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  1. Article ; Online: Two-Year Follow-up of a Multimodal Intervention on Functional Capacity and Muscle Power in Frail Patients With Type 2 Diabetes.

    Izquierdo, Mikel / Laosa, Olga / Cadore, Eduardo L / Abizanda, Pedro / Garcia-Garcia, Francisco J / Hornillos, Mercedes / López-Pavón, Ignacio / Sinclair, Alan J / Rodríguez-Mañas, Leocadio

    Journal of the American Medical Directors Association

    2021  Volume 22, Issue 9, Page(s) 1906–1911

    Abstract: Objectives: To analyze the effects of a program composed of resistance training and nutritional interventions on functional capacity, maximal strength, and power output after 2 years of follow-up, including 2 periods of 16 weeks of intervention followed ...

    Abstract Objectives: To analyze the effects of a program composed of resistance training and nutritional interventions on functional capacity, maximal strength, and power output after 2 years of follow-up, including 2 periods of 16 weeks of intervention followed by several weeks of intervention cessation in frail patients with type 2 diabetes.
    Design: MIDPOW is a substudy of a multicenter, multimodal intervention composed of resistance training combined with a structured diabetes and nutritional education program in frail and prefrail older people with type 2 diabetes (MID-Frail).
    Setting and participants: This study recruited 52 participants (mean age: 79 ± 5.6, 63% women), with type 2 diabetes mellitus, frail or prefrail using Fried's frailty phenotype.
    Methods: Primary outcomes of this substudy were Short Physical Performance Battery (SPPB) and maximal power output at 30% and 80% of 1RM.
    Results: Each set of 16 weeks of intervention resulted in significant improvements in SPPB performance by a mean of 36.1% at week 18 (P < .001) and 10.2% at week 68 (P < .05). Maximal power output improvements at 30% and 80% of the 1RM ranged from 45.2% to 57.2% at week 18 (P < .01-.001); and no significant changes were observed after the second period of intervention. After 2 years of follow-up, the SPPB and maximal power values observed remained significantly higher than the baseline.
    Conclusions and implications: Resistance training combined with nutritional program improved SPPB, maximal strength, and power output in older frail patients with diabetes. These improvements were maintained above the basal levels after several weeks of intervention cessation during a 2-year follow-up.
    MeSH term(s) Aged ; Aged, 80 and over ; Diabetes Mellitus, Type 2/therapy ; Female ; Follow-Up Studies ; Frail Elderly ; Frailty ; Humans ; Male ; Muscle Strength ; Muscles
    Language English
    Publishing date 2021-07-12
    Publishing country United States
    Document type Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 2171030-2
    ISSN 1538-9375 ; 1525-8610
    ISSN (online) 1538-9375
    ISSN 1525-8610
    DOI 10.1016/j.jamda.2021.06.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5971: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Risk factors for intestinal parasitosis, anaemia, and malnutrition among school children in Ethiopia.

    Mahmud, Mahmud Abdulkader / Spigt, Mark / Mulugeta Bezabih, Afework / López Pavon, Ignacio / Dinant, Geert-Jan / Blanco Velasco, Roman

    Pathogens and global health

    2013  Volume 107, Issue 2, Page(s) 58–65

    Abstract: Research on associated risk factors for intestinal parasitic infections and malnutrition in various geographic regions is needed for the development of appropriate control strategies. The aim of this study was to determine the risk factors associated ... ...

    Abstract Research on associated risk factors for intestinal parasitic infections and malnutrition in various geographic regions is needed for the development of appropriate control strategies. The aim of this study was to determine the risk factors associated with intestinal parasitic infections, anaemia, and malnutrition in school children, living in urban and rural areas of northern Ethiopia. Six hundred school children, aged 6-15 years, were randomly selected in a cross-sectional survey from 12 primary schools. Sociodemographic and anthropometric data were collected. Faecal samples were examined using direct, concentration, and the Kato-Katz methods. Urine specimens were analysed for Schistosoma haematobium ova. Haemoglobin was measured using a HemoCue spectrometer. The overall prevalence of intestinal parasitosis was 72% (95% confidence interval (CI): 66-76%). The prevalence of anaemia, stunting, and thinness were 11% (95% CI: 8-13%), 35% (95% CI: 31-38%), and 34% (95% CI: 30-38%), respectively. Poor personal hygiene habits were generally associated with anaemia and nutritional deficiency (low body mass index). Multivariate logistic regression models related Schistosoma mansoni infection with boys. Boys were also more likely to be malnourished. Hookworm infection was associated with anaemia and unhygienic finger nails. Access to clean water and latrines, with some hygiene and sanitation communication activities, could improve health of children in Ethiopia. The use of smartphone technology in demographic data collection proved to be successful. The potential advantage offered by this technology for parasitological field surveys merits further investigation.
    MeSH term(s) Adolescent ; Anemia/epidemiology ; Animals ; Ascariasis/drug therapy ; Ascariasis/epidemiology ; Ascariasis/prevention & control ; Ascaris lumbricoides/isolation & purification ; Child ; Child Nutrition Disorders/epidemiology ; Child Nutritional Physiological Phenomena ; Child Welfare ; Cross-Sectional Studies ; Ethiopia/epidemiology ; Feces/parasitology ; Female ; Humans ; Male ; Parasite Egg Count ; Prevalence ; Risk Factors ; Schistosomiasis mansoni/drug therapy ; Schistosomiasis mansoni/epidemiology ; Schistosomiasis mansoni/prevention & control ; Schools/statistics & numerical data ; Sex Distribution ; Socioeconomic Factors
    Language English
    Publishing date 2013-05-19
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2625162-0
    ISSN 2047-7732 ; 2047-7724
    ISSN (online) 2047-7732
    ISSN 2047-7724
    DOI 10.1179/2047773213Y.0000000074
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.196: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Evaluation of the relationship between effervescent paracetamol and blood pressure: clinical trial.

    Benitez-Camps, Mencia / Vinyoles-Bargalló, Ernest / Rebagliato-Nadal, Oriol / Morros-Pedrós, Rosa / Pera-Pujadas, Helena / Dalfó-Baqué, Antoni / López-Pavón, Ignacio / Roca-Sánchez, Carlos / Coma-Carbó, Rosa Maria / De La Figuera Von Wichmann, Mariano / Mengual-Martínez, Lucas / Yuste-Marco, Carmen / Teixidó-Colet, Montserrat / Pepió i Vilaubí, Josep M / Ciurana-Tost, Riera / Pou-Vila, Rosa / Vila-Coll, Ma Antònia / Bordas-Julve, Josep Maria / Aragonès-Forès, Rosa /
    Pelegrina-Rodríguez, Francisco Javier / Agudo-Ugena, Josep / Blanco-Mata, Carlos / de la Iglesia Berrojalbiz, Jon / Burgos-Alonso, Natalia / Gómez-Fernández, Maria Cruz

    BMC cardiovascular disorders

    2015  Volume 15, Page(s) 167

    Abstract: Background: Paracetamol's solubility is achieved by adding to the excipient sodium salts, either as bicarbonate, carbonate or citrate. As the relationship between salt and hypertension is well known, due to the sodium content it has raised a hypothesis ... ...

    Abstract Background: Paracetamol's solubility is achieved by adding to the excipient sodium salts, either as bicarbonate, carbonate or citrate. As the relationship between salt and hypertension is well known, due to the sodium content it has raised a hypothesis that may interfere with the control of that risk factor. Therefore, the objective of this study is to evaluate the effect on blood pressure of effervescent paracetamol compared to non-effervescent, in hypertensive patients.
    Methods/design: This is the protocol of a phase IV multicenter clinical trial, randomized, controlled, crossover, open, which will compare the effect of two different formulations of paracetamol (effervescent or non-effervescent) in the blood pressure of hypertensive patients, with a seven weeks follow up. 49 controlled hypertensive patients will be included (clinical BP lower than 150 and 95 mmHg, and lower than 135 mmHg and 85 mmHg in patients with diabetes or a history of cardiovascular event, and daytime ambulatory measurements lower than 140 and 90 mmHg) and mild to moderate pain (Visual Analog Scale between 1 and 4). The study was approved by the ethics committee of the Fundació Jordi Gol i Gurina and following standards of good clinical practice. The primary endpoint will be the variations in systolic BP in 24 h Ambulatory Blood Pressure Monitoring, considering significant differences 2 or more mmHg among those treated with non-effervescent and effervescent formulations. Intention-to-treat and per-protocol analysis will be held.
    Discussion: Despite the broad recommendation not to use effervescent drugs in patients with hypertension, there are relatively little studies that show exactly this pressor effect due to sodium in salt that gives the effervescence of the product. This is the first clinical trial designed to study the effect of effervescence compared to the non-effervescent, in well-controlled hypertensive patients with mild to moderate pain, performed in routine clinical practice.
    Trial registration: NCT 02514538.
    MeSH term(s) Acetaminophen/adverse effects ; Acetaminophen/chemistry ; Acetaminophen/therapeutic use ; Analgesics, Non-Narcotic/adverse effects ; Analgesics, Non-Narcotic/chemistry ; Analgesics, Non-Narcotic/therapeutic use ; Antihypertensive Agents/therapeutic use ; Blood Pressure/drug effects ; Blood Pressure Monitoring, Ambulatory ; Carbon Dioxide/chemistry ; Chemistry, Pharmaceutical ; Clinical Protocols ; Cross-Over Studies ; Humans ; Hypertension/diagnosis ; Hypertension/drug therapy ; Hypertension/physiopathology ; Intention to Treat Analysis ; Polypharmacy ; Research Design ; Risk Assessment ; Risk Factors ; Solubility ; Spain ; Time Factors ; Treatment Outcome
    Chemical Substances Analgesics, Non-Narcotic ; Antihypertensive Agents ; Carbon Dioxide (142M471B3J) ; Acetaminophen (362O9ITL9D)
    Language English
    Publishing date 2015-12-10
    Publishing country England
    Document type Clinical Trial, Phase IV ; Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2059859-2
    ISSN 1471-2261 ; 1471-2261
    ISSN (online) 1471-2261
    ISSN 1471-2261
    DOI 10.1186/s12872-015-0161-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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