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Article ; Online: Network Analysis as an Emerging Method in Adversity Research - a Reflection on Pollman et al. (2022).

Lacey, Rebecca

Research on child and adolescent psychopathology

2023 Volume 51, Issue 12, Page(s) 1785–1787

Abstract: In this issue, Pollmann and colleagues (2022) apply network analyses to childhood and adolescent adversity data. They use the rich, longitudinal data from the Avon Longitudinal Study of Parents and Children. By applying network analyses, they draw-out ... ...

Abstract	In this issue, Pollmann and colleagues (2022) apply network analyses to childhood and adolescent adversity data. They use the rich, longitudinal data from the Avon Longitudinal Study of Parents and Children. By applying network analyses, they draw-out clusters of adversities and the strength of relationships between these clusters and individual adversities with later mental health, substance use and wellbeing. The authors additionally look at adversity clusters in two developmental stages - childhood and adolescence. This commentary discusses how adversity clustering has typically been captured in studies in the past, what network analyses might offer this area of research, and the contribution of the study by Pollmann et al. (2022). The commentary concludes with some reflections and recommendations for the future of adversity clustering research.
MeSH term(s)	Adolescent ; Child ; Humans ; Longitudinal Studies ; Cluster Analysis ; Mental Health ; Parents
Language	English
Publishing date	2023-04-10
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	3041907-4
ISSN	2730-7174 ; 2730-7166
ISSN (online)	2730-7174
ISSN	2730-7166
DOI	10.1007/s10802-023-01063-y
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Article: Can You Go the Distance: Collagenase

Pflibsen, Lacey R / Jain, Nirbhay S / Benhaim, Prosper

Plastic and reconstructive surgery. Global open

2023 Volume 11, Issue 9, Page(s) e5239

Abstract: ... ...

Abstract	Collagenase
Language	English
Publishing date	2023-09-07
Publishing country	United States
Document type	Case Reports
ZDB-ID	2851682-5
ISSN	2169-7574 ; 2169-7574
ISSN (online)	2169-7574
ISSN	2169-7574
DOI	10.1097/GOX.0000000000005239
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Article ; Online: Intergenerational transmission of child maltreatment.

Gilbert, Ruth / Lacey, Rebecca

The Lancet. Public health

2021 Volume 6, Issue 7, Page(s) e435–e436

MeSH term(s)	Child ; Child Abuse ; Humans ; Parenting
Language	English
Publishing date	2021-04-30
Publishing country	England
Document type	Journal Article ; Comment
ISSN	2468-2667
ISSN (online)	2468-2667
DOI	10.1016/S2468-2667(21)00076-1
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Article ; Online: Do Health and Well-Being Change Around the Transition to Informal Caring in Early Adulthood? A Longitudinal Comparison Between the United Kingdom and Germany.

Xue, Baowen / King, Markus / Deindl, Christian / Lacey, Rebecca / Di Gessa, Giorgio / McMunn, Anne

The Journal of adolescent health : official publication of the Society for Adolescent Medicine

2024 Volume 74, Issue 5, Page(s) 885–891

Abstract: Purpose: Providing care in early adulthood may have long-term consequences, given the importance of this life stage for life-course transitions. This study aimed to analyze how the transition into caring during young adulthood (17-29 years old) ... ...

Abstract	Purpose: Providing care in early adulthood may have long-term consequences, given the importance of this life stage for life-course transitions. This study aimed to analyze how the transition into caring during young adulthood (17-29 years old) influenced health and life satisfaction in the United Kingdom and Germany. Methods: Datasets were from 10 annual waves of the UK Household Longitudinal Study and the German Socioeconomic Panel between the years 2009-2018. We used propensity score matching to match young adult carers (YACs) to similar noncarers to address the endogeneity of unpaid care provision. Then we applied piecewise growth curves to observe changes in self-rated health (United Kingdom N = 2,851; Germany N = 454) and life satisfaction (United Kingdom N = 2,263; Germany N = 449) between YAC and noncarers before, during, and after the onset of care. We assessed carer status, weekly hours spent on care, and duration of care. Results: In the United Kingdom, life satisfaction decreased and the probability of reporting poor health increased after becoming a YAC, particularly for those who reported caring for more weekly hours. However, no such differences were found between YAC and noncarers in Germany. Discussion: The onset and intensity of caring responsibilities during early adulthood influenced health and life satisfaction in the United Kingdom but not in Germany. One possible interpretation for these differences may be attributed to the different welfare contexts in which YACs are providing informal care. Our results highlight the importance of identifying and supporting the needs of young adults who are providing informal care while making key life-course transitions.
MeSH term(s)	Young Adult ; Humans ; Adult ; Adolescent ; Longitudinal Studies ; United Kingdom ; Patient Care ; Germany ; Family Characteristics ; Caregivers
Language	English
Publishing date	2024-01-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	1063374-1
ISSN	1879-1972 ; 1054-139X
ISSN (online)	1879-1972
ISSN	1054-139X
DOI	10.1016/j.jadohealth.2023.11.398
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Article ; Online: 'On paper, you're normal': narratives of unseen health needs among women who have had children removed from their care.

Grant, Claire / Powell, Claire / Philip, Georgia / Blackburn, Ruth / Lacey, Rebecca / Woodman, Jenny

Journal of public health (Oxford, England)

2024 Volume 45, Issue 4, Page(s) 863–869

Abstract: Background: Mothers who have children removed from their care often have complex needs. These women have poor health outcomes and are dying earlier than their peers from preventable and amenable causes. Yet there is little known about how health care ... ...

Abstract	Background: Mothers who have children removed from their care often have complex needs. These women have poor health outcomes and are dying earlier than their peers from preventable and amenable causes. Yet there is little known about how health care services might mitigate these risks. This study aimed to listen to the voices of women who had children removed from their care to understand their experiences of health and healthcare. Methods: We used a narrative approach to collect and analyse interview data with six mothers who had experienced child removal in England. Each participant was asked to reflect on their life and main health challenges. Results: Three narrative subplots were developed to consolidate experiences of unmet health need: (i) 'on paper you're normal': narratives of complex need, (ii) 'in my family, everyone had issues': narratives of whole family need and (iii) 'I'm still mummy, no matter where they are': narratives of maternal identity and health. Conclusions: Findings highlight limitations within current systems of support, including a culture of distrust and women falling between the gaps of services. Women's narratives illustrate opportunities for health intervention, especially immediately following child removal.
MeSH term(s)	Female ; Child ; Humans ; Mothers ; Delivery of Health Care ; Qualitative Research ; England
Language	English
Publishing date	2024-04-24
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2142082-8
ISSN	1741-3850 ; 1741-3842
ISSN (online)	1741-3850
ISSN	1741-3842
DOI	10.1093/pubmed/fdad137
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Article ; Online: Assessing trade-offs in avian behaviour using remotely collected data from a webcam.

Wood, Kevin A / Lacey, Rebecca / Rose, Paul E

PloS one

2022 Volume 17, Issue 7, Page(s) e0271257

Abstract: Individual animals engage in many behaviours which are mutually exclusive, and so where individuals increase the duration of time spent on one type of behavioural activity, this must be offset by a corresponding decrease in at least one other type of ... ...

Abstract	Individual animals engage in many behaviours which are mutually exclusive, and so where individuals increase the duration of time spent on one type of behavioural activity, this must be offset by a corresponding decrease in at least one other type of behaviour. To understand the variation observed in animal behaviour, researchers need to know how individuals trade-off these mutually-exclusive behaviours within their time-activity budget. In this study, we used remotely collected behavioural observations made from a live-streaming webcam to investigate trade-offs in the behaviour of two bird species, the mute swan (Cygnus olor) and whooper swan (Cygnus cygnus). For both species, we tested for correlations in the duration of time spent on key mutually exclusive behaviours: aggression, foraging, maintenance, and resting. We detected a negative association between aggression and resting behaviours in both species, indicating that increased aggression is achieved at the expense of resting behaviour. In contrast, there was no apparent trade-off between aggression and foraging, aggression and maintenance, or maintenance and resting. Foraging and resting behaviours were negatively correlated in both species, highlighting a trade-off between these distinct modes of behaviour. A trade-off between foraging and maintenance behaviours was detected for the sedentary mute swans, but not the migratory whooper swans. Our findings show how birds can trade-off their time investments in mutually exclusive behaviours within their time-activity budgets. Moreover, our study demonstrates how remotely-collected data can be used to investigate fundamental questions in behavioural research.
MeSH term(s)	Animals ; Anseriformes ; Birds ; Influenza in Birds
Language	English
Publishing date	2022-07-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0271257
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Article ; Online: Adverse childhood experiences and severity levels of inflammation and depression from childhood to young adulthood: a longitudinal cohort study.

Iob, Eleonora / Lacey, Rebecca / Giunchiglia, Valentina / Steptoe, Andrew

Molecular psychiatry

2022 Volume 27, Issue 4, Page(s) 2255–2263

Abstract: Adverse childhood experiences (ACEs) are associated with depression and systemic inflammation in adults. However, limited longitudinal research has tested these relationships in children and young people, and it is unclear whether inflammation is an ... ...

Abstract	Adverse childhood experiences (ACEs) are associated with depression and systemic inflammation in adults. However, limited longitudinal research has tested these relationships in children and young people, and it is unclear whether inflammation is an underlying mechanism through which ACEs influence depression. We examined the longitudinal associations of several ACEs across different early-life periods with longitudinal patterns of early-life inflammation and depression in young adulthood and assessed the mediating role of inflammation. The data came from the Avon Longitudinal Study of Parents and Children (N = 3931). ACEs from the prenatal period through to adolescence were operationalised using cumulative scores, single adversities, and dimensions derived through factor analysis. Inflammation (C-reactive protein) was measured on three occasions (9-18 years) and depressive symptoms were ascertained on four occasions (18-23 years). Latent class growth analysis was employed to delineate group-based trajectories of inflammation and depression. The associations between ACEs and the inflammation/depression trajectories were tested using multinomial logistic regression analysis. Most types of ACEs across all early-life periods were associated with elevated depression trajectories, with larger associations for threat-related adversities compared with other ACEs. Bullying victimisation and sexual abuse in late childhood/adolescence were associated with elevated CRP trajectories, while other ACEs were unrelated to inflammation. Inflammation was also unrelated to depression and did not mediate the associations with ACEs. These results suggest that ACEs are consistently associated with depression, whereas the associations of inflammation with ACEs and depression are weak in young people. Interventions targeting inflammation in this population might not offer protection against depression.
MeSH term(s)	Adolescent ; Adult ; Adverse Childhood Experiences ; Child ; Child Abuse ; Depression/epidemiology ; Humans ; Inflammation ; Longitudinal Studies ; Young Adult
Language	English
Publishing date	2022-03-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1330655-8
ISSN	1476-5578 ; 1359-4184
ISSN (online)	1476-5578
ISSN	1359-4184
DOI	10.1038/s41380-022-01478-x
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Article ; Online: Young Adult Carers in the UK-New Evidence from the UK Household Longitudinal Study.

Di Gessa, Giorgio / Xue, Baowen / Lacey, Rebecca / McMunn, Anne

International journal of environmental research and public health

2022 Volume 19, Issue 21

Abstract: Despite growing interest in young adult carers, little is known about trends in prevalence of caregiving among young adults aged 16-29. Furthermore, few studies have so far investigated demographic, health, and socioeconomic inequalities in the duration ... ...

Abstract	Despite growing interest in young adult carers, little is known about trends in prevalence of caregiving among young adults aged 16-29. Furthermore, few studies have so far investigated demographic, health, and socioeconomic inequalities in the duration of care among young carers as well as demographic differences in caregiving characteristics. Using data from 11 waves of the nationally representative UK Household Longitudinal Study (2009-2021), we first estimated the prevalence of caregiving among 16-29 years-old adults at each wave. Results show that about 9% of those aged 16-29 provided care, and that this prevalence remained stable throughout the 2010s. Then, selecting respondents who participated for three waves of more, we assessed demographic, socioeconomic, and health characteristics associated with duration of care using ordinal regression models. Almost 52% of carers cared at two or more waves. Compared to non-carers, those who cared had more disadvantaged socioeconomic backgrounds, were from ethnic minorities and reported poorer health, particularly if they cared at two or more waves. Finally, focusing on carers, we tested differences by sex, age, and urbanicity in care relationships, intensity, and duration. Overall, women and those aged 25-29 cared for longer hours, for more people, and for more years than men and younger carers respectively. Put together, these findings provide an up-to-date description of young carers in the 2010s in the UK.
MeSH term(s)	Male ; Young Adult ; Humans ; Female ; Adolescent ; Adult ; Longitudinal Studies ; Caregivers ; Family Characteristics ; Research Design ; United Kingdom/epidemiology
Language	English
Publishing date	2022-10-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph192114076
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Article ; Online: Microenvironmental Factors that Shape Bacterial Metabolites in Inflammatory Bowel Disease.

Lopez, Lacey R / Ahn, Ju-Hyun / Alves, Tomaz / Arthur, Janelle C

Frontiers in cellular and infection microbiology

2022 Volume 12, Page(s) 934619

Abstract: Inflammatory bowel disease (IBD) is a significant global health problem that involves chronic intestinal inflammation and can involve severe comorbidities, including intestinal fibrosis and inflammation-associated colorectal cancer (CRC). Disease- ... ...

Abstract	Inflammatory bowel disease (IBD) is a significant global health problem that involves chronic intestinal inflammation and can involve severe comorbidities, including intestinal fibrosis and inflammation-associated colorectal cancer (CRC). Disease-associated alterations to the intestinal microbiota often include fecal enrichment of
MeSH term(s)	Bacteria ; Dysbiosis/microbiology ; Enterobacteriaceae ; Fibrosis ; Gastrointestinal Microbiome ; Humans ; Inflammation/microbiology ; Inflammatory Bowel Diseases/microbiology
Language	English
Publishing date	2022-07-15
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, N.I.H., Extramural
ZDB-ID	2619676-1
ISSN	2235-2988 ; 2235-2988
ISSN (online)	2235-2988
ISSN	2235-2988
DOI	10.3389/fcimb.2022.934619
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Article ; Online: The Effect of Anticoagulation on the Treatment of Dupuytren Contracture with Collagenase.

Noland, Shelley S / Paul, Aaron W / Pflibsen, Lacey R / Rizzo, Marco

Plastic and reconstructive surgery

2022 Volume 149, Issue 5, Page(s) 914e–920e

Abstract: Background: There have been no formal studies of the use of collagenase clostridium histolyticum (Xiaflex; Endo Pharmaceuticals, Malvern, Pa.) in the anticoagulated patient. Previous study on its use excluded patients receiving anticoagulation therapy. ... ...

Abstract	Background: There have been no formal studies of the use of collagenase clostridium histolyticum (Xiaflex; Endo Pharmaceuticals, Malvern, Pa.) in the anticoagulated patient. Previous study on its use excluded patients receiving anticoagulation therapy. This study reviewed the effects of anticoagulation use in patients undergoing collagenase clostridium histolyticum injection and cord rupture to determine safety and efficacy. Methods: The authors retrospectively reviewed patients receiving collagenase clostridium histolyticum injections for Dupuytren contracture between 2010 and 2017. Outcomes included type of anticoagulation, skin tear, tendon rupture, lymphadenopathy, sensory abnormality, hematoma, and bleeding. Results: A total of 388 injections were performed in 197 patients. The average clinical follow-up was 311 days. Fifty-two percent of patients (n = 201) were anticoagulated. The vast majority were taking aspirin (acetylsalicylic acid) (n = 182), followed by warfarin (n = 27), clopidogrel (n = 9), apixaban (n = 8), rivaroxaban (n = 4), and dabigatran (n = 2). There were 42 skin tears, 21 in the anticoagulated group. One tendon rupture occurred in the anticoagulated group (acetylsalicylic acid) and none occurred in the nonanticoagulated group (p = 0.34). No patients experienced sensory abnormalities, a hematoma requiring intervention, or uncontrollable bleeding. Conclusions: Anticoagulation is commonly encountered by hand surgeons treating Dupuytren contracture. There is no significant difference in complications in the anticoagulated patient versus the nonanticoagulated patient. It is safe to perform collagenase clostridium histolyticum injections for Dupuytren contracture in the anticoagulated patient, regardless of the type of anticoagulation. Clinical question/level of evidence: Therapeutic, III.
MeSH term(s)	Anticoagulants/adverse effects ; Aspirin ; Clostridium histolyticum ; Dupuytren Contracture/surgery ; Hematoma/chemically induced ; Humans ; Injections, Intralesional ; Lacerations ; Microbial Collagenase ; Retrospective Studies ; Tendon Injuries ; Treatment Outcome
Chemical Substances	Anticoagulants ; Microbial Collagenase (EC 3.4.24.3) ; Aspirin (R16CO5Y76E)
Language	English
Publishing date	2022-03-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	208012-6
ISSN	1529-4242 ; 0032-1052 ; 0096-8501
ISSN (online)	1529-4242
ISSN	0032-1052 ; 0096-8501
DOI	10.1097/PRS.0000000000009038
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