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  1. Article ; Online: Exogenous maltose enhances Zebrafish immunity to levofloxacin-resistant Vibrio alginolyticus.

    Jiang, Ming / Yang, Lifen / Chen, Zhuang-Gui / Lai, Shi-Shi / Zheng, Jun / Peng, Bo

    Microbial biotechnology

    2020  Volume 13, Issue 4, Page(s) 1213–1227

    Abstract: Understanding the interplay between bacterial fitness, antibiotic resistance, host immunity and host metabolism could guide treatment and improve immunity against antibiotic-resistant pathogens. The acquisition of levofloxacin (Lev) resistance affects ... ...

    Abstract Understanding the interplay between bacterial fitness, antibiotic resistance, host immunity and host metabolism could guide treatment and improve immunity against antibiotic-resistant pathogens. The acquisition of levofloxacin (Lev) resistance affects the fitness of Vibrio alginolyticus in vitro and in vivo. Lev-resistant (Lev-R) V. alginolyticus exhibits slow growth, reduced pathogenicity and greater resistance to killing by the host, Danio rerio (zebrafish), than Lev-sensitive (Lev-S) V. alginolyticus, suggesting that Lev-R V. alginolyticus triggers a weaker innate immune response in D. rerio than Lev-S V. alginolyticus. Differences were detected in the metabolome of D. rerio infected with Lev-S or Lev-R V. alginolyticus. Maltose, a crucial metabolite, is significantly downregulated in D. rerio infected with Lev-R V. alginolyticus, and exogenous maltose enhances the immune response of D. rerio to Lev-R V. alginolyticus, leading to better clearance of the infection. Furthermore, we demonstrate that exogenous maltose stimulates the host production of lysozyme and its binding to Lev-R V. alginolyticus, which depends on bacterial membrane potential. We suggest that exogenous exposure to crucial metabolites could be an effective strategy for treating and/or managing infections with antibiotic-resistant bacteria.
    MeSH term(s) Animals ; Fish Diseases ; Immunity, Innate ; Levofloxacin ; Maltose ; Vibrio Infections ; Vibrio alginolyticus ; Zebrafish
    Chemical Substances Maltose (69-79-4) ; Levofloxacin (6GNT3Y5LMF)
    Language English
    Publishing date 2020-05-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2406063-X
    ISSN 1751-7915 ; 1751-7915
    ISSN (online) 1751-7915
    ISSN 1751-7915
    DOI 10.1111/1751-7915.13582
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Na

    Jiang, Ming / Kuang, Su-Fang / Lai, Shi-Shi / Zhang, Song / Yang, Jun / Peng, Bo / Peng, Xuan-Xian / Chen, Zhuang-Gui / Li, Hui

    mBio

    2020  Volume 11, Issue 6

    Abstract: Sodium-translocating NADH:quinone oxidoreductase ( ... ...

    Abstract Sodium-translocating NADH:quinone oxidoreductase (Na
    MeSH term(s) Alanine/metabolism ; Aminoglycosides/pharmacology ; Anti-Bacterial Agents/analysis ; Anti-Bacterial Agents/pharmacology ; Aspartic Acid/metabolism ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Biological Transport ; Drug Resistance, Bacterial ; Gentamicins/analysis ; Gentamicins/pharmacology ; Glutamic Acid/metabolism ; Membrane Potentials/drug effects ; Metabolome ; Metabolomics ; Oxidation-Reduction ; Sequence Deletion ; Sodium-Potassium-Exchanging ATPase/genetics ; Sodium-Potassium-Exchanging ATPase/metabolism ; Vibrio alginolyticus/drug effects ; Vibrio alginolyticus/genetics ; Vibrio alginolyticus/growth & development
    Chemical Substances Aminoglycosides ; Anti-Bacterial Agents ; Bacterial Proteins ; Gentamicins ; Aspartic Acid (30KYC7MIAI) ; Glutamic Acid (3KX376GY7L) ; Sodium-Potassium-Exchanging ATPase (EC 7.2.2.13) ; Alanine (OF5P57N2ZX)
    Language English
    Publishing date 2020-11-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mBio.02086-20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Alanine Enhances Aminoglycosides-Induced ROS Production as Revealed by Proteomic Analysis.

    Ye, Jin-Zhou / Su, Yu-Bin / Lin, Xiang-Min / Lai, Shi-Shi / Li, Wan-Xin / Ali, Farman / Zheng, Jun / Peng, Bo

    Frontiers in microbiology

    2018  Volume 9, Page(s) 29

    Abstract: Metabolite-enabled killing of antibiotic-resistant pathogens by antibiotics is an attractive strategy to manage antibiotic resistance. Our previous study demonstrated that alanine or/and glucose increased the killing efficacy of kanamycin on antibiotic- ... ...

    Abstract Metabolite-enabled killing of antibiotic-resistant pathogens by antibiotics is an attractive strategy to manage antibiotic resistance. Our previous study demonstrated that alanine or/and glucose increased the killing efficacy of kanamycin on antibiotic-resistant bacteria, whose action is through up-regulating TCA cycle, increasing proton motive force and enhancing antibiotic uptake. Despite the fact that alanine altered several metabolic pathways, other mechanisms could be potentially involved in alanine-mediated kanamycin killing of bacteria which remains to be explored. In the present study, we adopted proteomic approach to analyze the proteome changes induced by exogenous alanine. Our results revealed that the expression of three outer membrane proteins was altered and the deletion of
    Language English
    Publishing date 2018-01-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2018.00029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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