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  1. Article ; Online: The first indoor radon mapping in the Campania region, Italy

    Ambrosino, Fabrizio / La Verde, Giuseppe / Sabbarese, Carlo / Roca, Vincenzo / D’Onofrio, Antonio / Pugliese, Mariagabriella

    Isotopes in Environmental and Health Studies. 2023 Mar. 04, v. 59, no. 2 p.192-201

    2023  

    Abstract: For the first time, a map of the ²²²Rn gas has been produced in the Campania region, the southern part of Italy, based on the activity concentration measured in indoor environments. This work is part of the radon mitigation policy and complies with the ... ...

    Abstract For the first time, a map of the ²²²Rn gas has been produced in the Campania region, the southern part of Italy, based on the activity concentration measured in indoor environments. This work is part of the radon mitigation policy and complies with the recent Italian Legislative Decree 101/2020, which implements the European Basic Safety Standards, Euratom Directive 59/2013, where Member States must declare areas with elevated levels of indoor radon concentration. The obtained map, divided by Campania municipalities, identifies priority areas with activity concentration values exceeding the reference level of 300 Bq m–³. In addition, an effective statistical analysis of the dataset has been carried out.
    Keywords data collection ; environmental policy ; radon ; statistical analysis ; Italy ; Campania ; indoor air radon ; ionogenic radiation exposure ; LR-115 and CR-39 detectors ; radioecology ; Radon-222 ; radon map ; reference level 300 Bq m–3
    Language English
    Dates of publication 2023-0304
    Size p. 192-201.
    Publishing place Taylor & Francis
    Document type Article ; Online
    ZDB-ID 2100190-X
    ISSN 1477-2639 ; 0021-1915 ; 1025-6016
    ISSN (online) 1477-2639
    ISSN 0021-1915 ; 1025-6016
    DOI 10.1080/10256016.2023.2189249
    Database NAL-Catalogue (AGRICOLA)

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  2. Article ; Online: Role of the mechanical microenvironment on CD-44 expression of breast adenocarcinoma in response to radiotherapy.

    Frascogna, Crescenzo / Mottareale, Rocco / La Verde, Giuseppe / Arrichiello, Cecilia / Muto, Paolo / Netti, Paolo A / Pugliese, Mariagabriella / Panzetta, Valeria

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 391

    Abstract: The biological effects of ionizing radiation are exploited in the clinical practice of radiotherapy to destroy tumour cells while sparing the surrounding normal tissue. While most of the radiotherapy research focused on DNA damage and repair, recently a ... ...

    Abstract The biological effects of ionizing radiation are exploited in the clinical practice of radiotherapy to destroy tumour cells while sparing the surrounding normal tissue. While most of the radiotherapy research focused on DNA damage and repair, recently a great attention is going to cells' interactions with the mechanical microenvironment of both malignant and healthy tissues after exposure. In fact, the stiffness of the extracellular matrix can modify cells' motility and spreading through the modulation of transmembrane proteins and surface receptors' expression, such as CD-44. CD-44 receptor has held much interest also in targeted-therapy due to its affinity with hyaluronic acid, which can be used to functionalize biodegradable nanoparticles loaded with chemotherapy drugs for targeted therapy. We evaluated changes in CD-44 expression in two mammary carcinoma cell lines (MCF10A and MDA-MB-231) after exposure to X-ray (2 or 10 Gy). To explore the role of the mechanical microenvironment, we mimicked tissues' stiffness with polyacrylamide's substrates producing two different elastic modulus values (0.5 and 15 kPa). We measured a dose dependent increase in CD-44 relative expression in tumour cells cultured in a stiffer microenvironment. These findings highlight a crucial connection between the mechanical properties of the cell's surroundings and the post-radiotherapy expression of surface receptors.
    MeSH term(s) Female ; Humans ; Adenocarcinoma/metabolism ; Breast Neoplasms/genetics ; Breast Neoplasms/radiotherapy ; Breast Neoplasms/metabolism ; Elastic Modulus ; Extracellular Matrix/metabolism ; MCF-7 Cells ; Tumor Microenvironment ; Hyaluronan Receptors
    Chemical Substances Hyaluronan Receptors
    Language English
    Publishing date 2024-01-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-50473-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The first indoor radon mapping in the Campania region, Italy.

    Ambrosino, Fabrizio / La Verde, Giuseppe / Sabbarese, Carlo / Roca, Vincenzo / D'Onofrio, Antonio / Pugliese, Mariagabriella

    Isotopes in environmental and health studies

    2023  Volume 59, Issue 2, Page(s) 192–201

    Abstract: For the first time, a map of ... ...

    Abstract For the first time, a map of the
    MeSH term(s) Radon/analysis ; Air Pollution, Indoor/analysis ; Radiation Monitoring ; Air Pollutants, Radioactive/analysis ; Italy ; Housing
    Chemical Substances Radon (Q74S4N8N1G) ; Air Pollutants, Radioactive
    Language English
    Publishing date 2023-03-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2100190-X
    ISSN 1477-2639 ; 0021-1915 ; 1025-6016
    ISSN (online) 1477-2639
    ISSN 0021-1915 ; 1025-6016
    DOI 10.1080/10256016.2023.2189249
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Use of Thermoluminescence Dosimetry for QA in High-Dose-Rate Skin Surface Brachytherapy with Custom-Flap Applicator.

    Manna, Francesco / Pugliese, Mariagabriella / Buonanno, Francesca / Gherardi, Federica / Iannacone, Eva / La Verde, Giuseppe / Muto, Paolo / Arrichiello, Cecilia

    Sensors (Basel, Switzerland)

    2023  Volume 23, Issue 7

    Abstract: Surface brachytherapy (BT) lacks standard quality assurance (QA) protocols. Commercially available treatment planning systems (TPSs) are based on a dose calculation formalism that assumes the patient is made of water, resulting in potential deviations ... ...

    Abstract Surface brachytherapy (BT) lacks standard quality assurance (QA) protocols. Commercially available treatment planning systems (TPSs) are based on a dose calculation formalism that assumes the patient is made of water, resulting in potential deviations between planned and delivered doses. Here, a method for treatment plan verification for skin surface BT is reported. Chips of thermoluminescent dosimeters (TLDs) were used for dose point measurements. High-dose-rate treatments were simulated and delivered through a custom-flap applicator provided with four fixed catheters to guide the Iridium-192 (Ir-192) source by way of a remote afterloading system. A flat water-equivalent phantom was used to simulate patient skin. Elekta TPS Oncentra Brachy was used for planning. TLDs were calibrated to Ir-192 through an indirect method of linear interpolation between calibration factors (CFs) measured for 250 kV X-rays, Cesium-137, and Cobalt-60. Subsequently, plans were designed and delivered to test the reproducibility of the irradiation set-up and to make comparisons between planned and delivered dose. The obtained CF for Ir-192 was (4.96 ± 0.25) μC/Gy. Deviations between measured and TPS calculated doses for multi-catheter treatment configuration ranged from -8.4% to 13.3% with an average of 0.6%. TLDs could be included in clinical practice for QA in skin BT with a customized flap applicator.
    MeSH term(s) Humans ; Brachytherapy/methods ; Reproducibility of Results ; Iridium Radioisotopes/therapeutic use ; Radiotherapy Dosage ; Thermoluminescent Dosimetry ; Water ; Radiometry
    Chemical Substances Iridium-192 ; Iridium Radioisotopes ; Water (059QF0KO0R)
    Language English
    Publishing date 2023-03-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s23073592
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Cytoskeleton Response to Ionizing Radiation: A Brief Review on Adhesion and Migration Effects.

    La Verde, Giuseppe / Artiola, Valeria / Panzetta, Valeria / Pugliese, Mariagabriella / Netti, Paolo A / Fusco, Sabato

    Biomedicines

    2021  Volume 9, Issue 9

    Abstract: The cytoskeleton is involved in several biological processes, including adhesion, motility, and intracellular transport. Alterations in the cytoskeletal components (actin filaments, intermediate filaments, and microtubules) are strictly correlated to ... ...

    Abstract The cytoskeleton is involved in several biological processes, including adhesion, motility, and intracellular transport. Alterations in the cytoskeletal components (actin filaments, intermediate filaments, and microtubules) are strictly correlated to several diseases, such as cancer. Furthermore, alterations in the cytoskeletal structure can lead to anomalies in cells' properties and increase their invasiveness. This review aims to analyse several studies which have examined the alteration of the cell cytoskeleton induced by ionizing radiations. In particular, the radiation effects on the actin cytoskeleton, cell adhesion, and migration have been considered to gain a deeper knowledge of the biophysical properties of the cell. In fact, the results found in the analysed works can not only aid in developing new diagnostic tools but also improve the current cancer treatments.
    Language English
    Publishing date 2021-08-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines9091102
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: COVID-19 and the Additional Radiological Risk during the Lockdown Period in the Province of Naples City (South Italy).

    La Verde, Giuseppe / Artiola, Valeria / La Commara, Marco / D'Avino, Vittoria / Angrisani, Leopoldo / Sabatino, Giuseppe / Pugliese, Mariagabriella

    Life (Basel, Switzerland)

    2022  Volume 12, Issue 2

    Abstract: The lockdown restrictions, as a first solution to contain the spread of the COVID-19 pandemic, have affected everyone's life and habits, including the time spent at home. The latter factor has drawn attention to indoor air quality and the impact on human ...

    Abstract The lockdown restrictions, as a first solution to contain the spread of the COVID-19 pandemic, have affected everyone's life and habits, including the time spent at home. The latter factor has drawn attention to indoor air quality and the impact on human health, particularly for chemical pollutants. This study investigated how the increasing time indoor influenced exposure to natural radioactive substances, such as radon gas. To calculate the radiological risk, we considered the most consolidated indices used for radiation protection: annual effective dose, excess lifetime cancer risk, and the lung cancer case. Furthermore, two different exposure times were considered: pre-lockdown and post-lockdown. The lockdown increased the indoor exposure time by 4% and, consequently, the radiological risk factors by 9%. Furthermore, the reference value of 300 Bq/m
    Language English
    Publishing date 2022-02-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life12020246
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Characterization of Thermoluminescent Dosimeters for Neutron Dosimetry at High Altitudes.

    D'Avino, Vittoria / Ambrosino, Fabrizio / Bedogni, Roberto / Campoy, Abner Ivan C / La Verde, Giuseppe / Vernetto, Silvia / Vigorito, Carlo Francesco / Pugliese, Mariagabriella

    Sensors (Basel, Switzerland)

    2022  Volume 22, Issue 15

    Abstract: Neutrons constitute a significant component of the secondary cosmic rays and are one of the most important contributors to natural cosmic ray radiation background dose. The study of the cosmic ray neutrons' contribution to the dose equivalent received by ...

    Abstract Neutrons constitute a significant component of the secondary cosmic rays and are one of the most important contributors to natural cosmic ray radiation background dose. The study of the cosmic ray neutrons' contribution to the dose equivalent received by humans is an interesting and challenging task for the scientific community. In addition, international regulations demand assessing the biological risk due to radiation exposure for both workers and the general population. Because the dose rate due to cosmic radiation increases significantly with altitude, the objective of this work was to characterize the thermoluminescent dosimeter (TLDs) from the perspective of exposing them at high altitudes for longtime neutron dose monitoring. The pair of TLD-700 and TLD-600 is amply used to obtain the information on gamma and neutron dose in mixed neutron-gamma fields due to the present difference in 6Li isotope concentration. A thermoluminescence dosimeter system based on pair of TLD-600/700 was characterized to enable it for neutron dosimetry in the thermal energy range. The system was calibrated in terms of neutron ambient dose equivalent in an experimental setup using a 241Am-B radionuclide neutron source coated by a moderator material, polyethylene, creating a thermalized neutron field. Afterward, the pair of TLD-600/700 was exposed at the CERN-EU High-Energy Reference Field (CERF) facility in Geneva, which delivers a neutron field with a spectrum similar to that of secondary cosmic rays. The dosimetric system provided a dose value comparable with the calculated one demonstrating a good performance for neutron dosimetry.
    MeSH term(s) Altitude ; Americium ; Humans ; Neutrons ; Radiation Dosage ; Radiation Dosimeters ; Thermoluminescent Dosimetry
    Chemical Substances Americium-241 (SK9YL6NK5M) ; Americium (VW92PHU2UY)
    Language English
    Publishing date 2022-07-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s22155721
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Measurement of Natural Radionuclides in Drinking Water and Risk Assessment in a Volcanic Region of Italy, Campania

    La Verde, Giuseppe / Artiola, Valeria / D’Avino, Vittoria / La Commara, Marco / Panico, Marianna / Polichetti, Salvatore / Pugliese, Mariagabriella

    Water. 2021 Nov. 18, v. 13, no. 22

    2021  

    Abstract: The physical–chemical properties of water are closely linked to the geological nature of the site where they are located. This aspect becomes even more interesting when analyzing the natural radionuclides in the drinking water of a volcanic territory ... ...

    Abstract The physical–chemical properties of water are closely linked to the geological nature of the site where they are located. This aspect becomes even more interesting when analyzing the natural radionuclides in the drinking water of a volcanic territory such as Campania in southern Italy. This study concerned the measurement of activity concentration of gross alpha and beta, radon, and tritium to evaluate their biological impact. The measurements were carried out using alpha spectrometry for alpha emitters, proportional counter for beta emitters, the electret system for radon in water, and finally liquid scintillation for the measurement of tritium concentration. The biological impact was assessed considering the indicative dose, if applicable, and the effective annual dose of radon. Although the results show that the values are below international and national references, the radiological characterization of drinking water is of fundamental importance to optimize the radiation protection of the population.
    Keywords liquids ; radon ; risk assessment ; spectroscopy ; tritium ; water ; Italy
    Language English
    Dates of publication 2021-1118
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2521238-2
    ISSN 2073-4441
    ISSN 2073-4441
    DOI 10.3390/w13223271
    Database NAL-Catalogue (AGRICOLA)

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  9. Article: A Preliminary Study of the Characteristics of Radon Data from Indoor Environments and Building Materials in the Campania Region Using PCA and K-Means Statistical Analyses

    Sabbarese, Carlo / Feola, Maria Luisa / Ambrosino, Fabrizio / Roca, Vincenzo / D’Onofrio, Antonio / La Verde, Giuseppe / D’Avino, Vittoria / Pugliese, Mariagabriella / Festa, Vittorio

    Environments. 2022 June 30, v. 9, no. 7

    2022  

    Abstract: For a healthy indoor environment, it is important to understand which materials and factors favor the generation of high levels of indoor radon. A preliminary multivariate statistical analysis was carried out on two datasets concerning indoor radon and ... ...

    Abstract For a healthy indoor environment, it is important to understand which materials and factors favor the generation of high levels of indoor radon. A preliminary multivariate statistical analysis was carried out on two datasets concerning indoor radon and building materials in the Campania Region using Principal Component Analysis (PCA) and the k-means partitional analysis technique. A total of 13 parameters related to building materials were used. The results show the greater contribution of building materials of volcanic origin to the concentration of indoor radon and thoron activity and the different influence of the parameters of the 31 materials analyzed. The same analyses applied to the indoor radon values of 694 rooms in the Campania Region were equally effective in assessing the structural characteristics of indoor environments that most influence indoor radon levels. The study provided an effective assessment of the influence on radon activity of several environmental parameters, which are often not adequately considered.
    Keywords data collection ; multivariate analysis ; principal component analysis ; radon ; Italy
    Language English
    Dates of publication 2022-0630
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2777960-9
    ISSN 2076-3298
    ISSN 2076-3298
    DOI 10.3390/environments9070082
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: Pietra Leccese and Other Natural Stones in Puglia Region: A New Category of Building Materials for Radiation Protection?

    La Verde, Giuseppe / Raulo, Adelaide / D'Avino, Vittoria / Paternoster, Giovanni / Roca, Vincenzo / La Commara, Marco / Pugliese, Mariagabriella

    International journal of environmental research and public health

    2021  Volume 18, Issue 21

    Abstract: In this paper, an in-depth and systematic study of the radiological characterization of three types of Puglia region natural limestones ( ...

    Abstract In this paper, an in-depth and systematic study of the radiological characterization of three types of Puglia region natural limestones (
    MeSH term(s) Background Radiation ; Construction Materials ; Potassium Radioisotopes/analysis ; Radiation Dosage ; Radiation Monitoring ; Radiation Protection ; Radium/analysis ; Spectrometry, Gamma ; Thorium/analysis
    Chemical Substances Potassium Radioisotopes ; Thorium (60YU5MIG9W) ; Radium (W90AYD6R3Q)
    Language English
    Publishing date 2021-10-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph182111213
    Database MEDical Literature Analysis and Retrieval System OnLINE

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