using nationally representative data.
    Methods: 5787 full-time employees were analyzed using cross-sectional design with the fourth Korean National Health and Nutrition Examination Survey (K-NHANES IV). Work-related psychosocial factors and mental health status were measured through face-to-face interviews. Multi-stage and stratified survey designs were considered in the analysis, and the mental health effects of ED were analyzed using multivariable logistic analysis. The Cochran-Armitage trend test was conducted to investigate increases in the relationship between the severity of ED and mental health outcomes.
    Results: The subjects comprised 3089 men and 2698 women. ED was reported by 36.7% of men and 39.3% of women. The estimated prevalence of distress was 27.5% in men and 34.6% in women. Adjusted odds ratios (ORs) of ED for distress were 2.62 (95% confidence interval (CI) = 2.10-3.28) for men and 2.57 (95% CI = 1.92-3.45) for women. DS was significantly related to ED (men: OR = 1.72, 95% CI = 1.18-2.50; women: OR = 1.91, 95% CI = 1.33-2.74). ED was also significant psychosocial risk factor for DE (men: OR = 1.88, 95% CI = 1.07-3.29; women: OR = 1.77, 95% CI = 1.15-2.75) and SI (men: OR = 1.64, 95% CI = 1.11-2.41; women: OR = 2.31, 95% CI = 1.63-3.28).
    Conclusions: ED was a risk factor for distress, DS, DE, and SI in the general workforce. Legal and social safety networks should be constructed for workers whose emotions may be hidden at work, as well as workers in emotion-related fields.
    Mesh-Begriff(e) Cross-Sectional Studies ; Depression/epidemiology ; Emotions ; Female ; Humans ; Male ; Mental Health ; Nutrition Surveys ; Republic of Korea/epidemiology ; Risk Factors ; Suicidal Ideation
    Sprache Englisch
    Erscheinungsdatum 2021-07-08
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph18147312
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  7. Artikel: Aspiration-Retriever Technique for Stroke with Large Bore Intermediate Catheter : A Single Center Experience.

    Nam, Ji Won / Jung, Na Young / Park, Eun Suk / Kwon, Soon Chan

    Journal of Korean Neurosurgical Society

    2021  Band 64, Heft 5, Seite(n) 732–739

    Abstract: Objective: Early successful reperfusion is associated with favorable outcomes in acute ischemic stroke (AIS). The purpose of this study was to achieve successful recanalization by a combined mechanical thrombectomy technique, the Aspiration-Retriever ... ...

    Abstract Objective: Early successful reperfusion is associated with favorable outcomes in acute ischemic stroke (AIS). The purpose of this study was to achieve successful recanalization by a combined mechanical thrombectomy technique, the Aspiration-Retriever Technique for Stroke (ARTS), which is composed of a flexible large lumen distal access catheter and a retrievable stent as the first-line strategy of mechanical thrombectomy.
    Methods: We retrospectively reviewed 62 patients with AIS who underwent mechanical thrombectomy from 2018 to 2019 at our institute by a senior neurointerventionalist. Among them, patients who were treated using the ARTS technique with the soft torqueable catheter optimized for intracranial access (SOFIA®; MicroVention-Terumo, Tustin, CA, USA) as the first-line treatment were included. Patients who had tandem occlusions or underlying intracranial artery stenosis were excluded. The angiographic and clinical outcomes were evaluated. The angiographic outcome was analyzed by the rate of successful recanalization, defined as a Thrombolysis in Cerebral Infarction score of 2b or 3 at the end of all procedures and the rate of successfully achieving the first pass effect (FPE), defined as complete recanalization with a single pass of the device. The clinical outcomes included the National Institutes of Health Stroke Scale (NIHSS) score, modified Rankin Scale (mRS), and mortality.
    Results: A total of 27 patients (mean age, 59.3 years) fulfilled the inclusion criteria. The successful recanalization rate was 96% (n=26) while the FPE rate was 41% (n=11). The mean post-procedural NIHSS change was -3.0. Thirteen patients (48%) showed good clinical outcomes after thrombectomy with the ARTS technique (mRS at 90 days ≤2). Postoperative complications occurred in seven of 25 patients : hemorrhagic transformation in six patients (22%) and distal embolization in one patient (4%). Mortality was 15% (n=4).
    Conclusion: Although the clinical outcomes using the ARTS technique with a flexible large lumen distal access catheter performed as the frontline thrombectomy in patients with AIS were not significantly superior than those of other studies, this study showed a high rate of successful endovascular recanalization which was comparable to that of other studies. Therefore, ARTS using the SOFIA® catheter can be considered as the first choice of treatment for AIS due to large vessel occlusion.
    Sprache Englisch
    Erscheinungsdatum 2021-09-01
    Erscheinungsland Korea (South)
    Dokumenttyp Journal Article
    ZDB-ID 2253817-3
    ISSN 1598-7876 ; 2005-3711 ; 1225-8245
    ISSN (online) 1598-7876
    ISSN 2005-3711 ; 1225-8245
    DOI 10.3340/jkns.2020.0308
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  8. Artikel ; Online: Association between Urinary Phthalate Metabolite Concentration and Atopic Dermatitis in Korean Adolescents Participating in the Third Korean National Environmental Health Survey, 2015-2017.

    Kim, Sang-Woo / Lee, Jeongho / Kwon, Soon-Chan / Lee, June-Hee

    International journal of environmental research and public health

    2021  Band 18, Heft 5

    Abstract: Previous studies have highlighted the potential health effects of phthalate exposure, such as atopic dermatitis and asthma. However, evidence supporting the association between phthalate exposure and atopic dermatitis is limited and based on data ... ...

    Abstract Previous studies have highlighted the potential health effects of phthalate exposure, such as atopic dermatitis and asthma. However, evidence supporting the association between phthalate exposure and atopic dermatitis is limited and based on data collected from Western populations. This study aimed to analyze the association between phthalate exposure and atopic dermatitis in Korean adolescents aged 12-17 years using a nationally representative dataset. We conducted a cross-sectional study using a publicly available dataset from the third Korean National Environmental Health Survey (
    Mesh-Begriff(e) Adolescent ; Child ; Cross-Sectional Studies ; Dermatitis, Atopic/chemically induced ; Dermatitis, Atopic/epidemiology ; Environmental Exposure/analysis ; Environmental Health ; Environmental Pollutants ; Humans ; Phthalic Acids ; Republic of Korea/epidemiology
    Chemische Substanzen Environmental Pollutants ; Phthalic Acids ; phthalic acid (6O7F7IX66E)
    Sprache Englisch
    Erscheinungsdatum 2021-02-25
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1660-4601
    ISSN (online) 1660-4601
    DOI 10.3390/ijerph18052261
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  9. Artikel: Relationship between job stress and impaired fasting glucose in male steel industry workers: a cross-sectional study.

    Lee, Hyun-Kyo / Lee, Inho / Yun, Jisuk / Lee, Yong-Jin / Jang, Eun-Chul / Min, Young-Sun / Kwon, Soon-Chan

    Annals of occupational and environmental medicine

    2023  Band 35, Seite(n) e12

    Abstract: Background: The purpose of this study is to investigate the relationship between job stress and impaired fasting glycemia (IFG) of male workers in a manufacturing industry.: Methods: Data were collected from 5,886 male workers in a manufacturing ... ...

    Abstract Background: The purpose of this study is to investigate the relationship between job stress and impaired fasting glycemia (IFG) of male workers in a manufacturing industry.
    Methods: Data were collected from 5,886 male workers in a manufacturing industry who participated in the medical examination from June 19 to August 14, 2020 through self-reported questionnaires. The general characteristics of the subjects, shift work, high blood pressure, dyslipidemia, and job stress were included. Job stress was measured using the Korean Occupational Stress Scale (KOSS) consisting of 8 items and 43 questions. Multivariable logistic regression analysis was used to investigate the IFG association with job stress.
    Results: Among the various factors that can cause job stress, only high job demand was associated with a risk of IFG (odds ratio, 1.43; 95% confidence interval, 1.13-1.82) especially in non-shift worker. For all other factors, no statistically significant results were obtained.
    Conclusions: In this study of male workers engaged in the Korean steel manufacturing industry, the 'job demand' item among job stress of non-shift worker was related to IFG.
    Sprache Englisch
    Erscheinungsdatum 2023-06-02
    Erscheinungsland Korea (South)
    Dokumenttyp Journal Article
    ZDB-ID 2729723-8
    ISSN 2052-4374
    ISSN 2052-4374
    DOI 10.35371/aoem.2023.35.e12
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  10. Artikel: Occupational and Psychological Factors Associated With Burnout in Night Shift Nurses.

    Min, Young-Sun / Lee, Hyeon-Ah / Kwon, Soon-Chan / Lee, Inho / Kim, Kiseok / Kim, Ji Sun / Han, Jae Hyun / Lee, Hwa-Young

    Psychiatry investigation

    2023  Band 20, Heft 10, Seite(n) 904–911

    Abstract: Objective: Providing inpatient nursing care inevitably involves night shift work. However, night shift work nurses often face psychiatric health problems such as burnout. If night shift work is an essential work type for nurses, it is necessary to ... ...

    Abstract Objective: Providing inpatient nursing care inevitably involves night shift work. However, night shift work nurses often face psychiatric health problems such as burnout. If night shift work is an essential work type for nurses, it is necessary to select personnel suitable for night shift work or establish improvement measures such as psychiatric intervention through psychiatric evaluation. The objective of this study was to identify factors that could be interventional among factors affecting burnout in shift-working nurses.
    Methods: A total of 231 night shift female nurses participated in this study. A questionnaire survey was given to assess their general characteristics. To assess burnout, the Maslach Burnout Inventory-General Survey Korean version was adopted. In addition, several mental health scales were used to identify individual psychological characteristics. To identify variables associated with the presence of burnout, odds ratios were calculated using a logistic regression model taking three dimensions of burnout as a dependent variable after adjusting for psychological and occupational factors.
    Results: High resilience was a significant preventive factor in the three dimensions of burnout. Regarding occupational factor, the longer the duration of employment, the higher depersonalization, but the professional efficacy was good.
    Conclusion: Our results indicate that resilience and social support could be prevention factors for burnout. This study is meaningful in examining items that require active intervention and support for burnout targeting night shift nurses who are indispensable for patient care.
    Sprache Englisch
    Erscheinungsdatum 2023-10-24
    Erscheinungsland Korea (South)
    Dokumenttyp Journal Article
    ZDB-ID 2414364-9
    ISSN 1976-3026 ; 1738-3684
    ISSN (online) 1976-3026
    ISSN 1738-3684
    DOI 10.30773/pi.2023.0084
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