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Article ; Online: Dipeptidyl Peptidase 4 Stimulation Induces Adipogenesis-Related Gene Expression of Adipose Stromal Cells.

Lai, Hsiao-Chi / Chen, Pei-Hsuan / Tang, Chia-Hua / Chen, Lee-Wei

International journal of molecular sciences

2023 Volume 24, Issue 22

Abstract: Adipogenesis has emerged as a new therapeutic target for regulating metabolism and achieving anti-inflammatory and anti-atherosclerotic effects via the release of adiponectin. However, at present, the effects and mechanism of action of dipeptidyl ... ...

Abstract	Adipogenesis has emerged as a new therapeutic target for regulating metabolism and achieving anti-inflammatory and anti-atherosclerotic effects via the release of adiponectin. However, at present, the effects and mechanism of action of dipeptidyl peptidase 4 (DPP4) stimulation on adiponectin production and adipogenesis have not been clarified. Here, we investigated the effects of DPP4 stimulation with monocyte chemoattractant protein-1 (MCP-1) on platelet-derived growth factor receptor alpha (PDGFRα) expression in adipose tissue and blood adiponectin levels. Stromal vascular fractions (SVFs) purified from human subcutaneous adipose tissue and inguinal adipose tissue of obese and diabetic (
MeSH term(s)	Animals ; Humans ; Mice ; Adipogenesis/genetics ; Adiponectin/metabolism ; Dipeptidyl Peptidase 4/genetics ; Gene Expression ; Interleukin-10/genetics ; PPAR gamma/metabolism ; Receptor, Platelet-Derived Growth Factor alpha/genetics ; RNA, Messenger/metabolism ; Stromal Cells/metabolism
Chemical Substances	Adiponectin ; Dipeptidyl Peptidase 4 (EC 3.4.14.5) ; Interleukin-10 (130068-27-8) ; PPAR gamma ; Receptor, Platelet-Derived Growth Factor alpha (EC 2.7.10.1) ; RNA, Messenger ; Dpp4 protein, mouse (EC 3.4.14.5)
Language	English
Publishing date	2023-11-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms242216101
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The effects of UVB irradiance on aberrant epidermal proliferation: Novel insights on how to improve currently available sunscreens

Lai, Hsiao-Chi / Lin, Chang-Shen / Wu, Ching-Shuang / Lan, Cheng-Che E.

Life sciences. 2022 Jan. 01, v. 288

2022

Abstract: Sunscreen use, which prolonged the time required to develop sunburn by reducing the irradiance (mW/cm²) of the UVB radiation, is thought to protect the skin from developing cancers. Recently, in addition to fluence (mJ/cm²), irradiance of the UVB ... ...

Abstract	Sunscreen use, which prolonged the time required to develop sunburn by reducing the irradiance (mW/cm²) of the UVB radiation, is thought to protect the skin from developing cancers. Recently, in addition to fluence (mJ/cm²), irradiance of the UVB radiation was demonstrated to play an important role leading to photocarcinogenesis of the skin. After equivalent fluence of UVB exposure, enhanced aberrant keratinocyte proliferation contributes significantly to the photocarcinogenic capacity of low irradiance (LI) UVB as compared to its high irradiance (HI) UVB counterpart. However, the mechanism involved remains unclear.Relevant cell and animal models were employed to investigate the effects of equivalent UVB fluence administered at HI or LI on keratinocyte proliferation. Additionally, the mechanisms involved were also explored.We found that at equivalent fluence, LIUVB induces significantly higher reactive oxidative species (ROS) production, cell proliferation, as well as phosphorylated AKT (pAKT) expression in both cell and animal models as compare to its HIUVB counterpart. Pretreating cultured keratinocytes with antioxidant or AKT inhibitor significantly reduced the UVB-induced ROS, cell proliferation, and pAKT expression. Additionally, these pretreatments abrogate the difference between the LI and HIUVB treated keratinocytes. Similar findings were noted using animal model treated with AKT inhibitor.In summary, at equivalent fluence, LIUVB induces significantly more aberrant epidermal proliferation via enhanced ROS and pAKT signaling. Reducing UVB-induced AKT phosphorylation presents a novel strategy to improve the protective capacity of the currently available sunscreens.
Keywords	animal models ; animals ; antioxidants ; cell proliferation ; keratinocytes ; light intensity ; phosphorylation ; sunburn ; sunscreens ; ultraviolet radiation
Language	English
Dates of publication	2022-0101
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	3378-9
ISSN	1879-0631 ; 0024-3205
ISSN (online)	1879-0631
ISSN	0024-3205
DOI	10.1016/j.lfs.2021.120181
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Article ; Online: The effects of UVB irradiance on aberrant epidermal proliferation: Novel insights on how to improve currently available sunscreens.

Lai, Hsiao-Chi / Lin, Chang-Shen / Wu, Ching-Shuang / Lan, Cheng-Che E

Life sciences

2021 Volume 288, Page(s) 120181

Abstract: Aims: Sunscreen use, which prolonged the time required to develop sunburn by reducing the irradiance (mW/cm: Main methods: Relevant cell and animal models were employed to investigate the effects of equivalent UVB fluence administered at HI or LI on ... ...

Abstract	Aims: Sunscreen use, which prolonged the time required to develop sunburn by reducing the irradiance (mW/cm Main methods: Relevant cell and animal models were employed to investigate the effects of equivalent UVB fluence administered at HI or LI on keratinocyte proliferation. Additionally, the mechanisms involved were also explored. Key findings: We found that at equivalent fluence, LIUVB induces significantly higher reactive oxidative species (ROS) production, cell proliferation, as well as phosphorylated AKT (pAKT) expression in both cell and animal models as compare to its HIUVB counterpart. Pretreating cultured keratinocytes with antioxidant or AKT inhibitor significantly reduced the UVB-induced ROS, cell proliferation, and pAKT expression. Additionally, these pretreatments abrogate the difference between the LI and HIUVB treated keratinocytes. Similar findings were noted using animal model treated with AKT inhibitor. Significance: In summary, at equivalent fluence, LIUVB induces significantly more aberrant epidermal proliferation via enhanced ROS and pAKT signaling. Reducing UVB-induced AKT phosphorylation presents a novel strategy to improve the protective capacity of the currently available sunscreens.
MeSH term(s)	Animals ; Cell Cycle ; Cell Proliferation ; Epidermis/pathology ; Epidermis/radiation effects ; Keratinocytes/pathology ; Keratinocytes/radiation effects ; Mice ; Mice, Hairless ; Phosphorylation ; Proto-Oncogene Proteins c-akt/genetics ; Proto-Oncogene Proteins c-akt/metabolism ; Skin/pathology ; Skin/radiation effects ; Sunscreening Agents ; Ultraviolet Rays/adverse effects
Chemical Substances	Sunscreening Agents ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
Language	English
Publishing date	2021-11-27
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	3378-9
ISSN	1879-0631 ; 0024-3205
ISSN (online)	1879-0631
ISSN	0024-3205
DOI	10.1016/j.lfs.2021.120181
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Article ; Online: The impact of irradiance on UVB-induced cutaneous immunosuppression: Implications on administering most efficient phototherapy.

Lai, Hsiao-Chi / Lin, Chang-Shen / Wu, Ching-Shuang / Lan, Cheng-Che E

Journal of dermatological science

2019 Volume 93, Issue 2, Page(s) 116–122

Abstract: Background: Ultraviolet B (UVB) is commonly used for treating dermatologic conditions. Recently, high irradiance UVB (HIUVB) has been suggested to be more effective for treating skin conditions as compared to its low irradiance (LI) counterpart. The ... ...

Abstract	Background: Ultraviolet B (UVB) is commonly used for treating dermatologic conditions. Recently, high irradiance UVB (HIUVB) has been suggested to be more effective for treating skin conditions as compared to its low irradiance (LI) counterpart. The biological impact of UVB radiation emitted at different irradiance on cutaneous immunity remains obscure. Objective: This study aimed to explore the impacts of UVB radiation administered at equivalent fluence (mJ/cm Methods: Cultured bone marrow derived dendritic cell (BMDC) were treated with equivalent fluence of UVB radiation with HIUVB or LIUVB. The phenotypic and functional alterations of BMDCs were documented. Animal models were used to validate the in vitro results in vivo and explore the mechanisms involved. Results: After equivalent fluence of UVB radiation, the HIUVB treated BMDC showed significantly lower MHCII and CD86 expressions, reduced capacity to stimulate T cell proliferation, and enhanced activation of aryl hydrocarbon receptor (AhR)-activated genes as compared to control while their LIUVB treated counterpart showed no significant change. Using animal model, the HIUVB induced significantly higher immune suppressive effect in mice as compared to their LIUVB counterpart after equivalent fluence of UVB treatment. The superior immune suppressive effect of HIUVB over LIUVB radiation was not observed when similar experiments were performed using AhR-deficient mice. Conclusion: We propose irradiance played an important role modulating UVB-induced cutaneous immune suppression. Future works on UVB phototherapy, both clinical and research, should incorporate this important parameter into consideration.
MeSH term(s)	Animals ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Cell Proliferation/radiation effects ; Cells, Cultured ; Dendritic Cells/immunology ; Dendritic Cells/radiation effects ; Dermatitis, Allergic Contact/etiology ; Dermatitis, Allergic Contact/radiotherapy ; Disease Models, Animal ; Humans ; Immune Tolerance/radiation effects ; Mice, Transgenic ; Primary Cell Culture ; Receptors, Aryl Hydrocarbon/genetics ; Receptors, Aryl Hydrocarbon/metabolism ; Signal Transduction/radiation effects ; Skin/cytology ; Skin/immunology ; Skin/radiation effects ; Specific Pathogen-Free Organisms ; T-Lymphocytes/immunology ; T-Lymphocytes/radiation effects ; Treatment Outcome ; Ultraviolet Therapy/methods
Chemical Substances	Ahr protein, mouse ; Basic Helix-Loop-Helix Transcription Factors ; Receptors, Aryl Hydrocarbon
Language	English
Publishing date	2019-01-11
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1024446-3
ISSN	1873-569X ; 0923-1811
ISSN (online)	1873-569X
ISSN	0923-1811
DOI	10.1016/j.jdermsci.2019.01.003
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Article ; Online: Corrigendum to "Letter to the Editor Ultraviolet B (UVB) induces development of early melanocytic progenitors via increased oxidative stress in vitro suggesting the use of antioxidants after regimentation in UVB phototherapy for vitiligo" [J. Dermatol. Sci. 87 (2017) 208-210].

Yu, Sebastian / Yu, Hsin-Su / Lai, Hsiao-Chi / Wu, Ching-Shuang / Jheng, Hui-Ying / Lan, Cheng-Che

Journal of dermatological science

2017 Volume 88, Issue 1, Page(s) 156

Language	English
Publishing date	2017-08-30
Publishing country	Netherlands
Document type	Journal Article ; Published Erratum
ZDB-ID	1024446-3
ISSN	1873-569X ; 0923-1811
ISSN (online)	1873-569X
ISSN	0923-1811
DOI	10.1016/j.jdermsci.2017.08.008
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Article ; Online: Ultraviolet B (UVB) induces development of early melanocytic progenitors via increased oxidative stress in vitro suggesting the use of antioxidants after repigmentation [corrected] in UVB phototherapy for vitiligo.

Yu, Sebastian / Yu, Hsin-Su / Lai, Hsiao-Chi / Wu, Ching-Shuang / Jheng, Hui-Ying / Lan, Cheng-Che

Journal of dermatological science

2017 Volume 87, Issue 2, Page(s) 208–210

MeSH term(s)	Animals ; Antioxidants/pharmacology ; Antioxidants/therapeutic use ; Cell Differentiation/drug effects ; Cell Differentiation/radiation effects ; Cell Line ; Combined Modality Therapy/methods ; Melanocytes/drug effects ; Melanocytes/metabolism ; Melanocytes/radiation effects ; Mice ; Oxidative Stress/drug effects ; Oxidative Stress/radiation effects ; Stem Cells/metabolism ; Stem Cells/radiation effects ; Time Factors ; Treatment Outcome ; Ultraviolet Therapy/adverse effects ; Vitiligo/therapy
Chemical Substances	Antioxidants
Language	English
Publishing date	2017-04-24
Publishing country	Netherlands
Document type	Letter
ZDB-ID	1024446-3
ISSN	1873-569X ; 0923-1811
ISSN (online)	1873-569X
ISSN	0923-1811
DOI	10.1016/j.jdermsci.2017.04.007
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Article ; Online: Irradiance, but not fluence, plays a crucial role in UVB-induced immature pigment cell development: new insights for efficient UVB phototherapy.

Lan, Cheng-Che E / Yu, Hsin-Su / Lu, Jian-He / Wu, Ching-Shuang / Lai, Hsiao-Chi

Pigment cell & melanoma research

2013 Volume 26, Issue 3, Page(s) 367–376

Abstract: Light exposure modulates development of living organisms. In the field of medicine, light has frequently been used for regenerative purposes. Excimer light (308 nm) has demonstrated superior efficacy in treating vitiligo, a condition requiring ... ...

Abstract	Light exposure modulates development of living organisms. In the field of medicine, light has frequently been used for regenerative purposes. Excimer light (308 nm) has demonstrated superior efficacy in treating vitiligo, a condition requiring development of melanoblasts and a model for studying nerve cell regeneration, as compared to narrow-band ultraviolet B (NBUVB; 311 nm). Using mouse-derived melanoblast cells to examine the pro-differentiation effects of these two light sources, we demonstrated that at equivalent fluence, excimer light induces melanoblast differentiation, while NBUVB failed to so. Mechanistically, activation of aryl hydrocarbon receptor pathway and nuclear translocation of epidermal growth factor receptor are involved in pro-differentiation effects of excimer light. Reduction in irradiance by filter abrogated the effects of excimer light in melanoblasts, even when equivalent fluence was delivered by the same light source. As ultraviolet B (UVB) irradiation is closely associated pigment cell development, future therapy employing UVB for pigmentation purposes should incorporate irradiance as a crucial specification.
MeSH term(s)	Animals ; Cell Differentiation/radiation effects ; Cell Nucleus/metabolism ; Cell Survival/radiation effects ; Chromatin Immunoprecipitation ; Cytochrome P-450 CYP1A1/biosynthesis ; Cytochrome P-450 CYP1A1/genetics ; Endocytosis/radiation effects ; Enzyme Induction/radiation effects ; Gene Expression Regulation, Enzymologic/radiation effects ; Gene Silencing/radiation effects ; Immunohistochemistry ; Melanocytes/cytology ; Melanocytes/enzymology ; Melanocytes/radiation effects ; Mice ; Monophenol Monooxygenase/biosynthesis ; Monophenol Monooxygenase/genetics ; Pigmentation/radiation effects ; Promoter Regions, Genetic/genetics ; Protein Transport/radiation effects ; Pyrimidine Dimers/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Receptor, Epidermal Growth Factor/antagonists & inhibitors ; Receptor, Epidermal Growth Factor/metabolism ; Receptors, Aryl Hydrocarbon/genetics ; Receptors, Aryl Hydrocarbon/metabolism ; Transcription, Genetic/radiation effects ; Ultraviolet Rays ; Ultraviolet Therapy ; src-Family Kinases/metabolism
Chemical Substances	Pyrimidine Dimers ; RNA, Messenger ; Receptors, Aryl Hydrocarbon ; Cytochrome P-450 CYP1A1 (EC 1.14.14.1) ; Monophenol Monooxygenase (EC 1.14.18.1) ; Receptor, Epidermal Growth Factor (EC 2.7.10.1) ; src-Family Kinases (EC 2.7.10.2)
Language	English
Publishing date	2013-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2409570-9
ISSN	1755-148X ; 1600-0749 ; 0893-5785 ; 1755-1471
ISSN (online)	1755-148X ; 1600-0749
ISSN	0893-5785 ; 1755-1471
DOI	10.1111/pcmr.12077
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Article ; Online: Irradiance-dependent UVB Photocarcinogenesis.

Lan, Cheng-Che E / Wu, Ching-Shuang / Huang, Shu-Mei / Wu, Chin-Han / Lai, Hsiao-Chi / Peng, Yu-Ting / Hou, Pao-Sheng / Yang, Hui-Jun / Chen, Gwo-Shing

Scientific reports

2016 Volume 6, Page(s) 37403

Abstract: Ultraviolet B (UVB) radiation from the sun may lead to photocarcinogenesis of the skin. Sunscreens were used to protect the skin by reducing UVB irradiance, but sunscreen use did not reduce sunburn episodes. It was shown that UVB-induced erythema depends ...

Abstract	Ultraviolet B (UVB) radiation from the sun may lead to photocarcinogenesis of the skin. Sunscreens were used to protect the skin by reducing UVB irradiance, but sunscreen use did not reduce sunburn episodes. It was shown that UVB-induced erythema depends on surface exposure but not irradiance of UVB. We previously showed that irradiance plays a critical role in UVB-induced cell differentiation. This study investigated the impact of irradiance on UVB-induced photocarcinogenesis. For hairless mice receiving equivalent exposure of UVB radiation, the low irradiance (LI) UVB treated mice showed more rapid tumor development, larger tumor burden, and more keratinocytes harboring mutant p53 in the epidermis as compared to their high irradiance (HI) UVB treated counterpart. Mechanistically, using cell models, we demonstrated that LI UVB radiation allowed more keratinocytes harboring DNA damages to enter cell cycle via ERK-related signaling as compared to its HI UVB counterpart. These results indicated that at equivalent exposure, UVB radiation at LI has higher photocarcinogenic potential as compared to its HI counterpart. Since erythema is the observed sunburn at moderate doses and use of sunscreen was not found to associate with reduced sunburn episodes, the biological significance of sunburn with or without sunscreen use warrants further investigation.
Language	English
Publishing date	2016-11-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/srep37403
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