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  1. Article ; Online: 'Lentiform fork sign' as a radiological feature of posterior reversible encephalopathy syndrome.

    Laespada-García, María Isabel / Azcárate-Díaz, Francisco Javier / Méndez-Guerrero, Antonio

    Acta neurologica Belgica

    2021  Volume 121, Issue 3, Page(s) 757–759

    MeSH term(s) Adult ; Corpus Striatum/diagnostic imaging ; Female ; Humans ; Magnetic Resonance Imaging/methods ; Posterior Leukoencephalopathy Syndrome/blood ; Posterior Leukoencephalopathy Syndrome/diagnostic imaging ; Pregnancy ; Pregnancy Complications/blood ; Pregnancy Complications/diagnostic imaging ; Tomography, X-Ray Computed/methods
    Language English
    Publishing date 2021-03-15
    Publishing country Italy
    Document type Case Reports ; Journal Article
    ZDB-ID 127315-2
    ISSN 2240-2993 ; 0300-9009
    ISSN (online) 2240-2993
    ISSN 0300-9009
    DOI 10.1007/s13760-021-01643-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Author Response: Acute Hypokinetic-Rigid Syndrome After SARS-CoV-2 Infection.

    Méndez-Guerrero, Antonio / Blanco-Palmero, Víctor Antonio / Laespada-García, María Isabel / Azcárate-Díaz, Francisco Javier / González de la Aleja, Jesús

    Neurology

    2021  Volume 96, Issue 9, Page(s) 461

    MeSH term(s) COVID-19 ; Consciousness ; Electroencephalography ; Heart Arrest ; Humans ; SARS-CoV-2
    Language English
    Publishing date 2021-02-27
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000011533
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Acute hypokinetic-rigid syndrome following SARS-CoV-2 infection.

    Méndez-Guerrero, Antonio / Laespada-García, María Isabel / Gómez-Grande, Adolfo / Ruiz-Ortiz, Mariano / Blanco-Palmero, Víctor Antonio / Azcarate-Diaz, Francisco Javier / Rábano-Suárez, Pablo / Álvarez-Torres, Eva / de Fuenmayor-Fernández de la Hoz, Carlos Pablo / Vega Pérez, Diana / Rodríguez-Montalbán, Raquel / Pérez-Rivilla, Alfredo / Sayas Catalán, Javier / Ramos-González, Ana / González de la Aleja, Jesús

    Neurology

    2020  Volume 95, Issue 15, Page(s) e2109–e2118

    Abstract: Objective: To report a case of a patient infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) who acutely developed a hypokinetic-rigid syndrome.: Methods: Patient data were obtained from medical records from the Hospital ... ...

    Abstract Objective: To report a case of a patient infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) who acutely developed a hypokinetic-rigid syndrome.
    Methods: Patient data were obtained from medical records from the Hospital Universitario 12 de Octubre in Madrid, Spain. [
    Results: We report a previously healthy 58-year-old man who developed hyposmia, generalized myoclonus, fluctuating and transient changes in level of consciousness, opsoclonus, and an asymmetric hypokinetic-rigid syndrome with ocular abnormalities after a severe SARS-CoV-2 infection. DaT-SPECT confirmed a bilateral decrease in presynaptic dopamine uptake asymmetrically involving both putamina. Significant improvement in the parkinsonian symptoms was observed without any specific treatment.
    Conclusion: This case study provides clinical and functional neuroimaging evidence to support that SARS-CoV-2 can gain access to the CNS, affecting midbrain structures and leading to neurologic signs and symptoms.
    MeSH term(s) Betacoronavirus ; Brain/diagnostic imaging ; Brain/metabolism ; COVID-19 ; Consciousness Disorders ; Coronavirus Infections/complications ; Coronavirus Infections/diagnostic imaging ; Coronavirus Infections/physiopathology ; Disease Progression ; Dopamine Plasma Membrane Transport Proteins/metabolism ; Electroencephalography ; Humans ; Hypokinesia/diagnostic imaging ; Hypokinesia/etiology ; Hypokinesia/physiopathology ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Muscle Rigidity/diagnostic imaging ; Muscle Rigidity/etiology ; Muscle Rigidity/physiopathology ; Nortropanes ; Ocular Motility Disorders ; Pandemics ; Parkinson Disease, Postencephalitic/diagnostic imaging ; Parkinson Disease, Postencephalitic/etiology ; Parkinson Disease, Postencephalitic/physiopathology ; Pneumonia, Viral/complications ; Pneumonia, Viral/diagnostic imaging ; Pneumonia, Viral/physiopathology ; Putamen/diagnostic imaging ; Putamen/metabolism ; SARS-CoV-2 ; Tomography, Emission-Computed, Single-Photon
    Chemical Substances Dopamine Plasma Membrane Transport Proteins ; Nortropanes ; ioflupane (VF232WE742)
    Keywords covid19
    Language English
    Publishing date 2020-07-08
    Publishing country United States
    Document type Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't ; Video-Audio Media
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000010282
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Acute hypokinetic-rigid syndrome following SARS-CoV-2 infection

    Méndez-Guerrero, Antonio / Laespada-García, María Isabel / Gómez-Grande, Adolfo / Ruiz-Ortiz, Mariano / Blanco-Palmero, Víctor Antonio / Azcarate-Diaz, Francisco Javier / Rábano-Suárez, Pablo / Álvarez-Torres, Eva / de Fuenmayor-Fernández de la Hoz, Carlos Pablo / Vega Pérez, Diana / Rodríguez-Montalbán, Raquel / Pérez-Rivilla, Alfredo / Sayas Catalán, Javier / Ramos-González, Ana / González de la Aleja, Jesús

    Neurology

    Abstract: OBJECTIVE: To report a case of a patient infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) who acutely developed a hypokinetic-rigid syndrome. METHODS: Patient data were obtained from medical records from the Hospital ... ...

    Abstract OBJECTIVE: To report a case of a patient infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) who acutely developed a hypokinetic-rigid syndrome. METHODS: Patient data were obtained from medical records from the Hospital Universitario 12 de Octubre in Madrid, Spain. [123I]-ioflupane dopamine transporter (DaT) SPECT images were acquired 4 hours after a single dose of 185 MBq of 123I-FP-CIT. Quantitative analysis was performed with DaTQUANT software providing the specific binding ratio and z score values of the striatum. RESULTS: We report a previously healthy 58-year-old man who developed hyposmia, generalized myoclonus, fluctuating and transient changes in level of consciousness, opsoclonus, and an asymmetric hypokinetic-rigid syndrome with ocular abnormalities after a severe SARS-CoV-2 infection. DaT-SPECT confirmed a bilateral decrease in presynaptic dopamine uptake asymmetrically involving both putamina. Significant improvement in the parkinsonian symptoms was observed without any specific treatment. CONCLUSION: This case study provides clinical and functional neuroimaging evidence to support that SARS-CoV-2 can gain access to the CNS, affecting midbrain structures and leading to neurologic signs and symptoms.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #638341
    Database COVID19

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  5. Article ; Online: Acute hypokinetic-rigid syndrome following SARS-CoV-2 infection

    Méndez-Guerrero, Antonio / Laespada-García, María Isabel / Gómez-Grande, Adolfo / Ruiz-Ortiz, Mariano / Blanco-Palmero, Víctor Antonio / Azcarate-Diaz, Francisco Javier / Rábano-Suárez, Pablo / Álvarez-Torres, Eva / de Fuenmayor-Fernández de la Hoz, Carlos Pablo / Pérez, Diana Vega / Rodríguez-Montalbán, Raquel / Pérez-Rivilla, Alfredo / Catalán, Javier Sayas / González, Ana Ramos- / González de la Aleja, Jesús

    Neurology

    2020  , Page(s) 10.1212/WNL.0000000000010282

    Abstract: OBJECTIVE: To report a case of a patient infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) who acutely developed a hypokinetic-rigid syndrome. METHODS: Patient data were obtained from medical records from the “Hospital ... ...

    Abstract OBJECTIVE: To report a case of a patient infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) who acutely developed a hypokinetic-rigid syndrome. METHODS: Patient data were obtained from medical records from the “Hospital Universitario 12 de Octubre” in Madrid, Spain. [ 123 I]-ioflupane dopamine transporter single-photon emission CT (DaT-SPECT) images were acquired 4 hours after a single dose of 185 MBq of 123 I-FP-CIT. Quantitative analysis was performed using DaTQUANT TM software providing the specific binding ratio (SBR) and z-score values of the striatum. RESULTS: We report a previously healthy 58-year-old man who developed hyposmia, generalized myoclonus, fluctuating and transient changes in level of consciousness, opsoclonus and an asymmetric hypokinetic-rigid syndrome with ocular abnormalities after a severe SARS-CoV-2 infection. DaT-SPECT confirmed a bilateral decrease in presynaptic dopamine uptake asymmetrically involving both putamina. Significant improvement in the parkinsonian symptoms was observed without any specific treatment. CONCLUSION: This case study provides clinical and functional neuroimaging evidence to support that SARS-CoV-2 can gain access to the central nervous system, affecting midbrain structures and leading to neurological signs and symptoms.
    Keywords Clinical Neurology ; covid19
    Language English
    Publisher Ovid Technologies (Wolters Kluwer Health)
    Publishing country us
    Document type Article ; Online
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/wnl.0000000000010282
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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