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  1. Article ; Online: Unlocking the therapeutic potential of targeting

    Samiksha, Samiksha / Chan, Lai N

    Haematologica

    2024  Volume 109, Issue 5, Page(s) 1317–1319

    MeSH term(s) Humans ; Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein/antagonists & inhibitors ; Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein/metabolism ; Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein/genetics ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/therapy ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/drug therapy ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/genetics ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/pathology ; Molecular Targeted Therapy ; Antineoplastic Agents/therapeutic use ; Antineoplastic Agents/pharmacology
    Chemical Substances Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein (EC 3.4.22.-) ; MALT1 protein, human (EC 3.4.22.-) ; Antineoplastic Agents
    Language English
    Publishing date 2024-05-01
    Publishing country Italy
    Document type Research Support, Non-U.S. Gov't ; Editorial ; Journal Article
    ZDB-ID 2333-4
    ISSN 1592-8721 ; 0017-6567 ; 0390-6078
    ISSN (online) 1592-8721
    ISSN 0017-6567 ; 0390-6078
    DOI 10.3324/haematol.2023.284237
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.76: Show issues Location:
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  2. Article ; Online: Sintilimab-induced autoimmune diabetes mellitus manifesting as diabetic ketoacidosis in a patient with advanced esophageal squamous cell carcinoma.

    Lai, Nannan / Fan, Xuemei / Liu, Shiwei

    Acta diabetologica

    2024  Volume 61, Issue 5, Page(s) 675–678

    MeSH term(s) Humans ; Esophageal Squamous Cell Carcinoma/drug therapy ; Diabetic Ketoacidosis/chemically induced ; Antibodies, Monoclonal, Humanized/adverse effects ; Antibodies, Monoclonal, Humanized/therapeutic use ; Male ; Diabetes Mellitus, Type 1/complications ; Diabetes Mellitus, Type 1/drug therapy ; Esophageal Neoplasms/drug therapy ; Aged ; Middle Aged
    Chemical Substances sintilimab (8FU7FQ8UPK) ; Antibodies, Monoclonal, Humanized
    Language English
    Publishing date 2024-02-09
    Publishing country Germany
    Document type Case Reports ; Journal Article ; Letter
    ZDB-ID 1097676-0
    ISSN 1432-5233 ; 0940-5429
    ISSN (online) 1432-5233
    ISSN 0940-5429
    DOI 10.1007/s00592-023-02232-7
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 611: Show issues Location:
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  3. Article ; Online: Protocol for labeling epileptic-status-related neuronal ensembles in mouse hippocampal kindling model.

    Lai, Nanxi / Li, Zhisheng / Chen, Zhong / Wang, Yi

    STAR protocols

    2023  Volume 4, Issue 2, Page(s) 102255

    Abstract: Epileptic networks are characterized by two states, seizures or more prolonged interictal periods. Here, we present the procedure for labeling seizure-activated and interictal-activated neuronal ensembles in mouse hippocampal kindling model using an ... ...

    Abstract Epileptic networks are characterized by two states, seizures or more prolonged interictal periods. Here, we present the procedure for labeling seizure-activated and interictal-activated neuronal ensembles in mouse hippocampal kindling model using an enhanced-synaptic-activity-responsive element. We describe the seizure model establishment, tamoxifen induction, electrical stimulation, and calcium signal recording of labeled ensembles. This protocol has demonstrated dissociated calcium activities in the two ensembles during focal seizure dynamics and can be applied to other animal models of epilepsy. For complete details on the use and execution of this protocol, please refer to Lai et al. (2022).
    Language English
    Publishing date 2023-04-25
    Publishing country United States
    Document type Journal Article
    ISSN 2666-1667
    ISSN (online) 2666-1667
    DOI 10.1016/j.xpro.2023.102255
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  4. Article: Alkyl carbamate ionic liquids for permeabilization of microalgae biomass to enhance lipid recovery for biodiesel production.

    Matchim Kamdem, Michele Corneille / Lai, Nanjun

    Heliyon

    2023  Volume 9, Issue 1, Page(s) e12754

    Abstract: Microalgae are potential biomass source for biodiesel production. However, their strong cell walls make efficient lipid extraction problematic. Disrupting the cell wall is a key point in enhancing lipid yield from microalgae biomass. A new type of ionic ... ...

    Abstract Microalgae are potential biomass source for biodiesel production. However, their strong cell walls make efficient lipid extraction problematic. Disrupting the cell wall is a key point in enhancing lipid yield from microalgae biomass. A new type of ionic liquid (IL) has been suggested in this work as a potentially viable solvent to permeabilize the strong microalgae cell structure for the efficient extraction of lipids. Morphological changes in microalgae cells were studied before and after ionic liquid permeabilization to understand the mechanism of ionic liquid treatment. Among the three selected CO
    Language English
    Publishing date 2023-01-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2022.e12754
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  5. Article ; Online: Neuronal pyroptosis mediated by STAT3 in early brain injury after subarachnoid hemorrhage.

    Tang, Shengjie / Lai, Niansheng / Xu, Liang

    Brain research

    2023  Volume 1822, Page(s) 148666

    Abstract: Neuroinflammation induced by early brain injury (EBI) seriously affects the prognosis of patients after subarachnoid hemorrhage (SAH). Pyroptosis can aggravate inflammatory injury by promoting the secretion of inflammatory cytokines. Meanwhile, STAT3 ... ...

    Abstract Neuroinflammation induced by early brain injury (EBI) seriously affects the prognosis of patients after subarachnoid hemorrhage (SAH). Pyroptosis can aggravate inflammatory injury by promoting the secretion of inflammatory cytokines. Meanwhile, STAT3 plays a critical role in the inflammatory response of EBI after SAH. However, whether it plays a pyroptotic role in SAH is mainly unknown. This study aimed to explore the mechanism of STAT3 in pyroptosis in EBI after SAH. C57BL/6J mice were used to establish the SAH model. Brain tissues were collected at different time points for q-RT-PCR and western blot to detect the expression level of STAT3. After intracerebroventricular injection of STAT3 inhibitor S3I-201, they were divided into sham, SAH, SAH + Vehicle, and SAH + S3I-201. Then, the SAH grade, cerebral edema content, blood-brain barrier (BBB) damage, and neurological scores of mice in each group were detected. qRT-PCR and western blot were used to detect related genes and proteins, and enzyme-linked immunosorbent assay (ELISA) was used to detect the expression levels of IL-18 and IL-1β. Immunofluorescence staining was used to observe the expression level of proteins. At the same time, S3I-201 was added to the primary neuron cells of the culture medium containing OxyHb to simulate the in vitro experiment, and the relevant indicators consistent with the in vivo experiment were detected. The expression of STAT3 was upregulated after SAH. Inhibition of STAT3 with S3I-201 attenuated neurological deficits, cerebral edema, and BBB damage after SAH. In addition, S3I-201 can also reduce the expression of pyroptosis-related inflammasomes such as GSDMD, NLRP3, Caspase 1, and AIM2 after SAH and the neurological damage caused by IL-18 and IL-1β. Further studies have shown that STAT3 regulates pyroptosis by promoting the nuclear translocation of NF-κB p65. Our finding demonstrated that STAT3 regulates neuronal pyroptosis in EBI after SAH. Inhibition of STAT3 may be a potential target to attenuate the damage that triggers neuroinflammation after SAH.
    MeSH term(s) Animals ; Mice ; Brain Edema/etiology ; Brain Edema/metabolism ; Brain Injuries/metabolism ; DNA-Binding Proteins/metabolism ; Interleukin-18/metabolism ; Mice, Inbred C57BL ; Neuroinflammatory Diseases ; Neurons/metabolism ; Pyroptosis ; Signal Transduction/physiology ; STAT3 Transcription Factor/metabolism ; Subarachnoid Hemorrhage/metabolism ; Subarachnoid Hemorrhage/pathology
    Chemical Substances DNA-Binding Proteins ; Interleukin-18 ; NSC 74859 ; STAT3 protein, human ; STAT3 Transcription Factor
    Language English
    Publishing date 2023-11-08
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1200-2
    ISSN 1872-6240 ; 0006-8993
    ISSN (online) 1872-6240
    ISSN 0006-8993
    DOI 10.1016/j.brainres.2023.148666
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 161: Show issues Location:
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  6. Article: An Uncommon Presentation of Cervical Myelopathy.

    Nguyen, Alyssa N / Niu, Ashley V / Ong, Lauren F / Lai, Neuzil

    Cureus

    2023  Volume 15, Issue 9, Page(s) e45609

    Abstract: Cervical myelopathy is a compressive spinal cord disease usually affecting individuals 55 and older. Involvement of C5-C7 is typical and classically presents with hand clumsiness, wide-based gait, and paresis. We present the case of a 38-year-old man ... ...

    Abstract Cervical myelopathy is a compressive spinal cord disease usually affecting individuals 55 and older. Involvement of C5-C7 is typical and classically presents with hand clumsiness, wide-based gait, and paresis. We present the case of a 38-year-old man with a pertinent history of a previous motor vehicle accident who presented to the emergency department for progressive numbness, weakness, and severe spasms in both lower extremities, and eventually developed bowel and bladder incontinence. Lumbar magnetic resonance imaging (MRI) showed moderate L3-L4/L5-S1 degenerative spinal changes; however, cervical MRI demonstrated severe C6-C7 spinal stenosis. The patient did not present with any upper extremity neurological changes. Given the relatively mild changes in the lumbar spine, the patient was concluded to have lower extremity and autonomic neurological issues due to severe cervical spinal stenosis. In this report, we present a relatively common case of cervical myelopathy and myelomalacia in a patient unusually presenting with no upper extremity signs and only lower extremity signs of progressive bilateral leg weakness and neurogenic urinary incontinence. This case emphasizes the importance of considering cervical spine workup in addition to thoracic and lumbar spine and conducting a comprehensive clinical neurological examination in the setting of lower extremity symptoms with progressive bilateral leg weakness and urinary incontinence.
    Language English
    Publishing date 2023-09-20
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.45609
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  7. Article ; Online: Diverse nature of interictal oscillations: EEG-based biomarkers in epilepsy.

    Lai, Nanxi / Li, Zhisheng / Xu, Cenglin / Wang, Yi / Chen, Zhong

    Neurobiology of disease

    2023  Volume 177, Page(s) 105999

    Abstract: Interictal electroencephalogram (EEG) patterns, including high-frequency oscillations (HFOs), interictal spikes (ISs), and slow wave activities (SWAs), are defined as specific oscillations between seizure events. These interictal oscillations reflect ... ...

    Abstract Interictal electroencephalogram (EEG) patterns, including high-frequency oscillations (HFOs), interictal spikes (ISs), and slow wave activities (SWAs), are defined as specific oscillations between seizure events. These interictal oscillations reflect specific dynamic changes in network excitability and play various roles in epilepsy. In this review, we briefly describe the electrographic characteristics of HFOs, ISs, and SWAs in the interictal state, and discuss the underlying cellular and network mechanisms. We also summarize representative evidence from experimental and clinical epilepsy to address their critical roles in ictogenesis and epileptogenesis, indicating their potential as electrophysiological biomarkers of epilepsy. Importantly, we put forwards some perspectives for further research in the field.
    MeSH term(s) Humans ; Epilepsy/diagnosis ; Electroencephalography ; Seizures ; Biomarkers ; Mental Disorders
    Chemical Substances Biomarkers
    Language English
    Publishing date 2023-01-10
    Publishing country United States
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1211786-9
    ISSN 1095-953X ; 0969-9961
    ISSN (online) 1095-953X
    ISSN 0969-9961
    DOI 10.1016/j.nbd.2023.105999
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  8. Article: Effect of Blood Flow on Hemoglobin and Myoglobin Oxygenation in Contracting Muscle Using Near-Infrared Spectroscopy.

    Koirala, B / Saidel, G M / Hernández, A / Gladden, L B / Lai, N

    Advances in experimental medicine and biology

    2021  Volume 1269, Page(s) 367–372

    Abstract: Insufficient ... ...

    Abstract Insufficient O
    MeSH term(s) Exercise ; Hemodynamics ; Hemoglobins/metabolism ; Humans ; Muscle, Skeletal/metabolism ; Myoglobin/analysis ; Myoglobin/metabolism ; Oxygen/metabolism ; Oxygen Consumption ; Spectroscopy, Near-Infrared
    Chemical Substances Hemoglobins ; Myoglobin ; Oxygen (S88TT14065)
    Language English
    Publishing date 2021-05-09
    Publishing country United States
    Document type Journal Article
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-3-030-48238-1_58
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  9. Article ; Online: Blood volume versus deoxygenated NIRS signal: computational analysis of the effects muscle O

    Koirala, B / Concas, A / Sun, Yi / Gladden, L B / Lai, N

    Journal of applied physiology (Bethesda, Md. : 1985)

    2021  Volume 131, Issue 5, Page(s) 1418–1431

    Abstract: Near-infrared spectroscopy (NIRS) signals quantify the oxygenated ( ... ...

    Abstract Near-infrared spectroscopy (NIRS) signals quantify the oxygenated (Δ
    MeSH term(s) Animals ; Blood Volume ; Dogs ; Muscle, Skeletal/metabolism ; Oxygen/metabolism ; Oxygen Consumption ; Spectroscopy, Near-Infrared
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2021-09-16
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 219139-8
    ISSN 1522-1601 ; 0021-8987 ; 0161-7567 ; 8750-7587
    ISSN (online) 1522-1601
    ISSN 0021-8987 ; 0161-7567 ; 8750-7587
    DOI 10.1152/japplphysiol.00105.2021
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    Uc I Zs.249: Show issues Location:
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  10. Book ; Online: Towards personalised music-therapy; a neurocomputational modelling perspective

    Lai, Nicole / Philiastides, Marios / Kawsar, Fahim / Deligianni, Fani

    2023  

    Abstract: Music therapy has emerged recently as a successful intervention that improves patient's outcome in a large range of neurological and mood disorders without adverse effects. Brain networks are entrained to music in ways that can be explained both via top- ... ...

    Abstract Music therapy has emerged recently as a successful intervention that improves patient's outcome in a large range of neurological and mood disorders without adverse effects. Brain networks are entrained to music in ways that can be explained both via top-down and bottom-up processes. In particular, the direct interaction of auditory with the motor and the reward system via a predictive framework explains the efficacy of music-based interventions in motor rehabilitation. In this manuscript, we provide a brief overview of current theories of music perception and processing. Subsequently, we summarise evidence of music-based interventions primarily in motor, emotional and cardiovascular regulation. We highlight opportunities to improve quality of life and reduce stress beyond the clinic environment and in healthy individuals. This relatively unexplored area requires an understanding of how we can personalise and automate music selection processes to fit individuals needs and tasks via feedback loops mediated by measurements of neuro-physiological responses.
    Keywords Quantitative Biology - Neurons and Cognition ; Computer Science - Artificial Intelligence
    Subject code 780
    Publishing date 2023-05-15
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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