Artikel ; Online: X-Ray Nanothermometry of Nanoparticles in Tumor-Mimicking Tissues under Photothermia.
2023 Band 12, Heft 31, Seite(n) e2301863
Abstract: Temperature plays a critical role in regulating body mechanisms and indicating inflammatory processes. Local temperature increments above 42 °C are shown to kill cancer cells in tumorous tissue, leading to the development of nanoparticle-mediated thermo- ... ...
| Abstract | Temperature plays a critical role in regulating body mechanisms and indicating inflammatory processes. Local temperature increments above 42 °C are shown to kill cancer cells in tumorous tissue, leading to the development of nanoparticle-mediated thermo-therapeutic strategies for fighting oncological diseases. Remarkably, these therapeutic effects can occur without macroscopic temperature rise, suggesting localized nanoparticle heating, and minimizing side effects on healthy tissues. Nanothermometry has received considerable attention as a means of developing nanothermosensing approaches to monitor the temperature at the core of nanoparticle atoms inside cells. In this study, a label-free, direct, and universal nanoscale thermometry is proposed to monitor the thermal processes of nanoparticles under photoexcitation in the tumor environment. Gold-iron oxide nanohybrids are utilized as multifunctional photothermal agents internalized in a 3D tumor model of glioblastoma that mimics the in vivo scenario. The local temperature under near-infrared photo-excitation is monitored by X-ray absorption spectroscopy (XAS) at the Au L |
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| Mesh-Begriff(e) | Humans ; X-Rays ; Nanoparticles/chemistry ; Temperature ; Thermometry/methods ; Neoplasms/diagnostic imaging ; Neoplasms/therapy ; Gold/chemistry |
| Chemische Substanzen | Gold (7440-57-5) |
| Sprache | Englisch |
| Erscheinungsdatum | 2023-08-10 |
| Erscheinungsland | Germany |
| Dokumenttyp | Journal Article |
| ZDB-ID | 2649576-4 |
| ISSN | 2192-2659 ; 2192-2640 |
| ISSN (online) | 2192-2659 |
| ISSN | 2192-2640 |
| DOI | 10.1002/adhm.202301863 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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