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  1. Article ; Online: [No title information]

    Stumpf, Ulla / Kraus, Moritz / Ladurner, Roland / Neuerburg, Carl / Böcker, Wolfgang

    Orthopadie (Heidelberg, Germany)

    2023  Volume 52, Issue 5, Page(s) 416

    Title translation Erratum zu: Osteoporose: Diagnostik und Behandlung.
    Language German
    Publishing date 2023-04-13
    Publishing country Germany
    Document type Published Erratum
    ISSN 2731-7153
    ISSN (online) 2731-7153
    DOI 10.1007/s00132-023-04378-2
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  2. Article ; Online: [No title information]

    Stumpf, Ulla / Kraus, Moritz / Ladurner, Roland / Neuerburg, Carl / Böcker, Wolfgang

    Zeitschrift fur Gerontologie und Geriatrie

    2023  Volume 56, Issue 3, Page(s) 239

    Title translation Erratum zu: Osteoporose: Diagnostik und Behandlung.
    Language German
    Publishing date 2023-04-27
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 1227032-5
    ISSN 1435-1269 ; 0044-281X ; 0948-6704
    ISSN (online) 1435-1269
    ISSN 0044-281X ; 0948-6704
    DOI 10.1007/s00391-023-02193-0
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    Zs.A 497: Show issues Location:
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  3. Article ; Online: Osteoporose: Diagnostik und Behandlung.

    Stumpf, Ulla / Kraus, Moritz / Ladurner, Roland / Neuerburg, Carl / Böcker, Wolfgang

    Orthopadie (Heidelberg, Germany)

    2023  Volume 52, Issue 3, Page(s) 246–258

    Abstract: Osteoporosis is the most common systemic skeletal disease worldwide. Its consequences have a substantial impact on the quality of life of patients and increases the overall morbidity and mortality. Standardized diagnostic procedures and treatment ... ...

    Title translation Osteoporosis: diagnostics and treatment.
    Abstract Osteoporosis is the most common systemic skeletal disease worldwide. Its consequences have a substantial impact on the quality of life of patients and increases the overall morbidity and mortality. Standardized diagnostic procedures and treatment recommendations have been available for years as German and international (S3) guidelines. Nevertheless, there is a considerable gap in the diagnosis and adequate treatment of osteoporosis, especially in Germany. The aim is to detect the disease at an early stage and to establish a specific and consistent treatment of osteoporosis. In this way the quality of life and independence of those affected can be maintained over a long period. In the acute and permanent treatment of manifest osteoporosis, surgeons, orthopedic and trauma surgeons play a key role.
    MeSH term(s) Humans ; Quality of Life ; Osteoporosis/diagnosis ; Germany ; Orthopedics
    Language German
    Publishing date 2023-02-21
    Publishing country Germany
    Document type English Abstract ; Journal Article
    ISSN 2731-7153
    ISSN (online) 2731-7153
    DOI 10.1007/s00132-023-04351-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Osteoporose: Diagnostik und Behandlung.

    Stumpf, Ulla / Kraus, Moritz / Ladurner, Roland / Neuerburg, Carl / Böcker, Wolfgang

    Chirurgie (Heidelberg, Germany)

    2022  Volume 93, Issue 11, Page(s) 1107–1120

    Abstract: Osteoporosis is the most common systemic skeletal disease worldwide. Its consequences have a substantial impact on the quality of life of patients and increases the overall morbidity and mortality. Standardized diagnostic procedures and treatment ... ...

    Title translation Osteoporosis: diagnostics and treatment.
    Abstract Osteoporosis is the most common systemic skeletal disease worldwide. Its consequences have a substantial impact on the quality of life of patients and increases the overall morbidity and mortality. Standardized diagnostic procedures and treatment recommendations have been available for years as German and international (S3) guidelines. Nevertheless, there is a considerable gap in the diagnosis and adequate treatment of osteoporosis, especially in Germany. The aim is to detect the disease at an early stage and to establish a specific and consistent treatment of osteoporosis. In this way the quality of life and independence of those affected can be maintained over a long period. In the acute and permanent treatment of manifest osteoporosis, surgeons, orthopedic and trauma surgeons play a key role.
    MeSH term(s) Humans ; Germany ; Orthopedics ; Osteoporosis/diagnosis ; Osteoporosis/drug therapy ; Quality of Life ; Surgeons ; Bone Density Conservation Agents/therapeutic use
    Chemical Substances Bone Density Conservation Agents
    Language German
    Publishing date 2022-04-06
    Publishing country Germany
    Document type English Abstract ; Journal Article
    ISSN 2731-698X
    ISSN (online) 2731-698X
    DOI 10.1007/s00104-022-01595-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Osteoporose: Diagnostik und Behandlung.

    Stumpf, Ulla / Kraus, Moritz / Ladurner, Roland / Neuerburg, Carl / Böcker, Wolfgang

    Zeitschrift fur Gerontologie und Geriatrie

    2022  Volume 55, Issue 8, Page(s) 703–714

    Abstract: Osteoporosis is the most common systemic skeletal disease worldwide. Its consequences have a substantial impact on the quality of life of patients and increases the overall morbidity and mortality. Standardized diagnostic procedures and treatment ... ...

    Title translation Osteoporosis: diagnostics and treatment.
    Abstract Osteoporosis is the most common systemic skeletal disease worldwide. Its consequences have a substantial impact on the quality of life of patients and increases the overall morbidity and mortality. Standardized diagnostic procedures and treatment recommendations have been available for years as German and international (S3) guidelines. Nevertheless, there is a considerable gap in the diagnosis and adequate treatment of osteoporosis, especially in Germany. The aim is to detect the disease at an early stage and to establish a specific and consistent treatment of osteoporosis. In this way the quality of life and independence of those affected can be maintained over a long period. In the acute and permanent treatment of manifest osteoporosis, surgeons, orthopedic and trauma surgeons play a key role.
    MeSH term(s) Humans ; Quality of Life ; Germany
    Language German
    Publishing date 2022-11-30
    Publishing country Germany
    Document type English Abstract ; Journal Article
    ZDB-ID 1227032-5
    ISSN 1435-1269 ; 0044-281X ; 0948-6704
    ISSN (online) 1435-1269
    ISSN 0044-281X ; 0948-6704
    DOI 10.1007/s00391-022-02148-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 497: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  6. Book ; Online ; Thesis: Systematische Behandlung abdomineller Stichverletzungen

    Krendl, Felix Julius [Verfasser] / Ladurner, Roland [Akademischer Betreuer]

    high quality treatment in a low incidence environment

    2022  

    Author's details Felix Julius Krendl ; Betreuer: Roland Ladurner
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitätsbibliothek der Ludwig-Maximilians-Universität
    Publishing place München
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  7. Article ; Online: Long-Term Progression-Free Survival of a Pre-Treated Patient with Metastatic Colorectal Cancer Receiving Trifluridine/Tipiracil.

    Michl, Gerlinde Maria / Vogt, Florian M / Nouriani, Andreas / Ladurner, Roland / Kremer, Marcus / Reisländer, Timo / Michl, Marlies

    Chemotherapy

    2023  Volume 69, Issue 1, Page(s) 27–34

    Abstract: Trifluridine/tipiracil is approved for the use in later or last-line setting in previously treated metastatic colorectal cancer (mCRC) patients who progressed on standard anti-tumor drugs including 5-fluorouracil (5-FU), irinotecan, oxaliplatin, anti- ... ...

    Abstract Trifluridine/tipiracil is approved for the use in later or last-line setting in previously treated metastatic colorectal cancer (mCRC) patients who progressed on standard anti-tumor drugs including 5-fluorouracil (5-FU), irinotecan, oxaliplatin, anti-VEGF and anti-EGFR antibodies, or who are not considered candidates for those standard therapies. In this report, we describe a 67-year-old male patient with KRAS-mutated mCRC and metachronous liver and lung metastasis who failed prior 5-FU- and irinotecan-containing regimens, but then showed long-term disease control for 31 months on single-agent trifluridine/tipiracil given as second-line treatment. According to our experience, trifluridine/tipiracil is a feasible and effective treatment option in earlier but not necessarily last-line therapy in mCRC patients who are not considered candidates for doublet or triplet chemotherapy. Besides its efficacy, it is associated with maintained quality of life and a manageable toxicity profile. Considering increasing age of mCRC patients and their wish for maintaining an independent lifestyle, further research on the use of trifluridine/tipiracil in earlier lines of systemic mCRC therapy is warranted.
    MeSH term(s) Male ; Humans ; Aged ; Progression-Free Survival ; Uracil/therapeutic use ; Colorectal Neoplasms/pathology ; Trifluridine/therapeutic use ; Trifluridine/adverse effects ; Irinotecan/therapeutic use ; Quality of Life ; Colonic Neoplasms/drug therapy ; Fluorouracil/therapeutic use ; Drug Combinations ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Pyrrolidines ; Thymine
    Chemical Substances tipiracil (NGO10K751P) ; Uracil (56HH86ZVCT) ; Trifluridine (RMW9V5RW38) ; Irinotecan (7673326042) ; Fluorouracil (U3P01618RT) ; Drug Combinations ; Pyrrolidines ; Thymine (QR26YLT7LT)
    Language English
    Publishing date 2023-06-19
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 6708-8
    ISSN 1421-9794 ; 0009-3157
    ISSN (online) 1421-9794
    ISSN 0009-3157
    DOI 10.1159/000531525
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    Uf I Zs.174: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  8. Article ; Online: Influence of insufflated carbon dioxide on abdominal temperature compared to oesophageal temperature during laparoscopic surgery.

    Groene, Philipp / Gündogar, Ufuk / Hofmann-Kiefer, Klaus / Ladurner, Roland

    Surgical endoscopy

    2020  Volume 35, Issue 12, Page(s) 6892–6896

    Abstract: Background: Body core temperature is an important vital parameter during surgery and anaesthesia. It is influenced by several patient-related and surgery-related factors. Laparoscopy is considered beneficial in terms of a variety of parameters, for ... ...

    Abstract Background: Body core temperature is an important vital parameter during surgery and anaesthesia. It is influenced by several patient-related and surgery-related factors. Laparoscopy is considered beneficial in terms of a variety of parameters, for example, postoperative pain and length of hospital stay. Non-humidified, non-warmed insufflated CO
    Methods: Seventy patients undergoing laparoscopic surgery were included in this prospective observational study. Temperature was measured oesophageal and abdominal before induction of anaesthesia (T1), right before skin incision (T2), 15 min, 30 min and 60 min after skin incision. All patients were treated according to actual guidelines for perioperative temperature measurement.
    Results: Body core temperature and abdominal temperature correlated moderately (r = 0.6123; p < 0.0001). Bland-Altman plot for comparison of methods showed an average difference of 0.4 °C (bias - 0.3955; 95% agreement of bias from - 2.365 to 1.574). Abdominal temperature further decreased after establishing pneumoperitoneum (T2: 36.2 °C (35.9/36.4) to T5: 36.1 °C (35.6/36.4); p < 0.0001), whereas oesophageal temperature increased (T2: 36.2 °C (35.9/36.4) to 36.4 °C (36.0/36.7); p = 0.0296). Values of oesophageal and abdominal measurement points differed at T4 (36.3 °C (36.0/36.6) vs. 36.1 °C (35.4/36.6); p < 0.0001) and T5 (36.4 °C (36.0/36.7) vs. 36.1 °C (35.6/36.4) p = 0.0003).
    Conclusion: This prospective observational trial shows the influence of insufflated, non-humidified carbon dioxide at room temperature on abdominal temperature during laparoscopic surgery. We show that carbon dioxide applied at these conditions decreases abdominal temperature and therefore might be a risk factor for perioperative hypothermia.
    MeSH term(s) Body Temperature ; Carbon Dioxide ; Humans ; Humidity ; Insufflation ; Laparoscopy ; Pneumoperitoneum, Artificial/adverse effects ; Temperature
    Chemical Substances Carbon Dioxide (142M471B3J)
    Language English
    Publishing date 2020-12-01
    Publishing country Germany
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 639039-0
    ISSN 1432-2218 ; 0930-2794
    ISSN (online) 1432-2218
    ISSN 0930-2794
    DOI 10.1007/s00464-020-08196-x
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    Zs.A 2214: Show issues Location:
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  9. Article ; Online: Schilddrüsenkarzinom – ist weniger (Therapie) mehr?

    Todica, Andrei / Ladurner, Roland / Spitzweg, Christine

    Deutsche medizinische Wochenschrift (1946)

    2018  Volume 143, Issue 7, Page(s) 453–458

    Title translation Differentiated thyroid cancer - is less (therapy) more?
    MeSH term(s) Humans ; Thyroid Neoplasms/diagnosis ; Thyroid Neoplasms/pathology ; Thyroid Neoplasms/therapy
    Language German
    Publishing date 2018-04
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 200446-x
    ISSN 1439-4413 ; 0012-0472
    ISSN (online) 1439-4413
    ISSN 0012-0472
    DOI 10.1055/s-0044-102192
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    Ua VI Zs.60: Show issues Location:
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  10. Article: Primary presentation and clinical course of pediatric and adolescent patients with differentiated thyroid carcinoma after radioiodine therapy.

    Burgard, Caroline / Zacherl, Mathias Johannes / Todica, Andrei / Hornung, Julia / Grawe, Freba / Pekrul, Isabell / Zimmermann, Petra / Schmid-Tannwald, Christine / Ladurner, Roland / Krenz, Detlef / Trupka, Arnold / Wagner, Johanna / Bartenstein, Peter / Spitzweg, Christine / Wenter, Vera

    Frontiers in oncology

    2023  Volume 13, Page(s) 1237472

    Abstract: Introduction: Differentiated thyroid carcinoma (DTC) in childhood and during adolescence is extremely rare. Pediatric DTC commonly presents with advanced disease at diagnosis including a high prevalence of cervical lymph node metastases and pulmonary ... ...

    Abstract Introduction: Differentiated thyroid carcinoma (DTC) in childhood and during adolescence is extremely rare. Pediatric DTC commonly presents with advanced disease at diagnosis including a high prevalence of cervical lymph node metastases and pulmonary metastases. Studies in children with DTC are limited. Therefore, we aimed to evaluate the initial presentation, effectiveness of radioiodine therapy (RIT), and long-term outcome of prepubertal in comparison to pubertal/postpubertal patients.
    Methods: Eighty-five pediatric and young patients aged 6.4 to 21.9 years with histopathologically confirmed DTC were retrospectively included. They all underwent total thyroidectomy followed by RIT. Initial presentation and outcome of prepubertal and pubertal/postpubertal patients were compared 1 year after RIT, during follow-up, and at the last visit of follow-up.
    Results: Prepubertal patients presented with significantly higher T and M stages. One year after RIT, 42/81 (52%) patients still presented with evidence of disease (ED). During follow-up of a median of 7.9 years, prepubertal patients were less often in complete remission (58% vs. 82% in pubertal patients). At the last visit of follow-up, 19/80 (24%) patients still had ED without statistical differences between the two groups (42% prepubertal vs. 18% pubertal/postpubertal,
    Conclusion: Prepubertal children with DTC presented with a more advanced tumor stage at the initial presentation. During follow-up, they present more often with ED. However, at the end of our study, we did not observe statistically relevant differences in patient outcomes between the prepubertal and pubertal/postpubertal groups.
    Language English
    Publishing date 2023-10-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1237472
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