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  1. Article ; Online: Development and validation of the first HBV qRT-PCR assay in the Mediterranean area targeting the X region.

    Madihi, Salma / Laassili, Chaimaa / Boukaira, Samia / Baha, Warda / Khyatti, Meriem / Zyad, Abdelmajid / Ben Mkaddem, Sanae / Benani, Abdelouaheb

    Journal of virological methods

    2024  Volume 326, Page(s) 114913

    Abstract: Hepatitis B virus (HBV) infection is a global public health burden and affects approximatively 300 million people around the world. Since, HBV population is represented with genetic diversity, having different viral effects. Development of a new ... ...

    Abstract Hepatitis B virus (HBV) infection is a global public health burden and affects approximatively 300 million people around the world. Since, HBV population is represented with genetic diversity, having different viral effects. Development of a new prognosis method play a key role on the efficiency of the different treatment. The HBx protein of HBV has a potential role in Hepatocellular Carcinoma (HCC), which makes it a valuable target for HCC prognosis. In this context, the first quantitative real-time PCR (qRT-PCR) assay in the Mediterranean area was developed and validated. Specific primers and probes of a conserved X region across all HBV genotypes were designed and the qRT-PCR was performed with the TaqPath 1-Step Multiplex Master Mix on 441 Moroccan plasma samples in Pasteur Institute of Morocco. The assay demonstrated a linear quantification range of 10
    MeSH term(s) Humans ; Hepatitis B virus/genetics ; Real-Time Polymerase Chain Reaction ; Carcinoma, Hepatocellular ; DNA, Viral/genetics ; Liver Neoplasms ; Hepatitis B/diagnosis ; Viral Load/methods ; Sensitivity and Specificity
    Chemical Substances DNA, Viral
    Language English
    Publishing date 2024-03-06
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 8013-5
    ISSN 1879-0984 ; 0166-0934
    ISSN (online) 1879-0984
    ISSN 0166-0934
    DOI 10.1016/j.jviromet.2024.114913
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Fc receptors act as innate immune receptors during infection?

    Laassili, Chaimaa / Ben El Hend, Fatiha / Benzidane, Riad / Oumeslakht, Loubna / Aziz, Abdel-Ilah / El Fatimy, Rachid / Bensussan, Armand / Ben Mkaddem, Sanae

    Frontiers in immunology

    2023  Volume 14, Page(s) 1188497

    Abstract: Innate immunity constitutes the first nonspecific immunological line of defense against infection. In this response, a variety of mechanisms are activated: the complement system, phagocytosis, and the inflammatory response. Then, adaptive immunity is ... ...

    Abstract Innate immunity constitutes the first nonspecific immunological line of defense against infection. In this response, a variety of mechanisms are activated: the complement system, phagocytosis, and the inflammatory response. Then, adaptive immunity is activated. Major opsonization mediators during infections are immunoglobulins (Igs), the function of which is mediated through Fc receptors (FcRs). However, in addition to their role in adaptive immunity, FcRs have been shown to play a role in innate immunity by interacting directly with bacteria in the absence of their natural ligands (Igs). Additionally, it has been hypothesized that during the early phase of bacterial infection, FcRs play a protective role via innate immune functions mediated through direct recognition of bacteria, and as the infection progresses to later phases, FcRs exhibit their established function as receptors in adaptive immunity. This review provides detailed insight into the potential role of FcRs as innate immune mediators of the host defense against bacterial infection independent of opsonins.
    MeSH term(s) Receptors, Fc ; Immunity, Innate ; Phagocytosis ; Immunoglobulins ; Complement System Proteins
    Chemical Substances Receptors, Fc ; Immunoglobulins ; Complement System Proteins (9007-36-7)
    Language English
    Publishing date 2023-07-26
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1188497
    Database MEDical Literature Analysis and Retrieval System OnLINE

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