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  1. Book: IgE antibodies: Generation and function

    Lafaille, Juan J. / Curotto de Lafaille, Maria A.

    (Current topics in microbiology and immunology ; 388)

    2015  

    Author's details Juan J. Lafaille ; Maria A. Curotto de Lafaille eds
    Series title Current topics in microbiology and immunology ; 388
    Collection
    Language English
    Size IX, 152 S. : graph. Darst.
    Publisher Springer
    Publishing place Cham u.a.
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT018546137
    ISBN 978-3-319-13724-7 ; 3-319-13724-7 ; 9783319137254 ; 3319137255
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Ud II Zs 24 -388- verfügbar in Königswinter Königswinter

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  2. Article ; Online: Learning-dependent dendritic spine plasticity is impaired in spontaneous autoimmune encephalomyelitis.

    Huang, Lianyan / Lafaille, Juan J / Yang, Guang

    Developmental neurobiology

    2021  Volume 81, Issue 5, Page(s) 736–745

    Abstract: Cognitive impairment is often observed in multiple sclerosis and its animal models, experimental autoimmune encephalomyelitis (EAE). Using mice with immunization-induced EAE, we have previously shown that the stability of cortical synapses is markedly ... ...

    Abstract Cognitive impairment is often observed in multiple sclerosis and its animal models, experimental autoimmune encephalomyelitis (EAE). Using mice with immunization-induced EAE, we have previously shown that the stability of cortical synapses is markedly decreased before the clinical onset of EAE. In this study, we examined learning-dependent structural synaptic plasticity in a spontaneous EAE model. Transgenic mice expressing myelin basic protein-specific T cell receptor genes develop EAE spontaneously at around 8 weeks of age. Using in vivo two-photon microscopy, we found that the elimination and formation rates of postsynaptic dendritic spines in somatosensory and motor cortices increased weeks before detectable signs of EAE and remained to be high during the disease onset. Despite the elevated basal spine turnover, motor learning-induced spine formation was reduced in presymptomatic EAE mice, in line with their impaired ability to retain learned motor skills. Additionally, we found a substantial elevation of IFN-γ mRNA in the brain of 4-week-old presymptomatic mice, and treatment of anti-IFN-γ antibody reduced dendritic spine elimination in the cortex. Together, these findings reveal synaptic instability and failure to form new synapses after learning as early brain pathology of EAE, which may contribute to cognitive and behavioral deficits seen in autoimmune diseases.
    MeSH term(s) Animals ; Dendritic Spines/pathology ; Encephalomyelitis/pathology ; Encephalomyelitis, Autoimmune, Experimental/chemically induced ; Encephalomyelitis, Autoimmune, Experimental/pathology ; Mice ; Mice, Inbred C57BL ; Neuronal Plasticity ; Synapses/pathology
    Language English
    Publishing date 2021-05-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2256184-5
    ISSN 1932-846X ; 1097-4695 ; 1932-8451 ; 0022-3034
    ISSN (online) 1932-846X ; 1097-4695
    ISSN 1932-8451 ; 0022-3034
    DOI 10.1002/dneu.22827
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 853: Show issues Location:
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  3. Article ; Online: Transcriptomic analysis of loss of Gli1 in neural stem cells responding to demyelination in the mouse brain.

    Samanta, Jayshree / Silva, Hernandez Moura / Lafaille, Juan J / Salzer, James L

    Scientific data

    2021  Volume 8, Issue 1, Page(s) 278

    Abstract: In the adult mammalian brain, Gli1 expressing neural stem cells reside in the subventricular zone and their progeny are recruited to sites of demyelination in the white matter where they generate new oligodendrocytes, the myelin forming cells. Remarkably, ...

    Abstract In the adult mammalian brain, Gli1 expressing neural stem cells reside in the subventricular zone and their progeny are recruited to sites of demyelination in the white matter where they generate new oligodendrocytes, the myelin forming cells. Remarkably, genetic loss or pharmacologic inhibition of Gli1 enhances the efficacy of remyelination by these neural stem cells. To understand the molecular mechanisms involved, we performed a transcriptomic analysis of this Gli1-pool of neural stem cells. We compared murine NSCs with either intact or deficient Gli1 expression from adult mice on a control diet or on a cuprizone diet which induces widespread demyelination. These data will be a valuable resource for identifying therapeutic targets for enhancing remyelination in demyelinating diseases like multiple sclerosis.
    MeSH term(s) Animals ; Cuprizone ; Demyelinating Diseases/genetics ; Mice ; Neural Stem Cells/cytology ; Oligodendroglia/cytology ; Transcriptome ; Zinc Finger Protein GLI1/genetics
    Chemical Substances Gli1 protein, mouse ; Zinc Finger Protein GLI1 ; Cuprizone (5N16U7E0AO)
    Language English
    Publishing date 2021-10-28
    Publishing country England
    Document type Dataset ; Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2775191-0
    ISSN 2052-4463 ; 2052-4463
    ISSN (online) 2052-4463
    ISSN 2052-4463
    DOI 10.1038/s41597-021-01063-x
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  4. Article ; Online: P2X7 receptor inhibition ameliorates dendritic spine pathology and social behavioral deficits in Rett syndrome mice.

    Garré, Juan Mauricio / Silva, Hernandez Moura / Lafaille, Juan J / Yang, Guang

    Nature communications

    2020  Volume 11, Issue 1, Page(s) 1784

    Abstract: Dysregulated immunity has been implicated in the pathogenesis of neurodevelopmental disorders but its contribution to synaptic and behavioral deficits in Rett syndrome (RTT) remains unknown. P2X7 receptors (P2X7Rs) are unique purinergic receptors with ... ...

    Abstract Dysregulated immunity has been implicated in the pathogenesis of neurodevelopmental disorders but its contribution to synaptic and behavioral deficits in Rett syndrome (RTT) remains unknown. P2X7 receptors (P2X7Rs) are unique purinergic receptors with pro-inflammatory functions. Here, we report in a MECP2-deficient mouse model of RTT that the border of the cerebral cortex exhibits increased number of inflammatory myeloid cells expressing cell-surface P2X7Rs. Total knockout of P2X7Rs in MECP2 deficient mice decreases the number of inflammatory myeloid cells, restores cortical dendritic spine dynamics, and improves the animals' neurological function and social behavior. Furthermore, either genetic depletion of P2X7Rs in bone-marrow derived leukocytes or pharmacological block of P2X7Rs primarily outside of the central nervous system parenchyma, recapitulates the beneficial effects of total P2X7R depletion on the social behavior. Together, our results highlight the pathophysiological roles of P2X7Rs in a mouse model of RTT.
    MeSH term(s) Animals ; Brain/drug effects ; Brain/metabolism ; Dendritic Spines/drug effects ; Dendritic Spines/metabolism ; Disease Models, Animal ; Flow Cytometry ; Male ; Mice ; Mice, Knockout ; Purinergic P2X Receptor Antagonists/pharmacology ; Purinergic P2X Receptor Antagonists/therapeutic use ; Receptors, Purinergic P2X7/metabolism ; Rett Syndrome/drug therapy ; Rett Syndrome/metabolism ; Rosaniline Dyes/pharmacology
    Chemical Substances Purinergic P2X Receptor Antagonists ; Receptors, Purinergic P2X7 ; Rosaniline Dyes ; coomassie Brilliant Blue (M1ZRX790SI)
    Language English
    Publishing date 2020-04-14
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-020-15590-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Induced CD4+Foxp3+ regulatory T cells in immune tolerance.

    Bilate, Angelina M / Lafaille, Juan J

    Annual review of immunology

    2012  Volume 30, Page(s) 733–758

    Abstract: Regulatory T lymphocytes are essential to maintain homeostasis of the immune system, limiting the magnitude of effector responses and allowing the establishment of immunological tolerance. Two main types of regulatory T cells have been identified-- ... ...

    Abstract Regulatory T lymphocytes are essential to maintain homeostasis of the immune system, limiting the magnitude of effector responses and allowing the establishment of immunological tolerance. Two main types of regulatory T cells have been identified--natural and induced (or adaptive)-and both play significant roles in tuning down effector immune responses. Adaptive CD4(+)Foxp3(+) regulatory T (iTreg) cells develop outside the thymus under a variety of conditions. These include not only antigen presentation under subimmunogenic or noninflammatory conditions, but also chronic inflammation and infections. We speculate that the different origin of iTreg cells (noninflammatory versus inflammatory) results in distinct properties, including their stability. iTreg cells are also generated during homeostasis of the gut and in cancer, although some cancers also favor expansion of natural regulatory T (nTreg) cells. Here we review how iTreg cells develop and how they participate in immunological tolerance, contrasting, when possible, iTreg cells with nTreg cells.
    MeSH term(s) Adoptive Transfer ; Animals ; Antigen-Presenting Cells/immunology ; Antigen-Presenting Cells/metabolism ; CD4 Antigens/metabolism ; Forkhead Transcription Factors/metabolism ; Humans ; Immune Tolerance/immunology ; Lymphoid Tissue/immunology ; Lymphoid Tissue/metabolism ; T-Lymphocytes, Regulatory/immunology ; T-Lymphocytes, Regulatory/metabolism
    Chemical Substances CD4 Antigens ; FOXP3 protein, human ; Forkhead Transcription Factors
    Language English
    Publishing date 2012
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 604953-9
    ISSN 1545-3278 ; 0732-0582
    ISSN (online) 1545-3278
    ISSN 0732-0582
    DOI 10.1146/annurev-immunol-020711-075043
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  6. Article ; Online: Maternal-fetal immune tolerance, block by block.

    Gobert, Michael / Lafaille, Juan J

    Cell

    2012  Volume 150, Issue 1, Page(s) 7–9

    Abstract: How difficult is to go from egg to implanted embryo? The evolution of placentation in eutherian mammals created enormous challenges, in particular to the maternal immune system, as the fetus expresses paternal antigens that are capable of triggering ... ...

    Abstract How difficult is to go from egg to implanted embryo? The evolution of placentation in eutherian mammals created enormous challenges, in particular to the maternal immune system, as the fetus expresses paternal antigens that are capable of triggering immune rejection. Samstein et al. reveal a role for inducible regulatory T cells in the enforcement of maternal-fetal immune tolerance.
    Language English
    Publishing date 2012-07-06
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2012.06.020
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    Zs.A 1167: Show issues Location:
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    Zs.MG 58: Show issues

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  7. Article ; Online: CX3CR1

    Garré, Juan Mauricio / Silva, Hernandez Moura / Lafaille, Juan J / Yang, Guang

    Nature medicine

    2017  Volume 23, Issue 6, Page(s) 714–722

    Abstract: Impaired learning and cognitive function often occurs during systemic infection or inflammation. Although activation of the innate immune system has been linked to the behavioral and cognitive effects that are associated with infection, the underlying ... ...

    Abstract Impaired learning and cognitive function often occurs during systemic infection or inflammation. Although activation of the innate immune system has been linked to the behavioral and cognitive effects that are associated with infection, the underlying mechanisms remain poorly understood. Here we mimicked viral immune activation with poly(I:C), a synthetic analog of double-stranded RNA, and longitudinally imaged postsynaptic dendritic spines of layer V pyramidal neurons in the mouse primary motor cortex using two-photon microscopy. We found that peripheral immune activation caused dendritic spine loss, impairments in learning-dependent dendritic spine formation and deficits in multiple learning tasks in mice. These observed synaptic alterations in the cortex were mediated by peripheral-monocyte-derived cells and did not require microglial function in the central nervous system. Furthermore, activation of CX3CR1
    MeSH term(s) Animals ; Behavior, Animal ; CX3C Chemokine Receptor 1 ; Dendritic Spines/immunology ; Dendritic Spines/pathology ; Enzyme-Linked Immunosorbent Assay ; Flow Cytometry ; Immunohistochemistry ; Intravital Microscopy ; Learning ; Mice ; Microscopy ; Monocytes/immunology ; Motor Cortex/immunology ; Neuronal Plasticity/immunology ; Poly I-C ; Polynucleotides/pharmacology ; Pyramidal Cells/immunology ; Pyramidal Cells/pathology ; Receptors, Chemokine/metabolism ; Tumor Necrosis Factor-alpha/immunology
    Chemical Substances CX3C Chemokine Receptor 1 ; Cx3cr1 protein, mouse ; Polynucleotides ; Receptors, Chemokine ; Tumor Necrosis Factor-alpha ; Poly I-C (O84C90HH2L)
    Language English
    Publishing date 2017-05-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1220066-9
    ISSN 1546-170X ; 1078-8956
    ISSN (online) 1546-170X
    ISSN 1078-8956
    DOI 10.1038/nm.4340
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    Zs.A 4212: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 39: Show issues

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  8. Article: Reaginic antibodies.

    Lafaille, Juan J / Curotto de Lafaille, Maria A

    Current topics in microbiology and immunology

    2015  Volume 388, Page(s) v–vii

    MeSH term(s) Animals ; Humans ; Immunoglobulin E/physiology
    Chemical Substances Immunoglobulin E (37341-29-0)
    Language English
    Publishing date 2015
    Publishing country Germany
    Document type Introductory Journal Article
    ISSN 0070-217X
    ISSN 0070-217X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book: IgE antibodies: generation and function

    Curotto de Lafaille, Maria A / Lafaille, Juan J

    (Current topics in microbiology and immunology ; 388)

    2015  

    Author's details Juan J. Lafaille ; Maria A. Curotto de Lafaille, ed
    Series title Current topics in microbiology and immunology ; 388
    Language English
    Size ix, 152 S, 235 mm x 155 mm
    Publisher Springer
    Publishing place Berlin u.a.
    Document type Book
    ISBN 9783319137247 ; 3319137247
    Database Special collection on veterinary medicine and general parasitology

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  10. Book ; Online: IgE Antibodies: Generation and Function

    Lafaille, Juan J / Curotto de Lafaille, Maria A

    (Current Topics in Microbiology and Immunology ; 388)

    2015  

    Abstract: This volume examines all facets of the complex biology of Immunoglobulin E (IgE) antibodies, which play an essential role in the pathophysiology of allergic diseases and immunity to parasites. It highlights the unique mechanisms involved in the ... ...

    Institution Maria A. Curotto de Lafaille
    Author's details edited by Juan J. Lafaille, Maria A. Curotto de Lafaille
    Series title Current Topics in Microbiology and Immunology ; 388
    Abstract This volume examines all facets of the complex biology of Immunoglobulin E (IgE) antibodies, which play an essential role in the pathophysiology of allergic diseases and immunity to parasites. It highlights the unique mechanisms involved in the regulation of IgE production at both the molecular and cellular level. Furthermore, it discusses in detail novel findings on how the affinity, specificity and cross-reactivity of IgE can fine-tune mast cell responses to allergens. The book also explores the beneficial roles of IgE antibodies in immunity to helminthes and protection against tumors, and how the properties of IgE-mediated immunity are employed in the development of IgE therapeutic antibodies. All chapters were written by respected experts in their fields and will appeal to scientists and clinicians alike
    Keywords Allergy ; Medical parasitology ; Medicine ; Monoclonal antibodies ; Medizin / Gesundheit Immunologie ; Medizin / Gesundheit Sonstiges ; Technik / Wissen Biologie
    Language English
    Size Online-Ressource
    Publisher Springer Science and Business Media
    Publishing place Place of publication not identified
    Document type Book ; Online
    Note Description based upon print version of record
    ISBN 9783319137247 ; 9783319137254 ; 3319137247 ; 3319137255
    DOI 10.1007/978-3-319-13725-4
    Database Former special subject collection: coastal and deep sea fishing

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