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  1. Article ; Online: Diagnostic features, management and prognosis of type 2 myocardial infarction compared to type 1 myocardial infarction

    Kyle White / Ian Scott / Mansey Kinarivala

    BMJ Open, Vol 12, Iss

    a systematic review and meta-analysis

    2022  Volume 2

    Keywords Medicine ; R
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher BMJ Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Structural state recognition facilitates tip tracking of EB1 at growing microtubule ends

    Taylor A Reid / Courtney Coombes / Soumya Mukherjee / Rebecca R Goldblum / Kyle White / Sneha Parmar / Mark McClellan / Marija Zanic / Naomi Courtemanche / Melissa K Gardner

    eLife, Vol

    2019  Volume 8

    Abstract: The microtubule binding protein EB1 specifically targets the growing ends of microtubules in cells, where EB1 facilitates the interactions of cellular proteins with microtubule plus-ends. Microtubule end targeting of EB1 has been attributed to high- ... ...

    Abstract The microtubule binding protein EB1 specifically targets the growing ends of microtubules in cells, where EB1 facilitates the interactions of cellular proteins with microtubule plus-ends. Microtubule end targeting of EB1 has been attributed to high-affinity binding of EB1 to GTP-tubulin that is present at growing microtubule ends. However, our 3D single-molecule diffusion simulations predicted a ~ 6000% increase in EB1 arrivals to open, tapered microtubule tip structures relative to closed lattice conformations. Using quantitative fluorescence, single-molecule, and electron microscopy experiments, we found that the binding of EB1 onto opened, structurally disrupted microtubules was dramatically increased relative to closed, intact microtubules, regardless of hydrolysis state. Correspondingly, in cells, the blunting of growing microtubule plus-ends by Vinblastine was correlated with reduced EB1 targeting. Together, our results suggest that microtubule structural recognition, based on a fundamental diffusion-limited binding model, facilitates the tip tracking of EB1 at growing microtubule ends.
    Keywords microtubule ; tip tracking ; EB1 ; systems modeling ; diffusion ; tubulin ; Medicine ; R ; Science ; Q ; Biology (General) ; QH301-705.5
    Subject code 612
    Language English
    Publishing date 2019-09-01T00:00:00Z
    Publisher eLife Sciences Publications Ltd
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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