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Article ; Online: Commissioning and implementing a Quality Assurance program for dedicated radiation oncology MRI scanners.

Poulin, Eric / Lacroix, Frederic / Archambault, Louis / Jutras, Jean-David

Journal of applied clinical medical physics

2024 Volume 25, Issue 3, Page(s) e14185

Abstract: Purpose: ACR and AAPM task group's guidelines addressing commissioning for dedicated MR simulators were recently published. The goal of the current paper is to present the authors' 2-year experience regarding the commissioning and introduction of a QA ... ...

Abstract	Purpose: ACR and AAPM task group's guidelines addressing commissioning for dedicated MR simulators were recently published. The goal of the current paper is to present the authors' 2-year experience regarding the commissioning and introduction of a QA program based on these guidelines and an associated automated workflow. Methods: All mandatory commissioning tests suggested by AAPM report 284 were performed and results are reported for two MRI scanners (MAGNETOM Sola and Aera). Visual inspection, vendor clinical or service platform, third-party software, or in-house python-based code were used. Automated QA and data analysis was performed via vendor, in-house or third-party software. QATrack+ was used for QA data logging and storage. 3D geometric distortion, B Results: Contrasting with AAPM report 284 recommendations, homogeneity and RF tests were performed monthly. The QA program allowed us to detect major failures over time (shimming, gradient calibration and RF interference). Automated QA, data analysis, and logging allowed fast ACR analysis daily and monthly QA to be performed in 3 h. On the Sola, the average distortion is 1 mm for imaging radii of 250 mm or less. For radii of up to 200 mm, the maximum, average (standard deviation) distortion is 1.2 and 0.4 mm (0.3 mm). Aera values are roughly double the Sola for radii up to 200 mm. EPI geometric distortion, ghosting ratio, and long-term stability were found to be under the maximum recommended values. Parallel imaging SNR ratio was stable and close to the theoretical value (ideal g-factor). No major failures were detected during commissioning. Conclusion: An automated workflow and enhanced QA program allowed to automatically track machine and environmental changes over time and to detect periodic failures and errors that might otherwise have gone unnoticed. The Sola is more geometrically accurate, with a more homogenous B
MeSH term(s)	Humans ; Radiation Oncology ; Phantoms, Imaging ; Magnetic Resonance Imaging/methods ; Software ; Workflow
Language	English
Publishing date	2024-02-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2010347-5
ISSN	1526-9914 ; 1526-9914
ISSN (online)	1526-9914
ISSN	1526-9914
DOI	10.1002/acm2.14185
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Article ; Online: Analgésie locorégionale périphérique continue chez l'enfant.

Lacroix, F

Annales francaises d'anesthesie et de reanimation

2007 Volume 26, Issue 6, Page(s) 554–559

Abstract: Continuous peripheral nerve blocks (CPNB) have important role in the therapeutic arsenal, anaesthetic or analgesic in children. Indications for CPNB depend on benefits/risks analysis for each patient. The indications include surgery associated with ... ...

Title translation	Continuous peripheral regional analgesia in children.
Abstract	Continuous peripheral nerve blocks (CPNB) have important role in the therapeutic arsenal, anaesthetic or analgesic in children. Indications for CPNB depend on benefits/risks analysis for each patient. The indications include surgery associated with intense postoperative pain, surgery requiring painful physical therapy, and complex regional pain syndrome. CPNB are usually performed under sedation or general anaesthesia, and require appropriate equipment in order to decrease the risk of nerve injury. Nevertheless, CPNB may mask compartment syndrome in trauma or certain surgical procedure. Finally, ropivacaine, and perhaps levobupivacaine, appears to be the best local anaesthetic for continuous peripheral nerve blocks in children, requiring low flow rate with low concentration.
MeSH term(s)	Anesthesia, Conduction/adverse effects ; Anesthesia, Conduction/methods ; Child ; Contraindications ; Humans ; Morbidity ; Nerve Block/adverse effects ; Nerve Block/methods
Language	French
Publishing date	2007-06
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	392411-7
ISSN	1769-6623 ; 0750-7658
ISSN (online)	1769-6623
ISSN	0750-7658
DOI	10.1016/j.annfar.2007.03.016
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Article: Investigations for Material Tracing in Selective Laser Sintering: Part ΙΙ: Validation of Modified Polymers as Marking Agents.

Eggers, Tom / von Lacroix, Frank / Goede, Martin Friedrich / Persch, Christoph / Berlin, Werner / Dröder, Klaus

Materials (Basel, Switzerland)

2023 Volume 16, Issue 7

Abstract: Selective laser sintering (SLS) is currently in transition to the production of functional components. However, the ability to apply it is confronted with new requirements for reliability and reproducibility. Therefore, an in-depth understanding of aging ...

Abstract	Selective laser sintering (SLS) is currently in transition to the production of functional components. However, the ability to apply it is confronted with new requirements for reliability and reproducibility. Therefore, an in-depth understanding of aging processes in polymers is essential. Regarding material traceability as well as defective component identification with subsequent cause tracing, the application of a material-inherent marking technology represents a solution. SLS in combination with modified polymers as a marking technology proves to be an efficient opportunity to produce reproducible and high-quality components due to an increased understanding of the process. Based on a selection of modified polymers for use in SLS, which were characterized in part I of the study, this work focuses on the experimental validation of the result. The influence of modified polymers on materials and component properties and the SLS process's influence on the traceability of modified polymers are examined. Intrinsic and extrinsic material properties as well as mechanical properties, surface quality and sinter density are analyzed. No discernible influences of the modified polymers on the investigated properties could be observed and the traceability of the modified polymers could also be confirmed in the aged powder and component using mass spectroscopy.
Language	English
Publishing date	2023-03-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma16072631
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Article: Influence Analysis of Modified Polymers as a Marking Agent for Material Tracing during Cyclic Injection Molding.

Eggers, Tom / Blumberg, Sonja Marit / von Lacroix, Frank / Berlin, Werner / Dröder, Klaus

Materials (Basel, Switzerland)

2023 Volume 16, Issue 18

Abstract: Injection molding (IM) is already an established technology for manufacturing polymer products. However, in the course of the increased use of recyclates for economic and ecological reasons, its application capability has been confronted with new ... ...

Abstract	Injection molding (IM) is already an established technology for manufacturing polymer products. However, in the course of the increased use of recyclates for economic and ecological reasons, its application capability has been confronted with new requirements for reliability and reproducibility. In addition, the IM process is confronted with regulations regarding a verifiable recycling degree in polymers. With regard to the material identification and storage of manufacturer-, process- or product-related data in polymers, the implementation of a material-inherent marking technology forms a potential answer. The IM process combined with modified polymers (MP) as a marking technology turns out to be a feasible approach to manufacturing reproducibly and offers a high quality based on increased process awareness and fulfilling the required traceability. Therefore, this work focuses on the trial evaluation of MP within the IM process. The influence of MP on the material process behavior and mechanical and thermal component properties, as well as the influence of the IM process and recycling on MP traceability, are investigated. No discernible influences of MP on the investigated properties could be identified, and the traceability from the initial material to a recyclate could be confirmed. MP is suitable for monitoring the aging state of polymers in IM.
Language	English
Publishing date	2023-09-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma16186304
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Article ; Online: Arctic soil CO

Schaller, Jörg / Stimmler, Peter / Göckede, Mathias / Augustin, Jürgen / Lacroix, Fabrice / Hoffmann, Mathias

The Science of the total environment

2023 Volume 870, Page(s) 161943

Abstract: Arctic soils are the largest pool of soil organic carbon worldwide. Temperatures in the Arctic have risen faster than the global average during the last decades, decreasing annual freezing days and increasing the number of freeze-thaw cycles (temperature ...

Abstract	Arctic soils are the largest pool of soil organic carbon worldwide. Temperatures in the Arctic have risen faster than the global average during the last decades, decreasing annual freezing days and increasing the number of freeze-thaw cycles (temperature oscillations passing through zero degrees) per year as the temperature is expected to fluctuate more around 0 °C. At the same time, proceeding deepening of seasonal thaw may increase silicon (Si) and calcium (Ca) concentrations in the active layer of Arctic soils as the concentrations in the thawing permafrost layer might be higher depending on location. We analyzed the importance of freeze-thaw cycles for Arctic soil CO
Language	English
Publishing date	2023-01-31
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2023.161943
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Article: Techniques de localisation des nerfs en anesthésie locorégionale pédiatrique.

Lacroix, F

Archives de pediatrie : organe officiel de la Societe francaise de pediatrie

2006 Volume 13, Issue 6, Page(s) 653–655

Title translation	Localization of nerves in pediatric regional anesthesia.
MeSH term(s)	Analgesia, Epidural/instrumentation ; Analgesics/administration & dosage ; Anesthesia, Conduction ; Catheterization ; Child ; Electrodiagnosis/instrumentation ; Humans ; Pain, Postoperative/drug therapy ; Pain, Postoperative/physiopathology ; Peripheral Nerves/drug effects ; Peripheral Nerves/physiopathology ; Radiography ; Transcutaneous Electric Nerve Stimulation/instrumentation ; Ultrasonography
Chemical Substances	Analgesics
Language	French
Publishing date	2006-06
Publishing country	France
Document type	Comparative Study ; Journal Article
ZDB-ID	1181947-9
ISSN	1769-664X ; 0929-693X
ISSN (online)	1769-664X
ISSN	0929-693X
DOI	10.1016/j.arcped.2006.03.095
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Article ; Online: Comparison of four-year toxicities and local control of ultra-hypofractionated vs moderate-hypofractionated image guided prostate radiation with HDR brachytherapy boost: A phase I-II single institution trial.

Beaudry, M M / Carignan, D / Foster, W / Lavallee, M C / Aubin, S / Lacroix, F / Poulin, E / Lachance, B / Després, P / Beaulieu, L / Vigneault, E / Martin, A G

Clinical and translational radiation oncology

2023 Volume 40, Page(s) 100593

Abstract: Purpose/objectives: To analyze the long term efficacy and safety of an ultra-hypofractionated (UHF) radiation therapy prostate treatment regimen with HDR brachytherapy boost (BB) and compare it to moderate-hypofractionated regimens (MHF).: Materials/ ... ...

Abstract	Purpose/objectives: To analyze the long term efficacy and safety of an ultra-hypofractionated (UHF) radiation therapy prostate treatment regimen with HDR brachytherapy boost (BB) and compare it to moderate-hypofractionated regimens (MHF). Materials/methods: In this single arm, prospective monocentric study, 28 patients with intermediate risk prostate cancer were recruited in an experimental treatment arm of 25 Gy in 5 fractions plus a 15 Gy HDR BB. They were then compared to two historical control groups, treated with either 36 Gy in 12 fractions or 37.5 Gy in 15 fractions with a similar HDR BB. The control groups included 151 and 311 patients respectively. Patient outcomes were reported using the International Prostate Symptom Score (IPSS) and Expanded Prostate Index Composite (EPIC-26) questionnaires at baseline and at each follow-up visit. Results: Median follow-up for the experimental arm was 48.5 months compared to 47 months and 60 months compared to the 36/12 and 37,5/15 groups respectively. The IPSS and EPIC scores did not demonstrate any significant differences in the gastrointestinal or genitourinary domains between the three groups over time. No biochemical recurrence occurred in the UHF arm as defined by the Phoenix criterion. Conclusion: The UHF treatment scheme with HDR BB seems equivalent to standard treatment arms in terms of toxicities and local control. Randomized control trials with larger cohorts are ongoing and needed to further confirm our findings.
Language	English
Publishing date	2023-02-08
Publishing country	Ireland
Document type	Journal Article
ISSN	2405-6308
ISSN (online)	2405-6308
DOI	10.1016/j.ctro.2023.100593
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Article ; Online: Genetic assessment of a conservation breeding program of the houbara bustard (Chlamydotis undulata undulata) in Morocco, based on pedigree and molecular analyses.

Rabier, Robin / Robert, Alexandre / Lacroix, Frédéric / Lesobre, Loïc

Zoo biology

2020 Volume 39, Issue 6, Page(s) 422–435

Abstract: Protection and restoration of species in the wild may require conservation breeding programs under genetic management to minimize deleterious effects of genetic changes that occur in captivity, while preserving populations' genetic diversity and ... ...

Abstract	Protection and restoration of species in the wild may require conservation breeding programs under genetic management to minimize deleterious effects of genetic changes that occur in captivity, while preserving populations' genetic diversity and evolutionary resilience. Here, through interannual pedigree analyses, we first assessed the efficiency of a 21-year genetic management, including minimization of mean kinship, inbreeding avoidance, and regular addition of founders, of a conservation breeding program targeting on Houbara bustard (Chlamydotis undulata undulata) in Morocco. Secondly, we compared pedigree analyses, the classical way of assessing and managing genetic diversity in captivity, to molecular analyses based on seven microsatellites. Pedigree-based results indicated an efficient maintenance of the genetic diversity (99% of the initial genetic diversity retained) while molecular-based results indicated an increase in allelic richness and an increase in unbiased expected heterozygosity across time. The pedigree-based average inbreeding coefficient F remained low (between 0.0004 and 0.003 in 2017) while the proportion of highly inbred individuals (F > .1) decreased over time and reached 0.2% in 2017. Furthermore, pedigree-based F and molecular-based individual multilocus heterozygosity were weakly negatively correlated, (Pearson's r = -.061 when considering all genotyped individuals), suggesting that they cannot be considered as alternatives, but rather as complementary sources of information. These findings suggest that a strict genetic monitoring and management, based on both pedigree and molecular tools can help mitigate genetic changes and allow to preserve genetic diversity and evolutionary resilience in conservation breeding programs.
MeSH term(s)	Animals ; Birds/classification ; Birds/genetics ; Conservation of Natural Resources ; DNA/genetics ; Female ; Genotype ; Inbreeding ; Male ; Microsatellite Repeats ; Morocco ; Pedigree ; Time Factors
Chemical Substances	DNA (9007-49-2)
Language	English
Publishing date	2020-09-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	1499116-0
ISSN	1098-2361 ; 0733-3188
ISSN (online)	1098-2361
ISSN	0733-3188
DOI	10.1002/zoo.21569
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Article: Assisted Reproduction Techniques to Improve Reproduction in a Non-Model Species: The Case of the Arabian Bustard (

Carreira, Janaina Torres / Lesobre, Loïc / Boullenger, Sylvain / Chalah, Toni / Lacroix, Frédéric / Hingrat, Yves

Animals : an open access journal from MDPI

2022 Volume 12, Issue 7

Abstract: Artificial reproductive technologies are highly valuable for ex situ conservation. While Arabian bustard populations are declining and extinct in some parts of the range, the International Fund for Houbara Conservation in the United Arab Emirates ... ...

Abstract	Artificial reproductive technologies are highly valuable for ex situ conservation. While Arabian bustard populations are declining and extinct in some parts of the range, the International Fund for Houbara Conservation in the United Arab Emirates implemented a conservation breeding program. Since 2012, a total of 1253 eggs were laid through natural reproduction, 1090 were incubated and 379 of these were fertile (fertility rate of 34.8%), leading to the production of 251 chicks. To improve fertility and acquire crucial knowledge for other endangered large birds, artificial reproduction was implemented in 2018 using fresh, refrigerated, and frozen sperm. A total of 720 ejaculates were collected from 12 birds. We analysed these samples for concentration, volume, motility score (0 to 5), viability (eosin/nigrosine), length, and morphology. The first age at collection was 35.7 ± 18.8 months, mean volume was 89.2 ± 65.3 µL, mean concentration was 928 ± 731 sptz/mL and mean motility score was 2.61 ± 0.95. Morphology analyses revealed a bimodal distribution of sperm length. Five hundred and thirty-five ejaculates were cryopreserved and the initial motility score was 3.4 ± 0.7 and 2.0 ± 0.6 after thawing, while the percentage of normal and intact membrane sperm cells decreased from 88.8 ± 7.5% to 52.9 ± 1%. Sixty-five artificial inseminations were performed, leading to a global fertility rate of 84.3%-more precisely, 85.2% and 83.3%, respectively, for fresh and cryopreserved semen. All methods successfully produced fertile eggs, indicating that artificial insemination is an efficient tool for the conservation and genetic management of the species.
Language	English
Publishing date	2022-03-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606558-7
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani12070851
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Article: Investigations for Material Tracing in Selective Laser Sintering: Part Ι: Methodical Selection of a Suitable Marking Agent.

Eggers, Tom / von Lacroix, Frank / van de Kraan, Fridolin / Reichler, Ann-Kathrin / Hürkamp, André / Dröder, Klaus

Materials (Basel, Switzerland)

2023 Volume 16, Issue 3

Abstract: Selective laser sintering (SLS) with polymers is currently at the transition stage for the production of functional components and holds great potential to revolutionize conventional production processes. Nevertheless, its application capability is ... ...

Abstract	Selective laser sintering (SLS) with polymers is currently at the transition stage for the production of functional components and holds great potential to revolutionize conventional production processes. Nevertheless, its application capability is confronted by newly imposed requirements regarding reliability and reproducibility. To safeguard these requirements, a deeper process understanding of material aging mechanisms in polymeric materials is needed. In order to enable the traceability of the materials as well as the identification of defective components with subsequent tracing of the cause, the use of a material marking process represents an alternative. SLS in combination with material marking is proving to be an efficient option for reproducible, high-quality manufacturing based on an increased understanding of the process. In this study, the idea of a marker-based traceability methodology for the purpose of process optimization is presented. Fundamental to the subsequent experimental investigation of the marking agent suitability, this work first focuses on the systematic selection of a suitable marking agent for use in SLS. Based on an analysis of the sinter material to be marked and a set of marking technologies, as well as using the selection methodology, the modified polymer marking technology was evaluated as the most suitable marking technology.
Language	English
Publishing date	2023-01-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma16031043
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