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  1. Article ; Online: Characterization of the novel HLA-C*03:552 allele by sequencing-based typing.

    Elsermans, Vincent / Visentin, Jonathan / Top, Isabelle / Pajot, Thibault / Labalette, Myriam

    HLA

    2023  Volume 102, Issue 2, Page(s) 237–238

    Abstract: HLA-C*03:552 differs from HLA-C*03:04:01:01 by one nucleotide substitution in codon 72 in exon 2. ...

    Abstract HLA-C*03:552 differs from HLA-C*03:04:01:01 by one nucleotide substitution in codon 72 in exon 2.
    MeSH term(s) Humans ; HLA-C Antigens/genetics ; Alleles ; Histocompatibility Testing ; Codon ; Genes, MHC Class I
    Chemical Substances HLA-C Antigens ; Codon
    Language English
    Publishing date 2023-04-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2845111-9
    ISSN 2059-2310 ; 2059-2302
    ISSN (online) 2059-2310
    ISSN 2059-2302
    DOI 10.1111/tan.15056
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    Zs.A 661: Show issues Location:
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  2. Article ; Online: Characterization of the novel HLA-B*40:539 allele by sequencing-based typing.

    Elsermans, Vincent / Visentin, Jonathan / Top, Isabelle / Pajot, Thibault / Labalette, Myriam

    HLA

    2023  Volume 103, Issue 1, Page(s) e15246

    Abstract: HLA-B*40:539 differs from HLA-B*40:01:01 by one nucleotide substitution in codon 46 in exon 2. ...

    Abstract HLA-B*40:539 differs from HLA-B*40:01:01 by one nucleotide substitution in codon 46 in exon 2.
    MeSH term(s) Humans ; Alleles ; Histocompatibility Testing ; Codon ; Genes, MHC Class I ; HLA-B Antigens/genetics ; Sequence Analysis, DNA
    Chemical Substances Codon ; HLA-B Antigens
    Language English
    Publishing date 2023-10-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2845111-9
    ISSN 2059-2310 ; 2059-2302
    ISSN (online) 2059-2310
    ISSN 2059-2302
    DOI 10.1111/tan.15246
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    Zs.A 661: Show issues Location:
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  3. Article ; Online: Characterization of the novel HLA-C*06:176:02 allele by sequencing-based typing.

    Elsermans, Vincent / Visentin, Jonathan / Cargou, Marine / Top, Isabelle / Labalette, Myriam

    HLA

    2023  Volume 103, Issue 1, Page(s) e15253

    Abstract: HLA-C*06:176:02 differs from HLA-C*06:176:01 by two nucleotide substitutions in codons 236 and 237 in exon 4. ...

    Abstract HLA-C*06:176:02 differs from HLA-C*06:176:01 by two nucleotide substitutions in codons 236 and 237 in exon 4.
    MeSH term(s) Humans ; HLA-C Antigens/genetics ; Alleles ; Histocompatibility Testing ; Genes, MHC Class I ; Exons/genetics ; Sequence Analysis, DNA
    Chemical Substances HLA-C Antigens
    Language English
    Publishing date 2023-10-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2845111-9
    ISSN 2059-2310 ; 2059-2302
    ISSN (online) 2059-2310
    ISSN 2059-2302
    DOI 10.1111/tan.15253
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  4. Article ; Online: Characterization of the novel HLA-A*30:02:28 allele by sequencing-based typing.

    Elsermans, Vincent / Visentin, Jonathan / Top, Isabelle / Varlet, Pauline / Labalette, Myriam

    HLA

    2021  Volume 99, Issue 4, Page(s) 377–378

    Abstract: HLA-A*30:02:28 differs from HLA-A*30:02:01:01 by one nucleotide substitution in codon 47 in exon 2. ...

    Abstract HLA-A*30:02:28 differs from HLA-A*30:02:01:01 by one nucleotide substitution in codon 47 in exon 2.
    MeSH term(s) Alleles ; Codon ; Exons/genetics ; HLA-A Antigens/genetics ; Histocompatibility Testing ; Humans ; Sequence Analysis, DNA
    Chemical Substances Codon ; HLA-A Antigens
    Language English
    Publishing date 2021-12-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2845111-9
    ISSN 2059-2310 ; 2059-2302
    ISSN (online) 2059-2310
    ISSN 2059-2302
    DOI 10.1111/tan.14513
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    Zs.A 661: Show issues Location:
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  5. Article ; Online: Characterization of the novel HLA-A*11:376 allele by sequencing-based typing.

    Elsermans, Vincent / Visentin, Jonathan / Top, Isabelle / Varlet, Pauline / Labalette, Myriam

    HLA

    2021  Volume 97, Issue 5, Page(s) 447–448

    Abstract: HLA-A*11:376 differs from HLA-A*11:01:01:01 by one nucleotide substitution in codon 168 in exon 3. ...

    Abstract HLA-A*11:376 differs from HLA-A*11:01:01:01 by one nucleotide substitution in codon 168 in exon 3.
    MeSH term(s) Alleles ; Codon ; Exons/genetics ; HLA-A Antigens/genetics ; Histocompatibility Testing ; Humans ; Mutation, Missense ; Sequence Analysis, DNA
    Chemical Substances Codon ; HLA-A Antigens
    Language English
    Publishing date 2021-01-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2845111-9
    ISSN 2059-2310 ; 2059-2302
    ISSN (online) 2059-2310
    ISSN 2059-2302
    DOI 10.1111/tan.14174
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  6. Article ; Online: Characterization of the novel HLA-DQB1*06:374 allele by sequencing-based typing.

    Elsermans, Vincent / Visentin, Jonathan / Top, Isabelle / Varlet, Pauline / Labalette, Myriam

    HLA

    2021  Volume 97, Issue 4, Page(s) 382–383

    Abstract: HLA-DQB1*06:374 differs from HLA-DQB1*06:02:01:01 by one nucleotide substitution in codon 62 in exon 2. ...

    Abstract HLA-DQB1*06:374 differs from HLA-DQB1*06:02:01:01 by one nucleotide substitution in codon 62 in exon 2.
    MeSH term(s) Alleles ; Codon ; Exons/genetics ; HLA-DQ beta-Chains/genetics ; Humans
    Chemical Substances Codon ; HLA-DQ beta-Chains ; HLA-DQB1 antigen
    Language English
    Publishing date 2021-01-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2845111-9
    ISSN 2059-2310 ; 2059-2302
    ISSN (online) 2059-2310
    ISSN 2059-2302
    DOI 10.1111/tan.14172
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  7. Article ; Online: Characterization of the novel HLA-A*02:939 allele by sequencing-based typing.

    Elsermans, Vincent / Visentin, Jonathan / Top, Isabelle / Varlet, Pauline / Labalette, Myriam

    HLA

    2021  Volume 97, Issue 5, Page(s) 436–437

    Abstract: HLA-A*02:939 differs from HLA-A*02:01:01:01 by one nucleotide substitution in codon 222 in exon 4. ...

    Abstract HLA-A*02:939 differs from HLA-A*02:01:01:01 by one nucleotide substitution in codon 222 in exon 4.
    MeSH term(s) Alleles ; Codon ; Exons/genetics ; HLA-A Antigens/genetics ; Histocompatibility Testing ; Humans ; Mutation, Missense ; Sequence Analysis, DNA
    Chemical Substances Codon ; HLA-A Antigens
    Language English
    Publishing date 2021-01-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2845111-9
    ISSN 2059-2310 ; 2059-2302
    ISSN (online) 2059-2310
    ISSN 2059-2302
    DOI 10.1111/tan.14173
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  8. Article ; Online: Assessing Sustained B-Cell Depletion and Disease Activity in a French Multiple Sclerosis Cohort Treated by Long-Term IV Anti-CD20 Antibody Therapy.

    Freeman, Sean A / Lemarchant, Bruno / Alberto, Tifanie / Boucher, Julie / Outteryck, Olivier / Labalette, Myriam / Rogeau, Stéphanie / Dubucquoi, Sylvain / Zéphir, Hélène

    Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

    2023  Volume 20, Issue 6, Page(s) 1707–1722

    Abstract: Few studies have investigated sustained B-cell depletion after long-term intravenous (IV) anti-CD20 B-cell depleting therapy (BCDT) in multiple sclerosis (MS) with respect to strict and/or minimal disease activity. The main objective of this study was to ...

    Abstract Few studies have investigated sustained B-cell depletion after long-term intravenous (IV) anti-CD20 B-cell depleting therapy (BCDT) in multiple sclerosis (MS) with respect to strict and/or minimal disease activity. The main objective of this study was to investigate how sustained B-cell depletion after BCDT influences clinical and radiological stability as defined by "no evidence of disease activity" (NEDA-3) and "minimal evidence of disease activity" (MEDA) status in MS patients at 12 and 18 months. Furthermore, we assessed the frequency of serious adverse events (SAE), and the influence of prior lymphocytopenia-inducing treatment (LIT) on lymphocyte subset counts and gammaglobulins in MS patients receiving long-term BCDT. We performed a retrospective, prospectively collected, study in a cohort of 192 MS patients of all clinical phenotypes treated by BCDT between January 2014 and September 2021. Overall, 84.2% and 96.9% of patients attained NEDA-3 and MEDA status at 18 months, respectively. Sustained CD19
    MeSH term(s) Humans ; Rituximab/therapeutic use ; Multiple Sclerosis/drug therapy ; Retrospective Studies ; Antibodies, Monoclonal, Murine-Derived ; Lymphocyte Depletion/methods ; Immunoglobulin G ; Lymphopenia
    Chemical Substances Rituximab (4F4X42SYQ6) ; Antibodies, Monoclonal, Murine-Derived ; Immunoglobulin G
    Language English
    Publishing date 2023-10-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2316693-9
    ISSN 1878-7479 ; 1933-7213
    ISSN (online) 1878-7479
    ISSN 1933-7213
    DOI 10.1007/s13311-023-01446-5
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  9. Article ; Online: Studying antigen-specific T cells through a streamlined, whole blood-based extracellular approach.

    Trauet, Jacques / Bourgoin, Penelope / Schuldt, Jana / Lefèvre, Guillaume / Labalette, Myriam / Busnel, Jean-Marc / Demaret, Julie

    Cytometry. Part A : the journal of the International Society for Analytical Cytology

    2023  Volume 105, Issue 4, Page(s) 288–296

    Abstract: Techniques currently used for the study of antigen-specific T-cell responses are either poorly informative or require a heavy workload. Consequently, many perspectives associated with the broader study of such approaches remain mostly unexplored in ... ...

    Abstract Techniques currently used for the study of antigen-specific T-cell responses are either poorly informative or require a heavy workload. Consequently, many perspectives associated with the broader study of such approaches remain mostly unexplored in translational research. However, these could benefit many fields including but not limited to infectious diseases, oncology, and vaccination. Herein, the main objective of this work was to develop a standardized flow cytometry-based approach that would combine ease of use together with a relevant study of antigen-specific T-cell responses so that they could be more often included in clinical research. To this extent, a streamlined approach relying on 1/ the use of whole blood instead of peripheral blood mononuclear cells and 2/ solely based on the expression of extracellular activation-induced markers (AIMs), called whole blood AIM (WAIM), was developed and further compared to more conventional techniques such as enzyme-linked immunospot (ELISpot) and flow cytometry-based intracellular cytokine staining (ICS). Based on a cohort of 20 individuals receiving the COVID-19 mRNA vaccine and focusing on SARS-CoV-2 and cytomegalovirus (CMV)-derived antigen T-cell-specific responses, a significant level of correlation between the three techniques was found. Based on the use of whole blood and on the expression of extracellular activation-induced markers (CD154, CD137, and CD107a), the WAIM technique appears to be very simple to implement and yet allows interesting patient stratification capabilities as the chosen combination of extracellular markers exhibited higher orthogonality than cytokines that are commonly considered in ICS (IFN-γ, TNF-α, and IL-2).
    MeSH term(s) Humans ; T-Lymphocytes ; COVID-19 Vaccines ; Interferon-gamma/metabolism ; Leukocytes, Mononuclear/metabolism ; Antigens ; Cytokines
    Chemical Substances COVID-19 Vaccines ; Interferon-gamma (82115-62-6) ; Antigens ; Cytokines
    Language English
    Publishing date 2023-12-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2099868-5
    ISSN 1552-4930 ; 0196-4763 ; 1552-4922
    ISSN (online) 1552-4930
    ISSN 0196-4763 ; 1552-4922
    DOI 10.1002/cyto.a.24818
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    Zs.A 1688: Show issues Location:
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  10. Article ; Online: Targeting CCR4 with mogamulizumab in refractory CD3-CD4

    Ledoult, Emmanuel / Groh, Matthieu / Meresse, Bertrand / Dubois, Romain / Trauet, Jacques / Toussaint, Elise / Delbeke, Marie / Hachulla, Eric / Terriou, Louis / De Masson, Adèle / Vasseur, Michele / Labalette, Myriam / Launay, David / Kahn, Jean-Emmanuel / Lefevre, Guillaume

    Haematologica

    2024  

    Abstract: Not available. ...

    Abstract Not available.
    Language English
    Publishing date 2024-02-08
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2333-4
    ISSN 1592-8721 ; 0017-6567 ; 0390-6078
    ISSN (online) 1592-8721
    ISSN 0017-6567 ; 0390-6078
    DOI 10.3324/haematol.2023.284429
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