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Article ; Online: Congenitally corrected transposition of the great arteries: have we shifted the disease 'trajectory?

Ladouceur, Magalie

2023 Volume 44, Issue 34, Page(s) 3292–3294

MeSH term(s)	Humans ; Congenitally Corrected Transposition of the Great Arteries ; Transposition of Great Vessels/complications ; Transposition of Great Vessels/diagnostic imaging ; Transposition of Great Vessels/surgery ; Arteries ; Heart Failure
Language	English
Publishing date	2023-08-17
Publishing country	England
Document type	Editorial ; Comment
ZDB-ID	603098-1
ISSN	1522-9645 ; 0195-668X
ISSN (online)	1522-9645
ISSN	0195-668X
DOI	10.1093/eurheartj/ehad482
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Zs.A 1563: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 640: Show issues

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Article: Epidemiology and Definition of Heart Failure in Adult Congenital Heart Disease.

Ladouceur, Magalie / Bouchardy, Judith

Heart failure clinics

2024 Volume 20, Issue 2, Page(s) 113–127

Abstract: Adults with congenital heart disease (ACHD) are facing lifelong complications, notably heart failure (HF). This review focuses on classifications, incidence, prevalence, and mortality of HF related to ACHD. Diagnosing HF in ACHD is intricate due to ... ...

Abstract	Adults with congenital heart disease (ACHD) are facing lifelong complications, notably heart failure (HF). This review focuses on classifications, incidence, prevalence, and mortality of HF related to ACHD. Diagnosing HF in ACHD is intricate due to anatomic variations, necessitating comprehensive clinical evaluations. Hospitalizations and resource consumption for ACHD HF have significantly risen compared with non-ACHD HF patients. With more than 30% prevalence in complex cases, HF has become the leading cause of death in ACHD. These alarming trends underscore the insufficient understanding of ACHD-related HF manifestations and management challenges within the context of aging, complexity, and comorbidity.
MeSH term(s)	Humans ; Adult ; Heart Defects, Congenital/complications ; Heart Defects, Congenital/diagnosis ; Heart Defects, Congenital/epidemiology ; Hospitalization ; Heart Failure/diagnosis ; Heart Failure/epidemiology ; Heart Failure/etiology
Language	English
Publishing date	2024-01-02
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2212019-1
ISSN	1551-7136
ISSN	1551-7136
DOI	10.1016/j.hfc.2023.12.001
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Article ; Online: Heart failure in adults with congenital heart disease: a call for action.

Ladouceur, Magalie

Heart (British Cardiac Society)

2021 Volume 107, Issue 10, Page(s) 774–775

MeSH term(s)	Adult ; Disease Progression ; Health Services Needs and Demand ; Heart Defects, Congenital/epidemiology ; Heart Failure/etiology ; Heart Failure/prevention & control ; Heart Transplantation ; Heart-Assist Devices ; Hospitalization/statistics & numerical data ; Humans ; Patient Acuity ; United States/epidemiology
Language	English
Publishing date	2021-02-23
Publishing country	England
Document type	Editorial
ZDB-ID	1303417-0
ISSN	1468-201X ; 1355-6037
ISSN (online)	1468-201X
ISSN	1355-6037
DOI	10.1136/heartjnl-2020-318757
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Ui IV Zs.40: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Arrhythmia and advanced heart failure in complex congenital heart diseases: What should we do?

Ladouceur, Magalie

International journal of cardiology

2020 Volume 310, Page(s) 94–95

MeSH term(s)	Arrhythmias, Cardiac/diagnosis ; Arrhythmias, Cardiac/epidemiology ; Arrhythmias, Cardiac/surgery ; Cardiomyopathies ; Catheter Ablation ; Heart Failure/diagnosis ; Heart Failure/epidemiology ; Humans
Language	English
Publishing date	2020-01-13
Publishing country	Netherlands
Document type	Editorial ; Comment
ZDB-ID	779519-1
ISSN	1874-1754 ; 0167-5273
ISSN (online)	1874-1754
ISSN	0167-5273
DOI	10.1016/j.ijcard.2020.01.022
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Article ; Online: Grossesse et hypertension artérielle pulmonaire.

Ladouceur, Magalie

Presse medicale (Paris, France : 1983)

2019 Volume 48, Issue 12, Page(s) 1422–1430

Abstract: Pulmonary hypertension in pregnant women is associated with high mortality and morbidity despite significant improvement in prognosis. Women with pulmonary arterial hypertension (PAH) should be still advised against pregnancy and advised on effective ... ...

Title translation	Pregnancy and pulmonary arterial hypertension.
Abstract	Pulmonary hypertension in pregnant women is associated with high mortality and morbidity despite significant improvement in prognosis. Women with pulmonary arterial hypertension (PAH) should be still advised against pregnancy and advised on effective contraceptive methods. Pregnancy may be manageable in women with well controlled PAH or mild pulmonary hypertension (sPAP<50mmHg). When women with PAH choose to continue their pregnancy, they need: management by a multidisciplinary team in an expert centre; continuation or early introduction of targeted PAH therapy; early planned delivery.
MeSH term(s)	Delivery, Obstetric/methods ; Delivery, Obstetric/standards ; Directive Counseling/methods ; Female ; Humans ; Maternal Mortality ; Preconception Care/methods ; Pregnancy ; Pregnancy Complications, Cardiovascular/epidemiology ; Pregnancy Complications, Cardiovascular/therapy ; Pregnancy Outcome/epidemiology ; Prenatal Care/methods ; Prenatal Care/standards ; Pulmonary Arterial Hypertension/epidemiology ; Pulmonary Arterial Hypertension/therapy ; Risk Factors ; Vasodilator Agents/therapeutic use
Chemical Substances	Vasodilator Agents
Language	French
Publishing date	2019-10-31
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	120943-7
ISSN	2213-0276 ; 0032-7867 ; 0755-4982 ; 0301-1518
ISSN (online)	2213-0276
ISSN	0032-7867 ; 0755-4982 ; 0301-1518
DOI	10.1016/j.lpm.2019.08.007
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Zs.A 794: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Ua VI Zs.87: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Predictive machine learning models for ascending aortic dilatation in patients with bicuspid and tricuspid aortic valves undergoing cardiothoracic surgery: a prospective, single-centre and observational study.

Gaye, Bamba / Vignac, Maxime / Gådin, Jesper R / Ladouceur, Magalie / Caidahl, Kenneth / Olsson, Christian / Franco-Cereceda, Anders / Eriksson, Per / Björck, Hanna M

BMJ open

2024 Volume 14, Issue 3, Page(s) e067977

Abstract: Objectives: The objective of this study was to develop clinical classifiers aiming to identify prevalent ascending aortic dilatation in patients with bicuspid aortic valve (BAV) and tricuspid aortic valve (TAV).: Design and setting: A prospective, ... ...

Abstract	Objectives: The objective of this study was to develop clinical classifiers aiming to identify prevalent ascending aortic dilatation in patients with bicuspid aortic valve (BAV) and tricuspid aortic valve (TAV). Design and setting: A prospective, single-centre and observational cohort. Participants: The study involved 543 BAV and 491 TAV patients with aortic valve disease and/or ascending aortic dilatation, excluding those with coronary artery disease, undergoing cardiothoracic surgery at the Karolinska University Hospital (Sweden). Main outcome measures: Predictors of high risk of ascending aortic dilatation (defined as ascending aorta with a diameter above 40 mm) were identified through the application of machine learning algorithms and classic logistic regression models. Exposures: Comprehensive multidimensional data, including valve morphology, clinical information, family history of cardiovascular diseases, prevalent diseases, demographic details, lifestyle factors, and medication. Results: BAV patients, with an average age of 60.4±12.4 years, showed a higher frequency of aortic dilatation (45.3%) compared with TAV patients, who had an average age of 70.4±9.1 years (28.9% dilatation, p <0.001). Aneurysm prediction models for TAV patients exhibited mean area under the receiver-operating-characteristic curve (AUC) values above 0.8, with the absence of aortic stenosis being the primary predictor, followed by diabetes and high-sensitivity C reactive protein. Conversely, prediction models for BAV patients resulted in AUC values between 0.5 and 0.55, indicating low usefulness for predicting aortic dilatation. Classification results remained consistent across all machine learning algorithms and classic logistic regression models. Conclusion and recommendation: Cardiovascular risk profiles appear to be more predictive of aortopathy in TAV patients than in patients with BAV. This adds evidence to the fact that BAV-associated and TAV-associated aortopathy involves different pathways to aneurysm formation and highlights the need for specific aneurysm preventions in these patients. Further, our results highlight that machine learning approaches do not outperform classical prediction methods in addressing complex interactions and non-linear relations between variables.
MeSH term(s)	Humans ; Middle Aged ; Aged ; Aortic Valve/surgery ; Heart Valve Diseases/complications ; Heart Valve Diseases/surgery ; Prospective Studies ; Dilatation ; Aortic Diseases/complications ; Bicuspid Aortic Valve Disease ; Aneurysm
Language	English
Publishing date	2024-03-20
Publishing country	England
Document type	Observational Study ; Journal Article
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2022-067977
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Article ; Online: Increased aortic pressures and pulsatile afterload components promote concentric left ventricular remodeling in adults with transposition of the great arteries and arterial switch operation.

Belhadjer, Zahra / Ladouceur, Magalie / Soulat, Gilles / Legendre, Antoine / Gencer, Umit / Dietenbeck, Thomas / Iserin, Laurence / Houyel, Lucile / Bonnet, Damien / Mousseaux, Elie

International journal of cardiology

2024 Volume 405, Page(s) 131969

Abstract: Background: Functional abnormalities of the ascending aorta (AA) have been mainly reported in young patients who underwent arterial switch operation (ASO) for transposition of the great arteries (TGA).: Objectives: To compare systolic, diastolic ... ...

Abstract	Background: Functional abnormalities of the ascending aorta (AA) have been mainly reported in young patients who underwent arterial switch operation (ASO) for transposition of the great arteries (TGA). Objectives: To compare systolic, diastolic brachial and central blood pressures (bSBP, bDBP, cSBP, cDBP), aortic biomechanical parameters, and left ventricular (LV) afterload criteria in adult ASO patients with healthy controls and to assess their relationships with LV remodeling and aortic size. Materials and methods: Forty-one prospectively enrolled patients (16.8 to 35.8 years) and 41 age- and sex-matched healthy volunteers underwent cardiac MRI to assess LV remodeling with simultaneous brachial BP estimation. After MRI, carotid-femoral tonometry was performed to measure pulse wave velocity (cfPWV), cSBP and cDBP for further calculation of pulse pressure (cPP), AA distensibility (AA Results: bSBP, bDBP, cSBP,cDBP and cPP were all significantly higher in ASO group than in controls: cSBP (116.5 ± 13.8 vs 106.1 ± 12.0, p < 0.001), cDBP (72.5 ± 6.9 vs 67.1 ± 9.4, p = 0.002), cPP (44.0 ± 12.1 vs 39.1 ± 8.9, p = 0.003) and not related to aortic size. AA Conclusion: Even without reaching arterial hypertension, aortic sBP and PP are increased in the adult TGA population after ASO, altering the pulsatile components of afterload and contributing to LV concentric remodeling.
MeSH term(s)	Humans ; Transposition of Great Vessels/surgery ; Transposition of Great Vessels/physiopathology ; Transposition of Great Vessels/diagnostic imaging ; Male ; Female ; Adult ; Arterial Switch Operation ; Ventricular Remodeling/physiology ; Young Adult ; Prospective Studies ; Adolescent ; Arterial Pressure/physiology ; Aorta/diagnostic imaging ; Aorta/physiopathology ; Pulse Wave Analysis ; Magnetic Resonance Imaging, Cine/methods ; Pulsatile Flow/physiology
Language	English
Publishing date	2024-03-14
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	779519-1
ISSN	1874-1754 ; 0167-5273
ISSN (online)	1874-1754
ISSN	0167-5273
DOI	10.1016/j.ijcard.2024.131969
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Article ; Online: Coronary artery disease in adults with Noonan syndrome: Case series and literature review.

Ly, Reaksmei / Soulat, Gilles / Iserin, Laurence / Ladouceur, Magalie

Archives of cardiovascular diseases

2021 Volume 114, Issue 8-9, Page(s) 598–605

Abstract: Noonan syndrome (NS) is a genetic disorder characterized by facial dysmorphism, congenital heart disease, and short stature. In very rare cases, patients with this syndrome have coronary disease. Their management and prognosis are currently unclear. We ... ...

Abstract	Noonan syndrome (NS) is a genetic disorder characterized by facial dysmorphism, congenital heart disease, and short stature. In very rare cases, patients with this syndrome have coronary disease. Their management and prognosis are currently unclear. We have described 4 cases of coronary aneurysms/coronary ectasia and 1 case of a single coronary artery in patients with adult Noonan syndrome, followed in a medical and surgical center of adult congenital heart disease. The average age was 49.4years old. The majority of them had both pulmonary stenosis and interauricular communication. None had symptoms of angina, at rest, or with stress. Only one patient who had any structural heart disease, had a thrombotic complication with chronic occlusion of the right coronary and anterior inter ventricular artery, fortuitous finding, with no ischemic signs to functional tests, treated only with anti-vitamin K. Finally, any deaths have also been reported in our series. Coronary artery diseases essentially coronary aneurysm/ectasia remain a rare condition in adult patients with NS. Evolution is unknown and complications such as coronary artery thrombosis do not necessarily require surgical treatment.
MeSH term(s)	Adult ; Coronary Aneurysm/diagnostic imaging ; Coronary Aneurysm/therapy ; Coronary Artery Disease/diagnosis ; Coronary Artery Disease/diagnostic imaging ; Heart Defects, Congenital ; Humans ; Middle Aged ; Noonan Syndrome/complications ; Noonan Syndrome/diagnosis ; Pulmonary Valve Stenosis
Language	English
Publishing date	2021-09-14
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2408778-6
ISSN	1875-2128 ; 1875-2136
ISSN (online)	1875-2128
ISSN	1875-2136
DOI	10.1016/j.acvd.2021.06.006
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Article ; Online: Cardiac Drugs in ACHD Cardiovascular Medicine.

Ladouceur, Magalie / Valdeolmillos, Estibaliz / Karsenty, Clément / Hascoet, Sébastien / Moceri, Pamela / Le Gloan, Laurianne

Journal of cardiovascular development and disease

2023 Volume 10, Issue 5

Abstract: Adult congenital heart disease (ACHD) is a growing population that requires life-long care due to advances in pediatric care and surgical or catheter procedures. Despite this, drug therapy in ACHD remains largely empiric due to the lack of clinical data, ...

Abstract	Adult congenital heart disease (ACHD) is a growing population that requires life-long care due to advances in pediatric care and surgical or catheter procedures. Despite this, drug therapy in ACHD remains largely empiric due to the lack of clinical data, and formalized guidelines on drug therapy are currently lacking. The aging ACHD population has led to an increase in late cardiovascular complications such as heart failure, arrhythmias, and pulmonary hypertension. Pharmacotherapy, with few exceptions, in ACHD is largely supportive, whereas significant structural abnormalities usually require interventional, surgical, or percutaneous treatment. Recent advances in ACHD have prolonged survival for these patients, but further research is needed to determine the most effective treatment options for these patients. A better understanding of the use of cardiac drugs in ACHD patients could lead to improved treatment outcomes and a better quality of life for these patients. This review aims to provide an overview of the current status of cardiac drugs in ACHD cardiovascular medicine, including the rationale, limited current evidence, and knowledge gaps in this growing area.
Language	English
Publishing date	2023-04-24
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2777082-5
ISSN	2308-3425 ; 2308-3425
ISSN (online)	2308-3425
ISSN	2308-3425
DOI	10.3390/jcdd10050190
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Article ; Online: Multimodality imaging before persistent truncus arteriosus repair in a 36-year-old woman.

Ly, Reaksmei / Mousseaux, Elie / Iserin, Laurence / Ladouceur, Magalie

European heart journal. Case reports

2020 Volume 4, Issue 6, Page(s) 1–2

Language	English
Publishing date	2020-11-09
Publishing country	England
Document type	Journal Article
ISSN	2514-2119
ISSN (online)	2514-2119
DOI	10.1093/ehjcr/ytaa385
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