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  1. Article ; Online: Latifolin protects against myocardial infarction by alleviating myocardial inflammatory via the HIF-1α/NF-κB/IL-6 pathway.

    Lai, Xiao-Xiao / Zhang, Ni / Chen, Lan-Ying / Luo, Ying-Ying / Shou, Bin-Yao / Xie, Xin-Xu / Liu, Rong-Hua

    Pharmaceutical biology

    2020  Volume 58, Issue 1, Page(s) 1156–1166

    Abstract: Context: The Traditional Chinese herb medicine : Objective: To investigate whether latifolin can improve myocardial infarction (MI) through attenuating myocardial inflammatory and to explore its possible mechanisms.: Materials and methods: Left ... ...

    Abstract Context: The Traditional Chinese herb medicine
    Objective: To investigate whether latifolin can improve myocardial infarction (MI) through attenuating myocardial inflammatory and to explore its possible mechanisms.
    Materials and methods: Left coronary artery was ligated to induce a rat model of MI, and the rats were treated with sodium carboxymethyl cellulose (CMC-Na) or different doses of latifolin (25, 50, 100 mg/kg/d) by oral gavage for 28 days. Serum contents of myocardial enzyme were measured at seven and fourteen days after treatment. Cardiac function, infarct size, histopathological changes and inflammatory cells infiltration was assessed at 28 days after treatment. Western blotting was used to investigate the underlying mechanisms.
    Results: Latifolin treatment markedly decreased the contents of myocardial enzymes, and increased left ventricular ejection fraction (85.27% vs. 59.11%) and left ventricular fractional shortening (62.71% vs. 45.53%). Latifolin was found to significantly reduced infarction size (27.78% vs. 39.07%), myocardial fibrosis and the numbers of macrophage infiltration (436 cells/mm
    Discussion and conclusions: Latifolin can protect against myocardial infarction by improving myocardial inflammation through the HIF-1α/NF-κB/IL-6 signalling pathway. Accordingly, latifolin may be a promising drug for pharmacological treatment of ischaemic cardiovascular disease.
    MeSH term(s) Animals ; Dalbergia/chemistry ; Enzymes/blood ; Heart Function Tests ; Hypoxia-Inducible Factor 1, alpha Subunit/drug effects ; Interleukin-6 ; Male ; Medicine, Chinese Traditional ; Myocardial Infarction/pathology ; Myocardial Infarction/prevention & control ; Myocarditis/drug therapy ; Myocarditis/pathology ; Myocardium/pathology ; NF-kappa B/drug effects ; Phenols/therapeutic use ; Rats ; Rats, Sprague-Dawley ; Signal Transduction/drug effects ; Stroke Volume
    Chemical Substances Enzymes ; Hif1a protein, rat ; Hypoxia-Inducible Factor 1, alpha Subunit ; Il6 protein, rat ; Interleukin-6 ; NF-kappa B ; Phenols ; latifolin
    Language English
    Publishing date 2020-11-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 1440131-9
    ISSN 1744-5116 ; 1388-0209
    ISSN (online) 1744-5116
    ISSN 1388-0209
    DOI 10.1080/13880209.2020.1840597
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article: Qingxin Kaiqiao Recipe Improves Cognitive Performance, Inhibits Apoptosis, and Reduces Pathological Deposits in APP/PS1 Double Transgenic Mice via the PI3K/Akt Pathway.

    Lin, Shi-Yi / Wang, Tian-Qi / Xu, Lu-Ting / Lai, Xiao-Xiao / Shen, Yan / Lin, Jian-Wei / Gao, Shi-Yu / Hu, Hai-Yan

    Evidence-based complementary and alternative medicine : eCAM

    2020  Volume 2020, Page(s) 3019674

    Abstract: The traditional Chinese medicine of Qingxin Kaiqiao Recipe (QKR) is effective in the treatment of Alzheimer's disease (AD). This study aims to investigate whether QKR improves the cognitive ability and takes neuroprotective effect on APP/PS1 double ... ...

    Abstract The traditional Chinese medicine of Qingxin Kaiqiao Recipe (QKR) is effective in the treatment of Alzheimer's disease (AD). This study aims to investigate whether QKR improves the cognitive ability and takes neuroprotective effect on APP/PS1 double transgenic mice via the PI3K/Akt pathway. APP/PS1 double transgenic mice were randomly divided into a model, donepezil-treated, or QKR-treated group (L-QKR: 4.75 mg/kg/d, M-QKR: 9.5 mg/kg/d, and H-QKR: 19 mg/kg/d, respectively). Wild-type C57/BL6J mice were used as the control group. Morris water maze (MWM) was used to test the ability of spatial navigation and memorization; terminal deoxynucleotidyl transferase-mediated dUTP nick end-labelling (TUNEL) assay was applied to test the apoptosis; amyloid protein granule deposition was detected via Methenamine silver staining; Western blot (WB) analysis, immunohistochemistry, and RT-PCR were applied to measure the expression of A
    Language English
    Publishing date 2020-04-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2020/3019674
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Qingxin Kaiqiao Fang Inhibits A

    Wang, Tian-Qi / Lai, Xiao-Xiao / Xu, Lu-Ting / Shen, Yan / Lin, Jian-Wei / Gao, Shi-Yu / Hu, Hai-Yan

    Evidence-based complementary and alternative medicine : eCAM

    2020  Volume 2020, Page(s) 9058135

    Abstract: Qingxin kaiqiao fang (QKF), a traditional Chinese medicine compound, has been applied to treat Alzheimer's disease (AD) for many years and has exhibited remarkable effects. However, the underlying mechanism is still not explicit. The current study aims ... ...

    Abstract Qingxin kaiqiao fang (QKF), a traditional Chinese medicine compound, has been applied to treat Alzheimer's disease (AD) for many years and has exhibited remarkable effects. However, the underlying mechanism is still not explicit. The current study aims to investigate whether QKF exerts an antiapoptotic role through the p38 MAPK pathway in the course of AD. Network pharmacology analysis was applied to study the effective components, possible therapeutic targets, and AD-related pathway of QKF. Further, the AD cell model was established using amyloid-beta (A
    Language English
    Publishing date 2020-08-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2020/9058135
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  4. Article: Latifolin protects against myocardial infarction by alleviating myocardial inflammatory via the HIF-1α/NF-κB/IL-6 pathway

    Lai, Xiao-Xiao / Zhang, Ni / Chen, Lan-Ying / Luo, Ying-Ying / Shou, Bin-Yao / Xie, Xin-Xu / Liu, Rong-Hua

    Pharmaceutical biology. 2020 Jan. 1, v. 58, no. 1

    2020  

    Abstract: The Traditional Chinese herb medicine Dalbergia odorifera T. Chen (Fabaceae), exerted a protective effect on myocardial ischaemia. Latifolin is a neoflavonoid extracted from Dalbergia odorifera. It has been reported to have the effects of anti- ... ...

    Abstract The Traditional Chinese herb medicine Dalbergia odorifera T. Chen (Fabaceae), exerted a protective effect on myocardial ischaemia. Latifolin is a neoflavonoid extracted from Dalbergia odorifera. It has been reported to have the effects of anti-inflammation and cardiomyocyte protection. To investigate whether latifolin can improve myocardial infarction (MI) through attenuating myocardial inflammatory and to explore its possible mechanisms. Left coronary artery was ligated to induce a rat model of MI, and the rats were treated with sodium carboxymethyl cellulose (CMC-Na) or different doses of latifolin (25, 50, 100 mg/kg/d) by oral gavage for 28 days. Serum contents of myocardial enzyme were measured at seven and fourteen days after treatment. Cardiac function, infarct size, histopathological changes and inflammatory cells infiltration was assessed at 28 days after treatment. Western blotting was used to investigate the underlying mechanisms. Latifolin treatment markedly decreased the contents of myocardial enzymes, and increased left ventricular ejection fraction (85.27% vs. 59.11%) and left ventricular fractional shortening (62.71% vs. 45.53%). Latifolin was found to significantly reduced infarction size (27.78% vs. 39.07%), myocardial fibrosis and the numbers of macrophage infiltration (436 cells/mm² vs. 690 cells/mm²). In addition, latifolin down-regulated the expression levels of hypoxia-inducible factor-1α (0.95-fold), phospho-nuclear factor-κB (0.2-fold) and interleukin-6 (1.11-fold). Latifolin can protect against myocardial infarction by improving myocardial inflammation through the HIF-1α/NF-κB/IL-6 signalling pathway. Accordingly, latifolin may be a promising drug for pharmacological treatment of ischaemic cardiovascular disease.
    Keywords Dalbergia odorifera ; Oriental traditional medicine ; animal models ; blood serum ; carboxymethylcellulose ; cardiac output ; cardiomyocytes ; coronary vessels ; drugs ; enzymes ; fibrosis ; histopathology ; infarction ; inflammation ; interleukin-6 ; macrophages ; myocardial infarction ; protective effect
    Language English
    Dates of publication 2020-0101
    Size p. 1165-1175.
    Publishing place Taylor & Francis
    Document type Article
    ZDB-ID 1440131-9
    ISSN 1744-5116 ; 1388-0209
    ISSN (online) 1744-5116
    ISSN 1388-0209
    DOI 10.1080/13880209.2020.1840597
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

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  5. Article: [Risk factors analysis and security application discussion of Polygonum multiflorum based on retrospective study].

    Lai, Xiao-Xiao / Wu, Jun-Biao / Chen, She / Lai, Ping / Wang, Xiao-Hui / Wang, Ying-Yan / Luo, Yi-Ni / Lin, Hua

    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

    2018  Volume 43, Issue 15, Page(s) 3205–3210

    Abstract: In recent years，hepatotoxicity problem of Polygonum multiflorum has caused high attention. Domestic scholars also explored the causes of liver damage caused by it. For example, the establishment of guideline for diagnosis and treatment of herb-induced ... ...

    Abstract In recent years，hepatotoxicity problem of Polygonum multiflorum has caused high attention. Domestic scholars also explored the causes of liver damage caused by it. For example, the establishment of guideline for diagnosis and treatment of herb-induced liver injury, and the theory about relationship between hepatocyte toxicity and chemical composition, solvents, processing, use and pathological basis of patients and so on. To try to combine theory with practice，author analyzed risk factors about the case reports of P. multiflorum causing liver damage, and made some suggestions on P. multiflorum about individualized application, drug selection and requirements for taking. This for providing reference for the safe use of P. multiflorum.
    MeSH term(s) Chemical and Drug Induced Liver Injury ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/toxicity ; Fallopia multiflora/chemistry ; Fallopia multiflora/toxicity ; Hepatocytes/drug effects ; Humans ; Retrospective Studies ; Risk Factors
    Chemical Substances Drugs, Chinese Herbal
    Language Chinese
    Publishing date 2018-08-29
    Publishing country China
    Document type Journal Article
    ZDB-ID 1004649-5
    ISSN 1001-5302 ; 0254-0029
    ISSN 1001-5302 ; 0254-0029
    DOI 10.19540/j.cnki.cjcmm.20180529.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: [Summary and analysis of safety warning on clinical application of anti-cold Chinese patent medicine preparations].

    Lai, Xiao-xiao / Lin, Hua / Luo, Yi-ni / Wang, Ying-yan / Duan, Xiao-hong / Wang, Lin / Luo, Rui / Chen, Yan-hong

    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

    2015  Volume 40, Issue 8, Page(s) 1594–1600

    Abstract: In China, many surveys have shown that most people do not have a correct understanding about cold and administration of anti-cold Chinese patent medicine preparations. The author conducted a systematic summary and analysis on the actual application of ... ...

    Abstract In China, many surveys have shown that most people do not have a correct understanding about cold and administration of anti-cold Chinese patent medicine preparations. The author conducted a systematic summary and analysis on the actual application of anti-cold Chinese patent medicine preparations as well as the warning on safe application of anti-cold Chinese patent medicine preparations in Clinical Medication Information of China Pharmacopoeia, in the expectation of reducing the blind application of anti-cold Chinese patent medicine preparations and providing traditional Chinese medicine pharmacists new ideas in monitoring the safe application of exterior syndrome-relieving Chinese patent medicine preparations.
    MeSH term(s) China ; Common Cold/drug therapy ; Drugs, Chinese Herbal/adverse effects ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/therapeutic use ; Humans ; Nonprescription Drugs/adverse effects ; Nonprescription Drugs/chemistry ; Nonprescription Drugs/therapeutic use
    Chemical Substances Drugs, Chinese Herbal ; Nonprescription Drugs
    Language Chinese
    Publishing date 2015-04
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 1004649-5
    ISSN 1001-5302 ; 0254-0029
    ISSN 1001-5302 ; 0254-0029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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