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  1. Article ; Online: Rapid molecular diagnostic tests fail to PERFORM in febrile children.

    Ladhani, Shamez N

    The Lancet regional health. Europe

    2023  Volume 32, Page(s) 100707

    Language English
    Publishing date 2023-08-04
    Publishing country England
    Document type Journal Article
    ISSN 2666-7762
    ISSN (online) 2666-7762
    DOI 10.1016/j.lanepe.2023.100707
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  2. Article ; Online: Face masking for children - time to reconsider.

    Ladhani, Shamez N

    The Journal of infection

    2022  Volume 85, Issue 6, Page(s) 623–624

    MeSH term(s) Child ; Humans ; Personal Protective Equipment
    Language English
    Publishing date 2022-09-25
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 424417-5
    ISSN 1532-2742 ; 0163-4453
    ISSN (online) 1532-2742
    ISSN 0163-4453
    DOI 10.1016/j.jinf.2022.09.020
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  3. Article ; Online: COVID-19 vaccination for children aged 5-11 years.

    Ladhani, Shamez N

    Lancet (London, England)

    2022  Volume 400, Issue 10346, Page(s) 74–76

    MeSH term(s) COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19 Vaccines ; Child ; Humans ; Influenza, Human ; Vaccination
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2022-07-01
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(22)01245-4
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  4. Article ; Online: Crossing the Rubicon: A fine line between waiting and vaccinating adolescents against COVID-19.

    Ladhani, Shamez N

    The Journal of infection

    2021  Volume 83, Issue 3, Page(s) 294–297

    Abstract: Several countries with advanced adult COVID-19 immunisation programmes have already started vaccinating adolescents with an mRNA vaccine that recently received emergency use authorisation for 12-15 year-olds. The decision to vaccinate adolescents remains ...

    Abstract Several countries with advanced adult COVID-19 immunisation programmes have already started vaccinating adolescents with an mRNA vaccine that recently received emergency use authorisation for 12-15 year-olds. The decision to vaccinate adolescents remains highly divisive among parents, clinicians, politicians and policy makers. There are very few downsides to immunising adolescents with a safe and effective COVID-19 vaccine because that would significantly reduce their risk of COVID-19 and all its complications. Based on current evidence, however, adolescents have a very low risk of severe or fatal COVID-19, even among those with comorbidities, or rare complications such as long COVID or Paediatric Multisystem Inflammatory Syndrome (PIMS-TS), a hyperinflammatory syndrome temporally associated with SARS-CoV-2. Additionally, currently authorised vaccines are very reactogenic and have limited post-marketing population-level safety data in adolescents and young adults, but these are emerging from countries that have forged ahead with vaccinating adolescents. Countries that have yet to make a recommendation can afford to wait until there is sufficient information to make informed decisions on the risk-benefits of vaccinating adolescents with current and future COVID-19 vaccines. Alternatives to two-dose vaccination in adolescents may include a single dose or a reduced dose schedule as is currently being trialled in younger children.
    MeSH term(s) Adolescent ; COVID-19/complications ; COVID-19 Vaccines ; Child ; Humans ; SARS-CoV-2 ; Systemic Inflammatory Response Syndrome
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2021-07-21
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 424417-5
    ISSN 1532-2742 ; 0163-4453
    ISSN (online) 1532-2742
    ISSN 0163-4453
    DOI 10.1016/j.jinf.2021.07.015
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  5. Article ; Online: Children and COVID-19 in schools.

    Ladhani, Shamez N

    Science (New York, N.Y.)

    2021  Volume 374, Issue 6568, Page(s) 680–682

    Abstract: The benefits of in-person schooling with mitigations in place outweigh the risks of COVID-19 for children. ...

    Abstract The benefits of in-person schooling with mitigations in place outweigh the risks of COVID-19 for children.
    MeSH term(s) Adolescent ; Asymptomatic Infections/epidemiology ; COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19/transmission ; COVID-19/virology ; COVID-19 Vaccines ; Child ; Child, Preschool ; Communicable Disease Control ; Community-Acquired Infections/epidemiology ; Community-Acquired Infections/transmission ; Humans ; SARS-CoV-2 ; Schools ; Seroepidemiologic Studies ; Severity of Illness Index
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2021-11-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.abj2042
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  6. Article ; Online: Monkeypox and children.

    Cohen, Jonathan / Ladhani, Shamez N

    Archives of disease in childhood

    2022  Volume 107, Issue 12, Page(s) 1065–1066

    MeSH term(s) Child ; Humans ; Mpox (monkeypox)
    Language English
    Publishing date 2022-09-02
    Publishing country England
    Document type Editorial
    ZDB-ID 524-1
    ISSN 1468-2044 ; 0003-9888 ; 1359-2998
    ISSN (online) 1468-2044
    ISSN 0003-9888 ; 1359-2998
    DOI 10.1136/archdischild-2022-324703
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  7. Article ; Online: Current state of COVID-19 in children: 4 years on.

    Powell, Annabel A / Dowell, Alexander C / Moss, Paul / Ladhani, Shamez N

    The Journal of infection

    2024  Volume 88, Issue 5, Page(s) 106134

    Abstract: Children have been disproportionately affected by the COVID-19 pandemic. Despite evidence of a very low risk of severe disease, children were subjected to extensive lockdown, restriction and mitigation measures, including school closures, to control the ... ...

    Abstract Children have been disproportionately affected by the COVID-19 pandemic. Despite evidence of a very low risk of severe disease, children were subjected to extensive lockdown, restriction and mitigation measures, including school closures, to control the rapid spread of SARS-CoV-2 in most parts of the world. In this review we summarise the UK experience of COVID-19 in children four years into the largest and longest pandemic of this century. We address the risks of SARS-CoV-2 infection, immunity, transmission, severity and outcomes in children. We also assess the implementation, uptake, effectiveness and impact of COVID-19 vaccination, as well as the emergence, evolution and near disappearance of PIMS-TS (paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2) and current understanding of long COVID in children. This review consolidates current knowledge on childhood COVID-19 and emphasises the importance of continued research and the need for research-driven public health actions and policy decisions, especially in the context of new variants and future vaccines.
    Language English
    Publishing date 2024-03-02
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 424417-5
    ISSN 1532-2742 ; 0163-4453
    ISSN (online) 1532-2742
    ISSN 0163-4453
    DOI 10.1016/j.jinf.2024.106134
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  8. Article ; Online: Pregnant women and measles: we need to be vigilant during outbreaks.

    Khalil, Asma / Samara, Athina / Campbell, Colin / Ladhani, Shamez N

    EClinicalMedicine

    2024  Volume 72, Page(s) 102594

    Abstract: A number of countries including the UK are currently experiencing large outbreaks of measles affecting mainly young children but also adolescents and young adults. Women of childbearing age are a particular group of concern because the 1988 Wakefield ... ...

    Abstract A number of countries including the UK are currently experiencing large outbreaks of measles affecting mainly young children but also adolescents and young adults. Women of childbearing age are a particular group of concern because the 1988 Wakefield Lancet paper, which falsely asserted a connection between the MMR vaccine and autism, was associated with a large and sharp decline in childhood MMR uptake over several years. This has left large cohorts of non-immune adolescents and young adults (born between 1998 and 2004), including young women who are now of childbearing age and remain susceptible to measles as well as rubella. Pregnant mothers are at higher risk of serious complications, such as pneumonia, with adverse pregnancy complications including fetal loss, premature birth, and neonatal death. Measles infection may also result in subacute sclerosing panencephalitis (SSPE), a very rare but very severe and invariably fatal neurodegenerative complication that typically manifests many years after acute measles infection but can have a short-onset latency with a fulminant course in pregnant women. Here, we summarise the epidemiology of measles infection, factors associated with the current measles outbreaks, as well as the risks and outcomes of measles, including SSPE, in pregnancy. We propose an algorithm for clinical management of measles infection in pregnancy. We also highlight the importance of early liaison with local health protection teams for risk assessment, diagnosis and management of suspected measles in pregnancy and close contacts as well as susceptible pregnant women exposed to a person with measles in the community.
    Language English
    Publishing date 2024-04-16
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2589-5370
    ISSN (online) 2589-5370
    DOI 10.1016/j.eclinm.2024.102594
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  9. Article ; Online: Lifting Universal School Masking - Covid-19 Incidence among Students and Staff.

    Ladhani, Shamez N / Andrews, Nick / Ramsay, Mary E

    The New England journal of medicine

    2023  Volume 389, Issue 6, Page(s) 579

    MeSH term(s) Humans ; Incidence ; Lifting ; COVID-19 ; Students
    Language English
    Publishing date 2023-08-17
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2215560
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  10. Article ; Online: Child mask mandates for COVID-19: a systematic review.

    Sandlund, Johanna / Duriseti, Ram / Ladhani, Shamez N / Stuart, Kelly / Noble, Jeanne / Høeg, Tracy Beth

    Archives of disease in childhood

    2024  Volume 109, Issue 3, Page(s) e2

    Abstract: Background: Mask mandates for children during the COVID-19 pandemic varied in different locations. A risk-benefit analysis of this intervention has not yet been performed. In this study, we performed a systematic review to assess research on the ... ...

    Abstract Background: Mask mandates for children during the COVID-19 pandemic varied in different locations. A risk-benefit analysis of this intervention has not yet been performed. In this study, we performed a systematic review to assess research on the effectiveness of mask wearing in children.
    Methods: We performed database searches up to February 2023. The studies were screened by title and abstract, and included studies were further screened as full-text references. A risk-of-bias analysis was performed by two independent reviewers and adjudicated by a third reviewer.
    Results: We screened 597 studies and included 22 in the final analysis. There were no randomised controlled trials in children assessing the benefits of mask wearing to reduce SARS-CoV-2 infection or transmission. The six observational studies reporting an association between child masking and lower infection rate or antibody seropositivity had critical (n=5) or serious (n=1) risk of bias; all six were potentially confounded by important differences between masked and unmasked groups and two were shown to have non-significant results when reanalysed. Sixteen other observational studies found no association between mask wearing and infection or transmission.
    Conclusions: Real-world effectiveness of child mask mandates against SARS-CoV-2 transmission or infection has not been demonstrated with high-quality evidence. The current body of scientific data does not support masking children for protection against COVID-19.
    MeSH term(s) Child ; Humans ; COVID-19/epidemiology ; COVID-19/prevention & control ; SARS-CoV-2 ; Pandemics/prevention & control ; Bias ; Antibodies
    Chemical Substances Antibodies
    Language English
    Publishing date 2024-02-19
    Publishing country England
    Document type Systematic Review ; Journal Article
    ZDB-ID 524-1
    ISSN 1468-2044 ; 0003-9888 ; 1359-2998
    ISSN (online) 1468-2044
    ISSN 0003-9888 ; 1359-2998
    DOI 10.1136/archdischild-2023-326215
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