LIVIVO - Search results -

Search results

Result 1 - 10 of total 16

Search options

Article ; Online: TET Enzymes in the Immune System: From DNA Demethylation to Immunotherapy, Inflammation, and Cancer.

López-Moyado, Isaac F / Ko, Myunggon / Hogan, Patrick G / Rao, Anjana

2024

Abstract: Ten-eleven translocation (TET) proteins are iron-dependent and α-ketoglutarate-dependent dioxygenases that sequentially oxidize the methyl group of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carboxylcytosine ( ... ...

Abstract	Ten-eleven translocation (TET) proteins are iron-dependent and α-ketoglutarate-dependent dioxygenases that sequentially oxidize the methyl group of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC). All three epigenetic modifications are intermediates in DNA demethylation. TET proteins are recruited by transcription factors and by RNA polymerase II to modify 5mC at enhancers and gene bodies, thereby regulating gene expression during development, cell lineage specification, and cell activation. It is not yet clear, however, how the established biochemical activities of TET enzymes in oxidizing 5mC and mediating DNA demethylation relate to the known association of TET deficiency with inflammation, clonal hematopoiesis, and cancer. There are hints that the ability of TET deficiency to promote cell proliferation in a signal-dependent manner may be harnessed for cancer immunotherapy. In this review, we draw upon recent findings in cells of the immune system to illustrate established as well as emerging ideas of how TET proteins influence cellular function. Expected final online publication date for the
Language	English
Publishing date	2024-02-15
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	604953-9
ISSN	1545-3278 ; 0732-0582
ISSN (online)	1545-3278
ISSN	0732-0582
DOI	10.1146/annurev-immunol-080223-044610
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Se 849: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Active DNA demethylation damages DNA.

López-Moyado, Isaac F / Rao, Anjana

Science (New York, N.Y.)

2022 Volume 378, Issue 6623, Page(s) 948–949

Abstract: Active DNA demethylation maintains enhancer activity in nonproliferating cells but can damage DNA. ...

Abstract	Active DNA demethylation maintains enhancer activity in nonproliferating cells but can damage DNA.
MeSH term(s)	DNA Demethylation ; Macrophages/metabolism ; Neurons/metabolism ; Enhancer Elements, Genetic ; Humans ; DNA Breaks, Single-Stranded
Language	English
Publishing date	2022-12-01
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Comment
ZDB-ID	128410-1
ISSN	1095-9203 ; 0036-8075
ISSN (online)	1095-9203
ISSN	0036-8075
DOI	10.1126/science.adf3171
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 27: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 77: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: DNMT3A and TET2 mutations reshape hematopoiesis in opposing ways.

López-Moyado, Isaac F / Rao, Anjana

Nature genetics

2020 Volume 52, Issue 6, Page(s) 554–556

MeSH term(s)	Cell Differentiation ; DNA Methylation ; Hematopoiesis ; Hematopoietic Stem Cell Transplantation ; Mutation
Language	English
Publishing date	2020-06-05
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	1108734-1
ISSN	1546-1718 ; 1061-4036
ISSN (online)	1546-1718
ISSN	1061-4036
DOI	10.1038/s41588-020-0641-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3613: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 46: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Inducible disruption of

Yuita, Hiroshi / López-Moyado, Isaac F / Jeong, Hyeongmin / Cheng, Arthur Xiuyuan / Scott-Browne, James / An, Jungeun / Nakayama, Toshinori / Onodera, Atsushi / Ko, Myunggon / Rao, Anjana

Proceedings of the National Academy of Sciences of the United States of America

2023 Volume 120, Issue 6, Page(s) e2214824120

Abstract: The three mammalian TET dioxygenases oxidize the methyl group of 5-methylcytosine in DNA, and the oxidized methylcytosines are essential intermediates in all known pathways of DNA demethylation. To define the in vivo consequences of complete TET ... ...

Abstract	The three mammalian TET dioxygenases oxidize the methyl group of 5-methylcytosine in DNA, and the oxidized methylcytosines are essential intermediates in all known pathways of DNA demethylation. To define the in vivo consequences of complete TET deficiency, we inducibly deleted all three
MeSH term(s)	Animals ; Mice ; Heterochromatin/genetics ; Euchromatin ; DNA Methylation ; 5-Methylcytosine/metabolism ; Leukemia, Myeloid, Acute/genetics ; Dioxygenases/genetics ; Dioxygenases/metabolism ; Mammals/genetics
Chemical Substances	Heterochromatin ; Euchromatin ; 5-Methylcytosine (6R795CQT4H) ; Dioxygenases (EC 1.13.11.-)
Language	English
Publishing date	2023-02-01
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2214824120
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1148: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: TET methylcytosine oxidases: new insights from a decade of research

Lio, Chan-Wang J / Yue, Xiaojing / López-Moyado, Isaac F / Tahiliani, Mamta / Aravind, L / Rao, Anjana

Journal of biosciences. 2020 Dec., v. 45, no. 1

2020

Abstract: In mammals, DNA methyltransferases transfer a methyl group from S-adenosylmethionine to the 5 position of cytosine in DNA. The product of this reaction, 5-methylcytosine (5mC), has many roles, particularly in suppressing transposable and repeat elements ... ...

Abstract	In mammals, DNA methyltransferases transfer a methyl group from S-adenosylmethionine to the 5 position of cytosine in DNA. The product of this reaction, 5-methylcytosine (5mC), has many roles, particularly in suppressing transposable and repeat elements in DNA. Moreover, in many cellular systems, cell lineage specification is accompanied by DNA demethylation at the promoters of genes expressed at high levels in the differentiated cells. However, since direct cleavage of the C-C bond connecting the methyl group to the 5 position of cytosine is thermodynamically disfavoured, the question of whether DNA methylation was reversible remained unclear for many decades. This puzzle was solved by our discovery of the TET (Ten-Eleven Translocation) family of 5-methylcytosine oxidases, which use reduced iron, molecular oxygen and the tricarboxylic acid cycle metabolite 2-oxoglutarate (also known as α-ketoglutarate) to oxidise the methyl group of 5mC to 5-hydroxymethylcytosine (5hmC) and beyond. TET-generated oxidised methylcytosines are intermediates in at least two pathways of DNA demethylation, which differ in their dependence on DNA replication. In the decade since their discovery, TET enzymes have been shown to have important roles in embryonic development, cell lineage specification, neuronal function and cancer. We review these findings and discuss their implications here.
Keywords	DNA ; DNA demethylation ; DNA methylation ; DNA replication ; S-adenosylmethionine ; cells ; cytosine ; embryogenesis ; genes ; iron ; mammals ; metabolites ; methyltransferases ; neurons ; oxygen ; research ; thermodynamics ; tricarboxylic acid cycle
Language	English
Dates of publication	2020-12
Size	p. 21.
Publishing place	Springer India
Document type	Article
Note	NAL-light
ZDB-ID	756157-x
ISSN	0973-7138 ; 0250-5991
ISSN (online)	0973-7138
ISSN	0250-5991
DOI	10.1007/s12038-019-9973-4
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Bonn / Germany

Z 5290: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Acute deletion of TET enzymes results in aneuploidy in mouse embryonic stem cells through decreased expression of Khdc3.

Georges, Romain O / Sepulveda, Hugo / Angel, J Carlos / Johnson, Eric / Palomino, Susan / Nowak, Roberta B / Desai, Arshad / López-Moyado, Isaac F / Rao, Anjana

Nature communications

2022 Volume 13, Issue 1, Page(s) 6230

Abstract: TET (Ten-Eleven Translocation) dioxygenases effect DNA demethylation through successive oxidation of the methyl group of 5-methylcytosine (5mC) in DNA. In humans and in mouse models, TET loss-of-function has been linked to DNA damage, genome instability ... ...

Abstract	TET (Ten-Eleven Translocation) dioxygenases effect DNA demethylation through successive oxidation of the methyl group of 5-methylcytosine (5mC) in DNA. In humans and in mouse models, TET loss-of-function has been linked to DNA damage, genome instability and oncogenesis. Here we show that acute deletion of all three Tet genes, after brief exposure of triple-floxed, Cre-ERT2-expressing mouse embryonic stem cells (mESC) to 4-hydroxytamoxifen, results in chromosome mis-segregation and aneuploidy; moreover, embryos lacking all three TET proteins showed striking variation in blastomere numbers and nuclear morphology at the 8-cell stage. Transcriptional profiling revealed that mRNA encoding a KH-domain protein, Khdc3 (Filia), was downregulated in triple TET-deficient mESC, concomitantly with increased methylation of CpG dinucleotides in the vicinity of the Khdc3 gene. Restoring KHDC3 levels in triple Tet-deficient mESC prevented aneuploidy. Thus, TET proteins regulate Khdc3 gene expression, and TET deficiency results in mitotic infidelity and genome instability in mESC at least partly through decreased expression of KHDC3.
MeSH term(s)	Animals ; Mice ; 5-Methylcytosine/metabolism ; Aneuploidy ; Dioxygenases/genetics ; Dioxygenases/metabolism ; DNA/metabolism ; DNA Methylation ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Genomic Instability ; Mouse Embryonic Stem Cells/metabolism ; Proteins/metabolism ; Proto-Oncogene Proteins/genetics ; Proto-Oncogene Proteins/metabolism ; RNA, Messenger/metabolism
Chemical Substances	5-Methylcytosine (6R795CQT4H) ; Dioxygenases (EC 1.13.11.-) ; DNA (9007-49-2) ; DNA-Binding Proteins ; filia protein, mouse ; Proteins ; Proto-Oncogene Proteins ; RNA, Messenger
Language	English
Publishing date	2022-10-20
Publishing country	England
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-022-33742-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: TET methylcytosine oxidases: new insights from a decade of research.

Lio, Chan-Wang J / Yue, Xiaojing / Lopez-Moyado, Isaac F / Tahiliani, Mamta / Aravind, L / Rao, Anjana

Journal of biosciences

2020 Volume 45

Abstract	In mammals, DNA methyltransferases transfer a methyl group from S-adenosylmethionine to the 5 position of cytosine in DNA. The product of this reaction, 5-methylcytosine (5mC), has many roles, particularly in suppressing transposable and repeat elements in DNA. Moreover, in many cellular systems, cell lineage specification is accompanied by DNA demethylation at the promoters of genes expressed at high levels in the differentiated cells. However, since direct cleavage of the C-C bond connecting the methyl group to the 5 position of cytosine is thermodynamically disfavoured, the question of whether DNA methylation was reversible remained unclear for many decades. This puzzle was solved by our discovery of the TET (Ten- Eleven Translocation) family of 5-methylcytosine oxidases, which use reduced iron, molecular oxygen and the tricarboxylic acid cycle metabolite 2-oxoglutarate (also known as a-ketoglutarate) to oxidise the methyl group of 5mC to 5-hydroxymethylcytosine (5hmC) and beyond. TET-generated oxidised methylcytosines are intermediates in at least two pathways of DNA demethylation, which differ in their dependence on DNA replication. In the decade since their discovery, TET enzymes have been shown to have important roles in embryonic development, cell lineage specification, neuronal function and cancer. We review these findings and discuss their implications here.
MeSH term(s)	5-Methylcytosine/metabolism ; Animals ; Cell Differentiation/genetics ; Cell Lineage/genetics ; Cytosine/metabolism ; DNA (Cytosine-5-)-Methyltransferase 1/genetics ; DNA Methylation/genetics ; DNA Replication/genetics ; DNA-Binding Proteins/genetics ; Dioxygenases/genetics ; Embryonic Development/genetics ; Humans ; Oxidation-Reduction ; S-Adenosylmethionine/metabolism
Chemical Substances	DNA-Binding Proteins ; 5-Methylcytosine (6R795CQT4H) ; S-Adenosylmethionine (7LP2MPO46S) ; Cytosine (8J337D1HZY) ; TET3 protein, human (EC 1.-) ; Dioxygenases (EC 1.13.11.-) ; DNA (Cytosine-5-)-Methyltransferase 1 (EC 2.1.1.37) ; Dnmt1 protein, mouse (EC 2.1.1.37)
Language	English
Publishing date	2020-01-22
Publishing country	India
Document type	Journal Article ; Review
ZDB-ID	756157-x
ISSN	0973-7138 ; 0250-5991
ISSN (online)	0973-7138
ISSN	0250-5991
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1907: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Paradoxical association of TET loss of function with genome-wide DNA hypomethylation.

López-Moyado, Isaac F / Tsagaratou, Ageliki / Yuita, Hiroshi / Seo, Hyungseok / Delatte, Benjamin / Heinz, Sven / Benner, Christopher / Rao, Anjana

Proceedings of the National Academy of Sciences of the United States of America

2019 Volume 116, Issue 34, Page(s) 16933–16942

Abstract: Cancer genomes are characterized by focal increases in DNA methylation, co-occurring with widespread hypomethylation. Here, we show that TET loss of function results in a similar genomic footprint. Both 5hmC in wild-type (WT) genomes and DNA ... ...

Abstract	Cancer genomes are characterized by focal increases in DNA methylation, co-occurring with widespread hypomethylation. Here, we show that TET loss of function results in a similar genomic footprint. Both 5hmC in wild-type (WT) genomes and DNA hypermethylation in
MeSH term(s)	Animals ; DNA (Cytosine-5-)-Methyltransferases/deficiency ; DNA (Cytosine-5-)-Methyltransferases/metabolism ; DNA Methylation ; DNA, Neoplasm/genetics ; DNA, Neoplasm/metabolism ; DNA-Binding Proteins/deficiency ; DNA-Binding Proteins/metabolism ; Genome-Wide Association Study ; Hematopoietic Stem Cells/metabolism ; Hematopoietic Stem Cells/pathology ; Heterochromatin/genetics ; Heterochromatin/metabolism ; Heterochromatin/pathology ; Humans ; Lymphoma, T-Cell/genetics ; Lymphoma, T-Cell/metabolism ; Lymphoma, T-Cell/pathology ; Mice ; Mice, Knockout ; Neoplasms, Experimental/genetics ; Neoplasms, Experimental/metabolism ; Neoplasms, Experimental/pathology ; Neoplastic Stem Cells/metabolism ; Neoplastic Stem Cells/pathology ; Proto-Oncogene Proteins/deficiency ; Proto-Oncogene Proteins/metabolism
Chemical Substances	DNA, Neoplasm ; DNA-Binding Proteins ; Heterochromatin ; Proto-Oncogene Proteins ; TET1 protein, mouse ; Tet2 protein, mouse (EC 1.13.11.-) ; DNA (Cytosine-5-)-Methyltransferases (EC 2.1.1.37) ; DNA methyltransferase 3A (EC 2.1.1.37)
Language	English
Publishing date	2019-08-01
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.1903059116
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1148: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: NR4A transcription factors limit CAR T cell function in solid tumours.

Chen, Joyce / López-Moyado, Isaac F / Seo, Hyungseok / Lio, Chan-Wang J / Hempleman, Laura J / Sekiya, Takashi / Yoshimura, Akihiko / Scott-Browne, James P / Rao, Anjana

Nature

2019 Volume 567, Issue 7749, Page(s) 530–534

Abstract: T cells expressing chimeric antigen receptors (CAR T cells) targeting human CD19 (hCD19) have shown clinical efficacy against B cell ... ...

Abstract	T cells expressing chimeric antigen receptors (CAR T cells) targeting human CD19 (hCD19) have shown clinical efficacy against B cell malignancies
MeSH term(s)	Adoptive Transfer ; Animals ; Antigens, CD19/immunology ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/metabolism ; CD8-Positive T-Lymphocytes/pathology ; Cell Line, Tumor ; Chromatin/genetics ; Chromatin/metabolism ; DNA-Binding Proteins/deficiency ; DNA-Binding Proteins/metabolism ; Female ; Gene Expression Profiling ; Humans ; Lymphocytes, Tumor-Infiltrating/immunology ; Lymphocytes, Tumor-Infiltrating/metabolism ; Lymphocytes, Tumor-Infiltrating/pathology ; Male ; Melanoma, Experimental/genetics ; Melanoma, Experimental/immunology ; Melanoma, Experimental/pathology ; Mice ; Mice, Inbred C57BL ; NF-kappa B/metabolism ; Neoplasms/genetics ; Neoplasms/immunology ; Neoplasms/pathology ; Nuclear Receptor Subfamily 4, Group A, Member 1/deficiency ; Nuclear Receptor Subfamily 4, Group A, Member 1/metabolism ; Nuclear Receptor Subfamily 4, Group A, Member 2/deficiency ; Nuclear Receptor Subfamily 4, Group A, Member 2/metabolism ; Receptors, Chimeric Antigen/immunology ; Receptors, Steroid/deficiency ; Receptors, Steroid/metabolism ; Receptors, Thyroid Hormone/deficiency ; Receptors, Thyroid Hormone/metabolism ; Survival Rate ; Transcription Factor AP-1/metabolism ; Transcription Factors/deficiency ; Transcription Factors/metabolism
Chemical Substances	Antigens, CD19 ; CD19 molecule, human ; Chromatin ; DNA-Binding Proteins ; NF-kappa B ; NR4A1 protein, human ; NR4A2 protein, human ; NR4A3 protein, human ; Nuclear Receptor Subfamily 4, Group A, Member 1 ; Nuclear Receptor Subfamily 4, Group A, Member 2 ; Receptors, Chimeric Antigen ; Receptors, Steroid ; Receptors, Thyroid Hormone ; Transcription Factor AP-1 ; Transcription Factors
Language	English
Publishing date	2019-02-27
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-019-0985-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 26: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 9: Show issues
Zs.MO 244: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Dynamic Changes in Chromatin Accessibility Occur in CD8

Scott-Browne, James P / López-Moyado, Isaac F / Trifari, Sara / Wong, Victor / Chavez, Lukas / Rao, Anjana / Pereira, Renata M

Immunity

2016 Volume 45, Issue 6, Page(s) 1327–1340

Abstract: In response to acute infection, naive ... ...

Abstract	In response to acute infection, naive CD8
MeSH term(s)	Animals ; Arenaviridae Infections/immunology ; CD8-Positive T-Lymphocytes/immunology ; Chromatin ; Chromatin Assembly and Disassembly/immunology ; Disease Models, Animal ; Gene Expression/immunology ; Gene Expression Profiling ; Immunologic Memory/immunology ; Lymphocyte Activation/immunology ; Lymphocytic choriomeningitis virus ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic
Chemical Substances	Chromatin
Language	English
Publishing date	2016--20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	1217235-2
ISSN	1097-4180 ; 1074-7613
ISSN (online)	1097-4180
ISSN	1074-7613
DOI	10.1016/j.immuni.2016.10.028
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4227: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 69: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito