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Article ; Online: Response to: Twelve tips to present an effective webinar.

Shahzad, Orthi / Kyriacou, Harry

2020 Volume 43, Issue 8, Page(s) 978

Language	English
Publishing date	2020-12-14
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	424426-6
ISSN	1466-187X ; 0142-159X
ISSN (online)	1466-187X
ISSN	0142-159X
DOI	10.1080/0142159X.2020.1859099
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Article ; Online: Important perioperative factors, guidelines and outcomes in the management of hip fracture.

Kyriacou, Harry / Khan, Wasim S

Journal of perioperative practice

2020 Volume 31, Issue 4, Page(s) 140–146

Abstract: Hip fractures are common injuries in the elderly and are associated with significant morbidity and mortality. There are multiple perioperative factors that must be considered when managing these patients. These include analgesia, timing of surgery, ... ...

Abstract	Hip fractures are common injuries in the elderly and are associated with significant morbidity and mortality. There are multiple perioperative factors that must be considered when managing these patients. These include analgesia, timing of surgery, choice of operation, type of anaesthesia, postoperative complications and comorbidities. Guidelines from The National Institute for Health and Care Excellence and the National Hip Fracture Database have been updated to reflect many of the above, but the importance of psychosocial factors is still emerging. This article focuses on the evidence for the key perioperative factors in hip fracture management and the tools available to predict hip fracture outcome.
MeSH term(s)	Aged ; Comorbidity ; Hip Fractures/surgery ; Humans ; Postoperative Complications/epidemiology ; Retrospective Studies
Language	English
Publishing date	2020-04-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2226186-2
ISSN	2515-7949 ; 1750-4589
ISSN (online)	2515-7949
ISSN	1750-4589
DOI	10.1177/1750458920915656
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Article ; Online: Tips for emergency medicine placements in the COVID-19 pandemic.

Kyriacou, Harry / Hellawell, Holly N / Sumal, Anoop S

Medical teacher

2021 Volume 44, Issue 3, Page(s) 334–335

MeSH term(s)	COVID-19 ; Emergency Medicine ; Emergency Service, Hospital ; Humans ; Pandemics
Language	English
Publishing date	2021-06-08
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	424426-6
ISSN	1466-187X ; 0142-159X
ISSN (online)	1466-187X
ISSN	0142-159X
DOI	10.1080/0142159X.2021.1934427
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Article ; Online: Twelve tips to maximise medical student learning during emergency medicine placements.

Hellawell, Holly N / Kyriacou, Harry / Sumal, Anoop S

Medical teacher

2020 Volume 43, Issue 2, Page(s) 148–151

Abstract: Placements in the emergency department provide medical students with countless clinical and practical learning opportunities. However, medical education may not always be optimised for students in this busy, potentially overwhelming environment. Prior ... ...

Abstract	Placements in the emergency department provide medical students with countless clinical and practical learning opportunities. However, medical education may not always be optimised for students in this busy, potentially overwhelming environment. Prior knowledge of how to make the most of emergency medicine placements helps to facilitate student learning and enjoyment. In this article, the authors compiled twelve tips based on the relevant literature and their experiences on emergency attachments. These tips will better prepare medical students for their emergency medicine placements and ensure that they experience the full benefits of working in the emergency department.
MeSH term(s)	Clinical Competence ; Education, Medical ; Emergency Medicine ; Humans ; Learning ; Students, Medical
Language	English
Publishing date	2020-06-10
Publishing country	England
Document type	Journal Article
ZDB-ID	424426-6
ISSN	1466-187X ; 0142-159X
ISSN (online)	1466-187X
ISSN	0142-159X
DOI	10.1080/0142159X.2020.1774531
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Article ; Online: Use of human induced pluripotent stem cells for cartilage regeneration in vitro and within chondral defect models of knee joint cartilage in vivo: a Preferred Reporting Items for Systematic Reviews and Meta-Analyses systematic literature review.

Kamaraj, Achi / Kyriacou, Harry / Seah, K T Matthew / Khan, Wasim S

Cytotherapy

2021 Volume 23, Issue 8, Page(s) 647–661

Abstract: Background aims: Articular cartilage has limited regenerative ability when damaged through trauma or disease. Failure to treat focal chondral lesions results in changes that inevitably progress to osteoarthritis. Osteoarthritis is a major contributor to ...

Abstract	Background aims: Articular cartilage has limited regenerative ability when damaged through trauma or disease. Failure to treat focal chondral lesions results in changes that inevitably progress to osteoarthritis. Osteoarthritis is a major contributor to disability globally, which results in significant medical costs and lost wages every year. Human induced pluripotent stem cells (hiPSCs) have long been considered a potential autologous therapeutic option for the treatment of focal chondral lesions. Although there are significant advantages to hiPSCs over other stem cell options, such as mesenchymal and embryonic stem cells, there are concerns regarding their ability to form bona fide cartilage and their tumorgenicity in vivo. Methods: The authors carried out a systematic literature review on the use of hiPSCs to produce differentiated progeny capable of producing high-quality cartilage in vitro and regenerate cartilage in osteochondral defects in vivo in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Eight studies were included in the review that used hiPSCs or their derived progeny in xenogeneic transplants in animal models to regenerate cartilage in osteochondral defects of the knee joint. The in vitro-differentiated, hiPSC-derived and in vivo defect repair ability of the hiPSC-derived progeny transplants were assessed. Results: Most studies reported the generation of high-quality cartilage-producing progeny that were able to successfully repair cartilage defects in vivo. No tumorigenicity was observed. Conclusions: The authors conclude that hiPSCs offer a valuable source of cartilage-producing progeny that show promise as an effective cell-based therapy in treating focal chondral lesions.
MeSH term(s)	Animals ; Cartilage, Articular ; Cell Differentiation ; Humans ; Induced Pluripotent Stem Cells ; Knee Joint ; Osteoarthritis
Language	English
Publishing date	2021-05-29
Publishing country	England
Document type	Journal Article ; Review ; Systematic Review
ZDB-ID	2039821-9
ISSN	1477-2566 ; 1465-3249
ISSN (online)	1477-2566
ISSN	1465-3249
DOI	10.1016/j.jcyt.2021.03.008
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Article ; Online: Tricuspid atresia: Where are we now?

Sumal, Anoop S / Kyriacou, Harry / Mostafa, Ahmed M H A M

Journal of cardiac surgery

2020 Volume 35, Issue 7, Page(s) 1609–1617

Abstract: Tricuspid atresia (TA) is a complex congenital heart disease that presents with cyanosis in the neonatal period. It is invariably fatal if left untreated and requires multiple stages of palliation. Early recognition and timely surgical intervention are ... ...

Abstract	Tricuspid atresia (TA) is a complex congenital heart disease that presents with cyanosis in the neonatal period. It is invariably fatal if left untreated and requires multiple stages of palliation. Early recognition and timely surgical intervention are therefore pivotal in the management of these infants. This literature review considers the pathophysiology, presentation, investigations, and classification of TA. Moreover, it discusses the evidence upon which the latest medical and surgical treatments are based, as well as numerous recent case reports. Further work is needed to elucidate the etiology of TA, clarify the role of pharmacotherapy, and optimize the surgical management that these patients receive.
MeSH term(s)	Alprostadil/therapeutic use ; Angiotensin-Converting Enzyme Inhibitors/therapeutic use ; Child, Preschool ; Female ; Fontan Procedure/methods ; Fontan Procedure/mortality ; Humans ; Infant ; Infant, Newborn ; Male ; Postoperative Care ; Survival Rate ; Treatment Outcome ; Tricuspid Atresia/classification ; Tricuspid Atresia/diagnosis ; Tricuspid Atresia/mortality ; Tricuspid Atresia/surgery ; Tricuspid Valve/surgery
Chemical Substances	Angiotensin-Converting Enzyme Inhibitors ; Alprostadil (F5TD010360)
Language	English
Publishing date	2020-06-02
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	639059-6
ISSN	1540-8191 ; 0886-0440
ISSN (online)	1540-8191
ISSN	0886-0440
DOI	10.1111/jocs.14673
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Article ; Online: Important considerations for designing CPR surveys.

Mostafa, Ahmed M H A M / Hellawell, Holly N / Kyriacou, Harry

International journal of cardiology

2020 Volume 318, Page(s) 25

MeSH term(s)	Cardiopulmonary Resuscitation ; Humans ; Out-of-Hospital Cardiac Arrest/diagnosis ; Out-of-Hospital Cardiac Arrest/epidemiology ; Out-of-Hospital Cardiac Arrest/therapy ; Students, Medical ; Surveys and Questionnaires
Language	English
Publishing date	2020-06-27
Publishing country	Netherlands
Document type	Letter ; Comment
ZDB-ID	779519-1
ISSN	1874-1754 ; 0167-5273
ISSN (online)	1874-1754
ISSN	0167-5273
DOI	10.1016/j.ijcard.2020.06.040
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Article ; Online: Aortic valve replacement in patients over 60: Real-world surgical outcomes.

Sumal, Anoop S / Ali, Jason M / Kyriacou, Harry / Tuttle, Christopher J / Moorjani, Narain

Journal of cardiac surgery

2021 Volume 36, Issue 4, Page(s) 1468–1476

Abstract: Objective: With the advent of transcatheter aortic valve implantation (TAVI) has come an expectation that there will be a decline in surgical aortic valve replacement (SAVR). This has been fueled by trials comparing outcomes between TAVI and SAVR in ... ...

Abstract	Objective: With the advent of transcatheter aortic valve implantation (TAVI) has come an expectation that there will be a decline in surgical aortic valve replacement (SAVR). This has been fueled by trials comparing outcomes between TAVI and SAVR in lower-risk patients. The aim of this study was to examine outcomes following SAVR in patients over the age of 60. Materials and methods: This retrospective cohort study observed 1005 patients ≥60 who underwent isolated primary SAVR from January 2015 to December 2018. The cohort was stratified by surgical risk, defined as European System for Cardiac Operative Risk Evaluation (EuroSCORE) II < 4 versus ≥4. The cohort was also divided by age (60-69, 70-79, ≥80) for additional comparisons. Outcomes included in-hospital complications and patient survival. Results: The median age and EuroSCORE II were 75 years and 1.6, respectively. The overall 30-day mortality was 1.7% and increased significantly with surgical risk (p = .007). The 30-day mortality of elective patients was 1.1%. Overall, 1- and 2-year survival rates were 94.3% and 91.7%, respectively, which significantly decreased with surgical risk (p < .001) and age (p = .002, p = .003). The rates of postoperative stroke and pacemaker implantations were 1.2% and 3.6%, respectively. Conclusions: SAVR can be performed in patients ≥60 years old with excellent outcomes, which compare favorably with outcomes from TAVI trials, with their highly selected patient cohorts. SAVR remains a reliable, tried and tested, treatment option in these patients.
MeSH term(s)	Aortic Valve/surgery ; Aortic Valve Stenosis/surgery ; Heart Valve Prosthesis Implantation ; Humans ; Middle Aged ; Retrospective Studies ; Risk Factors ; Transcatheter Aortic Valve Replacement ; Treatment Outcome
Language	English
Publishing date	2021-01-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	639059-6
ISSN	1540-8191 ; 0886-0440
ISSN (online)	1540-8191
ISSN	0886-0440
DOI	10.1111/jocs.15353
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Article ; Online: Principles and guidelines in the management of ankle fractures in adults.

Kyriacou, Harry / Mostafa, Ahmed M H A M / Davies, Benjamin M / Khan, Wasim S

Journal of perioperative practice

2021 Volume 31, Issue 11, Page(s) 427–434

Abstract: Ankle fractures are common injuries that have many physical and psychosocial complications. As a result, it is important to be aware of how these patients present and are managed perioperatively. Detailed guidelines from NICE and the British Orthopaedic ... ...

Abstract	Ankle fractures are common injuries that have many physical and psychosocial complications. As a result, it is important to be aware of how these patients present and are managed perioperatively. Detailed guidelines from NICE and the British Orthopaedic Association have been produced on this topic, including recent developments such as the decision to weight-bear early after surgery and the use of virtual fracture clinics. This article provides an overview of the key perioperative factors that need to be considered in cases of ankle fracture and the relevant clinical guidelines.
MeSH term(s)	Adult ; Ankle Fractures/surgery ; Humans ; Lower Extremity ; Orthopedics
Language	English
Publishing date	2021-04-07
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2226186-2
ISSN	2515-7949 ; 1750-4589
ISSN (online)	2515-7949
ISSN	1750-4589
DOI	10.1177/1750458920969029
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Article ; Online: Skeletal muscle deconditioning during partial weight-bearing in rodents - A systematic review and meta-analysis.

Swain, Patrick / Mortreux, Marie / Laws, Jonathan M / Kyriacou, Harry / De Martino, Enrico / Winnard, Andrew / Caplan, Nick

Life sciences in space research

2022 Volume 34, Page(s) 68–86

Abstract: Space agencies are planning to send humans back to the Lunar surface, in preparation for crewed exploration of Mars. However, the effect of hypogravity on human skeletal muscle is largely unknown. A recently established rodent partial weight-bearing ... ...

Abstract	Space agencies are planning to send humans back to the Lunar surface, in preparation for crewed exploration of Mars. However, the effect of hypogravity on human skeletal muscle is largely unknown. A recently established rodent partial weight-bearing model has been employed to mimic various levels of hypogravity loading and may provide valuable insights to better understanding how human muscle might respond to this environment. The aim of this study was to perform a systematic review regarding the effects of partial weight-bearing on the morphology and function of rodent skeletal muscle. Five online databases were searched with the following inclusion criteria: population (rodents), intervention (partial weight-bearing for ≥1 week), control (full weight-bearing), outcome(s) (skeletal muscle morphology/function), and study design (animal intervention). Of the 2,993 studies identified, eight were included. Partial weight-bearing at 20%, 40%, and 70% of full loading caused rapid deconditioning of skeletal muscle morphology and function within the first one to two weeks of exposure. Calf circumference, hindlimb wet muscle mass, myofiber cross-sectional area, front/rear paw grip force, and nerve-stimulated plantarflexion force were reduced typically by medium to very large effects. Higher levels of partial weight-bearing often attenuated deconditioning but failed to entirely prevent it. Species and sex mediated the deconditioning response. Risk of bias was low/unclear for most studies. These findings suggest that there is insufficient stimulus to mitigate muscular deconditioning in hypogravity settings highlighting the need to develop countermeasures for maintaining astronaut/cosmonaut muscular health on the Moon and Mars.
MeSH term(s)	Animals ; Astronauts ; Humans ; Hypogravity ; Muscle, Skeletal ; Rodentia ; Weight-Bearing/physiology
Language	English
Publishing date	2022-07-29
Publishing country	Netherlands
Document type	Journal Article ; Meta-Analysis ; Review ; Systematic Review
ISSN	2214-5532
ISSN (online)	2214-5532
DOI	10.1016/j.lssr.2022.06.007
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