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  1. Article ; Online: Identification and relative abundance of naturally presented and cross-reactive influenza A virus MHC class I-restricted T cell epitopes.

    Hamza, Hazem / Ghosh, Michael / Löffler, Markus W / Rammensee, Hans-Georg / Planz, Oliver

    Emerging microbes & infections

    2024  Volume 13, Issue 1, Page(s) 2306959

    Abstract: Cytotoxic T lymphocytes are key for controlling viral infection. Unravelling ... ...

    Abstract Cytotoxic T lymphocytes are key for controlling viral infection. Unravelling CD8
    MeSH term(s) Humans ; Epitopes, T-Lymphocyte/genetics ; Influenza A virus/genetics ; CD8-Positive T-Lymphocytes ; T-Lymphocytes, Cytotoxic ; Immunity, Cellular
    Chemical Substances Epitopes, T-Lymphocyte
    Language English
    Publishing date 2024-02-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2681359-2
    ISSN 2222-1751 ; 2222-1751
    ISSN (online) 2222-1751
    ISSN 2222-1751
    DOI 10.1080/22221751.2024.2306959
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  2. Article ; Online: Long-term recurrence-free survival following pancreatic surgery with HIPEC treatment for locally advanced pancreatic adenocarcinoma.

    Zimmermann, Valerie / Frauenfeld, Leonie / Löffler, Markus W / Mihaljevic, André L / Yurttas, Can

    BMJ case reports

    2024  Volume 17, Issue 2

    Abstract: More than 5 years previous to this report, a female patient in her 60s underwent oncological left-sided pancreatic resection and adrenalectomy including splenectomy for locally advanced pancreatic adenocarcinoma (PDAC), recommended by a multidisciplinary ...

    Abstract More than 5 years previous to this report, a female patient in her 60s underwent oncological left-sided pancreatic resection and adrenalectomy including splenectomy for locally advanced pancreatic adenocarcinoma (PDAC), recommended by a multidisciplinary tumour board (MDT). Additionally, she was treated with gemcitabine-containing hyperthermic intraperitoneal chemotherapy (HIPEC) for 60 minutes in the framework of a clinical trial (PanHIPEC), aiming to determine the safety and feasibility (not efficacy) of this approach. Following the postoperative MDT recommendation, she subsequently received adjuvant chemotherapy consisting of six cycles of gemcitabine and cisplatin for a histopathologically confirmed PDAC of the pancreatic tail with infiltration of the left-sided adrenal gland (pT3, pN1 (3/16), cM0, L0, V0, Pn1, R0, G2). Five years and five months after pancreatic surgery and HIPEC, the patient has no signs of tumour recurrence as determined by follow-up examination including CT scan and CA19-9 tumour marker serology.
    MeSH term(s) Humans ; Female ; Pancreatic Neoplasms/surgery ; Pancreatic Neoplasms/drug therapy ; Gemcitabine ; Hyperthermic Intraperitoneal Chemotherapy ; Adenocarcinoma/surgery ; Adenocarcinoma/drug therapy ; Neoplasm Recurrence, Local/drug therapy ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use
    Chemical Substances Gemcitabine
    Language English
    Publishing date 2024-02-19
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2023-258626
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  3. Book ; Thesis: Laktat verändert die Genexpression humaner Endothelzellen (HUVEC)

    Löffler, Markus W.

    2009  

    Author's details vorgelegt von Markus Willi Löffler
    Subject code 612.01
    Language German
    Size 125 S., Ill., graph. Darst., 21 cm
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Tübingen, Univ., Diss., 2009 (Nur beschränkt für den Austausch)
    HBZ-ID HT016507819
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2010 D 894 order for loan Magazin

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  4. Article ; Online: Individualisierte Immuntherapie von Tumorerkrankungen mittels Peptidimpfstoffen – Funktioniert das vielleicht doch?

    Rammensee, Hans-Georg / Löffler, Markus W

    Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz

    2020  Volume 63, Issue 11, Page(s) 1380–1387

    Abstract: The physician and scientist Paul Ehrlich put forward the thesis that the immune system not only fights infections but can also fight cancer. The possible positive effects of a simultaneous infection on the course of cancer were reported in ancient Egypt ... ...

    Title translation Individualized immunotherapy for malignant tumors using peptide vaccines-maybe it does work after all?
    Abstract The physician and scientist Paul Ehrlich put forward the thesis that the immune system not only fights infections but can also fight cancer. The possible positive effects of a simultaneous infection on the course of cancer were reported in ancient Egypt around 2600 BC. However, it was not until the 1960s that it became apparent that the immune system could specifically fight cancer cells, and it was not until the 1990s that researchers slowly clarified how this happens.Against this background, the efforts over the last 30 years to develop therapeutic vaccines against cancers are briefly summarized, and their lack of success to date is highlighted. In addition, potentially promising future developments in this context are discussed. The available scientific literature as well as our own results are taken into account.Central questions arise, such as the following: How do cancer cells differ from normal cells? How can the immune system recognize these differences? What are tumor-specific antigens? Why do they need to be selected and applied in an individualized fashion? How can an efficient immune response be induced? Which pharmaceutical formulations, adjuvants, and vaccination routes are effective?Finally, we explain why it may still be worth pursuing peptide vaccination, which has so far been completely unsuccessful (when measured in terms of already approved therapeutics).
    MeSH term(s) Antigens, Neoplasm ; Cancer Vaccines/therapeutic use ; Germany ; Humans ; Immunotherapy ; Neoplasms/prevention & control ; Vaccines, Subunit/therapeutic use
    Chemical Substances Antigens, Neoplasm ; Cancer Vaccines ; Vaccines, Subunit
    Language German
    Publishing date 2020-10-09
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1461973-8
    ISSN 1437-1588 ; 1436-9990
    ISSN (online) 1437-1588
    ISSN 1436-9990
    DOI 10.1007/s00103-020-03227-3
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  5. Article ; Online: Orf Virus-Based Vectors Preferentially Target Professional Antigen-Presenting Cells, Activate the STING Pathway and Induce Strong Antigen-Specific T Cell Responses.

    Müller, Melanie / Reguzova, Alena / Löffler, Markus W / Amann, Ralf

    Frontiers in immunology

    2022  Volume 13, Page(s) 873351

    Abstract: Background: Orf virus (ORFV)-based vectors are attractive for vaccine development as they enable the induction of potent immune responses against specific transgenes. Nevertheless, the precise mechanisms of immune activation remain unknown. This study ... ...

    Abstract Background: Orf virus (ORFV)-based vectors are attractive for vaccine development as they enable the induction of potent immune responses against specific transgenes. Nevertheless, the precise mechanisms of immune activation remain unknown. This study therefore aimed to characterize underlying mechanisms in human immune cells.
    Methods: Peripheral blood mononuclear cells were infected with attenuated ORFV strain D1701-VrV and analyzed for ORFV infection and activation markers. ORFV entry in susceptible cells was examined using established pharmacological inhibitors. Using the THP1-Dual™ reporter cell line, activation of nuclear factor-κB and interferon regulatory factor pathways were simultaneously evaluated. Infection with an ORFV recombinant encoding immunogenic peptides (PepTrio-ORFV) was used to assess the induction of antigen-specific CD8+ T cells.
    Results: ORFV was found to preferentially target professional antigen-presenting cells (APCs)
    Discussion: Our findings confirm that ORFV induces a strong antigen-specific immune response dependent on APC uptake and activation. These data support the notion that ORFV D1701-VrV is a promising vector for vaccine development and the design of innovative immunotherapeutic applications.
    MeSH term(s) Antigen-Presenting Cells/immunology ; Humans ; Leukocytes, Mononuclear ; Membrane Proteins/immunology ; Membrane Proteins/metabolism ; Orf virus/genetics ; T-Lymphocytes/immunology ; Transgenes/genetics
    Chemical Substances Membrane Proteins ; STING1 protein, human
    Language English
    Publishing date 2022-05-09
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.873351
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  6. Article ; Online: Aktueller Stand der chirurgischen Therapie peritonealer Metastasen bei kolorektalen Karzinomen.

    Yurttas, Can / Löffler, Markus W / Königsrainer, Alfred / Horvath, Philipp

    Chirurgie (Heidelberg, Germany)

    2022  Volume 93, Issue 12, Page(s) 1126–1132

    Abstract: Cytoreductive surgery, often in combination with hyperthermic intraperitoneal chemotherapy (HIPEC), has been instrumental in improving the survival of patients with peritoneal metastases from colorectal cancer. Recent studies have highlighted the ... ...

    Title translation Current status of surgical treatment of peritoneal metastases from colorectal cancer.
    Abstract Cytoreductive surgery, often in combination with hyperthermic intraperitoneal chemotherapy (HIPEC), has been instrumental in improving the survival of patients with peritoneal metastases from colorectal cancer. Recent studies have highlighted the benefits of complete cytoreduction, while the role of the HIPEC treatment remains unclear. An oxaliplatin-based HIPEC over 30 min could not achieve any clear benefits in studies on colorectal cancer, neither in the therapeutic nor in the prophylactic setting, but caused relevant side effects and increased the morbidity. The negative results of these studies with respect to oxaliplatin-based HIPEC require critical appraisal; however, they should by no means be regarded as a general setback for surgical treatment of peritoneal metastases and be misunderstood as a general failure of this treatment. While HIPEC after complete surgical cytoreduction of peritoneal metastases from colorectal cancer requires further research, cytoreductive surgery should still be regarded as a highly effective treatment for suitable patients with limited abdominal tumor dissemination.
    MeSH term(s) Humans ; Peritoneal Neoplasms/surgery ; Oxaliplatin/therapeutic use ; Hyperthermia, Induced/methods ; Colorectal Neoplasms ; Combined Modality Therapy
    Chemical Substances Oxaliplatin (04ZR38536J)
    Language German
    Publishing date 2022-08-20
    Publishing country Germany
    Document type English Abstract ; Journal Article ; Review
    ISSN 2731-698X
    ISSN (online) 2731-698X
    DOI 10.1007/s00104-022-01694-9
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  7. Article ; Online: ASO Author Reflections: First Do No Harm-Revisiting Adjuvant Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Trials to Reduce the Risk of Peritoneal Metastasis.

    Yurttas, Can / Königsrainer, Alfred / Löffler, Markus W

    Annals of surgical oncology

    2021  Volume 28, Issue 13, Page(s) 9096–9097

    MeSH term(s) Chemotherapy, Cancer, Regional Perfusion ; Cytoreduction Surgical Procedures ; Humans ; Hyperthermic Intraperitoneal Chemotherapy ; Peritoneal Neoplasms/therapy
    Language English
    Publishing date 2021-06-11
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-021-10263-z
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    Zs.A 4042: Show issues Location:
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  8. Article: Can Any Drug Be Repurposed for Cancer Treatment? A Systematic Assessment of the Scientific Literature.

    Stransky, Nicolai / Ruth, Peter / Schwab, Matthias / Löffler, Markus W

    Cancers

    2021  Volume 13, Issue 24

    Abstract: Drug repurposing is a complementary pathway for introducing new drugs against cancer. Broad systematic assessments of ongoing repurposing efforts in oncology are lacking, but may be helpful to critically appraise current and future efforts. Hence, we ... ...

    Abstract Drug repurposing is a complementary pathway for introducing new drugs against cancer. Broad systematic assessments of ongoing repurposing efforts in oncology are lacking, but may be helpful to critically appraise current and future efforts. Hence, we conducted a systematic PubMed search encompassing 100 frequently prescribed and 100 randomly selected drugs, and assessed the published preclinical anti-cancer effects. Furthermore, we evaluated all the identified original articles for methodological quality. We found reports indicating anti-cancer effects for 138/200 drugs, especially among frequently prescribed drugs (81/100). Most were reports suggesting single-agent activity of the drugs (61%). Basic information, such as the cell line used or control treatments utilized, were reported consistently, while more detailed information (e.g., excluded data) was mostly missing. The majority (56%) of in vivo studies reported randomizing animals, while only few articles stated that the experiments were conducted in a blinded fashion. In conclusion, we found promising reports of anti-cancer effects for the majority of the assessed drugs, but speculate that many of them are false-positive findings. Reward systems should be adjusted to encourage the widespread usage of high reporting quality and bias-reducing methodologies, aiming to decrease the rate of false-positive results, and thereby increasing the trust in the findings.
    Language English
    Publishing date 2021-12-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers13246236
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  9. Article ; Online: Quantitative Metabolomics and Lipoprotein Analysis of PDAC Patients Suggests Serum Marker Categories for Pancreatic Function, Pancreatectomy, Cancer Metabolism, and Systemic Disturbances.

    Bae, Gyuntae / Berezhnoy, Georgy / Flores, Alejandra / Cannet, Claire / Schäfer, Hartmut / Dahlke, Marc H / Michl, Patrick / Löffler, Markus W / Königsrainer, Alfred / Trautwein, Christoph

    Journal of proteome research

    2024  Volume 23, Issue 4, Page(s) 1249–1262

    Abstract: Pancreatic ductal adenocarcinoma (PDAC) is difficult to diagnose in the early stages and lacks reliable biomarkers. The scope of this project was to establish quantitative nuclear magnetic resonance (NMR) spectroscopy to comprehensively study blood serum ...

    Abstract Pancreatic ductal adenocarcinoma (PDAC) is difficult to diagnose in the early stages and lacks reliable biomarkers. The scope of this project was to establish quantitative nuclear magnetic resonance (NMR) spectroscopy to comprehensively study blood serum alterations in PDAC patients. Serum samples from 34 PDAC patients obtained before and after pancreatectomy as well as 83 age- and sex-matched control samples from healthy donors were analyzed with
    MeSH term(s) Humans ; Pancreatectomy ; Pancreatic Neoplasms/pathology ; Carcinoma, Pancreatic Ductal/diagnosis ; Carcinoma, Pancreatic Ductal/surgery ; Metabolomics/methods ; Biomarkers, Tumor
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2024-02-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2078618-9
    ISSN 1535-3907 ; 1535-3893
    ISSN (online) 1535-3907
    ISSN 1535-3893
    DOI 10.1021/acs.jproteome.3c00611
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  10. Article: Efficacy of Different Oncolytic Vaccinia Virus Strains for the Treatment of Murine Peritoneal Mesothelioma.

    Yurttas, Can / Beil, Julia / Berchtold, Susanne / Smirnow, Irina / Kloker, Linus D / Sipos, Bence / Löffler, Markus W / Königsrainer, Alfred / Mihaljevic, André L / Lauer, Ulrich M / Thiel, Karolin

    Cancers

    2024  Volume 16, Issue 2

    Abstract: Effective treatment options for peritoneal surface malignancies (PSMs) are scarce. Oncolytic virotherapy with recombinant vaccinia viruses might constitute a novel treatment option for PSM. We aimed to identify the most effective oncolytic vaccinia virus ...

    Abstract Effective treatment options for peritoneal surface malignancies (PSMs) are scarce. Oncolytic virotherapy with recombinant vaccinia viruses might constitute a novel treatment option for PSM. We aimed to identify the most effective oncolytic vaccinia virus strain in two murine mesothelioma cell lines and the oncolytic potential in a murine model of peritoneal mesothelioma. Cell lines AB12 and AC29 were infected in vitro with vaccinia virus strains Lister (GLV-1h254), Western Reserve (GLV-0b347), and Copenhagen (GLV-4h463). The virus strain GLV-0b347 was shown most effective in vitro and was further investigated by intraperitoneal (i.p.) application to AB12 and AC29 mesothelioma-bearing mice. Feasibility, safety, and effectiveness of virotherapy were assessed by evaluating the peritoneal cancer index (PCI), virus detection in tumor tissues and ascites, virus growth curves, and comparison of overall survival. After i.p. injection of GLV-0b347, virus was detected in both tumor cells and ascites. In comparison to mock-treated mice, overall survival was significantly prolonged, ascites was less frequent and PCI values declined. However, effective treatment was only observed in animals with limited tumor burden at the time point of virus application. Nonetheless, intraperitoneal virotherapy with GLV-0b347 might constitute a novel therapeutic option for the treatment of peritoneal mesothelioma. Additional treatment modifications and combinational regimes will be investigated to further enhance treatment efficacy.
    Language English
    Publishing date 2024-01-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16020368
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