LIVIVO - Search results -

Search results

Result 1 - 10 of total 23

Search options

Article ; Online: War in Europe: health implications of environmental nuclear disaster amidst war.

Laine, Jessica E

2022 Volume 37, Issue 3, Page(s) 221–225

Abstract: Recent incidents at nuclear facilities in Ukraine related to the attacks from Russian forces highlight the fragility of nuclear power plants and other nuclear facilities in war and the very real potential for another environmental nuclear disaster and ... ...

Abstract	Recent incidents at nuclear facilities in Ukraine related to the attacks from Russian forces highlight the fragility of nuclear power plants and other nuclear facilities in war and the very real potential for another environmental nuclear disaster and associated health risks in Europe. Nuclear catastrophes from war can occur from radioactive materials released from war threatened nuclear power plants and other nuclear facilities in war zones, in addition to the direct threat from the deployment of nuclear weaponry and can result in immediate and long-term health impacts. Despite historical nuclear catastrophic events, including the Chernobyl nuclear power plant accident and atomic bombings of Hiroshima and Nagasaki, and that for more than a century epidemiologists have studied the consequences of radiation exposures, there are still major unanswered questions regarding radiation risks and human health. Epidemiologists will need to continue to quantify the health effects from exposure to environmental radiation, including background radiation, and are able to contribute to conversations about reliance on nuclear energy and alternative energy futures. As a society we are compelled to rethink our ties to nuclear energy, especially with the potential of increasing reliance on nuclear power amid oil and gas crisis and considering climate change, nuclear warfare, including nuclear weapon testing, and the fragility of humanity and health to even low doses of radiation from these and other natural and unnatural sources.
MeSH term(s)	Chernobyl Nuclear Accident ; Disasters ; Europe ; Humans ; Nuclear Reactors ; Nuclear Weapons
Language	English
Publishing date	2022-04-15
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	632614-6
ISSN	1573-7284 ; 0393-2990
ISSN (online)	1573-7284
ISSN	0393-2990
DOI	10.1007/s10654-022-00862-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 2090: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾

Article ; Online: The exposome approach to study children's health

Handakas, Evangelos / Robinson, Oliver / Laine, Jessica E.

Current Opinion in Environmental Science & Health. 2023 Apr., v. 32 p.100455-

2023

Abstract: The exposome represents an interdisciplinary science and promising field of research that can identify how multiple facets of the environment influences health across the lifespan. A particular sensitive and critical window for environmental exposures ... ...

Abstract	The exposome represents an interdisciplinary science and promising field of research that can identify how multiple facets of the environment influences health across the lifespan. A particular sensitive and critical window for environmental exposures and exposure-associated health is during early life, especially childhood. Previous studies of the exposome during childhood are highlighted, including the external and internal exposome. Challenges, and potential ways to overcome them, of the childhood exposome are presented with the aims to improve exposome studies during early life.
Keywords	childhood ; environmental science ; exposome ; longevity ; Children's health ; Children ; Environmental pollutants ; Health
Language	English
Dates of publication	2023-04
Publishing place	Elsevier B.V.
Document type	Article ; Online
Note	Use and reproduction
ISSN	2468-5844
DOI	10.1016/j.coesh.2023.100455
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Accelerated ageing in the COVID-19 pandemic: A dilemma for healthy ageing.

Guo, Xiaolei / Franco, Oscar H / Laine, Jessica E

Maturitas

2021 Volume 157, Page(s) 68–69

MeSH term(s)	Aging ; COVID-19 ; Healthy Aging ; Humans ; Pandemics ; SARS-CoV-2
Language	English
Publishing date	2021-12-27
Publishing country	Ireland
Document type	Editorial
ZDB-ID	80460-5
ISSN	1873-4111 ; 0378-5122
ISSN (online)	1873-4111
ISSN	0378-5122
DOI	10.1016/j.maturitas.2021.12.009
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1432: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 575: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: A Systems Toxicology-based Approach Reveals Biological Pathways Dysregulated by Prenatal Arsenic Exposure.

Laine, Jessica E / Fry, Rebecca C

Annals of global health

2016 Volume 82, Issue 1, Page(s) 189–196

Abstract: Background: Prenatal exposure to inorganic arsenic (iAs) is associated with dysregulated fetal gene and protein expression. Potential biological mechanisms that underlie these changes include, but are not limited to, changes to the epigenome.: ... ...

Abstract	Background: Prenatal exposure to inorganic arsenic (iAs) is associated with dysregulated fetal gene and protein expression. Potential biological mechanisms that underlie these changes include, but are not limited to, changes to the epigenome. Objective: The aim of the present study was to identify whether the expression of key genes, proteins, or both and their associated biological pathways are perturbed by compiling datasets from studies on prenatal arsenic exposure. Methods: We compiled datasets from 12 studies that analyzed the relationship between prenatal iAs exposure and changes to the fetal epigenome (5-methyl cytosine), transcriptome (mRNA expression), and/or proteome (protein expression). Findings: Across the 12 studies, a set of 845 unique genes was identified and found to enrich for their role in biological pathways, including the peroxisome proliferator-activated receptor, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, and the glucocorticoid receptor. Tumor necrosis factor was identified as a putative cellular regulator underlying most (n = 277) of the identified iAs-associated gene or protein expression changes. Conclusions: The identification of the common set of genes across numerous human cohorts suggests a conserved biological response to prenatal arsenic exposure. The genes/proteins and their associated pathways may be useful in future mechanistic investigations of iAs associated diseases.
MeSH term(s)	5-Methylcytosine ; Arsenic/toxicity ; B-Lymphocytes ; Epigenomics ; Female ; Gene Expression Regulation, Developmental/drug effects ; Humans ; Peroxisome Proliferator-Activated Receptors ; Pregnancy ; Prenatal Exposure Delayed Effects ; Receptors, Glucocorticoid/genetics ; Receptors, Glucocorticoid/metabolism ; Signal Transduction/drug effects ; Toxicogenetics
Chemical Substances	Peroxisome Proliferator-Activated Receptors ; Receptors, Glucocorticoid ; 5-Methylcytosine (6R795CQT4H) ; Arsenic (N712M78A8G)
Language	English
Publishing date	2016-01
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, N.I.H., Extramural
ZDB-ID	2821756-1
ISSN	2214-9996 ; 2214-9996
ISSN (online)	2214-9996
ISSN	2214-9996
DOI	10.1016/j.aogh.2016.01.015
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Clinical presentation of simple and combined or syndromic arteriovenous malformations.

Bernhard, Sarah M / Tuleja, Aleksandra / Laine, Jessica E / Haupt, Fabian / Häberli, Dario / Hügel, Ulrike / Rössler, Jochen / Schindewolf, Marc / Baumgartner, Iris

Journal of vascular surgery. Venous and lymphatic disorders

2021 Volume 10, Issue 3, Page(s) 705–712

Abstract: Objective: Arteriovenous malformations of the lower extremities (AVM: Methods: We conducted a retrospective analysis of a consecutive series of patients with AVM: Results: Overall, 506 patients were prospectively enrolled in the Bernese Congenital ...

Abstract	Objective: Arteriovenous malformations of the lower extremities (AVM Methods: We conducted a retrospective analysis of a consecutive series of patients with AVM Results: Overall, 506 patients were prospectively enrolled in the Bernese Congenital Vascular Malformation Registry, 31 (6%) with AVM Conclusions: Patients with congenital simple AVM
MeSH term(s)	Adolescent ; Female ; Follow-Up Studies ; Humans ; Intracranial Arteriovenous Malformations/complications ; Intracranial Hemorrhages ; Male ; Retrospective Studies ; Treatment Outcome
Language	English
Publishing date	2021-10-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2213-3348
ISSN (online)	2213-3348
DOI	10.1016/j.jvsv.2021.10.002
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Menopause and cardiometabolic diseases: What we (don't) know and why it matters.

Roa-Díaz, Zayne M / Raguindin, Peter Francis / Bano, Arjola / Laine, Jessica E / Muka, Taulant / Glisic, Marija

Maturitas

2021 Volume 152, Page(s) 48–56

Abstract: This narrative review discusses the current understanding, knowledge gaps and challenges in expanding our knowledge of the association between menopause and the reproductive aging process and cardiometabolic disease (CMD) in women, with a focus on type 2 ...

Abstract	This narrative review discusses the current understanding, knowledge gaps and challenges in expanding our knowledge of the association between menopause and the reproductive aging process and cardiometabolic disease (CMD) in women, with a focus on type 2 diabetes and cardiovascular disease. The physiological changes that occur at different stages of the reproductive life span, as well as type of menopause and timing, are factors widely associated with CMD risk; however, the underlying mechanisms remain either unclear or insufficiently studied. Decreased ovarian estrogen production and relative androgen excess around menopause onset are the most studied factors linking menopause and cardiometabolic health; nevertheless, the evidence is not persuasive and other hypotheses might explain the changes in CMD risk during menopausal transition. In this context, hormone therapy has been widely adopted in the treatment and prevention of CMD, although uncertainty regarding its cardiometabolic effects has raised the need to optimize therapeutic modalities. Mechanisms such as the "iron overload theory" and new "omics" platforms could provide new insights into potential pathways underlying the association between menopause and cardiometabolic health, such as the DNA damage response. Although it has been widely reported that environmental and lifestyle factors affect both menopause and cardiometabolic health, there is little evidence on the role of these exposures in menopause-associated CMD risk.
MeSH term(s)	Aging ; Cardiovascular Diseases/etiology ; Diabetes Mellitus, Type 2/etiology ; Female ; Humans ; Menopause/physiology ; Reproduction ; Women's Health
Language	English
Publishing date	2021-07-02
Publishing country	Ireland
Document type	Journal Article ; Review
ZDB-ID	80460-5
ISSN	1873-4111 ; 0378-5122
ISSN (online)	1873-4111
ISSN	0378-5122
DOI	10.1016/j.maturitas.2021.06.013
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1432: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 575: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Eating behaviors and health-related quality of life: A scoping review.

Pano, Octavio / Gamba, Magda / Bullón-Vela, Vanessa / Aguilera-Buenosvinos, Inmaculada / Roa-Díaz, Zayne M / Minder, Beatrice / Kopp-Heim, Doris / Laine, Jessica E / Martínez-González, Miguel Ángel / Martinez, Alfredo / Sayón-Orea, Carmen

Maturitas

2022 Volume 165, Page(s) 58–71

Abstract: Discrepancies between total life expectancy and healthy life expectancy are in part due to unhealthy lifestyles, in which diet plays an important role. Despite this knowledge, observational studies and randomized trials have yet to show consistent ... ...

Abstract	Discrepancies between total life expectancy and healthy life expectancy are in part due to unhealthy lifestyles, in which diet plays an important role. Despite this knowledge, observational studies and randomized trials have yet to show consistent improvements in health and well-being, also known as health-related quality of life (HRQoL), given the variety of elements that conform a healthy diet aside from its content. As such, we aimed to describe the evidence and common topics concerning the effects of modifiable eating behaviors and HRQoL in patients with non-communicable diseases (NCD). This scoping review of six electronic databases included 174 reports (69 % were experimental studies, 10 % longitudinal studies, and 21 % cross-sectional studies). Using VOSviewer, a bibliometric tool with text mining functionalities, we identified relevant aspects of dietary assessments and interventions. Commonly observed topics in experimental studies were those related to diet quality (micro- and macronutrients, food items, and dietary patterns). In contrast, less was found regarding eating schedules, eating locations, culturally accepted food items, and the role of food insecurity in HRQoL. Disregarding these aspects of diets may be limiting the full potential of nutrition as a key element of health and well-being in order to ensure lengthy and fulfilling lives.
MeSH term(s)	Cross-Sectional Studies ; Diet ; Eating ; Feeding Behavior ; Humans ; Life Style ; Quality of Life
Language	English
Publishing date	2022-07-22
Publishing country	Ireland
Document type	Journal Article ; Review
ZDB-ID	80460-5
ISSN	1873-4111 ; 0378-5122
ISSN (online)	1873-4111
ISSN	0378-5122
DOI	10.1016/j.maturitas.2022.07.007
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1432: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 575: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Association Between Ultra-Processed Food Intake and All-Cause Mortality: A Systematic Review and Meta-Analysis.

Taneri, Petek Eylul / Wehrli, Faina / Roa-Díaz, Zayne M / Itodo, Oche Adam / Salvador, Dante / Raeisi-Dehkordi, Hamidreza / Bally, Lia / Minder, Beatrice / Kiefte-de Jong, Jessica C / Laine, Jessica E / Bano, Arjola / Glisic, Marija / Muka, Taulant

American journal of epidemiology

2022 Volume 191, Issue 7, Page(s) 1323–1335

Abstract: Consumption of ultra-processed foods (UPF) has increased worldwide during the last decades because they are hyperpalatable, cheap, and ready-to-consume products. However, uncertainty exists about their impact on health. We conducted a systematic review ... ...

Abstract	Consumption of ultra-processed foods (UPF) has increased worldwide during the last decades because they are hyperpalatable, cheap, and ready-to-consume products. However, uncertainty exists about their impact on health. We conducted a systematic review and meta-analysis evaluating the association of UPF consumption with all-cause mortality risk. Five bibliographic databases were searched for relevant studies. Random effects models were used to calculate pooled relative risks (RRs) and 95% confidence intervals (CIs). Of 6,951 unique citations, 40 unique prospective cohort studies comprising 5,750,133 individuals were included; publication dates ranged from 1984 to 2021. Compared with low consumption, highest consumption of UPF (RR = 1.29, 95% CI: 1.17, 1.42), sugar-sweetened beverages (RR = 1.11, 95% CI, 1.04, 1.18), artificially sweetened beverages (RR = 1.14, 95% CI, 1.05, 1.22), and processed meat/red meat (RR = 1.15, 95% CI, 1.10, 1.21) were significantly associated with increased risk of mortality. However, breakfast cereals were associated with a lower mortality risk (RR = 0.85, 95% CI, 0.79, 0.92). This meta-analysis suggests that high consumption of UPF, sugar-sweetened beverages, artificially sweetened beverages, processed meat, and processed red meat might increase all-cause mortality, while breakfast cereals might decrease it. Future studies are needed to address lack of standardized methods in UPF categorization.
MeSH term(s)	Eating ; Fast Foods/adverse effects ; Humans ; Meat ; Prospective Studies ; Sweetening Agents/adverse effects
Chemical Substances	Sweetening Agents
Language	English
Publishing date	2022-02-26
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	2937-3
ISSN	1476-6256 ; 0002-9262
ISSN (online)	1476-6256
ISSN	0002-9262
DOI	10.1093/aje/kwac039
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Un I Zs.310: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: A systematic review of the safety and efficacy of currently used treatment modalities in the treatment of patients with PIK3CA-related overgrowth spectrum.

Bernhard, Sarah M / Adam, Luise / Atef, Hady / Häberli, Dario / Bramer, Wichor M / Minder, Beatrice / Döring, Yvonne / Laine, Jessica E / Muka, Taulant / Rössler, Jochen / Baumgartner, Iris

Journal of vascular surgery. Venous and lymphatic disorders

2021 Volume 10, Issue 2, Page(s) 527–538.e2

Abstract: Background: PIK3CA (activating mutations of the p110α subunit of phosphatidylinositol 3-kinases)-related overgrowth spectrums (PROS) include a variety of clinical presentations that are associated with hypertrophy of different parts of the body. We ... ...

Abstract	Background: PIK3CA (activating mutations of the p110α subunit of phosphatidylinositol 3-kinases)-related overgrowth spectrums (PROS) include a variety of clinical presentations that are associated with hypertrophy of different parts of the body. We performed a systematic literature review to assess the current treatment options and their efficacy and safety for PROS. Methods: A literature search was performed in Embase, MEDLINE (Ovid), Web of Science Core Collection, Cochrane Central Register of Controlled Trials, ClinicalTrials.gov, and Google Scholar to retrieve studies on the treatment of hypertrophy in PROS. Randomized controlled trials, cohort studies, and case series with ≥10 patients were included in the present review. The titles, abstracts, and full text were assessed by two reviewers independently. The risk of bias was assessed using the Newcastle-Ottawa scale. Results: We included 16 studies of the treatment of hypertrophy in PROS patients, 13 (81.3%) from clinical retrospective studies and 3 (13.7%) from prospective cohort studies. The risk of bias grade was low for 2, medium for 12, and high for 2 studies. Of the 16 studies, 13 reported on surgical treatment and 3 reported pharmacologic treatment using phosphatidylinositol-3-kinase (PI3K)/mammalian target of rapamycin (mTOR) pathway inhibitors in PROS patients. In 3 studies, PROS was defined by a mutation in the PIK3CA gene, and 13 studies relied on a clinical definition of PROS. Surgical therapy was beneficial for a specific subgroup of PROS (macrodactyly). However, little has been reported concerning surgery and the potential benefits for other PROS entities. The reported side effects after surgical therapy were mostly prolonged wound healing or scarring. PI3K/mTOR pathway inhibition was beneficial in patients with PROS by reducing hypertrophy and systemic symptoms. The adverse effects reported included infection, changes in blood count, liver enzymes, and metabolic measures. Conclusions: Surgery is a locally limited treatment option for specific types of PROS. A promising treatment option for PROS is pharmacologic PIK3CA inhibition. However, the level of evidence on the treatment of overgrowth in PROS patients is limited.
MeSH term(s)	Class I Phosphatidylinositol 3-Kinases/antagonists & inhibitors ; Class I Phosphatidylinositol 3-Kinases/genetics ; Class I Phosphatidylinositol 3-Kinases/metabolism ; Genetic Predisposition to Disease ; Humans ; Hypertrophy/diagnosis ; Hypertrophy/enzymology ; Hypertrophy/genetics ; Hypertrophy/therapy ; MTOR Inhibitors/adverse effects ; MTOR Inhibitors/therapeutic use ; Molecular Targeted Therapy ; Mutation ; Phenotype ; Phosphoinositide-3 Kinase Inhibitors/adverse effects ; Phosphoinositide-3 Kinase Inhibitors/therapeutic use ; Signal Transduction ; Surgical Procedures, Operative/adverse effects ; Syndrome ; Treatment Outcome
Chemical Substances	MTOR Inhibitors ; Phosphoinositide-3 Kinase Inhibitors ; Class I Phosphatidylinositol 3-Kinases (EC 2.7.1.137) ; PIK3CA protein, human (EC 2.7.1.137)
Language	English
Publishing date	2021-08-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Systematic Review
ISSN	2213-3348
ISSN (online)	2213-3348
DOI	10.1016/j.jvsv.2021.07.008
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Correction to: Maternal one carbon metabolism and arsenic methylation in a pregnancy cohort in Mexico.

Laine, Jessica E / Ilievski, Vesna / Richardson, David B / Herring, Amy H / Stýblo, Miroslav / Rubio-Andrade, Marisela / Garcia-Vargas, Gonzalo / Gamble, Mary V / Fry, Rebecca C

Journal of exposure science & environmental epidemiology

2019 Volume 29, Issue 5, Page(s) 732

Abstract: A correction to this paper has been published and can be accessed via link at the top of the paper. ...

Abstract	A correction to this paper has been published and can be accessed via link at the top of the paper.
Language	English
Publishing date	2019-06-06
Publishing country	United States
Document type	Published Erratum
ZDB-ID	2218551-3
ISSN	1559-064X ; 1559-0631
ISSN (online)	1559-064X
ISSN	1559-0631
DOI	10.1038/s41370-019-0147-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Bonn / Germany

Z 7529: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

To top

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED