Article ; Online: Evolutionary analysis of endogenous intronic retroviruses in primates reveals an enrichment in transcription binding sites associated with key regulatory processes.
2022 Volume 10, Page(s) e14431
Abstract: Background: Endogenous retroviruses (ERVs) are the result of the integration of retroviruses into host DNA following germline infection. Endogenous retroviruses are made up of three main genes: : Results: In this work, we studied the evolutionary ... ...
| Abstract | Background: Endogenous retroviruses (ERVs) are the result of the integration of retroviruses into host DNA following germline infection. Endogenous retroviruses are made up of three main genes: Results: In this work, we studied the evolutionary history of endogenous retroviruses associated with five human genes ( Conclusions: With the data collected, and by observing the transcription factors annotated inside ERVs, we propose that these elements play a relevant role in gene expression regulation and they probably possess important features for tumorigenesis control. |
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| MeSH term(s) | Animals ; Humans ; Endogenous Retroviruses/genetics ; Phylogeny ; Introns/genetics ; Primates/genetics ; Binding Sites |
| Language | English |
| Publishing date | 2022-12-22 |
| Publishing country | United States |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2703241-3 |
| ISSN | 2167-8359 ; 2167-8359 |
| ISSN (online) | 2167-8359 |
| ISSN | 2167-8359 |
| DOI | 10.7717/peerj.14431 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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