Article: Utility of Urine N-acetyl-β-D-glucosaminidase for Prediction of Renal Damage in Obese Children.
2022 Volume 32, Issue 3, Page(s) 699–702
Abstract: The incidence of obesity has increased globally in children and adults. In addition, renal dysfunction is an important complication of childhood obesity. This study was performed to identify the diagnostic value of N-acetyl-β-D-glucosaminidase (NAG), a ... ...
| Abstract | The incidence of obesity has increased globally in children and adults. In addition, renal dysfunction is an important complication of childhood obesity. This study was performed to identify the diagnostic value of N-acetyl-β-D-glucosaminidase (NAG), a renal injury marker, for the early determination of renal damage in childhood obesity. Totally, 115 obese children and 115 healthy normal weight controls were enrolled in a cross-sectional case-control study. Urine NAG was measured in sample urine and normalized by urine creatinine (CR). In addition, correlation of urine NAG with other variables such as blood pressure (BP), blood glucose, and urine albumin was evaluated. Mean systolic BP (P <0.001), serum glucose (P = 0.047), urine albumin/Cr (P = 0.049), and urine NAG/Cr (P = 0.037) were significantly higher in obese children, compared with normal healthy controls. There was no correlation between urine NAG and urine albumin excretion. Urinary NAG/Cr was a simple and safe screening test for early determination of renal damage in children with obesity. |
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| MeSH term(s) | Acetylglucosaminidase/urine ; Acute Kidney Injury/diagnosis ; Acute Kidney Injury/urine ; Adolescent ; Albuminuria/urine ; Biomarkers/urine ; Body Weight/physiology ; Case-Control Studies ; Child ; Child, Preschool ; Creatinine/urine ; Cross-Sectional Studies ; Humans ; Pediatric Obesity/complications ; Pediatric Obesity/diagnosis | |||||
| Chemical Substances | Biomarkers ; Creatinine (AYI8EX34EU) ; Acetylglucosaminidase (EC 3.2.1.52) | |||||
| Language | English | |||||
| Publishing date | 2022-02-10 | |||||
| Publishing country | Saudi Arabia | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 1379955-1 | |||||
| ISSN | 1319-2442 | |||||
| ISSN | 1319-2442 | |||||
| DOI | 10.4103/1319-2442.336764 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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