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  1. Article ; Online: Mutations in coral soma and sperm imply lifelong stem cell renewal and cell lineage selection.

    López-Nandam, Elora H / Albright, Rebecca / Hanson, Erik A / Sheets, Elizabeth A / Palumbi, Stephen R

    Proceedings. Biological sciences

    2023  Volume 290, Issue 1991, Page(s) 20221766

    Abstract: In many animals, the germline differentiates early in embryogenesis, so only mutations that accumulate in germ cells are inherited by offspring. Exceptions to this developmental process may indicate other mechanisms have evolved to limit the effects of ... ...

    Abstract In many animals, the germline differentiates early in embryogenesis, so only mutations that accumulate in germ cells are inherited by offspring. Exceptions to this developmental process may indicate other mechanisms have evolved to limit the effects of deleterious mutation accumulation. Stony corals are animals that can live for hundreds of years and have been thought to produce gametes from somatic tissue. To clarify conflicting evidence about germline-soma distinction in corals, we sequenced high coverage, full genomes with technical replicates for parent coral branches and their sperm pools. We identified post-embryonic single nucleotide variants (SNVs) unique to each parent branch, then checked if each SNV was shared by the respective sperm pool. Twenty-six per cent of post-embryonic SNVs were shared by the sperm and 74% were not. We also identified germline SNVs, those that were present in the sperm but not in the parent. These data suggest that self-renewing stem cells differentiate into germ and soma throughout the adult life of the colony, with SNV rates and patterns differing markedly in stem, soma and germ lineages. In addition to informing the evolution of germlines in metazoans, these insights inform how corals may generate adaptive diversity necessary in the face of global climate change.
    MeSH term(s) Animals ; Male ; Cell Lineage ; Anthozoa/genetics ; Cell Self Renewal ; Semen ; Spermatozoa ; Mutation ; Germ Cells
    Language English
    Publishing date 2023-01-18
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 209242-6
    ISSN 1471-2954 ; 0080-4649 ; 0962-8452 ; 0950-1193
    ISSN (online) 1471-2954
    ISSN 0080-4649 ; 0962-8452 ; 0950-1193
    DOI 10.1098/rspb.2022.1766
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1364: Show issues Location:
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  2. Article ; Online: Correction: Blair et al. Molecular Phylogenetic Relationships and Unveiling Novel Genetic Diversity among Slow and Pygmy Lorises, including Resurrection of

    Blair, Mary E / Cao, Giang T H / López-Nandam, Elora H / Veronese-Paniagua, Daniel A / Birchette, Mark G / Kenyon, Marina / Md-Zain, Badrul M / Munds, Rachel A / Nekaris, K Anne-Isola / Nijman, Vincent / Roos, Christian / Thach, Hoàng M / Sterling, Eleanor J / Le, Minh D

    Genes

    2024  Volume 15, Issue 4

    Abstract: In the original publication [ ... ]. ...

    Abstract In the original publication [...].
    Language English
    Publishing date 2024-04-03
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2527218-4
    ISSN 2073-4425 ; 2073-4425
    ISSN (online) 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes15040451
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: MILBEMYCIN OXIME (INTERCEPTOR) TREATMENT OF PYCNOGONID SEA SPIDER INFESTATION IN THREE SPECIES OF CORALS.

    Krol, Lana / Dunker, Freeland H / LaDouceur, Elise / Biswell, Ethan / Dilly, Geoffrey F / Delbeek, J Charles / Albright, Rebecca / López-Nandam, Elora H / Reinbold, Nicholas / Igel, Anthony / Larkin, Lisa / Hill, Jessica

    Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians

    2023  Volume 54, Issue 2, Page(s) 292–300

    Abstract: A coral reef system at the Steinhart Aquarium in San Francisco, CA, USA experienced a population explosion of pycnogonid sea spiders (Arthropoda: Class Pycnogonida) with subsequent deleterious health effects on the corals in the system. Sixteen coral ... ...

    Abstract A coral reef system at the Steinhart Aquarium in San Francisco, CA, USA experienced a population explosion of pycnogonid sea spiders (Arthropoda: Class Pycnogonida) with subsequent deleterious health effects on the corals in the system. Sixteen coral colonies across three species (
    MeSH term(s) Animals ; Anthozoa ; Macrolides/therapeutic use
    Chemical Substances moxidectin (NGU5H31YO9) ; milbemycin oxime (0502PUN0GT) ; Macrolides
    Language English
    Publishing date 2023-07-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2174930-9
    ISSN 1937-2825 ; 1042-7260
    ISSN (online) 1937-2825
    ISSN 1042-7260
    DOI 10.1638/2022-0028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Molecular Phylogenetic Relationships and Unveiling Novel Genetic Diversity among Slow and Pygmy Lorises, including Resurrection of

    Blair, Mary E / Cao, Giang T H / López-Nandam, Elora H / Veronese-Paniagua, Daniel A / Birchette, Mark G / Kenyon, Marina / Md-Zain, Badrul M / Munds, Rachel A / Nekaris, K Anne-Isola / Nijman, Vincent / Roos, Christian / Thach, Hoàng M / Sterling, Eleanor J / Le, Minh D

    Genes

    2023  Volume 14, Issue 3

    Abstract: Genetic analysis of historical museum collections presents an opportunity to clarify the evolutionary history of understudied primate groups, improve taxonomic inferences, and inform conservation efforts. Among the most understudied primate groups, slow ... ...

    Abstract Genetic analysis of historical museum collections presents an opportunity to clarify the evolutionary history of understudied primate groups, improve taxonomic inferences, and inform conservation efforts. Among the most understudied primate groups, slow and pygmy lorises (genera
    MeSH term(s) Animals ; Phylogeny ; Lorisidae/anatomy & histology ; Lorisidae/genetics ; Bayes Theorem ; Asia, Southeastern ; Genetic Variation/genetics
    Language English
    Publishing date 2023-03-03
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2527218-4
    ISSN 2073-4425 ; 2073-4425
    ISSN (online) 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes14030643
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Molecular Phylogenetic Relationships and Unveiling Novel Genetic Diversity among Slow and Pygmy Lorises, including Resurrection of Xanthonycticebus intermedius

    Blair, Mary E. / Cao, Giang T. H. / López-Nandam, Elora H. / Veronese-Paniagua, Daniel A. / Birchette, Mark G. / Kenyon, Marina / Md-Zain, Badrul M. / Munds, Rachel A. / Nekaris, K. Anne-Isola / Nijman, Vincent / Roos, Christian / Thach, Hoàng M. / Sterling, Eleanor J. / Le, Minh D.

    Genes (Basel). 2023 Mar. 03, v. 14, no. 3

    2023  

    Abstract: Genetic analysis of historical museum collections presents an opportunity to clarify the evolutionary history of understudied primate groups, improve taxonomic inferences, and inform conservation efforts. Among the most understudied primate groups, slow ... ...

    Abstract Genetic analysis of historical museum collections presents an opportunity to clarify the evolutionary history of understudied primate groups, improve taxonomic inferences, and inform conservation efforts. Among the most understudied primate groups, slow and pygmy lorises (genera Nycticebus and Xanthonycticebus) are nocturnal strepsirrhines found in South and Southeast Asia. Previous molecular studies have supported five species, but studies using morphological data suggest the existence of at least nine species. We sequenced four mitochondrial loci, CO1, cytb, d-loop, and ND4, for a total of 3324 aligned characters per sample from 41 historical museum specimens for the most comprehensive geographic coverage to date for these genera. We then combined these sequences with a larger dataset composed of samples collected in Vietnam as well as previously published sequences (total sample size N = 62). We inferred phylogenetic relationships using Bayesian inference and maximum likelihood methods based on data from each locus and on concatenated sequences. We also inferred divergence dates for the most recent common ancestors of major lineages using a BEAST analysis. Consistent with previous studies, we found support for Xanthonycticebus pygmaeus as a basal taxon to the others in the group. We also confirmed the separation between lineages of X. pygmaeus from northern Vietnam/Laos/China and southern Vietnam/Cambodia and included a taxonomic revision recognizing a second taxon of pygmy loris, X. intermedius. Our results found support for multiple reciprocally monophyletic taxa within Borneo and possibly Java. The study will help inform conservation management of these trade-targeted animals as part of a genetic reference database for determining the taxonomic unit and provenance of slow and pygmy lorises confiscated from illegal wildlife trade activities.
    Keywords Bayesian theory ; Borneo ; Nycticebus ; data collection ; databases ; genetic analysis ; genetic variation ; loci ; mitochondria ; monophyly ; museums ; provenance ; sample size ; taxonomic revisions ; trade ; wildlife ; Cambodia ; China ; Laos ; Vietnam
    Language English
    Dates of publication 2023-0303
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2527218-4
    ISSN 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes14030643
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: The Mutationathon highlights the importance of reaching standardization in estimates of pedigree-based germline mutation rates.

    Bergeron, Lucie A / Besenbacher, Søren / Turner, Tychele / Versoza, Cyril J / Wang, Richard J / Price, Alivia Lee / Armstrong, Ellie / Riera, Meritxell / Carlson, Jedidiah / Chen, Hwei-Yen / Hahn, Matthew W / Harris, Kelley / Kleppe, April Snøfrid / López-Nandam, Elora H / Moorjani, Priya / Pfeifer, Susanne P / Tiley, George P / Yoder, Anne D / Zhang, Guojie /
    Schierup, Mikkel H

    eLife

    2022  Volume 11

    Abstract: In the past decade, several studies have estimated the human per-generation germline mutation rate using large pedigrees. More recently, estimates for various nonhuman species have been published. However, methodological differences among studies in ... ...

    Abstract In the past decade, several studies have estimated the human per-generation germline mutation rate using large pedigrees. More recently, estimates for various nonhuman species have been published. However, methodological differences among studies in detecting germline mutations and estimating mutation rates make direct comparisons difficult. Here, we describe the many different steps involved in estimating pedigree-based mutation rates, including sampling, sequencing, mapping, variant calling, filtering, and appropriately accounting for false-positive and false-negative rates. For each step, we review the different methods and parameter choices that have been used in the recent literature. Additionally, we present the results from a 'Mutationathon,' a competition organized among five research labs to compare germline mutation rate estimates for a single pedigree of rhesus macaques. We report almost a twofold variation in the final estimated rate among groups using different post-alignment processing, calling, and filtering criteria, and provide details into the sources of variation across studies. Though the difference among estimates is not statistically significant, this discrepancy emphasizes the need for standardized methods in mutation rate estimations and the difficulty in comparing rates from different studies. Finally, this work aims to provide guidelines for computational and statistical benchmarks for future studies interested in identifying germline mutations from pedigrees.
    MeSH term(s) Animals ; Genetic Techniques/instrumentation ; Germ Cells ; Germ-Line Mutation ; Laboratories ; Macaca mulatta/genetics ; Mutation Rate ; Pedigree ; Reference Standards
    Language English
    Publishing date 2022-01-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.73577
    Database MEDical Literature Analysis and Retrieval System OnLINE

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