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Book ; Online ; E-Book: Ovarian cancers

Pujade-Lauraine, Éric / Ray-Coquard, Isabelle / Lécuru, Fabrice

advances through international research cooperation (GINECO, ENGOT, GCIG)

2017

Author's details	Eric Pujade-Lauraine, Isabelle Ray-Coquard, Fabrice Lécuru editors
Keywords	Eierstockkrebs
Subject	Ovarialkarzinom ; Ovarialcarcinom ; Ovarialkrebs
Language	English
Size	1 Online Ressource (ix, 286 Seiten)
Publisher	Springer
Publishing place	Cham
Publishing country	Switzerland
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
HBZ-ID	HT019442257
ISBN	978-3-319-32110-3 ; 9783319321080 ; 3-319-32110-2 ; 3319321080
DOI	10.1007/978-3-319-32110-3
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article: Cervical Cancer Associated with Pregnancy: Current Challenges and Future Strategies.

Le Guévelou, Jennifer / Selleret, Lise / Laas, Enora / Lecuru, Fabrice / Kissel, Manon

Cancers

2024 Volume 16, Issue 7

Abstract: Cancer during pregnancy is defined as a tumor diagnosed in a pregnant woman or up to 1-year post-partum. While being a rare disease, cervical cancer is probably one of the most challenging medical conditions, with the dual stake of treating the cancer ... ...

Abstract	Cancer during pregnancy is defined as a tumor diagnosed in a pregnant woman or up to 1-year post-partum. While being a rare disease, cervical cancer is probably one of the most challenging medical conditions, with the dual stake of treating the cancer without compromising its chances for cure, while preserving the pregnancy and the health of the fetus and child. To date, guidelines for gynecological cancers are provided through international consensus meetings with expert panels, giving insights on both diagnosis, treatment, and obstetrical care. However, these expert guidelines do not discuss the various approaches than can be found within the literature, such as alternative staging modalities or innovative surgical approaches. Also, the obstetrical care of women diagnosed with cervical cancer during pregnancy requires specific considerations that are not provided within our current standard of care. This systematic review aims to fill the gap on current issues with regards to the management of cervical cancer during pregnancy and provide future directions within this evolving landscape.
Language	English
Publishing date	2024-03-29
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers16071341
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Predictors of Non-Sentinel Lymph Node Metastasis in Patients with Positive Sentinel Lymph Node in Early-Stage Cervical Cancer: A SENTICOL GROUP Study.

Pache, Basile / Tantari, Matteo / Guani, Benedetta / Mathevet, Patrice / Magaud, Laurent / Lecuru, Fabrice / Balaya, Vincent

Cancers

2023 Volume 15, Issue 19

Abstract: Background: The goal of this study was to identify the risk factors for metastasis in the remaining non-sentinel lymph nodes (SLN) in the case of positive SLN in early-stage cervical cancer.: Methods: An ancillary analysis of two prospective ... ...

Abstract	Background: The goal of this study was to identify the risk factors for metastasis in the remaining non-sentinel lymph nodes (SLN) in the case of positive SLN in early-stage cervical cancer. Methods: An ancillary analysis of two prospective multicentric databases on SLN biopsy for cervical cancer (SENTICOL I and II) was performed. Patients with early-stage cervical cancer (FIGO 2018 IA to IIA1), with bilateral SLN detection and at least one positive SLN after ultrastaging, were included. Results: 405 patients were included in SENTICOL I and Il. Fifty-two patients had bilateral SLN detection and were found to have SLN metastasis. After pelvic lymphadenectomy, metastatic involvement of non-SLN was diagnosed in 7 patients (13.5%). Patients with metastatic non-SLN were older (51.9 vs. 40.8 years, Conclusions: Age and LVSI seemed to be predictive of non-SLN metastasis in patients with SLN metastasis in early-stage cervical cancer. Larger cohorts are needed to confirm the results and clinical usefulness of such findings.
Language	English
Publishing date	2023-09-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15194737
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Article ; Online: The Use of Artificial Intelligence for Complete Cytoreduction Prediction in Epithelial Ovarian Cancer: A Narrative Review.

Parpinel, Giulia / Laudani, Maria Elena / Piovano, Elisa / Zola, Paolo / Lecuru, Fabrice

Cancer control : journal of the Moffitt Cancer Center

2023 Volume 30, Page(s) 10732748231159553

Abstract: Introduction: In patients affected by epithelial ovarian cancer (EOC) complete cytoreduction (CC) has been associated with higher survival outcomes. Artificial intelligence (AI) systems have proved clinical benefice in different areas of healthcare.: ... ...

Abstract	Introduction: In patients affected by epithelial ovarian cancer (EOC) complete cytoreduction (CC) has been associated with higher survival outcomes. Artificial intelligence (AI) systems have proved clinical benefice in different areas of healthcare. Objective: To systematically assemble and analyze the available literature on the use of AI in patients affected by EOC to evaluate its applicability to predict CC compared to traditional statistics. Material and methods: Data search was carried out through PubMed, Scopus, Ovid MEDLINE, Cochrane Library, EMBASE, international congresses and clinical trials. The main search terms were: Artificial Intelligence AND surgery/cytoreduction AND ovarian cancer. Two authors independently performed the search by October 2022 and evaluated the eligibility criteria. Studies were included when data about Artificial Intelligence and methodological data were detailed. Results: A total of 1899 cases were analyzed. Survival data were reported in 2 articles: 92% of 5-years overall survival (OS) and 73% of 2-years OS. The median area under the curve (AUC) resulted 0,62. The model accuracy for surgical resection reported in two articles reported was 77,7% and 65,8% respectively while the median AUC was 0,81. On average 8 variables were inserted in the algorithms. The most used parameters were age and Ca125. Discussion: AI revealed greater accuracy compared against the logistic regression models data. Survival predictive accuracy and AUC were lower for advanced ovarian cancers. One study analyzed the importance of factors predicting CC in recurrent epithelial ovarian cancer and disease free interval, retroperitoneal recurrence, residual disease at primary surgery and stage represented the main influencing factors. Surgical Complexity Scores resulted to be more useful in the algorithms than pre-operating imaging. Conclusion: AI showed better prognostic accuracy if compared to conventional algorithms. However further studies are needed to compare the impact of different AI methods and variables and to provide survival informations.
MeSH term(s)	Humans ; Female ; Carcinoma, Ovarian Epithelial/surgery ; Artificial Intelligence ; Cytoreduction Surgical Procedures/methods ; Neoplasm Recurrence, Local/drug therapy ; Ovarian Neoplasms/surgery
Language	English
Publishing date	2023-02-25
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	1328503-8
ISSN	1526-2359 ; 1073-2748
ISSN (online)	1526-2359
ISSN	1073-2748
DOI	10.1177/10732748231159553
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Zs.A 4467: Show issues

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Article: The Role of Systematic Lymphadenectomy in Low-Grade Serous Ovarian Cancer: A Systematic Review and Meta-Analysis.

Montero-Macías, Rosa / Segura-Sampedro, Juan José / Rigolet, Pascal / Lecuru, Fabrice / Craus-Miguel, Andrea / Castillo-Tuñón, Juan Manuel

Cancers

2024 Volume 16, Issue 5

Abstract: Objective: To evaluate the role of systematic lymphadenectomy in low-grade serous ovarian cancer (LGSOC) and determine its impact on clinical outcomes in overall survival (OS) and disease-free survival (DFS) terms.: Methods: A comprehensive, ... ...

Abstract	Objective: To evaluate the role of systematic lymphadenectomy in low-grade serous ovarian cancer (LGSOC) and determine its impact on clinical outcomes in overall survival (OS) and disease-free survival (DFS) terms. Methods: A comprehensive, systematic computer literature search on PubMed was performed using the following Medical Subject Headings (MeSH) terms: "low grade serous ovarian cancer" AND/OR "lymphadenectomy" AND/OR "staging" AND/OR "ovarian cancer" AND/OR "cytoreduction". Separate searches were performed with MeSH terms on MEDLINE and EMBASE to extract all the relevant literature available. We included only patients with histologically confirmed LGSOC. Results: Three studies were considered in the quantitative analysis. Systematic lymphadenectomy in LGSOC failed to provide a significant OS or PFS benefit in LGSOC when compared to no lymphadenectomy in the entire (all the stages) population (for OS: HR = 1.15, 95% CI [0.42, 3.18] I2 = 84% and for PFS: HR = 1.46, 95% CI [0.63, 3.41], I2 = 71%), nor did it in the subtype analysis regarding FIGO stages. For FIGO early-stage I-II LGSOC, the DFS data were pooled (HR = 1.48, 95% CI [0.58, 3.78], I2 = 75%). In patients with advanced-stage (FIGO II-IV), we also failed to prove survival benefit for lymphadenectomy in OS (HR = 1.74, 95% CI [0.87, 3.48], I2 = 11%) or DFS (HR = 1.48, 95% CI [0.58, 3.78], I2 = 75%) compared to no lymphadenectomy. Conclusion: More extensive prospective research is mandatory to understand the real impact of lymphadenectomy on survival in LGSOC. The existing literature does not provide strong evidence.
Language	English
Publishing date	2024-02-27
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers16050955
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Article ; Online: How to perform sentinel node detection in high-risk endometrial cancer: one step forward.

Balaya, Vincent / Lecuru, Fabrice / Laas, Enora

Journal of gynecologic oncology

2021 Volume 32, Issue 4, Page(s) e71

MeSH term(s)	Endometrial Neoplasms/surgery ; Female ; Humans ; Sentinel Lymph Node/diagnostic imaging ; Sentinel Lymph Node Biopsy
Language	English
Publishing date	2021-06-03
Publishing country	Korea (South)
Document type	Editorial ; Comment
ZDB-ID	2478405-9
ISSN	2005-0399 ; 2005-0380
ISSN (online)	2005-0399
ISSN	2005-0380
DOI	10.3802/jgo.2021.32.e71
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Zs.A 6484: Show issues

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Article ; Online: Laparoscopic vaginal radical trachelectomy in the post-LACC era: step-by-step surgical procedure.

Guani, Benedetta / Balaya, V / Ayoubi, J M / Feki, Anis / Lecuru, Fabrice R / Mathevet, Patrice

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

2022 Volume 32, Issue 12, Page(s) 1617–1618

MeSH term(s)	Female ; Humans ; Trachelectomy/methods ; Vagina/surgery ; Cervix Uteri/surgery ; Laparoscopy/methods ; Uterine Cervical Neoplasms/surgery ; Gynecologic Surgical Procedures/methods
Language	English
Publishing date	2022-12-05
Publishing country	England
Document type	Journal Article
ZDB-ID	1070385-8
ISSN	1525-1438 ; 1048-891X
ISSN (online)	1525-1438
ISSN	1048-891X
DOI	10.1136/ijgc-2022-003462
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Zs.A 3198: Show issues

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Article: Sentinel Lymph Node Biopsy in Uterine Cancer: Time for a Modern Approach.

Laas, Enora / Fourchotte, Virginie / Gaillard, Thomas / Pauly, Léa / Reyal, Fabien / Feron, Jean-Guillaume / Lécuru, Fabrice

Cancers

2023 Volume 15, Issue 2

Abstract: Since the validation of the sentinel node technique (SLN) for vulvar cancer 20 years ago, this technique has been introduced in the management of operable cervical cancer and endometrial cancer. For cervical cancer a "one fits all" attitude has mainly ... ...

Abstract	Since the validation of the sentinel node technique (SLN) for vulvar cancer 20 years ago, this technique has been introduced in the management of operable cervical cancer and endometrial cancer. For cervical cancer a "one fits all" attitude has mainly been presented. However, this approach, consisting of a frozen section during the operation, can be discussed in some stages. We present and discuss the main option for each stage, as well as some secondary possibilities. For endometrial cancer, SLN is now the technique of choice for the nodal staging of low- and intermediate-risk groups. Some discussion exists for the high-risk group. We also discuss the impacts of using preoperatively the molecular classification of endometrial cancer. Patients with POLE or TP53 mutations could have different nodal staging. The story of SLN in uterine cancers is not finished. We propose a comprehensive algorithm of SLN in early cervical and endometrial cancers. However, several ongoing trials will give us important data in the coming years. They could substantially change these propositions.
Language	English
Publishing date	2023-01-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15020389
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Article ; Online: Survival after sentinel lymph node biopsy for early cervical cancers: a systematic review and meta-analysis.

Parpinel, Giulia / Laas-Faron, Enora / Balaya, Vincent / Guani, Benedetta / Zola, Paolo / Mathevet, Patrice / Paoletti, Xavier / Lecuru, Fabrice R

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

2023 Volume 33, Issue 12, Page(s) 1853–1860

Abstract: Background: Sentinel lymph node biopsy represents an alternative to pelvic lymphadenectomy for lymph node staging of early-stage cervical carcinoma, but prospective evidence on long-term oncological safety of sentinel lymph node biopsy alone versus ... ...

Abstract	Background: Sentinel lymph node biopsy represents an alternative to pelvic lymphadenectomy for lymph node staging of early-stage cervical carcinoma, but prospective evidence on long-term oncological safety of sentinel lymph node biopsy alone versus pelvic lymphadenectomy is missing. Objective: To investigate, with this meta-analysis, the impact of sentinel lymph node biopsy alone versus pelvic lymphadenectomy on survival for patients with early-stage cervical cancer. Methods: A systematic literature review was performed. We excluded studies in which pelvic lymphadenectomy was systematically performed after every sentinel lymph node biopsy, including only articles where pelvic lymphadenectomy was performed because sentinel lymph node biopsy was not conclusive. A meta-analysis was carried out combining 5-year disease-free survival and overall survival rates with a random and fixed effect model. Heterogeneity was tested using the Cochran Χ Results: The search of databases and registers found 927 items and six articles (two retrospective and four prospective). The median time of follow-up was 34.8 months (range 13-53). Overall common effect disease-free survival was 98% while random effect disease-free survival was 94%. Overall heterogeneity was 77%. A subgroup analysis was applied, dividing studies into one group including sentinel lymph node biopsy negative data only (common effect disease-free survival 91%; random effect disease-free survival 90%), and one group with a negative and positive sentinel lymph node biopsy (common effect disease-free survival 98%; random effect disease-free survival 96%). In the analysis of overall survival, positive and negative sentinel lymph node biopsy cases were examined together (common and random effect overall survival 99%). Ultrastaging did not affect disease-free survival (common and random effect disease-free survival 92% in the ultrastaging group vs common effect disease-free survival 99% and random effect disease-free survival 96% in the non-ultrastaging group). Conclusions: Both 5-year disease-free survival and overall survival rate after sentinel lymph node biopsy alone are higher than 90% and do not differ from pelvic lymphadenectomy survival data. Ultrastaging did not impact survival.
MeSH term(s)	Female ; Humans ; Sentinel Lymph Node Biopsy ; Uterine Cervical Neoplasms/surgery ; Uterine Cervical Neoplasms/pathology ; Retrospective Studies ; Prospective Studies ; Lymph Node Excision ; Lymph Nodes/pathology ; Neoplasm Staging
Language	English
Publishing date	2023-12-04
Publishing country	England
Document type	Systematic Review ; Meta-Analysis ; Journal Article
ZDB-ID	1070385-8
ISSN	1525-1438 ; 1048-891X
ISSN (online)	1525-1438
ISSN	1048-891X
DOI	10.1136/ijgc-2023-004726
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Zs.A 3198: Show issues

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Article ; Online: État des lieux des résultats en termes de survie de la CHIP en primo-traitement et en récidive dans le cancer épithélial de l’ovaire.

Classe, Jean-Marc / Frenel, Jean-Sébastien / Berton, Dominique / Gladieff, Laurence / Ferron, Gwenaël / Lecuru, Fabrice / Bourgin, Charlotte / Narducci, Fabrice / Loaec, Cécile

Bulletin du cancer

2023 Volume 111, Issue 3, Page(s) 261–266

Abstract: Peritoneal carcinomatosis is an unavoidable development of ovarian cancer, from the first treatment to relapses, and is the main cause of patients death. Hyperthermic intraperitoneal chemotherapy (HIPEC), is a hope for cure for patients with ovarian ... ...

Title translation	State of results of HIPEC for epithelial ovarian cancer in the primary treatment or for relapse.
Abstract	Peritoneal carcinomatosis is an unavoidable development of ovarian cancer, from the first treatment to relapses, and is the main cause of patients death. Hyperthermic intraperitoneal chemotherapy (HIPEC), is a hope for cure for patients with ovarian cancer. HIPEC is based on direct application of chemotherapy on the perioneum with high concentration of chemotherapy enhanced with specific effects of hyperthermia. Theoretically, HIPEC could be proposed at different steps of ovarian cancer development. But the hypothesis of efficiency of a new treatment must be assessed before being routinely applied. Numerous clinical series are already published about HIPEC used in primary treatment of ovarian cancer or for relapses. These series are mostly retrospectives and based on heterogeneous parameters as inclusion criteria of patients, intra peritoneal chemotherapy, concentration, temperature, duration of HIPEC. Taking into account this heterogeneity it is not possible to draw strong scientific conclusions about HIPEC efficiency to treat ovarian cancer patients. We proposed a review allowing a better understanding of current recommendations of the use of HIPEC in ovarian cancer patients.
MeSH term(s)	Humans ; Female ; Carcinoma, Ovarian Epithelial/drug therapy ; Hyperthermic Intraperitoneal Chemotherapy ; Hyperthermia, Induced/methods ; Neoplasm Recurrence, Local/drug therapy ; Ovarian Neoplasms/drug therapy ; Combined Modality Therapy
Language	French
Publishing date	2023-03-09
Publishing country	France
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	213270-9
ISSN	1769-6917 ; 0007-4551
ISSN (online)	1769-6917
ISSN	0007-4551
DOI	10.1016/j.bulcan.2023.01.019
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