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  1. Article: Extracellular vesicles in the Chronic Myeloid Leukemia scenario: an update about the shuttling of disease markers and therapeutic molecules.

    Bernardi, Simona / Mulas, Olga / Mutti, Silvia / Costa, Alessandro / Russo, Domenico / La Nasa, Giorgio

    Frontiers in oncology

    2024  Volume 13, Page(s) 1239042

    Abstract: Extracellular vesicles (EVs) are various sets of cell-derived membranous structures containing lipids, nucleic acids, and proteins secreted by both eukaryotic and prokaryotic cells. It is now well recognized that EVs are key intercellular communication ... ...

    Abstract Extracellular vesicles (EVs) are various sets of cell-derived membranous structures containing lipids, nucleic acids, and proteins secreted by both eukaryotic and prokaryotic cells. It is now well recognized that EVs are key intercellular communication mediators, allowing the functional transfer of bioactive chemicals from one cell to another in both healthy and pathological pathways. It is evident that the condition of the producer cells heavily influences the composition of EVs. Hence, phenotypic changes in the parent cells are mirrored in the design of the secreted EVs. As a result, EVs have been investigated for a wide range of medicinal and diagnostic uses in different hematological diseases. EVs have only recently been studied in the context of Chronic Myeloid Leukemia (CML), a blood malignancy defined by the chromosomal rearrangement t(9;22) and the fusion gene BCR-ABL1. The findings range from the impact on pathogenesis to the possible use of EVs as medicinal chemical carriers. This review aims to provide for the first time an update on our understanding of EVs as carriers of CML biomarkers for minimal residual disease monitoring, therapy response, and its management, as well as the limited reports on the use of EVs as therapeutic shuttles for innovative treatment approaches.
    Language English
    Publishing date 2024-01-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1239042
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Prediction of severe infections in chronic lymphocytic leukemia: a simple risk score to stratify patients at diagnosis.

    Murru, Roberta / Galitzia, Andrea / Barabino, Luca / Presicci, Roberta / La Nasa, Giorgio / Caocci, Giovanni

    Annals of hematology

    2024  Volume 103, Issue 5, Page(s) 1655–1664

    Abstract: Chronic Lymphocytic Leukemia (CLL) is well-known for increasing susceptibility to infections. Factors such as immune dysregulation, IGHV status, hypogammaglobulinemia, and patient comorbidity and treatment, contribute to higher infection rates and ... ...

    Abstract Chronic Lymphocytic Leukemia (CLL) is well-known for increasing susceptibility to infections. Factors such as immune dysregulation, IGHV status, hypogammaglobulinemia, and patient comorbidity and treatment, contribute to higher infection rates and mortality. However, the impact of hypogammaglobulinemia on infection rates is controversial. We aimed to identify clinical and biological parameters linked to the risk of severe infectious events. Additionally, we set up a straightforward risk infection score to stratify CLL patients at diagnosis, thereby enabling the development of suitable infection prevention strategies. We retrospectively evaluated 210 unselected CLL patients diagnosed between 1988 and 2018. This evaluation encompassed demographics, Binet stage, immunoglobulin (Ig) levels, treatment history, comorbidities, and IGHV mutational status at diagnosis. The frequency and severity of infectious events were recorded. Analysis revealed that age, IGHV mutational status, Binet stage, and hypogammaglobulinemia were statistically associated with the Time to First Infection (TTFI) in univariate and multivariate analyses. Using hazard ratios from the multivariate analysis, we finally devised a risk scoring system that integrated age, IGHV mutational status, immunoglobulin levels, and Binet stage to stratify patients at diagnosis based on their specific infection risk. In our cohort, disease progression and infections were the leading cause of death. These findings pointed out the clinical need for a screening process strategic for defining infectious risk at the time of CLL diagnosis, with a significant enhancement in the clinical management of these patients.
    MeSH term(s) Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/complications ; Leukemia, Lymphocytic, Chronic, B-Cell/diagnosis ; Leukemia, Lymphocytic, Chronic, B-Cell/epidemiology ; Prognosis ; Retrospective Studies ; Agammaglobulinemia/diagnosis ; Agammaglobulinemia/epidemiology ; Mutation ; Risk Factors ; Immunoglobulins
    Chemical Substances Immunoglobulins
    Language English
    Publishing date 2024-01-18
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1064950-5
    ISSN 1432-0584 ; 0939-5555 ; 0945-8077
    ISSN (online) 1432-0584
    ISSN 0939-5555 ; 0945-8077
    DOI 10.1007/s00277-024-05625-y
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  3. Article: Systematic Review and Meta-Analysis of Health-Related Quality of Life in Patients with β-Thalassemia that Underwent Hematopoietic Stem Cell Transplantation.

    Mulas, Olga / Pili, Ilaria / Sanna, Marco / La Nasa, Giorgio

    Clinical practice and epidemiology in mental health : CP & EMH

    2023  Volume 19, Issue Suppl-1, Page(s) e174501792301031

    Abstract: Background: β-Thalassemia major (β-TM) represents one of the most important hemoglobinopathies worldwide. Remarkable improvements have been achieved in supportive therapy based on blood transfusions and iron chelation, and nowadays, this approach is ... ...

    Abstract Background: β-Thalassemia major (β-TM) represents one of the most important hemoglobinopathies worldwide. Remarkable improvements have been achieved in supportive therapy based on blood transfusions and iron chelation, and nowadays, this approach is capable of assuring a long life in these patients in industrialized countries. The only curative treatment is represented by hematopoietic stem cell transplantation (HSCT). However, this treatment may be burdened by deterioration in the Health-Related Quality of Life (HRQoL). This paper aimed to evaluate the role of HRQoL in transplanted β-TM patients with a systematic review and meta-analysis.
    Methods: PubMed database, Web of Science, and Scopus were systematically searched for studies published between January 1st, 2000 to September 2020. The following terms were entered in the database queries: β-thalassemia, HRQoL, and HSCT. The study was carried out according to the Preferred Reporting Items for Systematic and Meta-analyses (PRISMA) statement.
    Results: We identified a total of 33 potential studies. Among these, 10 were finally considered in the systematic review and 5 in the meta-analysis. Overall, good scores in the principal domains of HRQoL were reported by transplanted patients. These data were confirmed by results of meta-analysis that showed significant difference between transplanted and β-TM patients treated with conventional therapy in the physical and emotional dimension, with a medium effect size [d=0.65, 95% CI (0.29-1.02), z = 3.52, p =0.0004, I
    Conclusion: HRQoL is generally good in β-TM transplanted patients and may significantly contribute in deciding whether or not to transplant a β-TM patient treated with conventional therapy.
    Language English
    Publishing date 2023-12-10
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 2559748-6
    ISSN 1745-0179
    ISSN 1745-0179
    DOI 10.2174/17450179-v17-e211208-2021-HT2-1910-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Could ruxolitinib be effective in patients with COVID-19 infection at risk of acute respiratory distress syndrome (ARDS)?

    Caocci, Giovanni / La Nasa, Giorgio

    Annals of hematology

    2020  Volume 99, Issue 7, Page(s) 1675–1676

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/diagnosis ; Coronavirus Infections/drug therapy ; Humans ; Janus Kinases/antagonists & inhibitors ; Nitriles ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/drug therapy ; Pyrazoles/pharmacology ; Pyrazoles/therapeutic use ; Pyrimidines ; Respiratory Distress Syndrome/diagnosis ; Respiratory Distress Syndrome/drug therapy ; Respiratory Distress Syndrome/etiology ; Risk Factors ; SARS-CoV-2 ; Treatment Outcome
    Chemical Substances Nitriles ; Pyrazoles ; Pyrimidines ; ruxolitinib (82S8X8XX8H) ; Janus Kinases (EC 2.7.10.2)
    Keywords covid19
    Language English
    Publishing date 2020-05-14
    Publishing country Germany
    Document type Letter
    ZDB-ID 1064950-5
    ISSN 1432-0584 ; 0939-5555 ; 0945-8077
    ISSN (online) 1432-0584
    ISSN 0939-5555 ; 0945-8077
    DOI 10.1007/s00277-020-04067-6
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    In stock of ZB MED Cologne/Königswinter

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  5. Article: Conditioning Regimens in Patients with β-Thalassemia Who Underwent Hematopoietic Stem Cell Transplantation: A Scoping Review.

    Mulas, Olga / Mola, Brunella / Caocci, Giovanni / La Nasa, Giorgio

    Journal of clinical medicine

    2022  Volume 11, Issue 4

    Abstract: The success of transplant procedures in patients with beta-thalassemia major (β-thalassemia) goes hand-in-hand with improvements in disease knowledge, better supportive care, discoveries in immunogenetics, increase in stem cell sources, and enhancement ... ...

    Abstract The success of transplant procedures in patients with beta-thalassemia major (β-thalassemia) goes hand-in-hand with improvements in disease knowledge, better supportive care, discoveries in immunogenetics, increase in stem cell sources, and enhancement of conditioning regimens. The aim of this scoping review was to report the evolution of conditioning regimes for β-thalassemia hematopoietic stem cell transplantation. We performed a systematic search for all relevant articles published before July 2021, using the following Medical Subject Headings: "bone marrow transplantation", "stem cell transplantation", "allogeneic", "thalassemia", "β-thalassemia", and "thalassemia major". The final analysis included 52 studies, published between 1988 and 2021, out of 3877 records. The most common conditioning regimen was a combination of busulfan and cyclophosphamide, with successive dose adjustments or remodulation based on patient characteristics. Pre-transplant treatments, reductions in cyclophosphamide dosage, or the adoption of novel agents such as treosulphan all improved overall survival and thalassemia-free survival in transplant-related mortality high-risk patients. Conditioning regimes were modulated for those without a suitable fully matched sibling or unrelated donor, with encouraging results. Hematopoietic stem cell transplantation with haploidentical donors is currently available to virtually all patients with β-thalassemia. However, disparities in outcome are still present around the world. In developing and limited-resource countries, where most diagnoses are focused, transplants are not always available. Therefore, more efforts are needed to close this treatment gap.
    Language English
    Publishing date 2022-02-09
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11040907
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  6. Article ; Online: Defibrotide Has a Role in COVID-19 Therapy.

    Macciò, Antonio / La Nasa, Giorgio / Oppi, Sara / Madeddu, Clelia

    Chest

    2022  Volume 162, Issue 2, Page(s) 271–273

    MeSH term(s) COVID-19 ; Fibrinolytic Agents/therapeutic use ; Humans ; Polydeoxyribonucleotides
    Chemical Substances Fibrinolytic Agents ; Polydeoxyribonucleotides ; defibrotide (438HCF2X0M)
    Language English
    Publishing date 2022-08-06
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2022.04.143
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    In stock of ZB MED Cologne/Königswinter

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  7. Article ; Online: Autoimmune disorders associated with myelodysplastic syndromes: clinical, prognostic and therapeutic implications.

    Fozza, Claudio / Murtas, Andrea / Caocci, Giovanni / La Nasa, Giorgio

    Leukemia research

    2022  Volume 117, Page(s) 106856

    Abstract: Around one third of patients with myelodysplastic syndromes (MDS) suffer from concomitant autoimmune disorders (AD). However the actual burden of such an association appears to be quite heterogeneous in different studies probably due to variable criteria ...

    Abstract Around one third of patients with myelodysplastic syndromes (MDS) suffer from concomitant autoimmune disorders (AD). However the actual burden of such an association appears to be quite heterogeneous in different studies probably due to variable criteria in selecting both MDS patients and subtypes of AD. Moreover, both the prognostic implications and the potential applications of specific therapeutic approaches in this patient subgroup are still at least partially under debate. The present review will try to shed some further light on the clinical association between MDS and AD in order to better delineate its prognostic significance and to suggest potential therapeutic algorithms available for these patients.
    MeSH term(s) Autoimmune Diseases/complications ; Autoimmune Diseases/therapy ; Humans ; Myelodysplastic Syndromes/complications ; Myelodysplastic Syndromes/diagnosis ; Myelodysplastic Syndromes/therapy ; Prognosis
    Language English
    Publishing date 2022-05-02
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 752396-8
    ISSN 1873-5835 ; 0145-2126
    ISSN (online) 1873-5835
    ISSN 0145-2126
    DOI 10.1016/j.leukres.2022.106856
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  9. Article ; Online: Could ruxolitinib be effective in patients with COVID-19 infection at risk of acute respiratory distress syndrome (ARDS)?

    Caocci, Giovanni / La Nasa, Giorgio

    2020  

    Keywords covid19
    Language English
    Publishing country it
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Could ruxolitinib be effective in patients with COVID-19 infection at risk of acute respiratory distress syndrome (ARDS)?

    Caocci, Giovanni / La Nasa, Giorgio

    Annals of Hematology

    2020  Volume 99, Issue 7, Page(s) 1675–1676

    Keywords Hematology ; General Medicine ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    ZDB-ID 1064950-5
    ISSN 1432-0584 ; 0939-5555 ; 0945-8077
    ISSN (online) 1432-0584
    ISSN 0939-5555 ; 0945-8077
    DOI 10.1007/s00277-020-04067-6
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    In stock of ZB MED Cologne/Königswinter

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