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  1. Article ; Online: AA-type amyloidosis associated with lymphoma: a study of 19 cases including 5 new French cases and a systematic literature review.

    Collet, Aurore / Attias, Philippe / Lacou, Mathieu / Fieschi, Claire / Moktefi, Anissa / Sannier, Aurélie / Grateau, Gilles / Buob, David / Georgin-Lavialle, Sophie

    Leukemia & lymphoma

    2023  Volume 64, Issue 11, Page(s) 1857–1863

    MeSH term(s) Humans ; Amyloidosis/complications ; Amyloidosis/diagnosis ; Lymphoma/complications ; Lymphoma/diagnosis ; Serum Amyloid A Protein
    Chemical Substances Serum Amyloid A Protein
    Language English
    Publishing date 2023-07-26
    Publishing country United States
    Document type Case Reports ; Journal Article ; Systematic Review
    ZDB-ID 1042374-6
    ISSN 1029-2403 ; 1042-8194
    ISSN (online) 1029-2403
    ISSN 1042-8194
    DOI 10.1080/10428194.2023.2239971
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2997: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Muscle biopsy in anti-neutrophil cytoplasmic antibody-associated vasculitis: diagnostic yield depends on anti-neutrophil cytoplasmic antibody type, sex and neutrophil count.

    Lacou, Mathieu / Leroy, Maxime / Le Lan, Nowenn / Toquet, Claire / Espitia-Thibault, Alexandra / Graveleau, Julie / Masseau, Agathe / Agard, Christian / Volteau, Christelle / Mussini, Jean-Marie / Hamidou, Mohamed / Néel, Antoine

    Rheumatology (Oxford, England)

    2020  Volume 60, Issue 2, Page(s) 699–707

    Abstract: Objectives: This study aimed to examine the sensitivity of muscle biopsy (MB) in ANCA-associated vasculitis (AAV), identify factors predicting MB positivity and assess the prognostic value of a positive MB.: Methods: We conducted a single-centre ... ...

    Abstract Objectives: This study aimed to examine the sensitivity of muscle biopsy (MB) in ANCA-associated vasculitis (AAV), identify factors predicting MB positivity and assess the prognostic value of a positive MB.
    Methods: We conducted a single-centre retrospective study of AAV with an MB performed at diagnosis. AAV classification [granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), eosinophilic granulomatosis with polyangiitis (EGPA)] followed the European Medicines Agency algorithm. A logistic regression model was used to identify the factors associated with MB positivity. Survival curves were generated using the Kaplan-Meier method.
    Results: Among 276 AAV patients (1995-2018), 101 had an MB. Seventy-eight patients were included: 33 with GPA, 25 with MPA and 20 with EGPA. MB samples were positive in 45 cases (58%): 17 GPA, 16 MPA and 12 EGPA. Univariate analysis focussed on GPA and MPA, revealed that the MB yield was higher in females [22/31 (71%) vs 11/27 (41%); P = 0.02] and in anti-MPO patients [25/37 (68%) vs 6/19 (32%) for anti-PR3; P = 0.01]. By multivariate analysis, three factors predicted MB positivity: anti-MPO ANCA [odds ratio (OR) 10.67 (CI 2.09, 81.68)], female sex [OR 5.3 (CI 1.16, 32.35)] and neutrophil count [OR 1.33 (CI 1.07, 1.8)]. MB positivity had no impact on relapse, death or end-stage renal disease-free survival.
    Conclusions: MB is a safe and efficient diagnostic tool for AAV. Predictors of MB yield include ANCA type, sex and neutrophil count. MB cannot substitute for kidney biopsy when indicated, but should be considered in other cases.
    MeSH term(s) Aged ; Algorithms ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/diagnosis ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/epidemiology ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/immunology ; Antibodies, Antineutrophil Cytoplasmic/immunology ; Biopsy/methods ; Female ; France/epidemiology ; Humans ; Incidence ; Leukocyte Count ; Male ; Middle Aged ; Muscle, Skeletal/immunology ; Muscle, Skeletal/metabolism ; Muscle, Skeletal/pathology ; Neutrophils/immunology ; Neutrophils/pathology ; Prognosis ; Recurrence ; Retrospective Studies ; Sex Factors
    Chemical Substances Antibodies, Antineutrophil Cytoplasmic
    Language English
    Publishing date 2020-08-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/keaa233
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 240: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 497: Show issues

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  3. Article: Large-vessel involvement is predictive of multiple relapses in giant cell arteritis.

    de Mornac, Donatienne / Espitia, Olivier / Néel, Antoine / Connault, Jérôme / Masseau, Agathe / Espitia-Thibault, Alexandra / Artifoni, Mathieu / Achille, Aurélie / Wahbi, Anaïs / Lacou, Mathieu / Durant, Cécile / Pottier, Pierre / Perrin, François / Graveleau, Julie / Hamidou, Mohamed / Hardouin, Jean-Benoit / Agard, Christian

    Therapeutic advances in musculoskeletal disease

    2021  Volume 13, Page(s) 1759720X211009029

    Abstract: Background: Giant cell arteritis (GCA) is the most common systemic vasculitis. Relapses are frequent. The aim of this study was to identify relapse risk factors in patients with GCA with complete large-vessel imaging at diagnosis.: Methods: Patients ... ...

    Abstract Background: Giant cell arteritis (GCA) is the most common systemic vasculitis. Relapses are frequent. The aim of this study was to identify relapse risk factors in patients with GCA with complete large-vessel imaging at diagnosis.
    Methods: Patients with GCA followed in our institution between April 1998 and April 2018 were included retrospectively. We included only patients who had undergone large vascular imaging investigations at diagnosis by computed tomography (CT)-scan and/or positron emission tomography (PET)-scan and/or angio-magnetic resonance imaging (MRI). Clinical, biological, and radiological data were collected. Relapse was defined as the reappearance of GCA symptoms, with concomitant increase in inflammatory markers, requiring treatment adjustment. Relapsing patients (R) and non-relapsing patients (NR) were compared. Relapse and multiple relapses (>2) risk factors were identified in multivariable Cox analyses.
    Results: This study included 254 patients (73.2% women), with a median age of 72 years at diagnosis and a median follow up of 32.5 months. At diagnosis, 160 patients (63%) had an inflammatory large-vessel involvement on imaging, 46.1% (117 patients) relapsed at least once, and 21.3% (54 patients) had multiple relapses. The median delay of first relapse after diagnosis was 9 months. The second relapse delay was 21.5 months. NR patients had more stroke at diagnosis than R (
    Conclusion: Male gender was a protective factor for GCA relapse and peripheral musculoskeletal manifestations appeared as a relapsing risk factor. Moreover, this study identified a particular clinical phenotype of multi-relapsing patients with GCA, characterized by peripheral musculoskeletal manifestations, negative temporal artery biopsy, and large-vessel involvement with upper limb ischemia or inflammation of arm arteries.
    Plain language summary: At giant cell arteritis diagnosis, large-vessel inflammatory involvement is predictive of multiple relapses
    Language English
    Publishing date 2021-05-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2516075-8
    ISSN 1759-7218 ; 1759-720X
    ISSN (online) 1759-7218
    ISSN 1759-720X
    DOI 10.1177/1759720X211009029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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