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Article ; Online: On an Organ Donation Run.

Lew, Joey

2020 Volume 41, Issue 4, Page(s) 611–612

MeSH term(s)	Humans ; Tissue Donors ; Tissue and Organ Procurement
Language	English
Publishing date	2020-09-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2017000-2
ISSN	1573-3645 ; 1041-3545
ISSN (online)	1573-3645
ISSN	1041-3545
DOI	10.1007/s10912-020-09658-y
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Article ; Online: Cardiac implantable electronic device-induced tricuspid regurgitation: Implications and management.

Murphy, Sean P / Lew, Jeanney / Yucel, Evin / Singh, Jagmeet / Mela, Theofanie

Journal of cardiovascular electrophysiology

2024 Volume 35, Issue 5, Page(s) 1017–1025

Abstract: Tricuspid regurgitation (TR) secondary to cardiac implantable electronic devices (CIEDs) has been well documented and is associated with worse cardiovascular outcomes. A variety of mechanisms have been proposed including lead-induced mechanical ... ...

Abstract	Tricuspid regurgitation (TR) secondary to cardiac implantable electronic devices (CIEDs) has been well documented and is associated with worse cardiovascular outcomes. A variety of mechanisms have been proposed including lead-induced mechanical disruption of the tricuspid valvular or subvalvular apparatus and pacing-induced electrical dyssynchrony. Patient characteristics such as age, sex, baseline atrial fibrillation, and pre-existing TR have not been consistent predictors of CIED-induced TR. While two-dimensional echocardiography is helpful in assessing the severity of TR, three-dimensional echocardiography has significantly improved accuracy in identifying the etiology of TR and whether lead position contributes to TR. Three-dimensional echocardiography may therefore play a future role in optimizing lead positioning during implant to reduce the risk of CIED-induced TR. Optimal lead management strategies in addition to percutaneous interventions and surgery in alleviating TR are very important.
MeSH term(s)	Humans ; Tricuspid Valve Insufficiency/physiopathology ; Tricuspid Valve Insufficiency/etiology ; Tricuspid Valve Insufficiency/diagnostic imaging ; Tricuspid Valve Insufficiency/diagnosis ; Tricuspid Valve Insufficiency/surgery ; Defibrillators, Implantable/adverse effects ; Pacemaker, Artificial/adverse effects ; Tricuspid Valve/physiopathology ; Tricuspid Valve/diagnostic imaging ; Tricuspid Valve/surgery ; Risk Factors ; Treatment Outcome ; Echocardiography, Three-Dimensional
Language	English
Publishing date	2024-03-19
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1025989-2
ISSN	1540-8167 ; 1045-3873
ISSN (online)	1540-8167
ISSN	1045-3873
DOI	10.1111/jce.16251
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Zs.A 2863: Show issues

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Article ; Online: We Asked the Experts: Toward Personalized Immunosuppression for Liver Transplant Recipients.

Lew, Joey / Perito, Emily R / Feng, Sandy

World journal of surgery

2022 Volume 46, Issue 4, Page(s) 876–877

MeSH term(s)	Graft Rejection/prevention & control ; Humans ; Immunosuppression Therapy ; Immunosuppressive Agents/therapeutic use ; Liver Transplantation ; Transplant Recipients
Chemical Substances	Immunosuppressive Agents
Language	English
Publishing date	2022-01-17
Publishing country	United States
Document type	Editorial
ZDB-ID	224043-9
ISSN	1432-2323 ; 0364-2313
ISSN (online)	1432-2323
ISSN	0364-2313
DOI	10.1007/s00268-021-06417-5
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Zs.A 1336: Show issues

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Article ; Online: Algal extracellular organic matter pre-treatment enhances microalgal biofilm adhesion onto microporous substrate.

Tong, C Y / Lew, J K / Derek, C J C

Chemosphere

2022 Volume 307, Issue Pt 1, Page(s) 135740

Abstract: Adhesive biocoating has microstructure composed of biomolecules to entrap viable cells in a stabilized matrix over exposed surfaces. Although marine benthic diatoms are a common group of algae excreting substantial amount of extracellular polymeric ... ...

Abstract	Adhesive biocoating has microstructure composed of biomolecules to entrap viable cells in a stabilized matrix over exposed surfaces. Although marine benthic diatoms are a common group of algae excreting substantial amount of extracellular polymeric substances (EPS), studies regarding the utilization of these EPS are scarce. Using the soluble EPS derived from Navicula incerta and pre-deposition of it as a thin conditioning layer on microporous polyvinylidene fluoride (PVDF) membranes, the pre-coated surface was used to investigate the cell binding affinity of three marine microalgae, namely Amphora coffeaeformis, Cylindrotheca fusiformis and Navicula incerta. Microalgae actively engaged themselves on the pre-coated membranes which was 10 times greater than the initial cell adhesion degree. Soluble EPS is mainly comprised of polysaccharide while bounded EPS is mainly comprised of protein. On EPS pre-coated membranes, N. incerta released the least amount of bounded polysaccharides (<100 mg m
MeSH term(s)	Biofilms ; Diatoms ; Extracellular Polymeric Substance Matrix ; Fluorocarbon Polymers ; Microalgae/metabolism ; Polysaccharides/metabolism ; Polyvinyls
Chemical Substances	Fluorocarbon Polymers ; Polysaccharides ; Polyvinyls ; polyvinylidene fluoride (24937-79-9)
Language	English
Publishing date	2022-07-15
Publishing country	England
Document type	Journal Article
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2022.135740
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Article ; Online: Frequency-Based Motion Representation for Video Generative Adversarial Networks.

Hyun, Sangeek / Lew, Jaihyun / Chung, Jiwoo / Kim, Euiyeon / Heo, Jae-Pil

IEEE transactions on image processing : a publication of the IEEE Signal Processing Society

2023 Volume 32, Page(s) 3949–3963

Abstract: Videos contain motions of various speeds. For example, the motions of one's head and mouth differ in terms of speed - the head being relatively stable and the mouth moving rapidly as one speaks. Despite its diverse nature, previous video GANs generate ... ...

Abstract	Videos contain motions of various speeds. For example, the motions of one's head and mouth differ in terms of speed - the head being relatively stable and the mouth moving rapidly as one speaks. Despite its diverse nature, previous video GANs generate video based on a single unified motion representation without considering the aspect of speed. In this paper, we propose a frequency-based motion representation for video GANs to realize the concept of speed in video generation process. In detail, we represent motions as continuous sinusoidal signals of various frequencies by introducing a coordinate-based motion generator. We show, in that case, frequency is highly related to the speed of motion. Based on this observation, we present frequency-aware weight modulation that enables manipulation of motions within a specific range of speed, which could not be achieved with the previous techniques. Extensive experiments validate that the proposed method outperforms state-of-the-art video GANs in terms of generation quality by its capability to model various speed of motions. Furthermore, we also show that our temporally continuous representation enables to further synthesize intermediate and future frames of generated videos.
Language	English
Publishing date	2023-07-19
Publishing country	United States
Document type	Journal Article
ISSN	1941-0042
ISSN (online)	1941-0042
DOI	10.1109/TIP.2023.3293767
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Article ; Online: Thyroid and Adrenal Dysfunction in Hemoglobinopathies Before and After Allogeneic Hematopoietic Cell Transplant.

Mandava, Mamatha / Lew, Jeffrey / Tisdale, John F / Limerick, Emily / Fitzhugh, Courtney D / Hsieh, Matthew M

Journal of the Endocrine Society

2023 Volume 7, Issue 12, Page(s) bvad134

Abstract: Purpose: To determine the rate and clinical characteristics associated with abnormal thyroid and adrenal function in recipients of nonmyeloablative hematopoietic cell transplantation (HCT) for sickle cell disease (SCD) and beta-thalassemia.: Methods: ...

Abstract	Purpose: To determine the rate and clinical characteristics associated with abnormal thyroid and adrenal function in recipients of nonmyeloablative hematopoietic cell transplantation (HCT) for sickle cell disease (SCD) and beta-thalassemia. Methods: We retrospectively reviewed patients who enrolled in 4 nonmyeloablative HCT regimens with alemtuzumab and total body irradiation (TBI). Baseline and annual post-HCT data were compared, which included age, sex, sickle phenotype, thyroid panel (total T3, free T4, thyroid stimulating hormone, antithyroid antibodies), cortisol level, ACTH stimulation testing, ferritin, medications, and other relevant medical history. Results: Among 43 patients in haploidentical transplant and 84 patients in the matched related donor protocols with mostly SCD, the rate of any thyroid disorder pre-HCT was 3.1% (all subclinical hypothyroidism) and post-HCT was 29% (10 hypothyroidism, 4 Grave's disease, and 22 subclinical hypothyroidism). Ninety-two (72%) patients had ferritin >1000 ng/dL, of which 33 patients (35.8%) had thyroid dysfunction. Iron overload was noted in 6 of 10 patients with hypothyroidism and 12 of 22 patients with subclinical hypothyroidism.Sixty-one percent were on narcotics for pain control. With respect to adrenal insufficiency (AI) pre-HCT, 2 patients were maintained on corticosteroids for underlying rheumatologic disorder and 8 had AI diagnosed during pre-HCT ACTH stimulation testing (total 10, 7.9%). Post-HCT, an additional 4 (3%) developed AI from corticosteroid use for acute graft vs host disease, Evans syndrome, or hemolytic anemia. Conclusion: Although iron overload was common in SCD, thyroid dysfunction pre-HCT related to excess iron was less common. Exposure to alemtuzumab or TBI increased the rates of thyroid dysfunction post-HCT. In contrast, AI was more common pre-HCT, but no risk factor was identified. AI post-HCT was infrequent and associated with corticosteroid use for HCT-related complications.
Language	English
Publishing date	2023-10-31
Publishing country	United States
Document type	Journal Article
ISSN	2472-1972
ISSN (online)	2472-1972
DOI	10.1210/jendso/bvad134
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Article ; Online: Etonogestrel contraceptive implant uptake and safety among solid organ transplant recipients.

Lew, Jessica / Sheeder, Jeanelle / Lazorwitz, Aaron

Contraception

2021 Volume 104, Issue 5, Page(s) 556–560

Abstract: Objectives: To determine the safety of etonogestrel contraceptive implant use among reproductive-age women who are solid organ transplant recipients.: Study design: We conducted a retrospective cohort study with matching of reproductive-age women (14- ...

Abstract	Objectives: To determine the safety of etonogestrel contraceptive implant use among reproductive-age women who are solid organ transplant recipients. Study design: We conducted a retrospective cohort study with matching of reproductive-age women (14-45 years) who were solid organ transplant recipients and received care at a tertiary medical center in Denver, Colorado between 2011 and 2019. We identified cases who used an etonogestrel contraceptive implant post-transplant and then matched controls (no hormonal contraceptive use) in a 1:1 ratio according to age, transplant type, and institution. We compared pregnancy patterns, post-transplant infections, immunosuppressant therapy adjustments, and graft complications between cases and controls. We also evaluated implant-related side effect profiles and continuation rates among cases only. Results: We identified 24 cases and 24 matched controls. When compared to age and transplant organ-matched controls, contraceptive implant users were not at increased risk for adverse transplant-related outcomes. Graft rejection was the most common transplant-related complication in both groups (n = 11, 45.8% cases; n = 10, 41.7% controls). Additionally, outcomes concerning pregnancies, infections and immunosuppressant therapy changes showed no statistically significant difference between either group. Conclusions: This study provides the first data that the etonogestrel contraceptive implant is likely a safe contraceptive option for reproductive-age women who are solid organ transplant recipients. Given the solid organ transplant recommendations to avoid pregnancy during the first 1 to 2 years post-transplant, healthcare providers should continue to counsel solid organ transplant recipients at risk of pregnancy on the etonogestrel contraceptive implant as an effective and safe method of pregnancy prevention. Implications: Reproductive age women who are solid organ transplant recipients face additional health risks with unintended pregnancies. The etonogestrel contraceptive implant remains a safe and effective method of contraception for this specific population, with no increase in graft-related complications among contraceptive implant users.
MeSH term(s)	Adolescent ; Adult ; Contraceptive Agents, Female/adverse effects ; Desogestrel/adverse effects ; Drug Implants ; Female ; Humans ; Middle Aged ; Organ Transplantation ; Pregnancy ; Retrospective Studies ; Young Adult
Chemical Substances	Contraceptive Agents, Female ; Drug Implants ; etonogestrel (304GTH6RNH) ; Desogestrel (81K9V7M3A3)
Language	English
Publishing date	2021-06-18
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	80106-9
ISSN	1879-0518 ; 0010-7824
ISSN (online)	1879-0518
ISSN	0010-7824
DOI	10.1016/j.contraception.2021.06.007
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Article ; Online: CDK5: A new lead to survival.

Lew, John

Cell cycle (Georgetown, Tex.)

2013 Volume 12, Issue 13, Page(s) 1981–1982

MeSH term(s)	Animals ; Cell Survival ; Cyclin-Dependent Kinase 5/physiology ; Humans ; Protein Subunits/physiology ; Signal Transduction
Chemical Substances	Protein Subunits ; Cyclin-Dependent Kinase 5 (EC 2.7.11.1)
Language	English
Publishing date	2013-06-10
Publishing country	United States
Document type	Editorial
ZDB-ID	2146183-1
ISSN	1551-4005 ; 1538-4101 ; 1554-8627
ISSN (online)	1551-4005
ISSN	1538-4101 ; 1554-8627
DOI	10.4161/cc.25304
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Article: Algal extracellular organic matter pre-treatment enhances microalgal biofilm adhesion onto microporous substrate

Tong, C.Y. / Lew, J.K. / Derek, C.J.C.

Chemosphere. 2022 Nov., v. 307

2022

Abstract	Adhesive biocoating has microstructure composed of biomolecules to entrap viable cells in a stabilized matrix over exposed surfaces. Although marine benthic diatoms are a common group of algae excreting substantial amount of extracellular polymeric substances (EPS), studies regarding the utilization of these EPS are scarce. Using the soluble EPS derived from Navicula incerta and pre-deposition of it as a thin conditioning layer on microporous polyvinylidene fluoride (PVDF) membranes, the pre-coated surface was used to investigate the cell binding affinity of three marine microalgae, namely Amphora coffeaeformis, Cylindrotheca fusiformis and Navicula incerta. Microalgae actively engaged themselves on the pre-coated membranes which was 10 times greater than the initial cell adhesion degree. Soluble EPS is mainly comprised of polysaccharide while bounded EPS is mainly comprised of protein. On EPS pre-coated membranes, N. incerta released the least amount of bounded polysaccharides (<100 mg m⁻²) and vice versa for the other two because EPS production is usually maximized to assist cell adhesion onto unfavorable substrates. In stark contrast, when the adaptation period (first 6 h) ended, cells began to secrete more bounded protein for cell growth, and an increasing trend of protein content found in N. incerta has verified its optimal adaptation onto the biocoating itself. On pristine PVDF membranes, the adhesion degree was ranked in ascending order: C. fusiformis, N. incerta and A. coffeaeformis. Interestingly, after the pre-coating process, the order was reported as: A. coffeaeformis, N. incerta and C. fusiformis, but it should be noted that C. fusiformis demonstrated fluctuating cell colonization degree and bounded EPS production over time. In other words, the biofilm's susceptibility was confirmed since the cells latched loosely on the membranes rather than in a biofilm matrix. Biocoating enables uniform cell distribution and firmer biofilm growth, opening the door to vast future applications in environmental bioremediation and sensing.
Keywords	Amphora ; Cylindrotheca ; Navicula ; adhesion ; biofilm ; bioremediation ; cell adhesion ; cell growth ; microalgae ; microstructure ; organic matter ; polysaccharides ; porous media ; protein content ; thermoplastics
Language	English
Dates of publication	2022-11
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2022.135740
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Comparison of dry needling and trigger point manual therapy in patients with neck and upper back myofascial pain syndrome: a systematic review and meta-analysis.

Lew, Jennalyn / Kim, Jennifer / Nair, Preeti

The Journal of manual & manipulative therapy

2020 Volume 29, Issue 3, Page(s) 136–146

Abstract: Background: Patients with myofascial pain syndrome of the neck and upper back have active trigger points and may present with pain and decreased function. Dry needling (DN) and trigger point manual therapy (TMPT) techniques are often used to manage MPS.! ...

Abstract	Background: Patients with myofascial pain syndrome of the neck and upper back have active trigger points and may present with pain and decreased function. Dry needling (DN) and trigger point manual therapy (TMPT) techniques are often used to manage MPS. Objective: To compare DN and TPMT for reducing pain on the Visual Analog Scale (VAS) and Pressure Pain Threshold (PPT) scores and improving function on the Neck Disability Index (NDI) in patients with neck and upper back MPS. Methods: PubMed, PEDro, and CINAHL were searched for randomized controlled trials within the last 10 years comparing a group receiving DN and the other receiving TPMT. Studies were assessed using PEDro scale and Cochrane risk-of-bias tool to assess methodological quality. Meta-analyses were performed using random-effect model. Standardized mean differences (Cohen's d) and confidence intervals were calculated to compare DN to TPMT for effects on VAS, PPT, and NDI. Results: Six randomized controlled trials with 241 participants total were included in this systematic review. The effect size of difference between DN and TPMT was non-significant for VAS [d = 0.41 (-0.18, 0.99)], for PPT [d = 0.64 (-0.19, 1.47)], and for NDI [d = -0.66 (-1.33, 0.02)]. Conclusions: Both DN and TPMT improve pain and function in the short to medium term. Neither is more superior than the other.
MeSH term(s)	Dry Needling ; Humans ; Musculoskeletal Manipulations ; Myofascial Pain Syndromes/therapy ; Neck Pain/therapy ; Trigger Points
Keywords	covid19
Language	English
Publishing date	2020-09-22
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	920432-5
ISSN	2042-6186 ; 1066-9817
ISSN (online)	2042-6186
ISSN	1066-9817
DOI	10.1080/10669817.2020.1822618
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