Article ; Online: Receipt of at least 4 units of low titer group O whole blood with titer <100 does not lead to hemolysis in adult trauma patients.
2022 Volume 62 Suppl 1, Page(s) S72–S79
Abstract: Background: The serological safety of transfusing low titer group O whole blood (LTOWB) with an anti-A and anti-B titer of <100 was evaluated in group O and non-group O trauma recipients.: Methods: Civilian adult trauma patients who received ≥4 units ...
| Abstract | Background: The serological safety of transfusing low titer group O whole blood (LTOWB) with an anti-A and anti-B titer of <100 was evaluated in group O and non-group O trauma recipients. Methods: Civilian adult trauma patients who received ≥4 units of leukoreduced LTOWB during their initial resuscitation and who survived for >24 h after admission at two level 1 trauma centers were included in this retrospective study. Lactate dehydrogenase (LDH), total bilirubin, haptoglobin, potassium, creatinine were evaluated on the day of LTOWB transfusion (day 0) and on the next 3 days. Results: There were 77 injured recipients evaluated: 39 non-group O and 38 group O. The median (IQR) number of transfused LTOWB units was 4 (4-6) and 4 (4-5), respectively, and the maximum number of units was 8 and 11, respectively. The non-group O patients received a median (IQR) volume of 1710 ml (1368-2070) of ABO-incompatible plasma. Comparing non-group O to group O recipients, there were no significant differences in the median haptoglobin, LDH, or creatinine concentrations at any time point. The median concentration of total bilirubin was significantly higher amongst the non-group O recipients on days 1 and 2, while on day 0 the median potassium concentration was significantly higher amongst the group O recipients. All median elevated values were within the laboratory's normal range. Amongst the non-group O recipients there were no reported transfusion reactions. Conclusion: Receiving at least four LTOWB units (anti-A&B titer <100) was not associated with biochemical/clinical evidence of hemolysis in adult trauma patients. |
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| MeSH term(s) | ABO Blood-Group System ; Adult ; Bilirubin ; Creatinine ; Haptoglobins ; Hemolysis ; Humans ; Potassium ; Resuscitation ; Retrospective Studies ; Transfusion Reaction ; Wounds and Injuries/therapy | |||||
| Chemical Substances | ABO Blood-Group System ; Haptoglobins ; Creatinine (AYI8EX34EU) ; Bilirubin (RFM9X3LJ49) ; Potassium (RWP5GA015D) | |||||
| Language | English | |||||
| Publishing date | 2022-06-24 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 208417-x | |||||
| ISSN | 1537-2995 ; 0041-1132 | |||||
| ISSN (online) | 1537-2995 | |||||
| ISSN | 0041-1132 | |||||
| DOI | 10.1111/trf.16980 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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