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  1. Article ; Online: YAP/TAZ as Molecular Targets in Skeletal Muscle Atrophy and Osteoporosis.

    Kwon, Youngjoo

    Aging and disease

    2024  

    Abstract: Skeletal muscles and bones are closely connected anatomically and functionally. Age-related degeneration in these tissues is associated with physical disability in the elderly and significantly impacts their quality of life. Understanding the mechanisms ... ...

    Abstract Skeletal muscles and bones are closely connected anatomically and functionally. Age-related degeneration in these tissues is associated with physical disability in the elderly and significantly impacts their quality of life. Understanding the mechanisms of age-related musculoskeletal tissue degeneration is crucial for identifying molecular targets for therapeutic interventions for skeletal muscle atrophy and osteoporosis. The Hippo pathway is a recently identified signaling pathway that plays critical roles in development, tissue homeostasis, and regeneration. The Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) are key downstream effectors of the mammalian Hippo signaling pathway. This review highlights the fundamental roles of YAP and TAZ in the homeostatic maintenance and regeneration of skeletal muscles and bones. YAP/TAZ play a significant role in stem cell function by relaying various environmental signals to stem cells. Skeletal muscle atrophy and osteoporosis are related to stem cell dysfunction or senescence triggered by YAP/TAZ dysregulation resulting from reduced mechanosensing and mitochondrial function in stem cells. In contrast, the maintenance of YAP/TAZ activation can suppress stem cell senescence and tissue dysfunction and may be used as a basis for the development of potential therapeutic strategies. Thus, targeting YAP/TAZ holds significant therapeutic potential for alleviating age-related muscle and bone dysfunction and improving the quality of life in the elderly.
    Language English
    Publishing date 2024-03-14
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2625789-0
    ISSN 2152-5250 ; 2152-5250
    ISSN (online) 2152-5250
    ISSN 2152-5250
    DOI 10.14336/AD.2024.0306
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Assessing an Overall Toxicological Implication of Nail Care Product for Occupational and Consumer Health Improvement.

    Kwon, Yongbum

    Iranian journal of public health

    2022  Volume 51, Issue 5, Page(s) 1185–1187

    Language English
    Publishing date 2022-11-15
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2240935-X
    ISSN 2251-6093 ; 2251-6093
    ISSN (online) 2251-6093
    ISSN 2251-6093
    DOI 10.18502/ijph.v51i5.9436
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Potential Pro-Tumorigenic Effect of Bisphenol A in Breast Cancer via Altering the Tumor Microenvironment.

    Kwon, Youngjoo

    Cancers

    2022  Volume 14, Issue 12

    Abstract: BPA, a chemical used in the preparation of polycarbonate plastics, is an endocrine disruptor. Exposure to BPA has been suggested to be a risk factor for breast cancer because of its potential to induce estrogen receptor signaling in breast cancer cells. ... ...

    Abstract BPA, a chemical used in the preparation of polycarbonate plastics, is an endocrine disruptor. Exposure to BPA has been suggested to be a risk factor for breast cancer because of its potential to induce estrogen receptor signaling in breast cancer cells. More recently, it has been recognized that BPA also binds to the G protein-coupled estrogen receptor and other nuclear receptors, in addition to estrogen receptors, and acts on immune cells, adipocytes, and fibroblasts, potentially modulating the TME. The TME significantly impacts the behavior of cancer cells. Therefore, understanding how BPA affects stromal components in breast cancer is imperative to adequately assess the association between exposure to BPA and the risk of breast cancer. This review examines the effects of BPA on stromal components of tumors to highlight their potential role in the carcinogenic effect of BPA. As a result, I propose considerations for the risk assessment of BPA exposure and studies needed to improve understanding of the TME-mediated, breast cancer-promoting effect of BPA.
    Language English
    Publishing date 2022-06-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14123021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Possible Beneficial Effects of N-Acetylcysteine for Treatment of Triple-Negative Breast Cancer.

    Kwon, Youngjoo

    Antioxidants (Basel, Switzerland)

    2021  Volume 10, Issue 2

    Abstract: N-acetylcysteine (NAC) is a widely used antioxidant with therapeutic potential. However, the cancer-promoting effect of NAC observed in some preclinical studies has raised concerns regarding its clinical use. Reactive oxygen species (ROS) can mediate ... ...

    Abstract N-acetylcysteine (NAC) is a widely used antioxidant with therapeutic potential. However, the cancer-promoting effect of NAC observed in some preclinical studies has raised concerns regarding its clinical use. Reactive oxygen species (ROS) can mediate signaling that results in both cancer-promoting and cancer-suppressing effects. The beneficial effect of NAC may depend on whether the type of cancer relies on ROS signaling for its survival and metastasis. Triple-negative breast cancer (TNBC) has aggressive phenotypes and is currently treated with standard chemotherapy as the main systemic treatment option. Particularly, basal-like TNBC cells characterized by inactivated
    Language English
    Publishing date 2021-01-24
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox10020169
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Never put off until tomorrow what you can do today: the role of early temporary mechanical circulatory support in cardiogenic shock.

    Sidhu, Kiran / Kwon, Younghoon

    European heart journal. Acute cardiovascular care

    2024  

    Language English
    Publishing date 2024-04-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2663340-1
    ISSN 2048-8734 ; 2048-8726
    ISSN (online) 2048-8734
    ISSN 2048-8726
    DOI 10.1093/ehjacc/zuae051
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Estimation of Dietary Capsaicinoid Exposure in Korea and Assessment of Its Health Effects.

    Kwon, Youngjoo

    Nutrients

    2021  Volume 13, Issue 7

    Abstract: The consumption of capsaicinoids, the active components in chili peppers, has been associated with both positive and negative health effects, and the level of capsaicinoid exposure may be an important determinant. Dietary capsaicinoid exposure was ... ...

    Abstract The consumption of capsaicinoids, the active components in chili peppers, has been associated with both positive and negative health effects, and the level of capsaicinoid exposure may be an important determinant. Dietary capsaicinoid exposure was estimated using a previously developed database for capsaicinoid content and a 24-h dietary recall dataset obtained from the Korea National Health and Nutrition Examination Survey. The estimated consumption level was evaluated to determine its potential effects on weight reduction and gastrointestinal distress. The estimated daily mean capsaicinoid intake was 3.25 mg (2.17 mg capsaicin), and most Koreans consumed 1-30 mg of capsaicinoids (0.67-20 mg capsaicin) in a day. No adverse effect of capsaicin consumption was reported other than abdominal pain. For long-term repeated consumption, 30 mg may be the maximum tolerable dose. However, the effects on body weight or energy balance were inconsistent in 4-12 week clinical studies conducted with various capsaicin doses (2-135 mg), which was likely due to the complex interplay between capsaicin dose, study length, and participant characteristics. Therefore, the capsaicin consumption of most Koreans was below the levels that may cause adverse effects. However, more long-term studies for the dose range of 2-20 mg are required to further characterize capsaicin's health benefits in Koreans.
    MeSH term(s) Abdominal Pain/chemically induced ; Adolescent ; Adult ; Aged ; Body Weight/drug effects ; Capsaicin/administration & dosage ; Capsaicin/adverse effects ; Child ; Child, Preschool ; Cross-Sectional Studies ; Diet ; Dose-Response Relationship, Drug ; Energy Metabolism/drug effects ; Female ; Health Promotion ; Humans ; Infant ; Infant, Newborn ; Male ; Maximum Tolerated Dose ; Middle Aged ; Nutrition Surveys ; Republic of Korea ; Young Adult
    Chemical Substances Capsaicin (S07O44R1ZM)
    Language English
    Publishing date 2021-07-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu13072461
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Analysis of quantum key distribution based on unified model of sequential state discrimination strategy.

    Namkung, Min / Kwon, Younghun

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 10254

    Abstract: The quantum key distribution for multiparty is one of the essential subjects of study. Especially, without using entangled states, performing the quantum key distribution for multiparty is a critical area of research. For this purpose, sequential state ... ...

    Abstract The quantum key distribution for multiparty is one of the essential subjects of study. Especially, without using entangled states, performing the quantum key distribution for multiparty is a critical area of research. For this purpose, sequential state discrimination, which provides multiparty quantum communication and quantum key distribution for multiple receivers, has recently been introduced. Moreover, the sequential state discrimination is applicable for the security analysis against an eavesdropper's attack. In this work, we provide the security analysis of quantum key distribution by proposing a unified model of sequential state discrimination including an eavesdropper. In this model, the success probability of eavesdropping is used as a figure of merit for the security analysis. Moreover, we obtain a non-zero secret key rate between the sender and receiver, which implies that the sender and receiver can share a secret key despite the eavesdropper's scheme that optimizing the success probability of eavesdropping. Further, we propose an experimental methodology for the proposed model, which is implementable with linear optics. We observe that the secret key between the sender and receiver can be non-zero, even with imperfections.
    Language English
    Publishing date 2024-05-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-60020-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Antidepressant discontinuation patterns and characteristics across sociodemographic groups in the United States.

    Kwon, Yoojung / Lauffenburger, Julie C

    Journal of affective disorders

    2024  Volume 355, Page(s) 82–85

    Abstract: Background: While antidepressants are frequently used, less is known about contemporary discontinuation patterns, especially across different sociodemographic populations.: Methods: Patients 16-84 years initiating antidepressants between 2016 and ... ...

    Abstract Background: While antidepressants are frequently used, less is known about contemporary discontinuation patterns, especially across different sociodemographic populations.
    Methods: Patients 16-84 years initiating antidepressants between 2016 and 2019 within a large US health insurer were identified. The association between patient characteristics and time until antidepressant discontinuation was evaluated using adjusted Cox proportional hazard regression.
    Results: Across 1,365,576 patients, mean time to discontinuation was 168.1 days (SD: 223.6). Men were more likely to discontinue than women (HR: 0.94, 95%CI: 0.94-0.94). Younger patients (16-24 years) were more likely to discontinue than older patients. Patients who were non-White (Asian HR: 1.33, 95%CI: 1.31-1.34; Black HR: 1.27, 95%CI: 1.27-1.28; Hispanic HR: 1.34, 95%:CI 1.34-1.35), with evidence of a substance use disorder (HR: 1.31, 95%CI: 1.27-1.35), or taking tricyclic antidepressants (HR:1.26, 95%CI: 1.25-1.27) were more likely to discontinue.
    Limitations: Information on reasons for discontinuation was not available, and wide standard deviations for the primary outcome were reported. The results may not be generalized to non-commercially insured beneficiaries.
    Conclusions: Discontinuation is common within the first 6 months of treatment but varies across populations, highlighting patients who may benefit from potential intervention.
    MeSH term(s) Male ; Humans ; United States ; Female ; Antidepressive Agents/therapeutic use ; Antidepressive Agents, Tricyclic ; Retrospective Studies
    Chemical Substances Antidepressive Agents ; Antidepressive Agents, Tricyclic
    Language English
    Publishing date 2024-03-28
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 135449-8
    ISSN 1573-2517 ; 0165-0327
    ISSN (online) 1573-2517
    ISSN 0165-0327
    DOI 10.1016/j.jad.2024.03.132
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1485: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  9. Article ; Online: Online Social Capital and Health What: We Know, What We Need to Know.

    Kwon, Youngbum

    Journal of occupational and environmental medicine

    2020  Volume 63, Issue 1, Page(s) e42–e43

    MeSH term(s) Humans ; Social Capital ; Social Support
    Language English
    Publishing date 2020-11-06
    Publishing country United States
    Document type Letter
    ZDB-ID 1223932-x
    ISSN 1536-5948 ; 1076-2752
    ISSN (online) 1536-5948
    ISSN 1076-2752
    DOI 10.1097/JOM.0000000000002076
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 155: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: The Modes of the Poisson Distribution of Order 3 and 4.

    Kwon, Yeil / Philippou, Andreas N

    Entropy (Basel, Switzerland)

    2023  Volume 25, Issue 4

    Abstract: In this article, new properties of the Poisson distribution of ... ...

    Abstract In this article, new properties of the Poisson distribution of order
    Language English
    Publishing date 2023-04-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2014734-X
    ISSN 1099-4300 ; 1099-4300
    ISSN (online) 1099-4300
    ISSN 1099-4300
    DOI 10.3390/e25040699
    Database MEDical Literature Analysis and Retrieval System OnLINE

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