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  1. Article: Treatment of

    Herrera-Hidalgo, Laura / Fernández-Rubio, Beatriz / Luque-Márquez, Rafael / López-Cortés, Luis E / Gil-Navarro, Maria V / de Alarcón, Arístides

    Antibiotics (Basel, Switzerland)

    2023  Volume 12, Issue 4

    Abstract: Today, ...

    Abstract Today,
    Language English
    Publishing date 2023-04-04
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics12040704
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  2. Article: Stability of Ampicillin plus Ceftriaxone Combined in Elastomeric Infusion Devices for Outpatient Parenteral Antimicrobial Therapy.

    Fernández-Rubio, Beatriz / Herrera-Hidalgo, Laura / Luque-Márquez, Rafael / de Alarcón, Arístides / López-Cortés, Luis E / Luque-Pardos, Sonia / Gutiérrez-Urbón, José María / Fernández-Polo, Aurora / Gil-Navarro, María V / Gutiérrez-Valencia, Alicia

    Antibiotics (Basel, Switzerland)

    2023  Volume 12, Issue 3

    Abstract: Currently, ampicillin plus ceftriaxone (AC) is one of the preferred treatments ... ...

    Abstract Currently, ampicillin plus ceftriaxone (AC) is one of the preferred treatments for
    Language English
    Publishing date 2023-02-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics12030432
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  3. Article: Stability Studies of Antipseudomonal Beta Lactam Agents for Outpatient Therapy.

    Fernández-Rubio, Beatriz / Herrera-Hidalgo, Laura / de Alarcón, Arístides / Luque-Márquez, Rafael / López-Cortés, Luis E / Luque, Sònia / Gutiérrez-Urbón, José María / Fernández-Polo, Aurora / Gutiérrez-Valencia, Alicia / Gil-Navarro, María V

    Pharmaceutics

    2023  Volume 15, Issue 12

    Abstract: Outpatient parenteral antimicrobial therapy (OPAT) is a useful treatment strategy ... ...

    Abstract Outpatient parenteral antimicrobial therapy (OPAT) is a useful treatment strategy against
    Language English
    Publishing date 2023-11-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics15122705
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  4. Article ; Online: Enterococcal Endocarditis: Relapses or Reinfections?

    López-Cortés, Luis E / Fernández-Cuenca, Felipe / Luque-Márquez, Rafael / de Alarcón, Arístides

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2020  Volume 72, Issue 2, Page(s) 360–361

    MeSH term(s) Endocarditis, Bacterial/diagnosis ; Endocarditis, Bacterial/drug therapy ; Gram-Positive Bacterial Infections/diagnosis ; Gram-Positive Bacterial Infections/drug therapy ; Humans ; Reinfection
    Language English
    Publishing date 2020-05-02
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciaa515
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    In stock of ZB MED Cologne/Königswinter

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  5. Article ; Online: Stability of temocillin in outpatient parenteral antimicrobial therapy: is it a real option?

    Fernández-Rubio, Beatriz / Herrera-Hidalgo, Laura / López-Cortés, Luis E / Luque-Márquez, Rafael / De Alarcón, Arístides / Luque-Pardos, Sonia / Fernández-Polo, Aurora / Gutiérrez-Urbón, José María / Rodríguez-Baño, Jesús / Gil-Navarro, María Victoria / Gutiérrez-Valencia, Alicia

    The Journal of antimicrobial chemotherapy

    2023  Volume 78, Issue 10, Page(s) 2451–2456

    Abstract: Background: Temocillin is an interesting alternative to carbapenems for susceptible Enterobacteriaceae. Although its use in outpatient parenteral antimicrobial therapy (OPAT) programmes has generated interest, this has been hampered by the lack of ... ...

    Abstract Background: Temocillin is an interesting alternative to carbapenems for susceptible Enterobacteriaceae. Although its use in outpatient parenteral antimicrobial therapy (OPAT) programmes has generated interest, this has been hampered by the lack of stability data.
    Objectives: The purpose of the present study was to evaluate the physical and chemical stability of temocillin at the recommended dose for its use in OPAT programmes, contained in polypropylene infusion bags or polyisoprene elastomeric devices at different temperatures, and to describe a novel LC-MS/MS developed for the quantification of temocillin.
    Methods: Temocillin daily dose (6 g) was diluted in 500 mL of 0.9% sodium chloride to obtain a final concentration of 12 g/L. This solution was stored at 4°C, 25°C, 32°C and 37°C for 72 h, both in polypropylene infusion bags and in polyisoprene elastomeric pumps. Physical and chemical stability were evaluated during 72 h after manufacturing. Solutions were considered stable if colour, clearness and pH remained unchanged and if the percentage of intact drug was ≥90%.
    Results: Temocillin attained the chemical stability criterion of ≥90% of the original concentration for the whole experiment in both devices at 4°C, 25°C and 32°C. At 37°C, temocillin was stable for 24 h but its concentration dropped below 90% from that timepoint. No precipitation occurred and minor colour changes were observed.
    Conclusions: Temocillin is stable under OPAT conditions and it would be an appropriate candidate for the treatment of patients who can be discharged to complete therapy in an OPAT programme. For this study, an LC-MS/MS method was developed.
    MeSH term(s) Humans ; Polypropylenes ; Chromatography, Liquid ; Outpatients ; Tandem Mass Spectrometry ; Anti-Infective Agents ; Drug Stability
    Chemical Substances temocillin (03QB156W6I) ; Polypropylenes ; Anti-Infective Agents
    Language English
    Publishing date 2023-07-28
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 191709-2
    ISSN 1460-2091 ; 0305-7453
    ISSN (online) 1460-2091
    ISSN 0305-7453
    DOI 10.1093/jac/dkad251
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  6. Article ; Online: Decay kinetics of HIV-1-RNA in seminal plasma with dolutegravir/lamivudine versus dolutegravir plus emtricitabine/tenofovir alafenamide in treatment-naive people living with HIV.

    Saborido-Alconchel, Abraham / Serna-Gallego, Ana / Lopez-Cortes, Luis E / Trujillo-Rodriguez, María / Praena-Fernandez, Juan Manuel / Dominguez-Macias, Montserrat / Lozano, Carmen / Muñoz-Muela, Esperanza / Espinosa, Nuria / Roca-Oporto, Cristina / Sotomayor, Cesar / Herrero, Marta / Gutierrez-Valencia, Alicia / Lopez-Cortes, Luis F

    The Journal of antimicrobial chemotherapy

    2023  Volume 78, Issue 9, Page(s) 2354–2360

    Abstract: Background: This was a substudy of a Phase IV, randomized clinical trial (ClinicalTrials.gov identifier: NCT04295460) aiming to compare the activity of dolutegravir/lamivudine versus dolutegravir plus tenofovir alafenamide/emtricitabine (DTG + TAF/FTC) ... ...

    Abstract Background: This was a substudy of a Phase IV, randomized clinical trial (ClinicalTrials.gov identifier: NCT04295460) aiming to compare the activity of dolutegravir/lamivudine versus dolutegravir plus tenofovir alafenamide/emtricitabine (DTG + TAF/FTC) in the male genital tract.
    Methods: Participants were asymptomatic adults without sexually transmitted diseases, treatment-naive people living with HIV (PLWH), with CD4+ T cell counts >200 cells/mm3 and plasma HIV-1-RNA levels >5000 and <500 000 copies/mL, randomized (1:1) to DTG + TAF/FTC or dolutegravir/lamivudine. Blood plasma (BP) and seminal plasma (SP) were collected at baseline and Weeks 4, 8, 12 and 24. HIV-1-RNA was measured in BP and SP using the Cobas 6800 system (Roche Diagnostics) with a lower detection limit of 20 copies/mL. The primary efficacy endpoint was the proportion of subjects with undetectable SP HIV-1-RNA at Week 12 by intention-to-treat analysis.
    Results: Fifteen participants in the DTG + TAF/FTC and 16 in the dolutegravir/lamivudine arms were analysed, with basal SP viral load of 4.81 (4.30-5.43) and 4.76 (4.09-5.23), P = 0.469, respectively. At Week 12, only one participant in each treatment arm had a detectable SP HIV-1-RNA (DTG + TAF/FTC, 141 copies/mL; dolutegravir/lamivudine, 61 copies/mL). Based on the estimated means, there was no significant difference in the decay of HIV-1-RNA in both BP and SP over time between the two arms of treatment (F = 0.452, P = 0.662, and F = 1.147, P = 0.185, respectively).
    Conclusions: After 12 weeks of treatment, there were no differences in the percentage of undetectable SP HIV-1-RNA in naive PLWH who started dolutegravir/lamivudine compared with DTG + TAF/FTC.
    MeSH term(s) Adult ; Humans ; Male ; Lamivudine/therapeutic use ; HIV-1/genetics ; HIV Infections/drug therapy ; Semen ; Kinetics ; Drug Therapy, Combination ; Emtricitabine/therapeutic use ; Heterocyclic Compounds, 3-Ring/therapeutic use ; Pyridones/therapeutic use ; Oxazines/therapeutic use ; RNA, Viral ; Anti-HIV Agents/therapeutic use
    Chemical Substances Lamivudine (2T8Q726O95) ; dolutegravir (DKO1W9H7M1) ; emtricitabine tenofovir alafenamide ; Emtricitabine (G70B4ETF4S) ; Heterocyclic Compounds, 3-Ring ; Pyridones ; Oxazines ; RNA, Viral ; Anti-HIV Agents
    Language English
    Publishing date 2023-08-07
    Publishing country England
    Document type Randomized Controlled Trial ; Clinical Trial, Phase IV ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 191709-2
    ISSN 1460-2091 ; 0305-7453
    ISSN (online) 1460-2091
    ISSN 0305-7453
    DOI 10.1093/jac/dkad245
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  7. Article ; Online: Reply to Fries et al and Valentin et al.

    López-Cortés, Luis E / Rodríguez-Baño, Jesús

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2014  Volume 58, Issue 4, Page(s) 600–601

    MeSH term(s) Bacteremia/diagnosis ; Bacteremia/drug therapy ; Case Management ; Humans ; Staphylococcal Infections/diagnosis ; Staphylococcal Infections/drug therapy
    Language English
    Publishing date 2014-02
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/cit732
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  8. Article ; Online: Safety and effectiveness of isavuconazole in real-life non-neutropenic patients.

    Monzó-Gallo, Patricia / Lopera, Carlos / Badía-Tejero, Ana M / Machado, Marina / García-Rodríguez, Julio / Vidal-Cortés, Pablo / Merino, Esperanza / Calderón, Jorge / Fortún, Jesús / Palacios-Baena, Zaira R / Pemán, Javier / Sanchis, Joan Roig / Aguilar-Guisado, Manuela / Gudiol, Carlota / Ramos, Juan C / Sánchez-Romero, Isabel / Martin-Davila, Pilar / López-Cortés, Luis E / Salavert, Miguel /
    Ruiz-Camps, Isabel / Chumbita, Mariana / Aiello, Tommaso Francesco / Peyrony, Olivier / Puerta-Alcalde, Pedro / Soriano, Alex / Marco, Francesc / Garcia-Vidal, Carolina

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2024  , Page(s) 107070

    Abstract: Background: Information is scarce on clinical experiences with non-neutropenic patients with invasive fungal infection (IFI) receiving isavuconazole. We aimed to report the safety and effectiveness of this drug as a first-line treatment or rescue in ... ...

    Abstract Background: Information is scarce on clinical experiences with non-neutropenic patients with invasive fungal infection (IFI) receiving isavuconazole. We aimed to report the safety and effectiveness of this drug as a first-line treatment or rescue in real life.
    Methods: A retrospective, observational multicentric study of non-neutropenic patients who received isavuconazole as an IFI treatment at 12 different university hospitals (January 2018 - 2022). All patients met criteria for proven, probable or possible IFI according to EORTC-MSG.
    Results: A total of 238 IFIs were treated with isavuconazole during the study period. Combination therapy was administered in 27.7% of cases. The primary IFI was aspergillosis (217, 91.2%). Other IFIs treated with isavuconazole were candidemia (n= 10), mucormycosis (n= 8), histoplasmosis (n= 2), cryptococcosis (n= 2), and others (n= 4). Median time of isavuconazole treatment was 29 days. Only 5.9% (n = 14) of cases developed toxicity, mainly hepatic-related (10 patients, 4.2%). Nine patients (3.8%) had treatment withdrawn. Successful clinical response at 12 weeks was documented in 50.5% of patients.
    Conclusions: Isavuconazole is an adequate treatment for non-neutropenic patients with IFIs. Toxicity rates were low and its effectiveness was comparable to other antifungal therapies previously reported.
    Language English
    Publishing date 2024-04-23
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2024.107070
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  9. Article ; Online: Optimizing the Clinical Use of Vancomycin.

    Álvarez, Rocío / López Cortés, Luis E / Molina, José / Cisneros, José M / Pachón, Jerónimo

    Antimicrobial agents and chemotherapy

    2016  Volume 60, Issue 5, Page(s) 2601–2609

    Abstract: The increasing number of infections produced by beta-lactam-resistant Gram-positive bacteria and the morbidity secondary to these infections make it necessary to optimize the use of vancomycin. In 2009, the American Society of Health-System Pharmacists, ... ...

    Abstract The increasing number of infections produced by beta-lactam-resistant Gram-positive bacteria and the morbidity secondary to these infections make it necessary to optimize the use of vancomycin. In 2009, the American Society of Health-System Pharmacists, the Infectious Diseases Society of America, and the Society of Infectious Disease Pharmacists published specific guidelines about vancomycin dosage and monitoring. However, these guidelines have not been updated in the past 6 years. This review analyzes the new available information about vancomycin published in recent years regarding pharmacokinetics and pharmacodynamics, serum concentration monitoring, and optimal vancomycin dosing in special situations (obese people, burn patients, renal replacement therapy, among others). Vancomycin efficacy is linked to a correct dosage which should aim to reach an area under the curve (AUC)/MIC ratio of ≥400; serum trough levels of 15 to 20 mg/liter are considered a surrogate marker of an AUC/MIC ratio of ≥400 for a MIC of ≤1 mg/liter. For Staphylococcus aureus strains presenting with a MIC >1 mg/liter, an alternative agent should be considered. Vancomycin doses must be adjusted according to body weight and the plasma trough levels of the drug. Nephrotoxicity has been associated with target vancomycin trough levels above 15 mg/liter. Continuous infusion is an option, especially for patients at high risk of renal impairment or unstable vancomycin clearance. In such cases, vancomycin plasma steady-state level and creatinine monitoring are strongly indicated.
    MeSH term(s) Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/blood ; Anti-Bacterial Agents/pharmacokinetics ; Anti-Bacterial Agents/therapeutic use ; Drug Administration Schedule ; Humans ; Microbial Sensitivity Tests ; Staphylococcus aureus/drug effects ; Staphylococcus aureus/pathogenicity ; Vancomycin/administration & dosage ; Vancomycin/blood ; Vancomycin/pharmacokinetics ; Vancomycin/therapeutic use
    Chemical Substances Anti-Bacterial Agents ; Vancomycin (6Q205EH1VU)
    Language English
    Publishing date 2016-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 217602-6
    ISSN 1098-6596 ; 0066-4804
    ISSN (online) 1098-6596
    ISSN 0066-4804
    DOI 10.1128/AAC.03147-14
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    Einzelsignatur: Show issues

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  10. Article: Enterococcus faecalis

    Herrera-Hidalgo, Laura / de Alarcón, Arístides / López-Cortes, Luis E / Luque-Márquez, Rafael / López-Cortes, Luis F / Gutiérrez-Valencia, Alicia / Gil-Navarro, María V

    Antibiotics (Basel, Switzerland)

    2020  Volume 9, Issue 10

    Abstract: The selection of the best alternative ... ...

    Abstract The selection of the best alternative for
    Language English
    Publishing date 2020-09-30
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics9100657
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