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  1. Article ; Online: Minimizing the Risk of Donor-Derived Events and Maximizing Organ Utilization Through Education and Policy Development.

    La Hoz, Ricardo M

    Infectious disease clinics of North America

    2023  Volume 37, Issue 3, Page(s) 443–458

    Abstract: Herein, we review the current knowledge of donor-derived disease and current US Organ Procurement and Transplantation Network policies to minimize the risk. During the process, we also consider actions to further mitigate the risk of donor-derived ... ...

    Abstract Herein, we review the current knowledge of donor-derived disease and current US Organ Procurement and Transplantation Network policies to minimize the risk. During the process, we also consider actions to further mitigate the risk of donor-derived disease. The overarching goal is to provide an infectious disease perspective on the complex decision of organ acceptance for transplant programs and candidates.
    MeSH term(s) Humans ; Tissue Donors ; Tissue and Organ Procurement ; Policy Making
    Language English
    Publishing date 2023-06-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1077676-x
    ISSN 1557-9824 ; 0891-5520
    ISSN (online) 1557-9824
    ISSN 0891-5520
    DOI 10.1016/j.idc.2023.05.002
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  2. Article ; Online: Transplantation for chagas' disease: closing the knowledge gap.

    La Hoz, Ricardo M

    Current opinion in infectious diseases

    2022  Volume 35, Issue 5, Page(s) 397–403

    Abstract: Purpose of the review: This review examines the most recent literature on the epidemiology and treatment of Chagas Disease and the risk of Chagas Disease Reactivation and donor-derived disease in solid organ transplant recipients.: Recent findings: ... ...

    Abstract Purpose of the review: This review examines the most recent literature on the epidemiology and treatment of Chagas Disease and the risk of Chagas Disease Reactivation and donor-derived disease in solid organ transplant recipients.
    Recent findings: Chagas disease is caused by infection with the parasite Trypansoma cruzi . In nonendemic countries the disease is seen primarily in immigrants from Mexico, Central America and South America where the disease is endemic. Benznidazole or nifurtimox can be used for treatment. Posaconazole and fosravuconazole did not provide any additional benefit compared to benznidazole alone or in combination. A phase 2 randomized controlled trial suggests that shorter or reduced dosed regimes of benznidazole could be used. Based on a large randomized controlled trial, benznidazole is unlikely to have a significant preventive effect for established Chagas cardiomyopathy. Transplantation has become the treatment of choice for individuals with refractory Chagas cardiomyopathy. Cohort studies show similar posttransplant outcomes for these patients compared to other indications. Transplant candidates and donors with chronic T. cruzi infection are at risk for Chagas disease reactivation and transmitting infection. Screening them via serology is the first line of prevention. Recipients with chronic infection and those receiving organs from infected donors should undergo sequential monitoring with polymerase chain reaction for early detection of reactivation and preemptive treatment with antitrypanosomal therapy.
    Summary: Patients with chronic T. cruzi infection can be safely transplanted and be noncardiac organ donors.
    MeSH term(s) Chagas Cardiomyopathy/drug therapy ; Chagas Disease/drug therapy ; Chagas Disease/prevention & control ; Clinical Trials, Phase II as Topic ; Humans ; Nitroimidazoles/therapeutic use ; Randomized Controlled Trials as Topic ; Tissue Donors ; Transplant Recipients ; Trypanocidal Agents/therapeutic use ; Trypanosoma cruzi
    Chemical Substances Nitroimidazoles ; Trypanocidal Agents
    Language English
    Publishing date 2022-08-03
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 645085-4
    ISSN 1473-6527 ; 1535-3877 ; 0951-7375 ; 1355-834X
    ISSN (online) 1473-6527 ; 1535-3877
    ISSN 0951-7375 ; 1355-834X
    DOI 10.1097/QCO.0000000000000868
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  3. Article ; Online: Reevaluating severe acute respiratory syndrome coronavirus-2 donor testing policies: Balancing safety and efficiency in organ transplantation.

    Pouch, Stephanie M / La Hoz, Ricardo M

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

    2024  

    Language English
    Publishing date 2024-02-27
    Publishing country United States
    Document type Letter
    ZDB-ID 2060594-8
    ISSN 1600-6143 ; 1600-6135
    ISSN (online) 1600-6143
    ISSN 1600-6135
    DOI 10.1016/j.ajt.2024.02.024
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  4. Article ; Online: Understanding the Transplant Recipient Implications of Hearts From Donors With Active COVID-19.

    La Hoz, Ricardo M / Grodin, Justin L

    Journal of the American College of Cardiology

    2023  Volume 82, Issue 16, Page(s) e147

    MeSH term(s) Humans ; Transplant Recipients ; COVID-19 ; Tissue Donors ; Tissue and Organ Procurement ; Heart ; Heart Transplantation ; Graft Survival
    Language English
    Publishing date 2023-10-17
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2023.07.032
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  5. Article ; Online: The nuts and bolts of transplant infectious disease training.

    Harris, Courtney E / Kumar, Rebecca N / Haidar, Ghady / La Hoz, Ricardo M / Gorsline, Chelsea A

    Transplant infectious disease : an official journal of the Transplantation Society

    2024  Volume 26, Issue 2, Page(s) e14247

    Abstract: The number of transplant infectious disease (TID) fellowship programs has expanded rapidly in the past 5 years, with the creation of many new programs and the expansion of training tracks and dedicated years as the demand for TID physicians grows ... ...

    Abstract The number of transplant infectious disease (TID) fellowship programs has expanded rapidly in the past 5 years, with the creation of many new programs and the expansion of training tracks and dedicated years as the demand for TID physicians grows drastically. This editorial focuses on major factors and complexities that programs should consider in TID fellowship creation, as well as highlighting examples of formative experiences, programmatic structure, and fellow resources that trainees can use to identify their desired career path in TID.
    MeSH term(s) Humans ; Transplants ; Communicable Diseases ; Fellowships and Scholarships ; Physicians
    Language English
    Publishing date 2024-02-13
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 1476094-0
    ISSN 1399-3062 ; 1398-2273
    ISSN (online) 1399-3062
    ISSN 1398-2273
    DOI 10.1111/tid.14247
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  6. Article ; Online: Sodium-Glucose Co-transporter 2 Inhibitors and Mycotic Genital or Urinary Tract Infections in Heart Failure.

    Duvalyan, Angela / La Hoz, Ricardo M / McGuire, Darren K / Drazner, Mark H

    Journal of cardiac failure

    2024  

    Abstract: Sodium-glucose co-transporter 2 inhibitors (SGLT2i) improve clinical outcomes in persons with heart failure (HF). This class of agents has been consistently associated with an increased risk of mycotic genital infections (MGIs), and in some, but not all ... ...

    Abstract Sodium-glucose co-transporter 2 inhibitors (SGLT2i) improve clinical outcomes in persons with heart failure (HF). This class of agents has been consistently associated with an increased risk of mycotic genital infections (MGIs), and in some, but not all trials, urinary tract infections (UTIs). Since other medications widely used for cardiac conditions do not cause MGIs and UTIs, cardiologists and their supporting teams will be encountering clinical questions that they previously did not have to address. This review provides clinicians with practical recommendations about SGLT2i use in individuals with HF as related to the associated MGI and possible UTI risk. Overall, given the benefit of SGLT2 inhibitors on clinical outcomes, the threshold for not initiating or discontinuing SGLT2i due to concerns for MGI or UTI should be high for persons with HF. Likewise, when SGLT2 inhibitors are discontinued for such concerns, the threshold for re-initiation should be low.
    Language English
    Publishing date 2024-04-24
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1281194-4
    ISSN 1532-8414 ; 1071-9164
    ISSN (online) 1532-8414
    ISSN 1071-9164
    DOI 10.1016/j.cardfail.2024.04.009
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  7. Article ; Online: SARS-CoV-2 NAT+ donors for pediatric solid organ transplant recipients-Are they safe and provide good outcomes?

    La Hoz, Ricardo M / Green, Michael

    Pediatric transplantation

    2022  Volume 26, Issue 8, Page(s) e14406

    MeSH term(s) Humans ; Child ; SARS-CoV-2 ; COVID-19 ; Transplant Recipients ; Tissue Donors ; Organ Transplantation
    Language English
    Publishing date 2022-10-04
    Publishing country Denmark
    Document type Editorial ; Comment
    ZDB-ID 1390284-2
    ISSN 1399-3046 ; 1397-3142
    ISSN (online) 1399-3046
    ISSN 1397-3142
    DOI 10.1111/petr.14406
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    Zs.A 4947: Show issues Location:
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  8. Article ; Online: Challenging boundaries: Organ transplants from donors with Listeria central nervous system infections.

    Lueking, Richard / Fung, Monica / Ramos-Salazar, Elizabeth / Katari, Sreelatha / Funk, Geoffrey A / Wolfe, Cameron R / La Hoz, Ricardo M

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

    2024  

    Abstract: Pretransplant mortality rates in the US remain high and are connected to effective organ donation and utilization. Thus, there is a need to maximize the utilization of available donors. In some cases, this has been safely achieved using organs from ... ...

    Abstract Pretransplant mortality rates in the US remain high and are connected to effective organ donation and utilization. Thus, there is a need to maximize the utilization of available donors. In some cases, this has been safely achieved using organs from donors with infectious complications. For example, several studies describe the use of organs from donors with bacterial meningitis due to pathogens such as Streptococcus pneumoniae, Neisseria meningitidis, Haemophilus influenza, and Escherichia coli, with good outcomes. Listeria is an aerobic and facultatively anaerobic, nonspore-forming, Gram-positive rod that can affect the central nervous system, causing meningitis and meningoencephalitis. Due to its virulence, ability to cause intracellular infection, and lack of clinical data, people dying with listeria may not be evaluated for organ donation, may not have organs recovered, or may have their organs recovered but not transplanted. Herein, we describe the outcomes of 7 solid organ transplant recipients who received organs from 2 donors with Listeria monocytogenes central nervous system infection.
    Language English
    Publishing date 2024-02-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2060594-8
    ISSN 1600-6143 ; 1600-6135
    ISSN (online) 1600-6143
    ISSN 1600-6135
    DOI 10.1016/j.ajt.2024.02.025
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  9. Article ; Online: Successful Living Donor Liver Transplant from Donor with False-Positive HIV Test in Recipient without HIV.

    Fung, Monica / La Hoz, Ricardo M / Durand, Christine M / Lee, Dong Heun / Sears, David / Hohe, Caitlin / Chin-Hong, Peter / Roberts, John P

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

    2024  

    Language English
    Publishing date 2024-05-03
    Publishing country United States
    Document type Letter
    ZDB-ID 2060594-8
    ISSN 1600-6143 ; 1600-6135
    ISSN (online) 1600-6143
    ISSN 1600-6135
    DOI 10.1016/j.ajt.2024.04.021
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  10. Article ; Online: Short-term liver transplant outcomes from SARS-CoV-2 lower respiratory tract NAT positive donors.

    La Hoz, Ricardo M / Mufti, Arjmand R / Vagefi, Parsia A

    Transplant infectious disease : an official journal of the Transplantation Society

    2021  Volume 24, Issue 1, Page(s) e13757

    Abstract: On April 2021, the United States Organ Procurement and Transplantation Executive Committee approved the "lower respiratory SARS-CoV-2 testing for lung donors" emergency policy upon recommendation from the Ad Hoc Disease Transmission Advisory Committee. ... ...

    Abstract On April 2021, the United States Organ Procurement and Transplantation Executive Committee approved the "lower respiratory SARS-CoV-2 testing for lung donors" emergency policy upon recommendation from the Ad Hoc Disease Transmission Advisory Committee. This policy requires that all lung donors be tested for SARS-CoV-2 in a lower respiratory specimen by nucleic acid test (NAT) and that the results be available before the lungs are transplanted. The overarching goal of the emergency policy was to minimize the risk of donor-derived COVID-19 to lung recipients. However, an unintended consequence of the policy was the emergence of a new population of potential donors: the SARS-CoV-2 lower respiratory tract (LRT) NAT positive donor. We describe the use of two SARS-CoV-2 LRT NAT positive liver donors without a known history of COVID-19 infection with adequate short-term outcomes. The recipients did not have a prior history of COVID-19, nor did they receive monoclonal antibodies post-transplantation; one was unvaccinated. If the safety and long-term outcomes from SARS-CoV-2 LRT NAT positive donors are confirmed in larger studies, this strategy represents a promising way to increase the pool for organ donation.
    MeSH term(s) COVID-19 ; COVID-19 Testing ; Humans ; Liver Transplantation/adverse effects ; Nucleic Acids ; SARS-CoV-2 ; Tissue Donors ; United States
    Chemical Substances Nucleic Acids
    Language English
    Publishing date 2021-12-14
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 1476094-0
    ISSN 1399-3062 ; 1398-2273
    ISSN (online) 1399-3062
    ISSN 1398-2273
    DOI 10.1111/tid.13757
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