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  1. Book ; Online: Pankreaskarzinom

    Ladurner, Ruth

    Empfehlungen zur Diagnostik, Therapie und Nachsorge

    (Schriftenreihe "Therapieempfehlungen" des Südwestdeutschen Tumorzentrums - Comprehensive Cancer Center Tübingen)

    2009  

    Institution Südwestdeutsches Tumorzentrum
    Author's details Südwestdeutsches Tumorzentrum. Autoren: R. Ladurner
    Series title Schriftenreihe "Therapieempfehlungen" des Südwestdeutschen Tumorzentrums - Comprehensive Cancer Center Tübingen
    Subject code 610
    Language German
    Size VIII, 32 S.
    Edition 2., überarb. Aufl.
    Publisher Südwestdeutsches Tumorzentrum
    Publishing place Tübingen
    Publishing country Germany
    Document type Book ; Online
    HBZ-ID HT016299028
    DOI 10.4126/38m-003740031
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  2. Book ; Thesis: Die Bedeutung der O2C-Methode bei der intraoperativen Beurteilung der Mikrozirkulation der Leber

    Ladurner, Ruth

    Pilotstudie

    2011  

    Author's details vorgelegt von Ruth Ladurner
    Language English
    Size 20 S., 21 cm
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Tübingen, Univ., Diss., 2011
    HBZ-ID HT016777111
    Database Catalogue ZB MED Medicine, Health

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    2011 D 555 order for loan Magazin

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  3. Book ; Online ; Thesis: Nutzenanalyse der Blutentnahme am ersten postoperativen Tag nach Cholezystektomie

    Wiegand, Lisa [Verfasser] / Ladurner, Ruth [Akademischer Betreuer]

    2023  

    Author's details Lisa Wiegand ; Betreuer: Ruth Ladurner
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitätsbibliothek Tübingen
    Publishing place Tübingen
    Document type Book ; Online ; Thesis
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  4. Article ; Online: Predicting complicated appendicitis is possible without the use of sectional imaging-presenting the NoCtApp score.

    Strohäker, Jens / Brüschke, Martin / Feng, You-Shan / Beltzer, Christian / Königsrainer, Alfred / Ladurner, Ruth

    International journal of colorectal disease

    2023  Volume 38, Issue 1, Page(s) 218

    Abstract: Purpose: Appendicitis is among the most common acute conditions treated by general surgery. While uncomplicated appendicitis (UA) can be treated delayed or even non-operatively, complicated appendicitis (CA) is a serious condition with possible long- ... ...

    Abstract Purpose: Appendicitis is among the most common acute conditions treated by general surgery. While uncomplicated appendicitis (UA) can be treated delayed or even non-operatively, complicated appendicitis (CA) is a serious condition with possible long-term morbidity that should be managed with urgent appendectomy. Distinguishing both conditions is usually done with computed tomography. The goal of this study was to develop a model to reliably predict CA with widespread available clinical and laboratory parameters and without the use of sectional imaging.
    Methods: Data from 1132 consecutive patients treated for appendicitis between 2014 and 2021 at a tertiary care hospital were used for analyses. Based on year of treatment, the data was divided into training (n = 696) and validation (n = 436) samples. Using the development sample, candidate predictors for CA-patient age, gender, body mass index (BMI), American Society of Anesthesiologist (ASA) score, duration of symptoms, white blood count (WBC), total bilirubin and C-reactive protein (CRP) on admission and free fluid on ultrasound-were first investigated using univariate logistic regression models and then included in a multivariate model. The final development model was tested on the validation sample.
    Results: In the univariate analysis age, BMI, ASA score, symptom duration, WBC, bilirubin, CRP, and free fluid each were statistically significant predictors of CA (each p < 0.001) while gender was not (p = 0.199). In the multivariate analysis BMI and bilirubin were not predictive and therefore not included in the final development model which was built from 696 patients. The final development model was significant (x
    Conclusions: Correctly identifying CA is helpful for optimizing patient treatment when they are diagnosed with appendicitis. Our logistic regression model can aid in correctly distinguishing UA and CA even without utilizing computed tomography.
    MeSH term(s) Humans ; Appendicitis/diagnostic imaging ; Appendicitis/surgery ; Tomography, X-Ray Computed ; Appendectomy ; Bilirubin ; Body Mass Index ; C-Reactive Protein
    Chemical Substances Bilirubin (RFM9X3LJ49) ; C-Reactive Protein (9007-41-4)
    Language English
    Publishing date 2023-08-19
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 84975-3
    ISSN 1432-1262 ; 0179-1958
    ISSN (online) 1432-1262
    ISSN 0179-1958
    DOI 10.1007/s00384-023-04501-x
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  5. Article ; Online: Primary admission to a surgical service facilitates early cholecystectomy in acute cholecystitis but does not influence patient outcome.

    Strohäker, Jens / Sabrow, Julia / Meier, Anke / Königsrainer, Alfred / Ladurner, Ruth / Yurttas, Can

    Langenbeck's archives of surgery

    2023  Volume 408, Issue 1, Page(s) 225

    Abstract: Purpose: Early cholecystectomy is recommended for acute calculous cholecystitis to reduce complications and lower health care costs. However, not all patients admitted to emergency services due to acute calculous cholecystitis are considered for surgery ...

    Abstract Purpose: Early cholecystectomy is recommended for acute calculous cholecystitis to reduce complications and lower health care costs. However, not all patients admitted to emergency services due to acute calculous cholecystitis are considered for surgery immediately. Our intention was therefore to evaluate patient management and outcome parameters following cholecystectomy depending on the type of emergency service patients are primarily admitted to.
    Methods: We performed a retrospective analysis of all patients that were treated for acute cholecystitis at our hospital between 2014 and 2021. Only patients that underwent surgical treatment for acute calculous cholecystitis were included. Patients with cholecystectomies that were performed due to other medical conditions were not incorporated. Primary outcomes were the perioperative length of stay and postoperative complications. Perioperative antimicrobial management and disease deterioration according to Tokyo Guidelines from 2018 due to inhouse organization were assessed as secondary outcome parameters.
    Results: Of 512 patients included in our final analysis, 334 patients were primarily admitted to a surgical emergency service (SAG) whereas 178 were initially treated in a medical service (MAG). The latency between admission and cholecystectomy was significantly prolonged in the MAG with a median time to surgery of 2 days (Q25 1, Q75 3.25, IQR 2.25) compared to the SAG with a median time to surgery of 1 day (Q25 1, Q75 2, IQR 1) (p < 0.001). The duration of surgery was comparable between both groups. Necrotizing cholecystitis (27.2% vs. 38.8%, p = 0.007) and pericholecystic abscess or gallbladder perforation (7.5% vs. 14.6% p = 0.010) were less frequently described in the SAG. In the SAG, 85.7% of CCEs were performed laparoscopically, 6.0% were converted to open, and 10.4% were performed as open surgery upfront. In the MAG, 80.9% were completed laparoscopically, while 7.2% were converted and 11.2% were performed via primary laparotomy (p = 0.743). Histologically gangrenous cholecystitis was confirmed in 38.0% of the specimen in the SAG compared to 47.8% in the MAG (p = 0.033). While the prolonged preoperative stay led to prolonged overall length of stay, the postoperative length of stay was similar at a median of 3 days in both groups.
    Conclusions: To our knowledge, we present the largest single center cohort of acute calculous cholecystitis evaluating the perioperative management and outcome of patients admitted to either medical or surgical service prior to undergoing cholecystectomy. In patients that were primarily admitted to medical emergency services, we found disproportionately more gallbladder necrosis, perforation, and gangrene. Despite prolonged time intervals between admission and cholecystectomy in the MAG and advanced cases of cholecystitis, we did not record a prolonged procedure duration, conversion to open surgery, or complication rate. However, patients with acute calculous cholecystitis should either be primarily admitted to a surgical emergency service or at least a surgeon should be consulted at the time of diagnosis in order to avoid disease progression and unnecessary health care costs.
    MeSH term(s) Humans ; Retrospective Studies ; Cholecystectomy/adverse effects ; Cholecystitis, Acute/surgery ; Cholecystitis, Acute/diagnosis ; Hospitalization ; Cholecystitis/etiology ; Cholecystitis/surgery ; Cholecystectomy, Laparoscopic/adverse effects ; Cholecystectomy, Laparoscopic/methods ; Treatment Outcome ; Length of Stay
    Language English
    Publishing date 2023-06-05
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1423681-3
    ISSN 1435-2451 ; 1435-2443
    ISSN (online) 1435-2451
    ISSN 1435-2443
    DOI 10.1007/s00423-023-02957-7
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  6. Article ; Online: MASLD is related to impaired alcohol dehydrogenase (ADH) activity and elevated blood ethanol levels: Role of TNFα and JNK.

    Burger, Katharina / Jung, Finn / Staufer, Katharina / Ladurner, Ruth / Trauner, Michael / Baumann, Anja / Brandt, Annette / Bergheim, Ina

    Redox biology

    2024  Volume 71, Page(s) 103121

    Abstract: Elevated fasting ethanol levels in peripheral blood frequently found in metabolic dysfunction-associated steatohepatitis (MASLD) patients even in the absence of alcohol consumption are discussed to contribute to disease development. To test the ... ...

    Abstract Elevated fasting ethanol levels in peripheral blood frequently found in metabolic dysfunction-associated steatohepatitis (MASLD) patients even in the absence of alcohol consumption are discussed to contribute to disease development. To test the hypothesis that besides an enhanced gastrointestinal synthesis a diminished alcohol elimination through alcohol dehydrogenase (ADH) may also be critical herein, we determined fasting ethanol levels and ADH activity in livers and blood of MASLD patients and in wild-type ± anti-TNFα antibody (infliximab) treated and TNFα
    MeSH term(s) Mice ; Humans ; Animals ; Alcohol Dehydrogenase/genetics ; Alcohol Dehydrogenase/metabolism ; Tumor Necrosis Factor-alpha/genetics ; Infliximab/pharmacology ; Ethanol/adverse effects ; Fatty Liver ; Alcohol Drinking
    Chemical Substances Alcohol Dehydrogenase (EC 1.1.1.1) ; Tumor Necrosis Factor-alpha ; Infliximab (B72HH48FLU) ; Ethanol (3K9958V90M)
    Language English
    Publishing date 2024-03-12
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2701011-9
    ISSN 2213-2317 ; 2213-2317
    ISSN (online) 2213-2317
    ISSN 2213-2317
    DOI 10.1016/j.redox.2024.103121
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  7. Article ; Conference proceedings: Creation of a pharyngeal coecostomy and reconstruction of the trachea using a supraclavicular island flap for esophagotracheal fistula after radiotherapy for advanced esophageal carcinoma

    Schneider, Fritz / Potthast, Georg / Ladurner, Ruth / Thiel, Karolin / Becker, Sven / Königsrainer, Alfred

    Laryngo-Rhino-Otologie

    2024  Volume 103, Issue S 02

    Event/congress 95th Annual Meeting German Society of Oto-Rhino-Laryngology, Head and Neck Surgery e. V., Bonn, Messe Essen, 2024-05-08
    Language English
    Publishing date 2024-04-19
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 96005-6
    ISSN 1438-8685 ; 0935-8943 ; 0340-1588
    ISSN (online) 1438-8685
    ISSN 0935-8943 ; 0340-1588
    DOI 10.1055/s-0044-1784723
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  8. Book ; Online ; Thesis: Liposarkome

    Arya, Christian [Verfasser] / Ladurner, Ruth [Akademischer Betreuer]

    Rolle der adjuvanten bzw. neoadjuvanten Therapie bei der Primärmanifestation und beim Rezidiv

    2022  

    Author's details Christian Simon Arya ; Betreuer: Ruth Ladurner
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitätsbibliothek Tübingen
    Publishing place Tübingen
    Document type Book ; Online ; Thesis
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  9. Article: Perioperative Antibiotics in Appendicitis-Do We Need to Adjust Therapy for the Elderly? A Matched Pair Analysis.

    Strohäker, Jens / Brüschke, Martin / Leser, Nora / Königsrainer, Alfred / Ladurner, Ruth / Bachmann, Robert

    Antibiotics (Basel, Switzerland)

    2022  Volume 11, Issue 11

    Abstract: 1) Background: Perioperative Antibiotics for acute complicated appendicitis are a standard of care. While there are plenty of trials for pediatric patients, data for elderly patients are scarce. The goal of our study was to evaluate whether elderly ... ...

    Abstract (1) Background: Perioperative Antibiotics for acute complicated appendicitis are a standard of care. While there are plenty of trials for pediatric patients, data for elderly patients are scarce. The goal of our study was to evaluate whether elderly patients carry more resistant bacteria and thus have less favorable outcomes after an appendectomy that may warrant intensified perioperative antibiotic treatment (2) We present a retrospective single-center matched pair (139 patients each) analysis of perioperative and microbiological outcomes of an elderly appendicitis cohort (i.e., older than 60 years) compared with a younger adult cohort (i.e., ≤60 years). Both groups were matched one for one according to gender, duration of symptoms, c-reactive protein at presentation and whether they presented with uncomplicated or complicated appendicitis. (3) Results: After matching, complicated appendicitis was present in 76.3% of both groups. Elderly patients more frequently received preoperative diagnostic CT (p < 0.001) than the young. Both operative strategy (laparoscopic appendectomy in 92.1% each) and duration of surgery (57 vs. 56 min) were equal in both groups. Postoperative antibiotics were prescribed in ~57% for a median of 3 days in both groups and antibiotic selection was similar. The incidence of surgical site infections was higher in the young (12.2% vs. 7.9%) yet not significant. There was no difference in culture positivity or bacterial spectrum and the elderly cohort did not present with increased resistant bacterial isolates. (4) Conclusions: While overall resistant bacterial strains were rare, perioperative outcomes between the young and the elderly did not differ and did neither warrant longer nor intensified antibiotic treatment.
    Language English
    Publishing date 2022-11-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics11111525
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  10. Article: Management of Symptomatic Gallstone Disease during COVID-19 Lockdown in a High-Resource Setting: Is There a Need for Treatment Alterations?

    Strohaeker, Jens / Sabrow, Julia / Yurttas, Can / Königsrainer, Alfred / Ladurner, Ruth / Hoenes, Felix

    Visceral medicine

    2022  Volume 38, Issue 4, Page(s) 265–271

    Abstract: Introduction: Cholecystectomy (CCE) is the treatment of choice of symptomatic gallstones. Due to the SARS-CoV-2 pandemic, operating room (OR) capacities have been reduced. The goal of this study was to evaluate the duration of symptoms of patients ... ...

    Abstract Introduction: Cholecystectomy (CCE) is the treatment of choice of symptomatic gallstones. Due to the SARS-CoV-2 pandemic, operating room (OR) capacities have been reduced. The goal of this study was to evaluate the duration of symptoms of patients presenting with gallstone disease during a lockdown, the surgical management, and the severity grade of their disease.
    Materials and methods: A cohort study of 353 CCEs performed at a university hospital over two 10-week periods during 2 pandemic lockdowns in Germany compared to corresponding periods in 2018 and 2019.
    Results: During the lockdowns, 101 CCEs were performed compared to 252 in the prior years. The number of elective CCEs was reduced to save OR capacities (
    Conclusions: The incidence and severity of acute cholecystitis during the lockdowns were comparable to the prior years. Acute care surgery was provided at the expense of elective procedures, and there was no need for treatment alterations.
    Language English
    Publishing date 2022-01-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2850733-2
    ISSN 2297-475X ; 2297-4725
    ISSN (online) 2297-475X
    ISSN 2297-4725
    DOI 10.1159/000519789
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